著者

Kousuke Seki

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

pp.20159, (Released:2021-08-20)

被引用文献数

6

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Coupled with the reduction in sequencing costs, the number of RAD-seq analysis have been surging, generating vast genetic knowledge in relation with many crops. Specialized platforms might be intimidating to non-expert users and difficult to implement on each computer despite the growing interest in the usage of the dataset obtained by high-throughput sequencing. Therefore, RAD-R scripts were developed on Windows10 for RAD-seq analysis, allowing users who are not familiar with bioinformatics to easily analyze big sequence data. These RAD-R scripts that run a flow from raw sequence reads of F2 population for the self-fertilization plants to the linkage map construction as well as the QTL analysis can be also useful to many users with limited experience due to the simplicity of copying Excel cells into the R console. During the comparison of linkage maps constructed by RAD-R scripts and Stacks, RAD-R scripts were shown to construct the linkage map with less missing genotype data and a shorter total genetic distance. QTL analysis results can be easily obtained by selecting the reliable genotype data that is visually inferred to be appropriate for error correction from the genotype data files created by RAD-R scripts.

著者

高岡 恒郎

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.24, no.5, pp.412-418, 1966-05-01 (Released:2010-06-28)

参考文献数

52

被引用文献数

2 5

著者

長谷川 明紀

出版者

皇學館大学文学部 ; 2009-

雑誌

皇學館大学紀要 = Bulletin of Kogakkan University (ISSN:18836984)

巻号頁・発行日

no.55, pp.186-158, 2017-03

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醍醐寺蔵『諸経中陀羅尼集』の最初に掲載されている法華経陀羅尼と『法華経山家本』の法華経陀羅尼は、慈覚大師点本に由来するとされているので、両本における漢字加点が比較検討された。仮名、声点に加えて、ダッシュ(-) 印が醍醐寺本における加点に含まれる。このダッシュ印は、悉曇文字一字が漢字二文字を用いて音訳される場合、この漢字間に導入されていると結論された。 陀羅尼では、上声および去声の声点は、悉曇字に従ってそれぞれ短音および長音を識別する記号として代用されることが知られている。これら両本での声点を比較して、『法華経山家本』の声点の幾つかは時代の経過につれて変化しているものの、両本は慈覚大師を源流とする事を示す多くの共通した特徴をもつことが明らかにされた。 Since Lotus Sutra dhāran・īs in the first set of "A Collection of Dhāra n・īsin Sutras " stored in Daigo-ji Temple and contained in "The Hokekyo Sangebon " are believed to have their origins in a text of Jikaku Daishi(Ennin), the guiding notes added beside the kanji of the dhāran・īs were compared between these two texts.In addition to kana and accent marks, dash (-) marks are involved in the guiding notes in the Daigo-ji text. Each of the dash marks was concluded to be introduced between the two kanji into which a single original siddham・ script was transliterated.In dhāran・īs, the accent marks of jyosho (high pitch) and kyosho (rising pitch) are known to be substituted for the marks distinguishing between short and long sounds, respectively, according to the siddham・ scripts. The comparison of the accent marks between the two texts leads us to the conclusion that both texts have many common characteristics suggesting the origin from Jikaku Daishi, while some of the accent marks in "The Hokekyo Sangebon " were subject to alteration in the process of time.

著者

植野 研

出版者

一般社団法人 人工知能学会

雑誌

人工知能 (ISSN:21882266)

巻号頁・発行日

vol.35, no.1, pp.1, 2020-01-01 (Released:2020-09-29)

著者

井谷 善則

出版者

大阪教育大学

雑誌

大阪教育大学紀要 (0xF9C4)教育科学 04 教育科学 (ISSN:03893472)

巻号頁・発行日

no.22, pp.109-117, 1974-02

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As an attempt to make clear the mechanism of the maternal and filial affections in a disordered family, I made a survey of the mechanism of school phobia. A primary factor is maternal excessive cares of children or home education. In this attempt, the following aspects are considered important as the basis of further studies of family ties: 1) We refuse to trust others with our judgements of value. 2) We confront diversity of value. 3) We worry ourselves about want of feelings of worth and a measure of value. In this paper these three aspects are reviewed and to consider the mechanism of a family it is found that these aspects play a important role to bring the domestic felicity.

