著者

Pil-Sung Yang Jung-Hoon Sung Daehoon Kim Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jae-Sun Uhm Jong-Youn Kim Hui-Nam Pak Moon-Hyoung Lee Boyoung Joung

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.8, pp.1305-1313, 2021-07-21 (Released:2021-07-21)

参考文献数

20

被引用文献数

15

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Background:It is unclear whether catheter ablation is beneficial for frail elderly patients with atrial fibrillation (AF). This study evaluated the effect of ablation on outcomes in frail elderly patients with AF.Methods and Results:From the Korean National Health Insurance Service database, 194,928 newly diagnosed AF patients were treated with ablation or medical therapy (rhythm or rate control) between 2005 and 2015. Among these patients, the study included 1,818 (ablation; n=119) frail and 1,907 (ablation; n=230) non-frail elderly (≥75 years) patients. Propensity score matching was used to correct for differences between groups. During 28 months (median) follow up, the risk of all-cause death, composite outcome (all-cause death, heart failure admission, stroke/systemic embolism, and sudden cardiac arrest), and each outcome did not change after ablation in frail elderly patients. However, in non-frail elderly patients, ablation was associated with a lower risk of all-cause death (3.5 and 6.2 per 100 person-years; hazard ratio [HR] 0.48; 95% confidence interval [CI] 0.30–0.79; P=0.004), and composite outcome (6.9 and 11.2 per 100 person-years; HR 0.54; 95% CI 0.38–0.75; P<0.001).Conclusions:Ablation may be associated with a lower risk of death and composite outcome in non-frail elderly, but the beneficial effect of ablation was not significant in frail elderly patients with AF. The effect of frailty on the outcome of ablation should be evaluated in further studies.

著者

Ken-yu Hironao Yuji Mitsuhashi Shujiao Huang Hideaki Oike Hitoshi Ashida Yoko Yamashita

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.67, no.1, pp.53-60, 2020 (Released:2020-07-01)

参考文献数

45

被引用文献数

1 10

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Energy metabolism and circadian rhythms are closely related together, i.e., the timing of nutrient intake affects metabolism under the regulation of circadian rhythms. Previously, we have reported that cacao liquor procyanidin (CLPr) promotes energy metabolism, resulting in preventing obesity and hyperglycemia. However, it is not unclear whether CLPr regulates clock gene expression. In this study, we investigated whether the administration timing of CLPr affected clock gene expression and found that CLPr regulated the circadian clock gene expression through the glucagon-like peptide-1 (GLP-1) signaling pathway. CLPr administration at Zeitgeber time 3 increased the expression level of Per family and Dbp in the liver. At the same administration timing, CLPr increased GLP-1 and insulin concentration in the plasma and phosphorylation of AMPK in the liver. It was noteworthy that an antagonist for GLP-1 receptor Exendin (9-39) canceled CLPr-increased expression of Per family and Dbp and phosphorylation of AMPK in the liver, in addition to insulin secretion. These results strongly suggest that CLPr-induced GLP-1 regulates the changes in clock gene expression in the liver through increased insulin. Thus, CLPr is a possible functional food material for prevention and/or amelioration of metabolic disorders through preventing circadian disruption through GLP-1 and AMPK pathways.

著者

Elena Zapata-Arriaza Manuel Medina-Rodriguez Joaquin Ortega-Quintanilla Asier De Albóniga-Chindurza Leire Ainz-Gómez Blanca Pardo-Galiana Juan Antonio Cabezas-Rodriguez Lucía Lebrato-Herández Ana Barragán-Prieto Soledad Pérez-Sánchez Aynara Zamora Joan Montaner Alejandro González García Francisco Moniche

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63560, (Released:2022-08-21)

