著者
荒井献編
出版者
講談社
巻号頁・発行日
1998
著者
日本学術会議編
出版者
丸善 (発売)
巻号頁・発行日
1959
著者
日本学術会議編
出版者
大蔵省印刷局
巻号頁・発行日
1964
著者
Chikako Monoe Hiroyasu Shimizu Kanae Kitaguchi Hiraku Funakoshi
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.59, no.20, pp.2619-2622, 2020-10-15 (Released:2020-10-15)
参考文献数
9
被引用文献数
3

Amiodarone, prescribed for cardiac conditions, including dysrhythmia, is associated with bradycardia. However, few reports have demonstrated that bradycardia is observed when amiodarone is used in combination with sofosbuvir, a direct-acting antiviral drug for chronic hepatitis C. We herein report the case of a male patient in his 70s with chronic atrial fibrillation and prostatic hyperplasia and was also taking amiodarone, who experienced severe bradycardia and syncope a day after taking sofosbuvir and ribavirin for chronic hepatitis C. After discontinuing amiodarone, ribavirin, and sofosbuvir, bradycardia did not recur. Therefore, we must consider drug interactions between amiodarone and sofosbuvir in patients with severe bradycardia.
著者
Yuanying Li Hiroshi Yatsuya Sachiko Tanaka Hiroyasu Iso Akira Okayama Ichiro Tsuji Kiyomi Sakata Yoshihiro Miyamoto Hirotsugu Ueshima Katsuyuki Miura Yoshitaka Murakami Tomonori Okamura EPOCH-JAPAN Research Group
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
pp.58958, (Released:2020-10-10)
参考文献数
44
被引用文献数
9

Aims: We aimed to develop and validate risk prediction models to estimate the absolute 10-year risk of death from coronary heart disease (CHD), stroke, and cardiovascular disease (CVD). Methods: We evaluated a total of 44,869 individuals aged 40–79 years from eight Japanese prospective cohorts to derive coefficients of risk equations using cohort-stratified Cox proportional hazard regression models. Discrimination (C-index) of the equation was examined in each cohort and summarised using random-effect meta-analyses. Calibration of the equation was assessed using Hosmer-Lemeshow chi-squared statistic. Results: Within a median follow-up of 12.7 years, we observed 765 deaths due to CVD (276 CHDs and 489 strokes). After backward selection, age, sex, current smoking, systolic blood pressure (SBP), proteinuria, prevalent diabetes mellitus, the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDLC), interaction terms of age by SBP, and age by current smoking were retained as predictors for CHD. Sex was excluded in the stroke equation. We did not consider TC/HDLC as a risk factor for the stroke and CVD equations. The pooled C-indices for CHD, stroke, and CVD were 0.83, 0.80, and 0.81, respectively, and the corresponding p-values of the Hosmer-Lemeshow tests were 0.18, 0.003, and 0.25, respectively. Conclusions: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke.
著者
堤 由紀子 内山 真一郎 内山 由美子 佐々木 彰一 岩田 誠
出版者
東京女子医科大学
雑誌
東京女子医科大学雑誌 (ISSN:00409022)
巻号頁・発行日
vol.75, no.9, pp.377-379, 2005-09

機械弁置換患者において閃輝暗点と栓子シグナルとの関連を検討した.閃輝暗点を有する4名の機械弁置換患者に経頭蓋ドプラ(DWL社,MultiDopX4)を用いて栓子シグナルを記録し,神経学的症状を検討した.閃輝暗点は抗血小板療法またはワルファリン増量により改善し,栓子シグナルも減少した.この結果から機械弁置換患者における閃輝暗点は微小塞栓による症状と考えられた.

1 0 0 0 OA 使清日記

出版者
[ ]
巻号頁・発行日
1800

1 0 0 0 時評

出版者
時評社
巻号頁・発行日
vol.30(10), no.310, 1988-12
著者
Mai Hibino Koji Matsuzaki Kooichi Konishi
出版者
Carcinological Society of Japan
雑誌
Crustacean Research (ISSN:02873478)
巻号頁・発行日
vol.49, pp.9-14, 2020-01-15 (Released:2020-01-15)
参考文献数
23
被引用文献数
2

First stage larva of the deep-sea giant shrimp, Sclerocrangon rex is described and illustrated under laboratory conditions. The larvae hatched in the most advanced condition, such as in having stalked eyes, among the congeneric species with abbreviated development. The newly hatched first larvae were staying together by clinging maternal pleopods until the second stage.

1 0 0 0 物理學概論

著者
石原純著
出版者
岩波書店
巻号頁・発行日
1941
著者
稲村 泰弘 中村 充孝 新井 正敏
出版者
公益社団法人 日本アイソトープ協会
雑誌
RADIOISOTOPES (ISSN:00338303)
巻号頁・発行日
vol.65, no.7, pp.319-324, 2016-07-15 (Released:2016-07-15)
参考文献数
12

一般にガラスやアモルファスと呼ばれる構造的に無秩序な物質は,比熱や熱伝導率といった熱輸送現象において低温領域で結晶とは異なる性質を普遍的に持つことが知られている。これらの熱的物性は,中性子非弾性散乱実験やラマン散乱実験で観測されるBoson Peakと呼ばれる低エネルギー励起と直接関連付けられる。また,中性子非弾性散乱実験で得られる振動状態密度は,普遍的低温熱物性に対する2準位系理論モデルの正当性を支持する。