著者

矢数 道明

出版者

The Japan Society for Oriental Medicine

雑誌

日本東洋醫學會誌 (ISSN:1884202X)

巻号頁・発行日

vol.14, no.1, pp.6-17, 1963-07-31 (Released:2010-10-21)

参考文献数

11

著者

BUSTOS Itzel

出版者

名古屋大学

雑誌

若手研究

巻号頁・発行日

2018-04-01

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本研究は、抗PD-L1抗体を腫瘍溶解性ウイルス表面に発現させることにより、ウイルスにPD-L1発現細胞への指向性を付加するだけでなく、免疫チェックポイント阻害剤としての機能を付加した画期的な新規ウイルスを開発することを目的とした。抗PD-L1抗体遺伝子ベクターの構築に成功したが、目的のウイルス(HF10αPD-L1)の作成には至っていない。マウス扁平上皮癌SCCⅦの両側側腹部腫瘍に対するHF10と抗PD-L1抗体との併用により、両側の腫瘍に対して強い抗腫瘍効果を示した。この抗腫瘍効果の増強には腫瘍への免疫細胞の浸潤の関与が示唆された。

出版者

NPO法人 地下からのサイン測ろうかい

雑誌

コラボ : 地下からのサイン測ろうかい会報 : カーダス会報 (ISSN:24361534)

巻号頁・発行日

vol.6, pp.35, 2020 (Released:2021-03-30)

著者

小山 誠次

出版者

The Japan Society for Oriental Medicine

雑誌

日本東洋医学雑誌 (ISSN:02874857)

巻号頁・発行日

vol.45, no.3, pp.529-534, 1995-01-20 (Released:2010-03-12)

参考文献数

23

被引用文献数

2 1

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加味逍遙散の出典は書物により一定しない。今日の10種薬物の処方からみれば,『和剤局方』には単に逍遙散のみ収載され,『女科撮要』,『内科摘要』には生姜, 薄荷を含まない8種薬物の処方が収載されているだけである。薛己以後,『万病回春』に初めて10種薬物の処方が登場する。また四物湯合方の出典も書物により一定しない。『和剤局方』には四物湯合方の記載はないが,『内科摘要』に8種薬物処方の加味逍遙散合四物湯の医案例がある。更に『勿誤薬室方函口訣』には10種薬物処方の加味逍遙散合四物湯は確かに記載されているが, 今回の調査でそれより約90年前の『療治経験筆記』に周身痒瘡に対する同合方の記載を見出した。一般的に方剤の出典は, 加味逍遙散のように成立経緯が複雑な場合, 構成の各段階に貢献のあった所作は全て出典の一部分をなし, 合方については原則的に複数処方を用いて著明な治験例があった所作が出典になると考察した。

著者

Naoto Ishimaru Yohei Kanzawa Hiroyuki Seto Saori Kinami

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.58, no.15, pp.2251-2255, 2019-08-01 (Released:2019-08-01)

参考文献数

17

被引用文献数

2 3

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We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. The rapid plasma reagin ratio was 1:3. She was diagnosed with syphilitic cervicitis and treated with amoxicillin for four weeks. Initial cervical cytology showed cells with mild nuclear enlargement, which was thought to be metaplasia associated with syphilis. Repeated cytology a month later showed a high-grade squamous intraepithelial lesion. A punch biopsy of the lesion led to the pathological diagnosis of cervical carcinoma in situ. We performed cervical conization, and no recurrence occurred. Human papillomavirus (HPV) immunostaining was positive in the lesion. Mucosal lesions are an infrequently reported symptom of syphilis. When oropharyngeal lesions are found, the sexual history should be ascertained, and the patient should be screened for sexually transmitted diseases. HPV is especially significant because of its association with cervical cancer. Coinfection of HPV with cervical cancer must be ruled out during follow-up for women when oropharyngeal syphilis involves genital lesions.

著者

千成 俊夫

出版者

奈良教育大学

雑誌

奈良教育大学紀要 人文・社会科学 (ISSN:05472393)

巻号頁・発行日

vol.33, no.1, pp.p87-107, 1984-11

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Contmporary society is changing fundamentally and rapidly. We feel it is changing so fundamentally and rapidly that we have difficulty fitting ourselves into the present and projecting ourselves into the future. We, as educators, take on a responsibility that make children grow up in all aspects and help them live in the future. For the sake of fulfilling our such responsibility, it is always important for educators to be aware of international recent developments and trends in education. From the beginning of public school education to the present, Japanese music education has been owed the United States of America a great many things. Especially after World War II, we have to say its influence is very prominent. It may be said that the contemporary period of music education in the United States have begun in 1957. In that year the Ford Foundation began to explore the relationship of the arts and American society. The Music Educators National Conferrenc submitted a proposal to the Ford Foundation that a project about curricula innovation of music education, named the Contemporary Music Project for Creativity in Music Education be inaugurated. In 1963 the Ford Foundation accepted the proposal, and since then until today various projects have been started. There are various differences between music education in America and Japan, and therefore it is difficult to make many problems which have been taking place one after another in American music education clear. But we will be able to get many important informations from the movements of music curricula innovation in the United States. Curriculum is the structure and sequence of learning experiences in formalized instructional settings. Its immediate problem is the quality, content, and organization of in school learning experiences. We, as music teachers, have to arrange curricular experiences in music. We manage instruction and manipulate the learning enviroment for optimum achievement of predefined objectives. The intent of this study is to give essential suggestions which help us make better music education curriculum in Japan of today. The study divides into three parts. Part one, this treatise, presents an overview of the music curricula innovation movements of the United States concerning the period from the 1960s to the present. Part two, the next treatise, explores the contents and teaching methods of music education being related to the music curricula innovations. As the results of two prestudies Part three, the final treatise, will present the concrete suggestion for building music instructional programs.

