ランキング (合計) - Ceek.jp Altmetrics

We have developed a vaccine candidate for COVID-19 that is based on a self-amplifying RNA (replicon) vaccine vector expressing the receptor-binding domain (RBD) of SARS CoV-2 with modifications to optimize structure, presentation, and immunogenicity. Immunization with this replicon vector provides high expression levels of antigens and induction of strong immune responses using vectors that are safe and well tolerated. The high expression is due to the efficient intracellular replication of the RNA and amplified expression that also provides a significant dose-sparing effect. The dose-sparing effect is especially important during pandemics where large numbers of doses must be manufactured quickly. The focus on the RBD sequences for this vaccine was driven by the observation that the majority of virus neutralizing antibodies are directed at this region, and also by a concern that non-neutralizing antibodies directed at other domains on the spike (S) protein could contribute to immune-mediated pathologies as has been documented for other viruses in this family. Intramuscular immunization of mice with this replicon induces robust antibody responses as monitored by ELISA, inhibition of RBD binding to the ACE-2 receptor and SARS CoV-2 virus neutralization. We plan to manufacture this vaccine and enter clinical trials. This system represents a platform technology that could be used to address additional emerging viruses.

2022-08-28 22:47:12
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https://confit.atlas.jp/guide/event/pharm141/subject/S24-04/detail

3 0 0 0 花こう岩からなる山地の地形解析<br />―阿武隈高地における隆起準平原の再検討―

著者: 平岡太一尾方隆幸
雑誌: 日本地球惑星科学連合2022年大会
巻号頁・発行日: 2022-03-24

2022-08-19 23:30:56
3 + 6 Twitter

https://confit.atlas.jp/guide/event/jpgu2022/subject/HGM03-P03/detail

3 0 0 0 OA 北海道留萌管内の砂金・砂白金鉱床を構成する鉱物種

著者: 浜根大輔齋藤勝幸
雑誌: 一般社団法人日本鉱物科学会2019年年会・総会
巻号頁・発行日: 2019-08-13

北海道留萌管内は新第三紀の堆積岩を主体とする地質であり、超苦鉄質岩の分布は認められないが、多くの場所で砂金・砂白金を採集することができる。これは堆積岩の原岩に超苦鉄質岩体が含まれていたためと推測される。我々は原岩の超苦鉄質岩体の特徴を把握するために、砂金・砂白金鉱床を構成する鉱物について調査を行っている。今回報告する調査地は初山別村初山別川、羽幌町愛奴沢川、苫前町海岸、小平町上記念別沢川、小平町海岸であり、砂金・砂白金鉱床を構成する鉱物はカムチャツカの超苦鉄質岩から産出する鉱物との類似性が認められる。本発表では天然の炭化タングステンに該当するQusongite、およびPtCu3の化学組成をもつ未命名鉱物の産状について、特に報告する。