参考文献数

27

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Aims: Carotid reocclusion (CRO) after mechanical thrombectomy (MT) in acute ischemic stroke (AIS) due to tandem lesion (TL) or isolated internal carotid occlusion (ICO) is associated with worse clinical outcomes. Our aim was to analyze the predictors and clinical impact of CRO. Methods: A retrospective single-center analysis of all patients with anterior circulation strokes who underwent MT prospectively included in a registry between 2017 and 2020 was performed. ICO and TL as stroke causes were included. Stent deployment was left to the discretion of the interventionist. All patients received at least intravenous aspirin during MT. CRO was assessed using ultrasound within the first 24 h after MT. Efficacy and safety of stenting were assessed. Results: Among 1304 AIS cases, 218 (16.7%) were related to TL or ICO. Of them, 5% (n=11) were associated with internal CRO 24 h after the endovascular procedure. After adjusting per confounders, multivariate analysis showed that the independent variables associated with CRO were the TICI recanalization grade [TICI 2b-3; OR 0.1, 95% confidence interval (CI) 0.01-0.89, p=0.040], pial collateral circulation presence (OR 0.09, 95% CI 0.02-0.45, p=0.03), stent deployment during MT (OR 0.17, 95% CI 0.03-0.84, p=0.030), and general anesthesia use (OR 2.92, 95% CI 1.13-7.90, p=0.034). CRO showed a trend toward worst outcomes (modified Rankin scale 3-6) at 3 months (OR 3.4, 95% CI 0.96-12, p=0.057). After multivariate analysis, variables independently associated with worse outcomes at 90 days were intrastent platelet aggregation phenomena during endovascular therapy, admission National Institute of Health Stroke Scale, and age. Conversely, intravenous thrombolysis and TICI 2b-3 recanalization grade were identified as independent predictors of good outcomes at 90 days. Conclusions: CRO has a relevant clinical impact in our study, associating lower rates of good functional outcomes at 3 months. Independent factors of CRO were the recanalization degree, presence of pial collateral circulation, use of a stent as a protective factor, and use of general anesthesia during thrombectomy.

著者

ドメネク=ベルダ カロリーナ 阿部 俊大 Carolina Doménech-Belda Toshihiro Abe

出版者

同志社大学人文学会

雑誌

人文學 = Doshisha University Jinbungaku (Studies in Humanities) (ISSN:04477340)

巻号頁・発行日

no.206, pp.110-79, 2020-11-15

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この論考は、アル=アンダルス[中世のイスラーム=スペイン]におけるファーティマ朝(907−1171年)の貨幣の存在について、アンダルスの領域におけるこの外国貨幣の流通についての情報を見直し、アップデートしつつ、論じたものである。

著者

揚妻 直樹 揚妻-柳原 芳美 杉浦 秀樹

出版者

一般社団法人 日本生態学会

雑誌

保全生態学研究 (ISSN:13424327)

巻号頁・発行日

pp.1923, (Released:2021-04-20)

参考文献数

43

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捕獲圧がかかっていないニホンジカ個体群では、個体数が指数関数的に激増した後、短期間で大量死(個体群崩壊)を起こすものの、その後も再び急速に個体数を増加させ、安定しないと考えられてきた。ところが、捕獲圧が全くかかっていないシカ個体群を対象に長期動態を明らかにした研究例は少なく、知見は限られている。ニホンジカは多様な生態系に分布しており、各地域個体群に見られる動態のバリエーションが十分に把握されてきたとは言い難い。さらなる情報の蓄積が必要である。本研究の調査地である屋久島西部・世界自然遺産地域の照葉樹林では、過去数十年間シカの捕獲圧がほぼかけられてこなかった。そこで我々はこの地域の半山地区と、そこから 1.3 km離れた川原地区の 2か所で、 2001年から 2018年まで毎年夏に踏査によるルートセンサスを実施した。シカ生息密度は 2014年まで年率 9.1%で増加傾向にあったものの、その後は年率 15.2%の減少に転じていた。半山地区と川原地区の生息密度は増加期においても減少期においても違いがなく、同調して変化していた。半山地区で実施したカメラトラップ(自動撮影カメラ)による調査でも、シカ撮影率は 2014年から 2018年にかけて減少傾向にあった(年率 -10.0%)。この個体数の減少は、これまで報告されてきたような短期間の大量死によるものではなく、数年かけて進行していた。減少期間中( 2014年~ 2018年)に半山地区で識別していたシカ 19個体(メス 13頭・オス 6頭)を対象に地区内に定住(生存・死亡)していたか、地区外へ移出したかを直接観察により確認した。その結果、地区内の年定住率は 96.5%と高く、 3.5%は原因不明の消失であり、地区外へ移出した個体は確認できなかった。このことから、調査地域内で個体数減少が起きており、何らかの自然環境要因が関わっていた可能性が示された。今後も調査を継続し、捕獲圧のかからない地域におけるシカ個体群の挙動を明らかにしていくことが重要である。

