著者
滝沢 雅俊
出版者
Waseda University
巻号頁・発行日
2004

機能や構造未知のタンパク質のアミノ酸配列を問い合わせ配列とし、データベース中から、進化的に類縁関係にあるアミノ酸配列を収集する方法を相同性検索とよぶ。現在までに、BLASTやFASTAなど様々な相同性検索手法が開発されてきたが、検索精度を更に向上させることが求められている。本研究では、複数の検索手法について2手法の組み合わせを行うことにより、検索精度の向上を目指し、タンパク質ペアのE-valueによって、union、intersection操作を使い分ける手法を提案する。 E-value閾値3.0*E-3において、提案手法を適用したBLASTとFASTAの組み合わせでは、各手法単独で用いた場合と比較してspecificityを低下させることなく、BLASTのsensitivityを3.0%、FASTAのsensitivityを0.47%向上させることができた。
著者
石黒 晃子
出版者
京都大学
巻号頁・発行日
2009-01-23

新制・課程博士
著者
Yoshimura Shige H. Kumeta Masahiro Takeyasu Kunio
出版者
Elsevier Ltd.
雑誌
Structure (ISSN:09692126)
巻号頁・発行日
vol.22, no.12, pp.1699-1710, 2014-11
被引用文献数
28

タンパク質が核膜孔を通り抜ける際の構造変化を解明 -細胞核内部への遺伝子導入技術への応用に期待-. 京都大学プレスリリース. 2014-11-27.
著者
慶野 遥香
出版者
東京大学大学院教育学研究科
雑誌
東京大学大学院教育学研究科紀要 (ISSN:13421050)
巻号頁・発行日
vol.47, pp.221-229, 2008-03-10

Professional ethics is one of the essential factors needed by psychologists in order to provide their clients with high quality service and to be regarded as a professional. In this study, the psychologists'ethical codes, as well as articles on professional ethics were reviewed. There are studies about the psychologists'beliefs and behaviors in the case of an ethical dilemma, ethical decision making models and ethical training programs; however, it was found that most of the models and training programs were not assessed empirically. In addition, since the argument about psychologists'ethics in Japan were started quite recently, compared to other countries, neither the codes or research have been discussed enough. This review indicated that we need to clarify "what it is to be ethical" by continuing doing research and holding discussions.
著者
筑和 正格
出版者
北海道大学大学院国際広報メディア・観光学院 = Graduate School of International Media, Communication, and Tourism Studies, Hokkaido University
雑誌
国際広報メディア・観光学ジャーナル
巻号頁・発行日
vol.7, pp.23-44, 2008-11-28

The purpose of this paper is to examine the basic concepts of "International Regional Culture Studies", structure them and consider adequate methods of new "Community Development", which contribute to the promotion of tourism at the same time. It is indispensable first to construct conceptual systems in order to understand what "culture" is because it is "an historically transmitted pattern of meanings embodied in symbols" (Geertz) and therefore can hardly be recognized by external observations alone. The "culture" of a human group reflects the value of its members. Furthermore, we can formulate that the term "international" means the relationship between or among larger regions and can be characterized by the interrelationship of regional cultures and therefore of different values. The construction of "conceptual systems" is also required as part of activity of new "Community Development" because it means a sustainable revitalization based on the internalized common values of participants, and these values arise from self-recognition based on the conceptualization of their own culture. The further task of new "Community Development" is to somehow transform the concepts of their own "culture" into a tangible reality.
著者
西森 丈俊
巻号頁・発行日
2012

筑波大学博士 (システムズ・マネジメント) 学位論文・平成24年3月23日授与 (甲第5996号)