著者
[豊田天功] [著]
巻号頁・発行日
vol.[138], 1800
著者
佐々木 紀典 川津 邦雄 堤 貞衛 儀同 政一 中川 弘子 柏原 嘉子 松木 玄二 遠藤 博子
出版者
日本ハンセン病学会
雑誌
日本ハンセン病学会雑誌 (ISSN:13423681)
巻号頁・発行日
vol.66, no.3, pp.227-235, 1998-01-30 (Released:2008-02-26)
参考文献数
9
被引用文献数
1 3

カービル療養所から5回にわたり取り寄せたアルマジロ全頭20匹を、われわれ研究チームで飼育し、感染ヌードマウスより採取したらい菌で感染実験を行った。感染は10 8-9即の大量菌を静脈内及び皮下に接種の15匹と対照として非接種の5匹に分けた。菌液接種後最短7.5か月、最長34か月の期間に死亡した9匹と屠殺6匹を剖検し、スタンプ標本と病理標本を作成し検索した。結果2匹のみが軽度の感染状況に止まったが、その他は生存期間の長短には関係なく、いずれも重度広汎な感染の進展が観察された。臓器では静脈内と皮下接種のいずれにおいても、肝、脾に顕著な菌の増殖と病巣の進展拡大が確認され、その他、肺、副腎、リンパ節、胃、骨髄、腎、鼻等に菌の分布と浸潤性病巣が見られた。皮膚病巣は接種局所は勿論のこと、遠隔部の皮膚にも病変が見られ、ことに足底部における浸潤性病巣が明らかであり、その部位における末梢神経の病変は大腿部坐骨神経よりも顕著であった。しかしヒトの場合と異なり、末梢神経内の病巣は軽度であり、アルマジロでは頭部の甲羅下の組織に広汎な病巣を観察したが、精巣には病巣が見られないが、胃、肺、腎には病巣がみられるなど、ヒトとはやや異なる様相を呈し、動物種の特異性が考えられるので、アルマジロらいとして理解した方が良いと考えられる。しかし、ハンセン病との間に極めて高い類似性が示された。特に末梢神経病変の機序の解明などには実験価値が高いと考えられる。なおこの研究は厚生省特別研究費を受けて行われた。
著者
Yoshihiro AKASHI Nobuyuki YOSHIZAWA
出版者
Japanese Society of Nephrology
雑誌
日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日
vol.37, no.8, pp.462-467, 1995 (Released:2010-07-05)
参考文献数
22

To evaluate the role of histones and ubiquitin in lupus nephritis, we searched for glomerular deposits of histones and ubiquitin in renal biopsy specimens from 53 patients with systemic lupus erythematosus (SLE) and 30 with non-lupus glomerulonephritis. Glomerular immunofluorescence staining revealed positive for histone H2A, H1 + H3, H4 and ubiquitin in 49.1% (26/53), 45.3% (24/53), 32.1% (17/53) and 22.6% (12/53) of the SLE patients, respectively. Non-SLE renal biopsies revealed absence of positive staining with histone H2A, H1 + H3, H4 and ubiquitin. The positive incidence of histone H1 + H3 and ubiquitin in diffuse proliferative lupus nephritis was significantly different (p<0.01) from that in minor glomerular abnormality. Levels of CH50 in patients with glomerular deposition of histone H1+H3 (p < 0.001) and ubiquitin (p < 0.01) were significantly lower than in patients without deposition. Levels of anti-DNA antibody in patients with glomerular deposition of histone H1 + H3 were significantly higher than in patients without deposition (p < 0.05). Only the positive incidence of glomerular deposition of ubiquitin was correlated with the histological activity index (p <0.05). These results suggest that histones and ubiquitin may play an important role in the induction of lupus nephritis.
著者
安喰 勇平
出版者
中国四国教育学会
雑誌
教育学研究ジャーナル (ISSN:13495836)
巻号頁・発行日
vol.20, pp.1-10, 2017-03-20 (Released:2017-04-18)
参考文献数
20