著者

Sugawa-Shimada Akiko

出版者

Research Faculty of Media and Communication, Hokkaido University

雑誌

The Theory and Practice of Contents Tourism

巻号頁・発行日

pp.21-26, 2015-03-16

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本研究ノートでは、歴史上逆賊とされる石田三成に関する、「歴 女」(歴史好きな女性)の歴史ツーリズムについて論じている。『戦国無双』『戦 国BASARA』や『天地人』『江』において、三成が好人物に描かれたことで、生誕 地石田町(滋賀)に若い女性観光客が増加した。ここで顕著なのは、ホスト・ゲス ト関係を越えた「歴女」の地元への貢献と、地元顕彰会の草の根的なおもてなし が、三成を介して世代を超えた精神的繋がりとして構築されていることである。

著者

Isao Sano Takumi Saito Jun-Ichi Miyazaki Akihisa Shirai Takeru Uechi Takaki Kondo Satoshi Chiba

出版者

The Plankton Society of Japan, The Japanese Association of Benthology

雑誌

Plankton and Benthos Research (ISSN:18808247)

巻号頁・発行日

vol.15, no.2, pp.97-111, 2020-05-27 (Released:2020-05-30)

参考文献数

81

被引用文献数

7

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The evolutionary history and diversity of unionoid mussels in East Asia need to be clarified and would shed light on the formation process of the unique fauna of Japan. Unionoid mussels (Mollusca: Bivalvia) are unique models for understanding the process by which organisms have diversified before and after the formation of the Japanese archipelago. Unionoid mussels have poor dispersal ability, so it is thought that they would have been strongly influenced by the archipelago’s formation. Therefore, the speciation and diversification processes of mussels before and after the archipelago’s formation were investigated by analyzing the nuclear and mitochondrial DNA of a wide range of species, particularly those inhabiting East Asia. The evolutionary history and divergence time of these mussels were examined. Unionoid mussels were found to have higher endemicity than other freshwater organisms. Although most of the endemic unionoid mussels of Japan are likely to have diverged before the formation of the Japanese archipelago, some other Japanese unionoid mussel species, including species endemic to Lake Biwa, an ancient lake in Japan, potentially diverged after the Japanese archipelago began to separate from the continent. This suggest that adaptation to the unique habitat of the ancient lake has caused diversification in the mussels endemic to it.

著者

Hirotoshi UTSUNOMIYA Tadashi YAMAKAWA Junzo KAMEI Kazuaki KADONOSONO Shun-Ichi TANAKA

出版者

バイオメディカルリサーチプレス

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.26, no.5, pp.193-200, 2005 (Released:2005-12-05)

参考文献数

30

被引用文献数

11 24

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Dried plums, considered a healthy food in the West and used as medicine in India, contain phenolic compounds with protective actions against age-related diseases. Effects of oral plum ekisu (concentrated juice) on lipid and glucose tolerance were assessed in insulin-resistant obese Wistar fatty rats. Plum ingestion decreased blood glucose (P < 0.05) and plasma triglyceride concentrations (P < 0.01) compared with controls. Plum treatment for 2 weeks reduced areas under the curve (AUCs) for glucose and insulin during a glucose tolerance test. In db/db mice, plum decreased these AUCs, and also blood glucose during an insulin tolerance test. Plum treatment significantly increased plasma adiponectin concentrations and PPARγ mRNA expression in adipose tissue from Wistar fatty rats. Plum thus may increase insulin sensitivity in these rats via adiponectin-related mechanisms.

