著者

Nancy Ide C. Michael Sperberg-McQueen Lou Burnard

出版者

日本デジタル・ヒューマニティーズ学会

雑誌

デジタル・ヒューマニティーズ (ISSN:21897867)

巻号頁・発行日

vol.1, pp.3-28, 2018 (Released:2019-01-18)

著者

Mohammed M GAD Ahmed RAHOMA Ahmad M Al-THOBITY

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2017-191, (Released:2018-06-20)

参考文献数

42

被引用文献数

21

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The current study evaluated the effects of autoclave polymerization both with and without glass fiber (GF) reinforcement on the surface roughness and hardness of acrylic denture base material. Ninety disc specimens (30×2.5 mm) were prepared from Vertex resin and divided according to polymerization techniques into a water bath, short and long autoclave polymerization groups. Tested groups were divided into three subgroups according to the GF concentration (0, 2.5, and 5 wt%). Profilometer and Vickers hardness tests were performed to measure surface roughness and hardness. ANOVA and Tukey-Kramer multiple comparison tests analyzed the results, and p≤0.05 was considered statistically significant. Autoclave polymerization significantly decreased the surface roughness and increased the hardness of acrylic resin without GF reinforcement (p<0.05). However, 5 wt% GF addition significantly increased surface roughness and decreased hardness of the autoclave polymerized denture base resin (p<0.05). Surface properties of Polymethyl methacrylate (PMMA) denture base material improved with autoclave polymerization and negatively affected with GFs addition.

著者

Yoshimi KISHIMOTO Chie TAGUCHI Norie SUZUKI-SUGIHARA Emi SAITA Mika USUDA Wei WANG Yasunobu MASUDA Kazuo KONDO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.62, no.5, pp.361-365, 2016 (Released:2016-12-06)

参考文献数

26

被引用文献数

2 18

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The egg is a nutrient-dense food and contains a number of antioxidants. The consumption of eggs has been considered to improve the balance of diets, although its impact on serum cholesterol levels has been a matter of concern in many countries. Here, we conducted a pilot study to investigate whether daily additional consumption of an egg might affect serum lipid profiles and also antioxidant status in healthy subjects. Fourteen male subjects were provided with breakfasts including a boiled egg for 4 wk. At the end of intervention, serum concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were unchanged, despite the significant increase in the intake of dietary cholesterol. In contrast, a significant increase in high-density lipoprotein cholesterol (HDL-C) and a reduction of the LDL-C/HDL-C ratio were observed. Interestingly, the malondialdehyde modified-LDL (MDA-LDL)/LDL-C ratio and the oxidizability of LDL were significantly reduced. Serum total antioxidant capacity value after the intervention period was higher than at baseline. These data indicate that consuming one egg per day for 4 wk as breakfast in addition to a normal diet does not affect serum lipids, and suggests that it may improve serum antioxidant status in healthy males.

著者

Satoshi Hiraoka Ching-chia Yang Wataru Iwasaki

出版者

日本微生物生態学会 / 日本土壌微生物学会 / Taiwan Society of Microbial Ecology / 植物微生物研究会

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

pp.ME16024, (Released:2016-07-05)

被引用文献数

2 73

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Metagenomic approaches are now commonly used in microbial ecology to study microbial communities in more detail, including many strains that cannot be cultivated in the laboratory. Bioinformatic analyses make it possible to mine huge metagenomic datasets and discover general patterns that govern microbial ecosystems. However, the findings of typical metagenomic and bioinformatic analyses still do not completely describe the ecology and evolution of microbes in their environments. Most analyses still depend on straightforward sequence similarity searches against reference databases. We herein review the current state of metagenomics and bioinformatics in microbial ecology and discuss future directions for the field. New techniques will allow us to go beyond routine analyses and broaden our knowledge of microbial ecosystems. We need to enrich reference databases, promote platforms that enable meta- or comprehensive analyses of diverse metagenomic datasets, devise methods that utilize long-read sequence information, and develop more powerful bioinformatic methods to analyze data from diverse perspectives.

