著者
葉山 雅広 由井 正敏 今井 正
出版者
日本鳥学会
雑誌
日本鳥学会誌 (ISSN:0913400X)
巻号頁・発行日
vol.63, no.2, pp.297-310, 2014 (Released:2015-04-28)
参考文献数
55
被引用文献数
1 1

1990年から2008年にかけて山形県でクマタカ Nisaetus nipalensis の繁殖状況を調査し,ブナ Fagus crenata の種子生産の変動とクマタカの繁殖結果との相関の有無を検証した.そして,繁殖結果と環境要因(林相,林縁の複雑さ,前年の繁殖結果,降雪量など)との関係を明らかにするため一般化線形混合モデル(GLMM)を用いた.繁殖結果と環境要因との関係の解析では,ブナの結実状況の違いによって繁殖結果に影響する環境要因に違いがあるのかを検証するため,次の三通りの解析を行なった:(1)結実状況が良い場合,(2)結実状況が悪い場合,(3)結実状況による区分をしない場合.結果は,前年のブナの結実状況が良い場合には繁殖成功率が統計的に有意に高かった.しかし,繁殖結果に最も関連していた要因は前年の繁殖結果であった.天然林が占める割合が高い本調査地では,GLMMによる解析はブナの結実状況が悪い場合には繁殖結果に対し天然林面積が負に,人工林面積が正に作用する傾向を示した.繁殖結果に影響する要因は前年のブナの結実状況によって異なっており,これはクマタカが採食環境と主な食物とする種の両方かまたはどちらかをブナの種子の豊凶に応じて変化させていることを示唆している.
出版者
栃木県
巻号頁・発行日
vol.明治6年, 1874

1 0 0 0 OA 栃木県治提要

出版者
栃木県
巻号頁・発行日
1881
出版者
栃木県会
巻号頁・発行日
vol.明治25年通常会, 1892

1 0 0 0 OA 栃木県地誌略

著者
阪部教宜 編
出版者
集英堂
巻号頁・発行日
1877

1 0 0 0 OA 栃木県誌

著者
舟橋一也 編
出版者
両毛文庫本部
巻号頁・発行日
1904
著者
大野 晋
雑誌
学習院大学上代文学研究 (ISSN:09162453)
巻号頁・発行日
no.12, pp.1-2, 1987-03-31
著者
Masashi KOTSUGI Ichiro NAKAGAWA Kinta HATAKEYAMA HunSoo PARK Fumiya SATO Takanori FURUTA Fumihiko NISHIMURA Shuichi YAMADA Yasushi MOTOYAMA Young-Soo PARK Hiroyuki NAKASE
出版者
The Japan Neurosurgical Society
雑誌
Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日
pp.oa.2020-0154, (Released:2020-09-02)
参考文献数
33
被引用文献数
8

Carotid artery stenting (CAS) is performed as a treatment for carotid artery stenosis. However, lipid-rich plaques cause embolic complications and sequelae. Near-infrared spectroscopy (NIRS) can identify lipid components by applying a near-infrared absorption pattern, and the distribution of lipid components can be evaluated as the maximum lipid core burden index (maxLCBI). Intravascular ultrasound (IVUS) equipped with NIRS has been clinically applied recently, and its diagnostic usefulness and validation have been reported for coronary arteries; however, its consistency with actual pathological diagnosis in carotid artery lesions has not been validated. In this study, we investigated the consistency between the maxLCBI values and histopathological diagnoses. Patients with cervical carotid artery stenosis who underwent carotid endarterectomy (CEA) were examined in this prospective study. Pathological diagnosis was determined after NIRS evaluation, which was performed on the extracted plaques ex vivo. The histological slices of decalcified and paraffin-embedded sections were stained by hematoxylin–eosin (HE) and Elastica van Gieson (EVG), and for low-density lipoprotein (LDL), C-reactive protein (CRP), CD68, and glycophorin A. The correlation between maxLCBI values and histological findings. Seventy lesions assessed by NIRS were pathologically analyzed. There was a positive linear correlation between maxLCBI values and pathological findings as determined by HE (angle), HE (area%), EVG, CRP, and CD68 staining (respectively, r = 0.624, p <0.001; r = 0.578, p <0.001; r = 0.534, p <0.001; r = 0.723, p <0.001; r = 0.653, p <0.001). In conclusion, the maxLCBI values assessed by NIRS showed a significant positive linear correlation with pathological evaluations in carotid lesions. The maxLCBI values in carotid arteries are consistent with pathological evaluations.
著者
Masashi KOTSUGI Ichiro NAKAGAWA Kinta HATAKEYAMA HunSoo PARK Fumiya SATO Takanori FURUTA Fumihiko NISHIMURA Shuichi YAMADA Yasushi MOTOYAMA Young-Soo PARK Hiroyuki NAKASE
出版者
The Japan Neurosurgical Society
雑誌
Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日
vol.60, no.10, pp.499-506, 2020 (Released:2020-10-15)
参考文献数
33
被引用文献数
8