著者

Yo-ko CHINEN Kei SHIRAISHI Hideo MOROOKA Harumi MOROOKA

出版者

The Textile Machinery Society of Japan

雑誌

Journal of Textile Engineering (ISSN:13468235)

巻号頁・発行日

vol.55, no.2, pp.45-51, 2009-04-15 (Released:2009-07-18)

参考文献数

11

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Bust silhouette is one of several very important aesthetic points in the appeal of a women’s body, and it is also well known that an attractive silhouette is influenced by both inner and outer garments. Some odd protrusions can appear in outerwear because of the underlying brassiere, in particular, in spring-into-autumn apparel. As a result, many young Japanese women experience discomfort related to this silhouette. Thus we investigated the relationship between the brassiere and the bust silhouette in knit shirt. The experimental results are as follows: (1) unnatural protrusions result from four causes: the seam, the cup line, the trim lace, and the malformed top part of the brassiere, (2) seamless cup type brassiere makes a contribution to a beautiful bust silhouette, and (3) characteristics of the half-cup type brassiere which produces the worst bust silhouette in knit shirt are the total angle of cup top (BθU + BθL) ≤ 155°, the curved height of the under-cup line (BBL) ≤ 6 mm, and the compression recovery (RC) ≤ 50%.

著者

Chih-Wei Yang Shun-Neng Hsu Jhih-Syuan Liu Dueng-Yuan Hueng

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.15, pp.1665-1668, 2014 (Released:2014-08-01)

参考文献数

23

被引用文献数

3 12

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The formation of spinal epidural abscess following acupuncture is very rare. We herein report the case of a 54-year-old woman who presented with progressive low back pain and fever with a root sign. She underwent surgical decompression, with an immediate improvement of the low back pain. A culture of the epidural abscess grew Serratia marcescens. One year postoperatively, magnetic resonance imaging revealed the almost complete eradication of the abscess. This case is the first case of Serratia marcescens-associated spinal epidural abscess formation secondary to acupuncture. The characteristics of spinal epidural abscess that develop after acupuncture and how to prevent such complications are also discussed.

著者

Yung-Yee Chang Jia-Shou Liu Shung-Lon Lai Hsiu-Shan Wu Min-Yu Lan

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.47, no.5, pp.467-469, 2008 (Released:2008-03-03)

参考文献数

6

被引用文献数

14 16

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Nattokinase is used as a health-promoting medicine for preventing thrombosis due to its fibrinolytic activity. Cerebral microbleed is remnant of blood extravasations from the damaged vessels related to cerebral microangiopathies. We report a patient, having used aspirin for secondary stroke prevention, who had an acute cerebellar hemorrhage after taking nattokinase 400 mg daily for 7 consecutive days. In addition to the hemorrhagic lesion, multiple microbleeds were demonstrated on brain MR images. We suggest that nattokinase may increase risk of intracerebral hemorrhage in patients who have bleeding-prone cerebral microangiopathy and are receiving other antithrombotic agent at the same time.

著者

Ken Okumura Hirofumi Tomita Michikazu Nakai Eitaro Kodani Masaharu Akao Shinya Suzuki Kenshi Hayashi Mitsuaki Sawano Masahiko Goya Takeshi Yamashita Keiichi Fukuda Hisashi Ogawa Toyonobu Tsuda Mitsuaki Isobe Kazunori Toyoda Yoshihiro Miyamoto Hiroaki Miyata Tomonori Okamura Yusuke Sasahara for the J-RISK AF Research Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-1075, (Released:2021-03-25)

