著者
Daigo Ochiai Hirotaka Masuda Yushi Abe Toshimitsu Otani Marie Fukutake Tadashi Matsumoto Kei Miyakoshi Mamoru Tanaka
出版者
The Keio Journal of Medicine
雑誌
The Keio Journal of Medicine (ISSN:00229717)
巻号頁・発行日
pp.2017-0019-IR, (Released:2018-03-06)
参考文献数
51
被引用文献数
10

Mesenchymal stem cells (MSCs) have generated great interest in the fields of regenerative medicine and immunotherapy because of their unique biological properties. Among MSCs, amniotic fluid stem cells (AFS) have a number of characteristics that make them attractive candidates for tissue engineering and cell replacement strategies, particularly for perinatal medicine. If various neonatal conditions, including birth asphyxia, preterm birth, and congenital abnormalities, which result in long-lasting severe impairments, could be predicted during pregnancy, it would allow collection of small samples of amniotic fluid cells by amniocentesis. In vitro culture of these autologous AFS during pregnancy would make them available for use soon after birth. Hypoxic-ischemic encephalopathy (HIE) and myelomeningocele (MMC) are neonatal conditions that cause permanent neurological disability, for which the treatment options are extremely limited. Experiments using animal models of HIE and MMC and human clinical trials have demonstrated that MSCs, including AFS, have beneficial effects on the central nervous system through paracrine influences, indicating that autologous AFS treatment may be applicable for intractable neurological diseases, including HIE and MMC, during the perinatal period. In this review, we focus on recent research related to the therapeutic potential of AFS for perinatal neurological diseases such as HIE and MMC.
著者
田中 久雄 落合 清茂
出版者
山形大学
雑誌
一般研究(C)
巻号頁・発行日
1989

平成元年度〜3年度の3ケ年において、主に福島県鮫川村から塙町東部にわたる地域と、郡山市東部の宇津峰周辺の地域に分布する深成岩類と変成岩類の地質調査を行い、地質図を作成すると共に岩石の記載を行った。鮫川村から塙町東部にわたる地域には片状黒雲母角閃石ト-ナル岩、黒雲母花崗閃緑岩類、竹貫変成岩類が錯綜して分布する。それらの岩石は棚倉構造線に近づく従い、石英の細粒化・波動消光・伸長、斜長石の変形双晶・波動消光、黒雲母のキンクバンド・波動消光などの変形組織を呈する。この変形組織は棚倉構造線東縁部に近接した岩石で最も著しく、構造線から離れるに従い無変形組織の岩石に漸移しており、後者の岩石が生成した約1億年前には棚倉構造線がすでに活動したことを示している。塙町湯船の、石川深成岩体の閃緑岩と竹貫変成岩類の角閃岩が接する露頭において、角閃岩の部分融解により多数の細脈が生成した現象を見いだし、この露頭の岩石の詳細な記載を行った。角閃岩中の細脈は組織・鉱物組合せ・化学組成において、はんれい岩質から閃緑岩質・ト-ナル岩質・トロニエム岩質へと連続して変化しており、角閃岩の部分融解により生成した溶液が種々の程度に分泌・分化したと推定される。郡山市東部の宇津峰付近にはユ-クセン石、モナズ石、ゼノタイム等の希元素鉱物を含むペグマタイト脈が分布する。このペグマタイト脈をもたらした深成岩類について調査・研究を行い、深成岩類のモ-ド組成、主要・微量化学組成、造岩鉱物の化学組成を明らかにした。含希元素鉱物ペグマタイトをもたらしたと推定されている新期斑状両雲母花崗岩類は、阿武隈山地の深成岩類の中では最もSiO_2に富み、Sタイプに類似した岩石学的性質を示す。
著者
入間田 宣夫
出版者
中世文学会
雑誌
中世文学 (ISSN:05782376)
巻号頁・発行日
vol.42, pp.34-41, 1997

