著者

Akihiko Nakamura Kei-ichi Okazaki Tadaomi Furuta Minoru Sakurai Jun Ando Ryota Iino

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.17, pp.51-58, 2020 (Released:2020-07-10)

参考文献数

26

被引用文献数

4 5

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Motor proteins are essential units of life and are well-designed nanomachines working under thermal fluctuations. These proteins control moving direction by consuming chemical energy or by dissipating electrochemical potentials. Chitinase A from bacterium Serratia marcescens (SmChiA) processively moves along crystalline chitin by hydrolysis of a single polymer chain to soluble chitobiose. Recently, we directly observed the stepping motions of SmChiA labeled with a gold nanoparticle by dark-field scattering imaging to investigate the moving mechanism. Time constants analysis revealed that SmChiA moves back and forth along the chain freely, because forward and backward states have a similar free energy level. The similar probabilities of forward-step events (83.5%=69.3%+14.2%) from distributions of step sizes and chain-hydrolysis (86.3%=(1/2.9)/(1/2.9+1/18.3)×100) calculated from the ratios of time constants of hydrolysis and the backward step indicated that SmChiA moves forward as a result of shortening of the chain by a chitobiose unit, which stabilizes the backward state. Furthermore, X-ray crystal structures of sliding intermediate and molecular dynamics simulations showed that SmChiA slides forward and backward under thermal fluctuation without large conformational changes of the protein. Our results demonstrate that SmChiA is a burnt-bridge Brownian ratchet motor.

著者

Tatsuya Nomoto Takehiro Seta Koichi Nomura Yukihiro Shikama Tadashi Katagiri Ken-ichiro Katsura Takeo Kato Yasuo Katayama

出版者

The Medical Association of Nippon Medical School

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.74, no.3, pp.261-264, 2007 (Released:2007-07-12)

参考文献数

6

被引用文献数

3 8

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Recently, an outbreak of acute encephalopathy associated with Sugihiratake mushroom ingestion has been reported in northern Japan. Patients with chronic kidney diseases are thought to be at risk for severe encephalopathy following Sugihiratake mushroom ingestion. We report a case of encephalopathy associated with Sugihiratake mushroom ingestion in a patient with diabetic nephropathy. Brain magnetic resonance imaging showed discriminative intensity in the medial temporal lobe, claustrum, and insula cortex bilaterally. Cerebrospinal fluid examination revealed mildly elevated protein and marked elevation of myelin basic protein without pleocytosis. Twenty-five days after admission, these signal-intensity changes had markedly improved, and the patient was discharged without sequelae. Although the exact mechanism of this acute encephalopathy remains undetermined, demyelination is believed to be a possible associated pathological change. In cases of encephalopathy of undetermined cause with distinct magnetic resonance findings, Sugihiratake mushroom intoxication should be considered in areas where ingestion of this mushroom is common.

著者

Masato Nakamura Hitoshi Yaku Junya Ako Hirokuni Arai Tohru Asai Taishiro Chikamori Hiroyuki Daida Kiyoshi Doi Toshihiro Fukui Toshiaki Ito Kazushige Kadota Junjiro Kobayashi Tatsuhiko Komiya Ken Kozuma Yoshihisa Nakagawa Koichi Nakao Hiroshi Niinami Takayuki Ohno Yukio Ozaki Masataka Sata Shuichiro Takanashi Hirofumi Takemura Takafumi Ueno Satoshi Yasuda Hitoshi Yokoyama Tomoyuki Fujita Tokuo Kasai Shun Kohsaka Takashi Kubo Susumu Manabe Naoya Matsumoto Shigeru Miyagawa Tomohiro Mizuno Noboru Motomura Satoshi Numata Hiroyuki Nakajima Hirotaka Oda Hiromasa Otake Fumiyuki Otsuka Ken-ichiro Sasaki Kazunori Shimada Tomoki Shimokawa Toshiro Shinke Tomoaki Suzuki Masao Takahashi Nobuhiro Tanaka Hiroshi Tsuneyoshi Taiki Tojo Dai Une Satoru Wakasa Koji Yamaguchi Takashi Akasaka Atsushi Hirayama Kazuo Kimura Takeshi Kimura Yoshiro Matsui Shunichi Miyazaki Yoshitaka Okamura Minoru Ono Hiroki Shiomi Kazuo Tanemoto on behalf of the Japanese Circulation Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-1282, (Released:2022-01-31)