著者

千成 俊夫 八木 正一 吉田 孝

出版者

北海道大学教育学部教育方法学研究室

雑誌

教授学の探究 (ISSN:02883511)

巻号頁・発行日

no.3, pp.1-32, 1985-03-26

著者

佐々木 憲介

出版者

北海道大学大学院経済学研究科

雑誌

經濟學研究 (ISSN:04516265)

巻号頁・発行日

vol.60, no.3, pp.241-253, 2010-12

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1870年代から20世紀初頭にかけて, イギリスにおいても歴史学派と称される一群の経済学者が現われ経済学上の有力な潮流となった。歴史学派は古典派の理論的・演繹的方法に対して歴史的方法を対置し, 古典派の方法論をさまざまな角度から批判した。しかし, 古典派を代表する経済学者の一人であったJ.S.ミルは, その『論理学体系』においてすでに歴史的方法について語っており, それ以外にも歴史学派のものとされる主張を展開していた。はたして, ミルの経済学方法論はイギリス歴史学派とどのような関係にあったのか。クリフ・レズリーは, ミルとリカードウとの違いを強調したが, 歴史学派の多くはむしろ両者の共通性に注目した。ミルは, 経済学の原理に関してはリカードウ派の立場を堅持しており, 新しく示された観点は観点の提示に留まっていて歴史研究の先駆的な業績があったわけではなかった。そのような意味で, 歴史学派にとってのミルは旧学派の一員であった。しかし, 実践的な意味では, ミルの学説は社会改良主義への突破口の一つになった。何人かの歴史学派がミルを評価したのはむしろこの点であった。

著者

Kenshi Watanabe Kim Hazel V. Arafiles Risa Higashi Yoshiko Okamura Takahisa Tajima Yukihiko Matsumura Yutaka Nakashimada Keisuke Matsuyama Tsunehiro Aki

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.67, no.5, pp.571-578, 2018 (Released:2018-05-01)

参考文献数

50

被引用文献数

12 35

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The marine eukaryotic microheterotroph thraustochytrid genus Aurantiochytrium is a known producer of polyunsaturated fatty acids, carotenoids, and squalene. We previously constructed a lipid fermentation system for Aurantiochytrium sp. strains using underutilized biomass, such as canned syrup and brown macroalgae. To improve the productivity, in this study, Aurantiochytrium sp. RH-7A and RH-7A-7 that produced high levels of carotenoids, such as astaxanthin and canthaxanthin, were isolated through chemical mutagenesis. Moreover, metabolomic analysis of the strain RH-7A revealed that oxidative stress impacts carotenoid accumulation. Accordingly, the addition of ferrous ion (Fe2+), as an oxidative stress compound, to the culture medium significantly enhanced the production of astaxanthin by the mutants. These approaches improved the productivity of astaxanthin up to 9.5 mg/L/day at the flask scale using not only glucose but also fructose which is the main carbon source in fermentation systems with syrup and brown algae as the raw materials.

著者

坂本 賢三 Kenzo Sakamoto

出版者

桃山学院大学経済学会

雑誌

桃山学院大学経済学論集 (ISSN:0286990X)