Carotid artery stenting (CAS) is performed as a treatment for carotid artery stenosis. However, lipid-rich plaques cause embolic complications and sequelae. Near-infrared spectroscopy (NIRS) can identify lipid components by applying a near-infrared absorption pattern, and the distribution of lipid components can be evaluated as the maximum lipid core burden index (maxLCBI). Intravascular ultrasound (IVUS) equipped with NIRS has been clinically applied recently, and its diagnostic usefulness and validation have been reported for coronary arteries; however, its consistency with actual pathological diagnosis in carotid artery lesions has not been validated. In this study, we investigated the consistency between the maxLCBI values and histopathological diagnoses. Patients with cervical carotid artery stenosis who underwent carotid endarterectomy (CEA) were examined in this prospective study. Pathological diagnosis was determined after NIRS evaluation, which was performed on the extracted plaques ex vivo. The histological slices of decalcified and paraffin-embedded sections were stained by hematoxylin–eosin (HE) and Elastica van Gieson (EVG), and for low-density lipoprotein (LDL), C-reactive protein (CRP), CD68, and glycophorin A. The correlation between maxLCBI values and histological findings. Seventy lesions assessed by NIRS were pathologically analyzed. There was a positive linear correlation between maxLCBI values and pathological findings as determined by HE (angle), HE (area%), EVG, CRP, and CD68 staining (respectively, r = 0.624, p <0.001; r = 0.578, p <0.001; r = 0.534, p <0.001; r = 0.723, p <0.001; r = 0.653, p <0.001). In conclusion, the maxLCBI values assessed by NIRS showed a significant positive linear correlation with pathological evaluations in carotid lesions. The maxLCBI values in carotid arteries are consistent with pathological evaluations.
著者
Naoko Kato Koichiro Kinugawa Etsuko Nakayama Takako Tsuji Yumiko Kumagai Teruhiko Imamura Hisataka Maki Taro Shiga Masaru Hatano Atsushi Yao Chikako Miura Issei Komuro Ryozo Nagai
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
vol.54, no.6, pp.382-389, 2013 (Released:2013-12-03)
参考文献数
36
被引用文献数
26 45

Self-care is a cornerstone for the successful management of heart failure (HF). The purpose of this study was to examine the impacts of HF self-care on prognosis in Japanese patients with HF. A total of 283 HF outpatients (age 64 ± 14, 70% male, 52% HFrEF) were enrolled. We asked patients to answer about their adhevence to 5 self-care behaviors (medication, eating a low-sodium diet, regular exercise, daily weight check, and treatment seeking behavior). On the basis of the results, we classified patients into a good self-care group and a poor self-care group. The primary outcome was HF hospitalization and/or cardiac death. In total, 65% of patients were classifi ed into the poor self-care group. During a median follow-up of 2 years, cardiac events occurred more frequently in the poor self-care group (22% versus 9.6%, P = 0.013). Poor self-care was an independent risk factor for cardiac events in Cox regression analysis adjusted for clinical parameters (hazard ratio = 2.86, P = 0.005). Poor self-care was also associated with an increased number of HF hospitalizations as well as an extended length of hospital stay for HF. Poor knowledge about HF was an independent determinant for poor self-care in multivariate logistic regression analysis (odds ratio = 0.92, P = 0.019). Insufficient self-care is an independent risk factor for cardiac events in Japanese patients with HF.
著者
花井 信広
出版者
一般社団法人 日本耳鼻咽喉科学会
雑誌
日本耳鼻咽喉科学会会報 (ISSN:00306622)
巻号頁・発行日
vol.122, no.8, pp.1107-1112, 2019-08-20 (Released:2019-09-05)
参考文献数
11
被引用文献数
1

本研究の目的は Stage I/II (T1-2N0) の舌癌を対象に, 舌部分切除単独が標準治療である舌部分切除 + 予防的頸部郭清術に対して全生存期間において非劣性であることをランダム化比較にて検証することである. 頭頸部癌の領域は, これまで適切な多施設共同臨床試験が行われてこなかったために, 治療法は施設毎に異なり, エビデンスに乏しい治療が汎用されている現状がある. これまで海外においても日本においても, 早期舌癌の頸部リンパ節郭清に関する標準治療は確立しておらず, 各施設や医師の判断により予防的頸部郭清が行われたり行われなかったりしてきた. 2015年に報告された D'Cruz らのインドの第 Ⅲ 相試験は舌部分切除単独に対する予防的頸部郭清の優越性を示したが, 医療環境や術後フォローアップの診断技術が明らかに異なるため, その結果をそのまま日本の日常診療に外挿することはできないと考えられている. 舌部分切除は口腔内のみで行われるため, 舌部分切除術単独が最善であると考える外科医も多く, 予防的頸部郭清省略の意義の検証が必要である. 本臨床試験の対象は発生率が人口10万人あたり6人未満/年の希少がんのため, 全国規模の実施体制が不可欠であり, JCOG 頭頸部がんグループにおける多施設共同ランダム化比較第 Ⅲ 相試験 (JCOG1601) として2017年11月末より開始している. そして日本医療研究開発機構 (AMED) の公的研究費「革新的がん医療実用化研究事業」(領域6-2) 希少がんの標準的治療法の開発に関する臨床研究「Stage I/II 舌癌に対する予防的頸部郭清省略の意義を検証するための多施設共同臨床試験 (代表者: 花井信広)」を獲得し運営している.