参考文献数

1179

被引用文献数

38

著者

Akira Kuwano-Yoshida

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.10, pp.199-203, 2014 (Released:2014-12-06)

参考文献数

29

被引用文献数

9 18

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The “Local deepening rate (LDR)”, the local surface pressure tendency, which is normalized by the sine of latitude and similar to the definition of an explosive cyclone, is introduced to extratropical cyclone activity analysis. The LDR has the advantage of being much simpler than conventional methods such as cyclone tracking and time filtering. The time average of positive LDR, which implies cyclone deepening, captures not only individual explosive cyclone's deepening but also the mid-latitude storm track climatology. The probability of explosive deepening, defined as LDR ≥ 1 hPa h-1 and based on ensemble forecasts, accurately represents the deepening potential and provides information regarding the influence area of storms—analogous to the strong wind area used in typhoon forecasts. The LDR can also be used to assess the quality of storm tracks in reanalyses products. In the 20th century reanalysis, the storm track activity, calculated from ensemble mean surface pressure, is too weak before 1910 in the North Pacific, and in the South Pacific low activity is observed up to the end of the 20th century, because of large ensemble spread due to few surface pressure observations.

著者

Tae OHGAKI Hideshige TAKADA Ryu YOSHIDA Kaoruko MIZUKAWA Bee Geok YEO Mona ALIDOUST Natsuki HIRAI Rei YAMASHITA Takashi TOKUMARU Izumi WATANABE Siaw ONWONA-AGYEMAN Patricia GARDINER Marcus ERIKSEN Jay F. KELLY Carlos J. RODRÍGUEZ-SIERRA Laurent COLASSE Juan BAZTAN Fabiano Prado BARRETTO Gabriel Mendes IZAR Denis ABESSA Mohamad Pauzi ZAKARIA Charita S. KWAN Mahua SAHA Peter G. RYAN Steven WEERTS John OFOSU-ANIM Edward Benjamin SABI Lailah Gifty AKITA Heidi TAIT Cecilia ERIKSSON Harry BURTON

出版者

Japan Society for Environmental Chemistry

雑誌

Environmental Monitoring and Contaminants Research (ISSN:24357685)

巻号頁・発行日

vol.1, pp.75-90, 2021 (Released:2021-08-18)

参考文献数

67

被引用文献数

4

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Polybrominated diphenyl ethers (PBDEs) were measured in plastic resin pellets collected from 65 beaches across 27 countries worldwide. They were detected at 49 locations at concentrations of the sum of 49 congeners of up to 46 ng/g-pellet and a median of 2 ng/g-pellet. These values are one to two orders of magnitude lower than those of polychlorinated biphenyls (PCBs) (median, 51 ng/g-pellet). This difference can be attributed to lower production of the Penta-BDE technical mixture, which is used extensively in some countries, and lower availability of brominated flame retardants for equilibrium partitioning than PCBs. Tetra-, penta-, and hexa-brominated congeners (BDE-47, 99, 100, 153, 154) were dominant over a deca-substituted congener (BDE-209) in many samples; this was significantly detected in pellets from some locations. Results indicate that pellets reflect the pollution status of PBDEs in the dissolved phase in seawater. From the ranking of the summed concentrations of six major PBDE congeners (Σ6PBDEs), we propose five levels of pollution categorization (ng/g-pellet): no (<0.2), slight (0.2–0.78), moderate (0.78–2.6), high (2.6–8.5), and extreme (>8.5) local pollution. The USA and neighboring countries were categorized as extreme (17–36 ng/g-pellet), western Europe and Japan were categorized as high (≤8.8), and most Asian and African countries were categorized as slight (<0.8). Notably, extreme or high pollution levels were also observed in countries with no history of PBDE production, such as Ghana (Σ6PBDEs up to 16 ng/g-pellet), the Philippines (7.5), and Hong Kong (7.7). Scrapped electrical and electronic waste might explain these anomalously high values.