参考文献数

22

被引用文献数

1 15

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Background:Recently, identification of independent risk factors for ischemic stroke in Japanese non-valvular atrial fibrillation (NVAF) patients was made by analyzing the 5 major Japanese registries: J-RHYTHM Registry, Fushimi AF Registry, Shinken Database, Keio interhospital Cardiovascular Studies, and the Hokuriku-Plus AF Registry.Methods and Results:The predictive value of the risk scheme in Japanese NVAF patients was assessed. Of 16,918 patients, 12,289 NVAF patients were analyzed (mean follow up, 649±181 days). Hazard ratios (HRs) of each significant, independent risk factor were determined by using adjusted Cox-hazard proportional analysis. Scoring system for ischemic stroke was created by transforming HR logarithmically and was estimated by c-statistic. During the 21,820 person-years follow up, 241 ischemic stroke events occurred. Significant risk factors were: being elderly (aged 75–84 years [E], HR=1.74), extreme elderly (≥85 years [EE], HR=2.41), having hypertension (H, HR=1.60), previous stroke (S, HR=2.75), type of AF (persistent/permanent) (T, HR=1.59), and low body mass index <18.5 kg/m2(L, HR=1.55) after adjusting for oral anticoagulant treatment. The score was assigned as follows: 1 point to H, E, L, and T, and 2 points to EE and S (HELT-E2S2score). The C-statistic, using this score, was 0.681 (95% confidence interval [CI]=0.647–0.714), which was significantly higher than those using CHADS2(0.647; 95% CI=0.614–0.681, P=0.027 for comparison) and CHA2DS2-VASc scores (0.641; 95% CI=0.608–0.673, P=0.008).Conclusions:The HELT-E2S2score may be useful for identifying Japanese NVAF patients at risk of ischemic stroke.

著者

Paula SERRANO-GONZÁLEZ César CUESTA-GARCÍA Eva GIROL-LÓPEZ Ferran CUENCA-MARTÍNEZ

出版者

Japanese Society of Physical Therapy

雑誌

Physical Therapy Research (ISSN:21898448)

巻号頁・発行日

pp.E10134, (Released:2022-01-12)

参考文献数

24

被引用文献数

2

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Objective: Among solid tumours, medulloblastoma is the most common of the posterior fossa neoplasms, given that it represents 15%-20% of childhood brain tumours. The main aim of the present study was to assess the effects of action observation training on the activities of daily living (ADL) and the manipulation skills of children with acquired brain injury secondary to an oncological process. Methods: We recruited a consecutive convenience sample of 5 patients diagnosed with acquired brain injury secondary to an oncological process. ADL and manipulation skills were assessed using the ABILHAND-Kids and Jebsen-Taylor Hand Function Test, respectively. After conducting the initial evaluation, we planned the intervention, which lasted 10 weeks and consisted of 40 sessions for each participant, 10 in the occupational therapy department and 30 at home. After completing the intervention, we re-evaluated the main variables. Results: Overall, the results of the postintervention ABILHAND-Kids questionnaire showed a 5-point improvement, with a statistically significant difference and a large effect size. Eighty per cent of the sample showed better results in the total score, with differences between 4 and 8 points. In relation to manual dexterity, as measured by the Jebsen-Taylor Hand Function Test, there were no significant changes, except in one of the participants. Conclusion: It appears that action observation training can elicit positive changes with respect to the development of ADL, but the influence on manual dexterity was almost nonexistent.

著者

Keisuke KAWASE Jumpei TOMIYASU Kazuyuki BAN Ryosuke ONO Satoshi ANDO Aya ONO Ran KIMURA Kanako TOMISAWA Motozumi MATSUI Shun-ichi SHIIHARA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0032, (Released:2021-07-19)

被引用文献数

2

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Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vaccine as a method of suppressing reproductive activity in a sexually matured female lion. Under behavioral restraint, the vaccine was injected twice (days 0 and 109). After the initial vaccination, ovarian activity is still observed. After the second vaccination, contraceptive effect was confirmed for 246 days until restart of estrous cycles. We confirmed only a slight swelling around the injection site after the second vaccination. This study may suggest an alternative option for a contraceptive method in lions.