巻号頁・発行日

vol.5, no.4, 1964-07

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An attempt is made in the present article to rescrutinize the definition of the means of labour and to reclassify them by an investigation of the innovation in technology. The means of labour as understood by the author is the thing or a complex of things which the labourer inserts between him and the object and which serves as conductor of activity on this object. This definition was given by Karl Marx in 1867. Preface I. Definition of the means of labour. II. The means as a moment of the process of production. III. Teleology and the process of production. IV. Particularity of the means. V. The means and human being--communication, control and projection. VI. Traditional classifications of the means of labour. VII. Specialization and evolution of the organs. VIII. Specialization and evolution of the means of labour. IX. An attempt to an improved classification of the means of labour, Conclusion. In this issue only the first four paragraphs are reported. First, the definition of the means of labour is re-examined by semantic treatment, and insisted that the means of labour is a moment in the process of production as the labour and the object. Considered in the second paragraph are the relation of <<Moment>>, <<Aufheben>> and <<(Dialektik>>, and the different content of the idea of <<Moment>> on each stage of logical development. On the stage of the most abstract conception, for instance, being, becoming, quality, quantity etc., each moment dissolves into the other. This process is only "transition". On the stage of essence, e. g. matter and form, the whole and its parts, force and its expression, substance and its attribute, cause and its effect, essence and its apparence etc., each moment returns to itself by relating to its own opposite. This process is called "reflexion". And on the stage of development, e. g. concept--universality, particurality and individuality --, judgment -- subject, predicate andcopula--, inference--major premise, minor premise and conclusion--, mechanism, chemical process, teleological process -- end, means, realization etc., each moment is the whole itself and independent. This mode is very peculiar. Though each moment maintains his direct form, relating each other the product are yielded. This process is named "development". The process of production is teleological. Then, compared is the logical structure of Hegel's <<Teleologie>> with the structure of Marx's conception of production process. Among the three moments in the process of production, the means of labour has a particularity of predominance as pointed out by Hegel, for example, the plough is superior than those consumption goods produced by the human work using the plough which are the objectives of the human work itself. The means (tool) preserves itself, in spite of the enjoyments disappear and are forgotten.

著者

吉田 文和

出版者

北海道大学經濟學部

雑誌

経済学研究 (ISSN:04516265)

巻号頁・発行日

vol.33, no.4, pp.p483-500, 1984-03

著者

坂本 賢三 Kenzo Sakamoto

雑誌

桃山学院大学経済学論集 = ST. ANDREW'S UNIVERSITY ECONOMIC REVIEW (ISSN:0286990X)

巻号頁・発行日

vol.5, no.4, 1964-06-01

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An attempt is made in the present article to rescrutinize the definition of the means of labour and to reclassify them by an investigation of the innovation in technology. The means of labour as understood by the author is the thing or a complex of things which the labourer inserts between him and the object and which serves as conductor of activity on this object. This definition was given by Karl Marx in 1867. Preface I. Definition of the means of labour. II. The means as a moment of the process of production. III. Teleology and the process of production. IV. Particularity of the means. V. The means and human being--communication, control and projection. VI. Traditional classifications of the means of labour. VII. Specialization and evolution of the organs. VIII. Specialization and evolution of the means of labour. IX. An attempt to an improved classification of the means of labour, Conclusion. In this issue only the first four paragraphs are reported. First, the definition of the means of labour is re-examined by semantic treatment, and insisted that the means of labour is a moment in the process of production as the labour and the object. Considered in the second paragraph are the relation of <<Moment>>, <<Aufheben>> and <<(Dialektik>>, and the different content of the idea of <<Moment>> on each stage of logical development. On the stage of the most abstract conception, for instance, being, becoming, quality, quantity etc., each moment dissolves into the other. This process is only "transition". On the stage of essence, e. g. matter and form, the whole and its parts, force and its expression, substance and its attribute, cause and its effect, essence and its apparence etc., each moment returns to itself by relating to its own opposite. This process is called "reflexion". And on the stage of development, e. g. concept--universality, particurality and individuality --, judgment -- subject, predicate andcopula--, inference--major premise, minor premise and conclusion--, mechanism, chemical process, teleological process -- end, means, realization etc., each moment is the whole itself and independent. This mode is very peculiar. Though each moment maintains his direct form, relating each other the product are yielded. This process is named "development". The process of production is teleological. Then, compared is the logical structure of Hegel's <<Teleologie>> with the structure of Marx's conception of production process. Among the three moments in the process of production, the means of labour has a particularity of predominance as pointed out by Hegel, for example, the plough is superior than those consumption goods produced by the human work using the plough which are the objectives of the human work itself. The means (tool) preserves itself, in spite of the enjoyments disappear and are forgotten.

著者

吉田 文和

出版者

北海道大学經濟學部

雑誌

經濟學研究 (ISSN:04516265)

巻号頁・発行日

vol.33, no.4, pp.31-48, 1984-03

著者

市川 佳宏

出版者

福島大学経済学会

雑誌

商学論集 (ISSN:02878070)

巻号頁・発行日

vol.51, no.4, pp.p91-119, 1983-03

著者

沢田 幸治

出版者

神奈川大学経済学会

雑誌

商経論叢 (ISSN:02868342)

巻号頁・発行日

vol.45, no.2, pp.79-94, 2010-01

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論説