著者

Al Imran Malik Pasajee Kongsil Vũ Anh Nguyễn Wenjun Ou Sholihin Pao Srean MN Sheela Luis Augusto Becerra López-Lavalle Yoshinori Utsumi Cheng Lu Piya Kittipadakul Hữu Hỷ Nguyễn Hernan Ceballos Trọng Hiển Nguyễn Michael Selvaraj Gomez Pornsak Aiemnaka Ricardo Labarta Songbi Chen Suwaluk Amawan Sophearith Sok Laothao Youabee Motoaki Seki Hiroki Tokunaga Wenquan Wang Kaimian Li Hai Anh Nguyễn Văn Đồng Nguyễn Lê Huy Hàm Manabu Ishitani

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

pp.18180, (Released:2020-03-05)

被引用文献数

70

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In Asia, cassava (Manihot esculenta) is cultivated by more than 8 million farmers, driving the rural economy of many countries. The International Center for Tropical Agriculture (CIAT), in partnership with national agricultural research institutes (NARIs), instigated breeding and agronomic research in Asia, 1983. The breeding program has successfully released high-yielding cultivars resulting in an average yield increase from 13.0 t ha–1 in 1996 to 21.3 t ha–1 in 2016, with significant economic benefits. Following the success in increasing yields, cassava breeding has turned its focus to higher-value traits, such as waxy cassava, to reach new market niches. More recently, building resistance to invasive pests and diseases has become a top priority due to the emergent threat of cassava mosaic disease (CMD). The agronomic research involves driving profitability with advanced technologies focusing on better agronomic management practices thereby maintaining sustainable production systems. Remote sensing technologies are being tested for trait discovery and large-scale field evaluation of cassava. In summary, cassava breeding in Asia is driven by a combination of food and market demand with technological innovations to increase the productivity. Further, exploration in the potential of data-driven agriculture is needed to empower researchers and producers for sustainable advancement.

著者

Silvano GALLUS Alessandra LUGO Xiaoqiu LIU Panagiotis BEHRAKIS Roberto BOFFI Cristina BOSETTI Giulia CARRERAS Liliane CHATENOUD Luke CLANCY Xavier CONTINENTE Ruaraidh DOBSON Tobias EFFERTZ Filippos T. FILIPPIDIS Marcela FU Gergana GESHANOVA Giuseppe GORINI Sheila KEOGAN Hristo IVANOV Maria-José LOPEZ Angel LOPEZ-NICOLAS José PRECIOSO Krzysztof PRZEWOZNIAK Cornel RADU-LOGHIN Ario RUPRECHT Sean SEMPLE Joan B SORIANO Polina STARCHENKO Marta TRAPERO-BERTRAN Olena TIGOVA Anna S TZORTZI Constantine VARDAVAS Vergina K VYZIKIDOU Paolo COLOMBO Esteve FERNANDEZ the TackSHS Project Investigators

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20190344, (Released:2020-04-04)

参考文献数

35

被引用文献数

51

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Background: Population data on tobacco use and its determinants require continuous monitoring and careful inter-country comparison. We aimed to provide the most up-to-date estimates on tobacco smoking from a large cross-sectional survey, conducted in selected European countries.Methods: Within the TackSHS Project, a face-to-face survey on smoking was conducted in 2017-2018 in 12 countries: Bulgaria, England, France, Germany, Greece, Ireland, Italy, Latvia, Poland, Portugal, Romania and Spain, representing around 80% of the 432 million European Union (EU) adult population. In each country, a representative sample of around 1,000 subjects aged 15 years and older was interviewed, for a total of 11,902 participants.Results: Overall 25.9% of participants were current smokers (31.0% among men and 21.2% among women, p<0.001), while 16.5% were former smokers. Smoking prevalence ranged from 18.9% in Italy to 37.0% in Bulgaria. It decreased with increasing age (compared to <45, multivariable odds ratio, OR, for ≥65 years was 0.31; 95% confidence interval, CI: 0.27-0.36), level of education (OR for low vs. high was 1.32; 95% CI: 1.17-1.48) and self-rated household economic level (OR for low vs. high was 2.05; 95% CI: 1.74-2.42). The same patterns were found in both sexes.Conclusions: These smoking prevalence estimates represent the most up-to-date evidence in Europe. From them it can be derived that there are more than 112 million current smokers in the EU-28. Lower socio-economic status is a major determinant of smoking habit in both sexes.