著者

Chan-Won Kim Sungwoo Hong Yoosoo Chang Jung Ah Lee Hocheol Shin Seungho Ryu

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0692, (Released:2020-12-11)

参考文献数

30

被引用文献数

7

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Background:A high level of apolipoprotein B (apoB) is associated with incident coronary artery disease (CAD) when low-density lipoprotein cholesterol (LDL-C) level is discordantly low or concordantly high. However, data on the relationship of apoB with subclinical measure of CAD are limited.Methods and Results:A total of 14,205 men (mean age 41.0 years) who were free of cardiovascular disease at baseline and who underwent a health checkup exam, including measurement of coronary artery calcium (CAC), were studied. Of the study group, 2,773 participants (19.5%) had CAC at baseline, and CAC progression was observed in 2,550 (18.0%). The multivariate-adjusted CAC score ratios (95% confidence interval) comparing discordantly high apoB/low LDL-C and concordantly high apoB/high LDL-C with concordantly low apoB/low LDL-C were 1.51 (0.98–2.32) and 2.70 (2.19–3.33), respectively. The corresponding relative risks for CAC progression were 1.26 (1.02–1.56) and 1.49 (1.34–1.66), respectively. These associations did not change appreciably after adjustment for insulin resistance and subclinical inflammation.Conclusions:Discordant analysis showed that a high apoB level was strongly associated with prevalence and progression of CAC independent of LDL-C in a large cohort of healthy adults. The present study results highlighted the importance of an apoB measure as a potential target for primary prevention of coronary atherosclerosis in healthy adults.

著者

Wei-Ting Wang Pai-Feng Hsu Chung-Chi Lin Yuan-Jen Wang Yaw-Zon Ding Teh-Ling Liou Ying-Wen Wang Shao-Sung Huang Tse-Min Lu Po-Hsun Huang Jaw-Wen Chen Wan-Leong Chan Shing-Jong Lin Hsin-Bang Leu

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.51425, (Released:2019-12-27)

参考文献数

20

被引用文献数

7

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Aim: Coronary atherosclerotic plaques can be detected in asymptomatic subjects and are related to low-density lipoprotein cholesterol (LDL) levels in patients with coronary artery disease. However, researchers have not yet determined the associations between various plaque characteristics and other lipid parameters, such as HDL-C and TG levels, in low-risk populations. Methods: One thousand sixty-four non-diabetic subjects (age, 57.86±9.73 years; 752 males) who underwent coronary computed tomography angiography (CCTA) were enrolled and the severity and patterns of atherosclerotic plaques were analyzed. Results: Statin use was reported by 25% of the study population, and subjects with greater coronary plaque involvement (segment involvement score, SIS) were older and had a higher body mass index (BMI), blood pressure, unfavorable lipid profiles and comorbidities. After adjusting for comorbidities, only age (β=0.085, p<0.001), the male gender (β=1.384, p<0.001), BMI (β=0.055, p=0.019) and HbA1C levels (β=0.894, p<0.001) were independent factors predicting the greater coronary plaque involvement in non-diabetic subjects. In the analysis of significantly different (>50%) stenosis plaque patterns, age (OR: 1.082, 95% CI: 10.47-1.118) and a former smoking status (OR: 2.061, 95% CI: 1.013-4.193) were independently associated with calcified plaques. For partial calcified (mixed type) plaques, only age (OR: 1.085, 95% CI: 1.052-1.119), the male gender (OR: 7.082, 95% CI: 2.638-19.018), HbA1C levels (OR: 2.074, 95% CI: 1.036-4.151), and current smoking status (OR: 1.848, 95% CI: 1.089-3.138) were independently associated with the risk of the presence of significant stenosis in mixed plaques. Conclusions: A higher HbA1c levels is independently associated with the presence and severity of coronary artery atherosclerosis in non-diabetic subjects, even when LDL-C levels are tightly controlled.