2 0 0 0 OA 十二ヶ月花合

著者
豊原国周 筆
出版者
武川清吉
巻号頁・発行日
vol.4, 1880
著者
Hiroshi Ueda
出版者
The Plankton Society of Japan, The Japanese Association of Benthology
雑誌
Plankton and Benthos Research (ISSN:18808247)
巻号頁・発行日
vol.13, no.1, pp.28-31, 2018-02-28 (Released:2018-03-14)
参考文献数
14
被引用文献数
1

High-concentration pure glycerol has been used as a medium for permanent preservation of micro-crustacean specimens. However, glycerol-mounted permanent slide preparations are rare because of the difficulty in sealing the coverslip over the long term. I devised a glycerol-mounted permanent preparation method, especially for a small dissected piece of a micro-crustacean using a glass depression slide and a coverslip with secure sealing, in order to overcome some of the disadvantages of the popular permanent mountants that solidify, such as discoloration of specimens and difficulty in remounting. Unique characteristics of the preparation method are: (1) the central glycerol being of a few millimeters in diameter, which embeds the specimen and is retained in the depression center by a paraffin wax circle painted on the depression bottom; (2) the marginal glycerol, which fills up the clearance between the glass slide and the coverslip and prevents intrusion of the sealant into the clearance; (3) sealing with nail polish first and Canada balsam second, where the latter can seal securely over the long term and the former, being a fast-drying sealant, prevents intrusion of the latter into the marginal glycerol. By following this method, even a small dissected piece can be easily found under a microscope and taken out from the preparation for detailed examination with a low risk of going missing. The procedure to make the preparation is presented in detail.
著者
Kotaro Ozasa Eric J Grant Kazunori Kodama
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20170321, (Released:2018-03-17)
参考文献数
66
被引用文献数
69

Cohorts of atomic bomb survivors—including those exposed in utero—and children conceived after parental exposure were established to investigate late health effects of atomic bomb radiation and its transgenerational effects by the Atomic Bomb Casualty Commission (ABCC) in the 1950s. ABCC was reorganized to the Radiation Effects Research Foundation (RERF) in 1975, and all work has been continued at RERF. The Life Span Study, the cohort of survivors, consists of about 120,000 subjects and has been followed since 1950. Cohorts of in utero survivors and the survivors’ children include about 3,600 and 77,000 subjects, respectively, and have been followed since 1945. Atomic bomb radiation dose was estimated for each subject based on location at the time of the bombing and shielding conditions from exposure, which were obtained through enormous efforts of investigators and cooperation of subjects. Outcomes include vital status, cause of death, and cancer incidence. In addition, sub-cohorts of these three cohorts were constructed to examine clinical features of late health effects, and the subjects have been invited to periodic health examinations at clinics of ABCC and RERF. They were also asked to donate biosamples for biomedical investigations. Epidemiological studies have observed increased radiation risks for malignant diseases among survivors, including those exposed in utero, and possible risks for some non-cancer diseases. In children of survivors, no increased risks due to parental exposure to radiation have been observed for malignancies or other diseases, but investigations are continuing, as these cohorts are still relatively young.
著者
村上 幸史
出版者
日本社会心理学会
雑誌
社会心理学研究 (ISSN:09161503)
巻号頁・発行日
vol.18, no.1, pp.11-24, 2002

In Japan, the term "strength of luck" (as directly translated from Japanese) commonly refers to a fixed dispositional trait. In order to gain a more concrete understanding of the usage of the term "strength of luck," a questionnaire was designed and survey conducted of subjects to study the belief that some people have "strong luck" and others have "weak luck." The results showed that people who see themselves as having "strong luck" differ from those who see themselves as having "weak luck" in that : 1. They believe that they have many "lucky" experiences and few "unlucky" experiences. 2. Most of these "lucky" experiences occurred in "important situations." There was no difference between people who see themselves as having "strong luck" and those who see themselves as having "weak luck" when the occurrence probability of the event was considered low from the start. 3. They think that their "strength of luck" is correlated with their amount of effort. 4. It wasquite rare for them to make social comparisons. On the other hand, according to these results, people who see themselves as having "weak luck" don't necessarily feel they have few successful experiences in daily life, nor did they feel helpless. It was concluded that how one interprets one's own "strength of luck" is based on particular "lucky" and/or "unlucky" experiences.