著者

Yumiko Imai Keiji Kuba Takayo Ohto-Nakanishi Josef M. Penninger

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.74, no.3, pp.405-410, 2010 (Released:2010-02-25)

参考文献数

66

被引用文献数

29 146

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Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. For instance, in the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in SARS pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis. (Circ J 2010; 74: 405 - 410)

著者

Aya MATSUU Shin-ichi YOKOTA Keiko ITO Tatsunori MASATANI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.11, pp.1853-1856, 2017 (Released:2017-11-17)

参考文献数

11

被引用文献数

14

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On Amami Oshima Island, free-ranging and feral cats are harmful to wildlife populations. In this study, the seroprevalence of Toxoplasma gondii in these cats was examined using a newly developed Gaussia luciferase immunoprecipitation system assay. Of 1,363 cats, 123 cats (9.0%) was positive for T. gondii. The prevalence was significantly different in different areas; among cats in the rural area, where many wild animals live, including endangered species, T. gondii infection was more prevalent than in the urban area of the island. This finding indicates a possible risk to wildlife of infection from free-ranging and feral cats. Therefore, management of cats is important for wildlife conservation.

著者

張 淑倩 SHU-CHIEN CHANG 湘北短期大学非常勤講師 Shohoku College

出版者

湘北短期大学・紀要委員会

雑誌

湘北紀要 (ISSN:03859096)

巻号頁・発行日

no.28, pp.89-99, 2007

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Chinese language has many words containing a color related Chinese character. These words not simply indicate colors but also imply other meanings deriving from these colors. In China, colors often have symbolic meanings. The present paper discusses these social, cultural, and ideologieal meanings of colors used in Chinese language.

著者

Ji-Hyun Lee Sangyong Lee SeokJoo Choi Yoon-Hee Choi Kwansub Lee

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.3, pp.536-538, 2017 (Released:2017-03-22)

参考文献数

17

被引用文献数

1 23

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[Purpose] The purpose of this study was to identify the effects of extracorporeal shock wave therapy on the pain and function of patients with degenerative knee arthritis. [Subjects and Methods] Twenty patients with degenerative knee arthritis were divided into a conservative physical therapy group (n=10) and an extracorporeal shock wave therapy group (n=10). Both groups received general conservative physical therapy, and the extracorporeal shock wave therapy was additionally treated with extracorporeal shock wave therapy after receiving conservative physical therapy. Both groups were treated three times a week over a four-week period. The visual analogue scale was used to evaluate pain in the knee joints of the subjects, and the Korean Western Ontario and McMaster Universities Osteoarthritis Index was used to evaluate the function of the subjects. [Results] The comparison of the visual analogue scale and Korean Western Ontario and McMaster Universities Osteoarthritis Index scores within each group before and after the treatment showed statistically significant declines in scores in both the conservative physical therapy group and extracorporeal shock wave therapy group. A group comparison after the treatment showed statistically significant differences in these scores in the extracorporeal shock wave therapy group and the conservative physical therapy group. [Conclusion] extracorporeal shock wave therapy may be a useful nonsurgical intervention for reducing the pain of patients with degenerative knee arthritis and improving these patients’ function.

著者

Meiji Honda Akira Yamazaki Akira Kuwano-Yoshida Yusuke Kimura Katsushi Iwamoto

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.12, pp.259-264, 2016 (Released:2016-09-22)

参考文献数

17

被引用文献数

8

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Synoptic conditions causing an extreme snowfall event in the Kanto-Koshin district occurred on 14-15 February 2014 are investigated through a reanalysis data set. Associated with a developing cyclone passing the south coast of Japan, persistent snowfall exceeding more than 24 hours over the Kofu-Basin resulted in 112 cm snowfall at Kofu. Slow progress of the south-coast cyclone also contributed to the long snowfall duration. An anticyclone developed over the northern Japan (∼1032 hPa) also contributed to this extreme snowfall. This anticyclone brought warm and moist air inflow by southeasterlies forming moisture flux convergence over the Kanto-Koshin district on the morning of 14th when snowfall started in the Koshin district in spite that the south-coast cyclone was located to the south of Kyushu. Further, ageostrophic cold northerlies with high pressure extension from the anticyclone by “cold-air damming (CAD)” would suppress warming with the approaching south-coast cyclone and keep snowfall until the morning of 15th. In other four heavy snowfall events at Kofu, snowfall durations were almost 12 hours. Although anticyclone to the north and CAD were identified in each case, the moisture transport from the southeast was not evident and moisture flux convergence was not formed earlier.