著者

Jeong-Il Kang Young-Jun Moon Dae-Keun Jeong Hyun Choi Joon-Su Park Hyun-Ho Choi Young-Kee Song

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.7, pp.906-909, 2018 (Released:2018-07-03)

参考文献数

18

被引用文献数

3

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[Purpose] The current study aimed to identify the effects of dynamic neural mobilization on cerebral cortical activity in patients with stroke, and to present efficient intervention methods for stroke management. [Subjects and Methods] A total of 20 hemiplegic patients diagnosed with stroke over the past 6 months were sampled, and randomly divided into groups I (n=10) and II (n=10). Groups I and II underwent neural mobilization and dynamic neural mobilization, respectively, on the paralyzed arm. Both interventions were administered for 30 min, once a day, for 4 days a week, over a course of 4 weeks. β-waves and μ-rhythms in the C3 and C4 areas of the cerebral cortex were measured using electroencephalography, both before and after the intervention. [Results] After the intervention, both groups showed significant changes in the β-waves and μ-rhythms in the C3 area alone. Further, significant inter-group differences in the β-waves and μ-rhythms were only present in the C3 area. [Conclusion] Dynamic neural mobilization is an efficient intervention because it increases β-waves and μ-rhythms in the cerebral cortex. Therefore, the effects of continuous intervention programs involving dynamic neural mobilization in patients with stroke should be investigated in the future.

著者

Moises Torres-Gonzalez Jeff S. Volek Jose O. Leite Heather Fraser Maria Luz Fernandez

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.15, no.5, pp.235-243, 2008 (Released:2008-11-01)

参考文献数

42

被引用文献数

4 9

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Aim: There is limited information on how dietary carbohydrate restriction (CR) or the combination of dietary cholesterol (chol) and CR may affect atherosclerosis development. Guinea pigs were used to evaluate the effects of chol and CR on aortic cholesterol accumulation, mechanical properties of aortas and cytokine production.Methods: Ten male guinea pigs were fed either low (L) or high (H) chol in combination with CR or high carbohydrate (control) for 12 wk.Results: Groups fed the high chol (control-H and CR-H) had significantly higher concentrations of cholesterol in aortas and higher activity of serum phospholipase A2 than the L groups. CR resulted in significantly lower concentrations of small LDL particles and aortic cytokines and chemokynes than the control groups. Aortas from the control-H and the CR-L were stiffer than those from the control-L and the CR-H groups. This finding could be explained by the reduction in arterial stiffness during the early stages of atherosclerotic.Conclusion: these results demonstrate that CR has a major impact on atherogenicity.

著者

Sung Joon Yun Moon-Hwan Kim Jong-Hyuck Weon Young Kim Sung-Hoon Jung Oh-Yun Kwon

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.8, pp.2241-2244, 2016 (Released:2016-08-31)

参考文献数

26

被引用文献数

15

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[Purpose] This study assessed the relationships between peak toe flexor muscle strength, ankle dorsiflexion range of motion, and countermovement jump height. [Subjects and Methods] Eighteen healthy volunteers participated in the study. Each participant completed tests for peak toe flexor muscle strength, ankle dorsiflexion range of motion, and countermovement jump height. [Results] The results showed (1) a moderate correlation between ankle dorsiflexion range of motion and countermovement jump height and (2) a high correlation between peak first toe flexor muscle strength and countermovement jump height. Peak first toe flexor muscle strength and ankle dorsiflexion range of motion are the main contributors to countermovement jump performance. [Conclusion] These findings indicate that the measurement of peak first toe flexor muscle strength and ankle dorsiflexion range of motion may be useful in clinical practice for improving jump performance in athletes training for sports such as volleyball and basketball.

著者

Shin-ichiro Ohmura Yusuke Ohkubo Ryuhei Ishihara Yoshiro Otsuki Toshiaki Miyamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0293-22, (Released:2022-09-06)

参考文献数

28

被引用文献数

5

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Coronavirus disease 2019 (COVID-19) vaccines have been delivered worldwide to prevent the spread of the disease, and almost all Japanese have received the mRNA vaccines "BNT162b2" (Pfizer-Biotech) or "mRNA-1273" (Moderna). These vaccines have shown efficacy and safety with only minor adverse drug reactions. However, some patients develop severe adverse drug reactions, including autoimmune reactions. In addition, systemic vasculitis, mainly small-vessel vasculitis, following COVID-19 vaccination, has been reported. However, only a few investigators have reported medium-vessel vasculitis following vaccination. We herein report a case of medium-vessel vasculitis presenting with myalgia as the initial clinical manifestation following COVID-19 Moderna vaccination.