In educational study, an encounter with the Other is seen as an important moment in ethical growth. Through the encounter, the Other is said to challenge one's existing identity and give one the responsibility to react ethically. A theoretical base of this is Emmanuel Lévinas's conception of subjectivity. Based on its interpretation, many theorists hold that Lévinas discussed the process of the production of subjectivity. Educational discourses on Lévinas, however, miss the fact that he avoided considering the production of subjectivity as a process and narrative. In this paper I aim to clarify the implication of Lévinas's conception of subjectivity for educational study. The first section explains the reason behind the application of Lévinas's conception of subjectivity to educational theory and shows the tendency of the application. Educational discourses on Lévinas's subjectivity have the tendency to focus on the openness and passivity of the self; thus, they miss the temporality. The second section clarifies how educational theorist Clarence Joldersma reconsiders the educational relationship by applying Lévinas's conception of subjectivity. To elucidate Lévinas's treatment of the production of subjectivity, the third section shows his attempt to discuss the production of subjectivity without narrative form. In the fourth section, it turns out that Lévinas allows various interpretations of his conception of subjectivity, and our interpretations complement his conception. His conception of subjectivity implies that educational theorists need to consider the self-contradictory character of an argument about the production of subjectivity.
著者
尾川 明穂
出版者
ASSOCIATION FOR CALLIGRAPHIC STUDIES
雑誌
書学書道史研究 (ISSN:18832784)
巻号頁・発行日
vol.2010, no.20, pp.11-25, 2010

In this article I trace changes in Dong Qichang's 董其昌 perceptions of the reception of old techniques on the basis of his dated writings dealing with calligraphic and painting theory up until his mid-fifties. 1 confirm (1) changes in his perception of a change from the faithful transmission of old techniques to innovations in old techniques, and I then ascertain when (2) his viewpoint of differences according to historical periods and (3) his differentiation of the relative merits of early calligraphers appeared in his perception of innovations in old techniques. Further, with respect to the theory of Northern and Southern schools of painting, said to have been put forward by Dong Qichang, I suggest when he may have proposed this theory and ascertain that it does not conflict with my conjectural results regarding the above changes in his view of innovations in old techniques. I also take up for consideration passages in his writings that show evidence of his theory about the distinctive character of the calligraphy of particular periods, verifying their reliability in light of the circumstances regarding the above changes in his perceptions, and I further examine the question of whether he regarded the calligraphy of the Tang 唐 or the Song 宋 as superior, a question about which there has been no consensus in the past.<br>   The results of my investigations were as follows. It is to be surmised that the changes concerning (1) occurred between the ages of 37 and 44 with regard to calligraphy and at the age of 42-43 with regard to painting. I was able to confirm that the emergence of his viewpoint regarding (2) occurred at the age of 48 or later in the case of calligraphy and at the age of 51 in the case of painting. The differentiation of (3) can be seen at the age of 48 for both calligraphy and painting and would seem to have been discussed from this time onwards. Changes in his view of innovations in old techniques occurred at roughly the same time in his theories about both calligraphy and painting, and this would suggest that his views of calligraphy and painting were inseparable. As regards his proposal of a theory of Northern and Southern schools of painting, I surmise that this took place in the third month of his 45th year. This is not inconsistent with changes in his above view of innovations in old techniques and may be considered to guarantee the validity of my conjectures regarding both. With regard to his theory about the distinctive character of the calligraphy of particular periods, having ascertained in light of their dates and content that the writings in question are indeed by Dong Qichang, I take the view that, at least when he proposed this theory, he rated the calligraphy of the Tang dynasty more highly than that of the Song dynasty.
著者
内田 良
出版者
朝日新聞出版
雑誌
一冊の本
巻号頁・発行日
vol.22, no.8, pp.58-61, 2017-08
著者
田中 敬一
出版者
八戸学院短期大学
雑誌
八戸学院短期大学研究紀要 (ISSN:21878110)
巻号頁・発行日
vol.44, pp.13-20, 2017-03-31

近年東京圏を始めとする都市部の待機児童問題が社会問題となり、政府は子ども子育て支援制度を施策として掲げ、企業立の保育業界への参入を促進やこども園への移行推進等を実施してきた。その結果、地方から都市部への学生の流出が加速し、地方での保育士不足が深刻化している。保育士養成校である本学においても、地元に十分に保育者を供給できない状況が恒常化し始めている。今年度12月現在で、都市部の事業所から内定を得た学生の率は過去最高に迫っている。しかしその副産物として保育士の雇用条件、賃金、正規雇用率などは、緩やかではあるが改善しつつあり、内定の早期化も急激に進んでいる。