著者

Ki Hun Cho Min Kyu Kim Hwang-Jae Lee Wan Hee Lee

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.236, no.4, pp.273-280, 2015 (Released:2015-07-31)

参考文献数

33

被引用文献数

34

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Virtual reality training is considered as an effective intervention method of stroke patients, and the virtual reality system for therapeutic rehabilitation has emphasized the cognitive factors to improve walking function. The purpose of current study was to investigate the effect of virtual reality training with cognitive load (VRTCL) on walking function of chronic stroke. Chronic stroke patients were randomly assigned to the VRTCL group (11 patients, including 5 men; mean age, 60.0 years; post-stroke duration, 273.9 days) or control group (11 patients, including 2 men; mean age, 58.6 years; post-stroke duration, 263.9 days). All subjects participated in the standard rehabilitation program that consisted of physical and occupational therapies. In addition, VRTCL group participated in the VRTCL for 4 weeks (30 min per day and five times a week), while those in the control group participated in virtual reality treadmill training. Walking function under single (walking alone) and dual task (walking with cognitive tasks) conditions was assessed using an electrical walkway system. After the 4-week intervention, under both single and dual task conditions, significant improvement on walking function was observed in VRTCL and control groups (P < 0.05). In addition, in the dual task condition, greater improvement on walking function was observed in the VRTCL group, compared with the control group (P < 0.05). These findings demonstrated the efficacy of VRTCL on the walking function under the dual task condition. Therefore, we suggest that VRTCL may be an effective method for the achievement of independent walking in chronic stroke patients.

著者

HIROMI YOSHIDA-KOMIYA AYA GOTO SEIJI YASUMURA KEIYA FUJIMORI MASAFUMI ABE FOR THE PREGNANCY AND BIRTH SURVEY GROUP OF THE FUKUSHIMA HEALTH MANAGEMENT SURVEY

出版者

福島医学会

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

vol.61, no.1, pp.66-71, 2015 (Released:2015-07-08)

参考文献数

22

被引用文献数

6

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Background: The Fukushima Pregnancy and Birth Survey was launched to monitor pregnant mothers’ health after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant (NPP) accident. Several lines of investigations have indicated that a disaster impacts maternal mental health with childbirth. However, there is no research regarding mental health of mothers with fetal loss after a disaster. In this report, we focus on those women immediately after the Great East Japan Earthquake and Fukushima NPP accident and discuss their support needs.Materials and Methods: Data regarding 61 miscarriages, 5 abortions, and 22 stillbirths were analyzed among the women who were pregnant at the time of the accident in the present study. We used a two-item case-finding instrument for depression screening, and compared the childbirth group with the fetal loss groups. We also analyzed mothers’ opinions written as free-form text.Results: Among the three fetal loss groups, the proportion of positive depression screens was significantly higher in the miscarriage and stillbirth group than in the childbirth group. Mothers’ opinions were grouped into six categories, with pregnancy-related items being most common, especially in the miscarriage and stillbirth groups.Conclusion: A higher proportion of Fukushima mothers with fetal loss, especially those with miscarriage and stillbirth, had depressive symptoms compared to those who experienced childbirth. Health care providers need to pay close attention to this vulnerable group and respond to their concerns regarding the effects on their fertility.

著者

Ko Yamamoto Hiroki Shiomi Takeshi Morimoto Hiroki Watanabe Akiyoshi Miyazawa Kyohei Yamaji Masanobu Ohya Sunao Nakamura Satoru Mitomo Satoru Suwa Takenori Domei Shojiro Tatsushima Koh Ono Hiroki Sakamoto Kiyotaka Shimamura Masataka Shigetoshi Ryoji Taniguchi Yuji Nishimoto Hideki Okayama Kensho Matsuda Kenji Nakatsuma Yohei Takayama Jun Kuribara Hidekuni Kirigaya Kohei Yoneda Yuta Imai Umihiko Kaneko Hiroshi Ueda Kota Komiyama Naotaka Okamoto Satoru Sasaki Kengo Tanabe Mitsuru Abe Kiyoshi Hibi Kazushige Kadota Kenji Ando Takeshi Kimura on behalf of the OPTIVUS-Complex PCI Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0837, (Released:2023-03-11)

参考文献数

11

被引用文献数

5

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Background: There is a paucity of data on the effect of optimal intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) compared with standard PCI or coronary artery bypass grafting (CABG) in patients with multivessel disease.Methods and Results: The OPTIVUS-Complex PCI study multivessel cohort was a prospective multicenter single-arm study enrolling 1,021 patients undergoing multivessel PCI including the left anterior descending coronary artery using IVUS aiming to meet the prespecified criteria for optimal stent expansion. We conducted propensity score matching analyses between the OPTIVUS group and historical PCI or CABG control groups from the CREDO-Kyoto registry cohort-3 (1,565 and 899 patients) fulfilling the inclusion criteria for this study. The primary endpoint was a composite of death, myocardial infarction, stroke, or any coronary revascularization. In the propensity score-matched cohort (OPTIVUS vs. historical PCI control: 926 patients in each group; OPTIVUS vs. historical CABG control: 436 patients in each group), the cumulative 1-year incidence of the primary endpoint was significantly lower in the OPTIVUS group than in the historical PCI control group (10.4% vs. 23.3%; log-rank P<0.001) or the historical CABG control group (11.8% vs. 16.5%; log-rank P=0.02).Conclusions: IVUS-guided PCI targeting the OPTIVUS criteria combined with contemporary clinical practice was associated with superior clinical outcomes at 1 year compared with not only the historical PCI control, but also the historical CABG control.

著者

Kyung-Duk Min Sun-Young Kim Sung-il Cho

出版者

The Japanese Society for Hygiene

雑誌

Environmental Health and Preventive Medicine (ISSN:1342078X)

巻号頁・発行日

vol.28, pp.48, 2023 (Released:2023-08-31)

参考文献数

42

被引用文献数

1

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Background: The effect of ambient PM2.5 on the incidence of tuberculosis (TB) has been investigated in epidemiological studies. However, they did not separately study new and relapsed TB infection and focused on relatively short-term effects of PM2.5. In this regard, we examined the associations of long-term PM2.5 exposures with both new and relapsed TB incidences in South Korea, where the disease burden of TB is greatest among high-income countries.Methods: An area-level ecological study of 250 districts was conducted from 2015 to 2019. Age- and sex-standardized TB incidence ratios for each district and year were used as outcome variables, and their associations with PM2.5 concentrations for one to five-year average were examined. Negative binomial regression models incorporating spatiotemporal autocorrelation were employed using integrated nested Laplace approximations. Stratified analyses were conducted by type of TB (total, new, and relapsed cases).Results: Districts with higher PM2.5 concentrations tended to have significantly higher TB recurrence rate. The relative risks per 10 µg/m3 PM2.5 increase were 1.218 (95% credible interval 1.051–1.411), 1.260 (1.039–1.527) and 1.473 (1.015–2.137) using the two, three and five-year average PM2.5 exposures, respectively.Conclusions: The results imply that interventions for reducing air pollution might help prevent TB recurrence.

著者

Ayumu Fujioka Kenji Yanishi Arito Yukawa Kojiro Imai Isao Yokota Kei Fujikawa Ayumu Yamada Akari Naito Keisuke Shoji Hirofumi Kawamata Yukihito Higashi Tomoaki Ishigami Ken-ichiro Sasaki Syuhei Tara Koichiro Kuwahara Satoshi Teramukai Satoaki Matoba

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0046, (Released:2023-03-10)

参考文献数

24

被引用文献数

4

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Background: Thromboangiitis obliterans (TAO) can lead to the development of critical limb-threatening ischemia (CLTI). Despite conventional treatments, such as smoking cessation or revascularization, young patients (<50 years) still require limb amputation. Therapeutic angiogenesis using bone marrow-derived mononuclear cell (BM-MNC) implantation has been tested and shown to have reasonable efficacy in CLTI. In this multicenter prospective clinical trial, we evaluated the safety and efficacy of BM-MNC implantation in CLTI patients with TAO.Methods and Results: We enrolled 22 CLTI patients with skin perfusion pressure (SPP) <30 mmHg. The primary endpoint of this trial is the recovery of SPP in the treated limb after a 180-day follow-up period. Secondary endpoints include the pain scale score and transcutaneous oxygen pressure (TcPO2). One patient dropped out during follow-up, leaving 21 patients (mean age 48 years, 90.5% male, Fontaine Class IV) for analysis. BM-MNC implantation caused no serious adverse events and increased SPP by 1.5-fold compared with baseline. Surprisingly, this effect was sustained over the longer term at 180 days. Secondary endpoints also supported the efficacy of this novel therapy in relieving pain and increasing TcPO2. Major amputation-free and overall survival probabilities at 3 years among all enrolled patients were high (95.5% and 89.5%, respectively).Conclusions: BM-MNC implantation showed safety and significant efficacy in CLTI patients with TAO.

著者

Yen-Ting Yeh Jung-Chung Hsu Pen-Chih Liao Ai-Hsien Li Yuan-Hung Liu Kuo-Chin Chen Wenpo Chuang Shin-Rong Ke Yu-Wei Chiu Yen-Wen Wu

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.2, pp.166-174, 2021-01-25 (Released:2021-01-25)

参考文献数

21

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Background:Studies investigating the modulators of mortality benefit conferred by peri-angioplasty glycoprotein IIb/IIIa inhibitors in ST-elevation myocardial infarction (STEMI) are still lacking.Methods and Results:A prospective database (n=1,025) of consecutive cases undergoing primary percutaneous coronary intervention for STEMI was retrospectively analyzed. For patients in Killip class I, II or III, IV, the multivariate-adjusted hazard ratios of 30-day all-cause mortality associated with adjunctive tirofiban were 3.873 (95% CI 0.504–29.745; P=0.193), 0.550 (95% CI 0.188–1.609; P=0.275), and 0.264 (95% CI 0.099–0.704; P=0.008), respectively. The P value for a linear trend was 0.032. Patients who had a body mass index (BMI) within 22.9–25.0 kg/m2had a significant benefit from tirofiban (adjusted HR 0.344; 95% CI 0.145–0.814; P=0.015) compared to other BMI groups. The P value for a quadratic trend was 0.012. A novel Killip−BMI score (KBS = 2.5 × Killip category − | BMI − 24 |) was calculated to select the beneficial population. A KBS ≥2 was associated with significant mortality benefit, whereas a KBS <0 predicted increased 30-day mortality with tirofiban use.Conclusions:Survival benefit from peri-angioplasty tirofiban therapy for STEMI was positively correlated with the Killip class. Tirofiban should be used cautiously in either underweight or overweight patients. The novel KBS used in this study can guide peri-angioplasty use of adjunctive tirofiban in patients with STEMI undergoing primary angioplasty.

著者

Chao ZHAO Kun ZHAO Xiaoyan LIU Yi-fan HUANG Bin LIU

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.19, no.4, pp.661-667, 2013 (Released:2013-09-05)

参考文献数

35

被引用文献数

6 10

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Orthogonal experiment was used to optimize the extraction conditions of Flammulina velutipes mycelia polysaccharides (FvP). Four independent variables (ratio of water to raw material, initial pH value, extracting temperature, and extracting time) were taken into consideration. A yield of FvP of 2.19% was obtained under an optimized condition (ratio of water to material of 50:1, initial pH value of 6.0, extracting temperature of 85°C, and extracting time of 6 h). Subsequently, antioxidative properties of FvP-2 (crude polysaccharides) and FvP-3 (deproteinized polysaccharides) prepared from F. velutipes mycelia were evaluated by monitoring the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and hydroxyl radical scavenging activity, together with antitumor activity against the human hepatocellular carcinoma BEL-7402 cells. DPPH scavenging rate of 65.85% and hydroxyl radical scavenging rate of 71.24% were obtained at 200 μg/mL of FvP-3. The inhibition rate of BEL-7402 cells was up to 45% at 640 μg/mL of FvP-2. These results suggested that FvP possesses potent antioxidant and antitumor properties. The polysaccharide may be useful as a functional food additive and an antioxidant and antitumor agent.

著者

YS-11エアラインの記録編集委員会編

出版者

日本航空技術協会

巻号頁・発行日

1998