著者

Michifumi Tokuda Seigo Yamashita Satoko Shiomi Ryutaro Sakurai Hidenori Sato Hirotsuna Oseto Masaaki Yokoyama Kenichi Tokutake Mika Kato Ryohsuke Narui Shin-ichi Tanigawa Michihiro Yoshimura Teiichi Yamane

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0048, (Released:2023-05-30)

参考文献数

24

被引用文献数

2

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Background: Pulmonary vein stenosis (PVS) after PV isolation (PVI) for atrial fibrillation (AF) is a severe complication that requires angioplasty. This study aimed to compare the reduction of the cross-sectional PV area (PVA) and the incidence of PVS after cryoballoon (CB)-PVI, hot balloon (HB)-PVI, or laser balloon (LB)-PVI.Methods and Results: A total of 320 patients who underwent an initial catheter ablation procedure for AF using a CB, HB, or LB in 2 hospitals were included. They underwent contrast-enhanced multidetector CT before and 3 months after the procedure. In all 4 PVs, the reduction in PVA was more significant in the LB group than in the CB or HB groups, respectively. Moderate (50–75%) and severe (>75%) PVS were observed in 5.3% and 0.5% of the PVs, respectively. Although moderate PVS was more frequently observed in the LB group than in the CB or HB groups (8.2%, 3.8%, and 5.0%; P=0.03), the incidence of severe PVS was similar in the LB, CB, and HB groups (0.3%, 0.5%, and 1.0%; P=0.46). Symptomatic PVS requiring intervention occurred in 1 (0.3%) patient.Conclusions: Although the reduction in cross-sectional PVA and the incidence of moderate PVS after LB-PVI was more significant than after CB-PVI or HB-PVI, it rarely led to severe PVS. Symptomatic PVS requiring intervention was rare after the balloon ablation of AF.

著者

鄭 栄桓 CHONG Yong-hwan

出版者

明治学院大学国際平和研究所

雑誌

PRIME = プライム (ISSN:13404245)

巻号頁・発行日

no.36, pp.49-65, 2013-03

著者

Shu-Ming Chen Cheng-Deng Kuo Low-Tone Ho Jyh-Fei Liao

出版者

THE PHYSIOLOGICAL SOCIETY OF JAPAN

雑誌

The Japanese Journal of Physiology (ISSN:0021521X)

巻号頁・発行日

vol.55, no.4, pp.211-219, 2005 (Released:2006-01-28)

参考文献数

58

被引用文献数

8 8

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Both hypothyroid (Hypo) and hypozincemia are commonly observed in patients and animals with chronic renal failure (CRF). In CRF whether the hypothyroid plays a role in the pathogenesis of hypozincemia is unclear. This study is designed to investigate the effects of hypothyroid on intestinal zinc absorption and urinary zinc excretion in 5/6 nephrectomized (Nx) rats, because plasma zinc balance is attained through a controlled rate of intestinal uptake as well as renal reabsorption. Intestinal zinc absorption was carried out in jejunum and ileum segments by an in vivo perfusion technique and the renal zinc disposal was evaluated by a conventional method using a standard formula to calculate the zinc tubular reabsorption and the excretion of urinary zinc in 5/6 Nx rats with hypothyroidism. The Hypo-NxT rats showed a significant decrease in the rate of intestinal zinc absorption and in the response of plasma zinc levels during intestinal zinc perfusion compared with Eu-NxT rats. They also had significantly lower levels of mucosal zinc and MT as well as lower content of liver zinc than Eu-NxT rats after intestinal zinc perfusion for 80 min. Hypo-NxT rats showed low plasma zinc levels, but had a similar output of pancreaticobiliary zinc and excretion of 24-h urine zinc compared with the Eu-NxT rats. When 2% alcohol intestinal perfusion was used to produce water diuresis, the Hypo-NxT rats presented a higher excretion of urinary zinc than the Eu-NxT rats did, especially during 2% alcohol intestinal zinc perfusion. In the Hypo-NxT rats, the lower plasma zinc levels may thus result from the hypothyroid because it reduces intestinal zinc absorption. Increasing the urine flow rate may aggravate the reduction of plasma zinc level in Hypo-NxT rats because of the increased excretion of urinary zinc.

著者

Tomomi Ide Hidetaka Kaku Shouji Matsushima Takeshi Tohyama Nobuyuki Enzan Kouta Funakoshi Yoko Sumita Michikazu Nakai Kunihiro Nishimura Yoshihiro Miyamoto Miyuki Tsuchihashi-Makaya Masaru Hatano Issei Komuro Hiroyuki Tsutsui the JROADHF Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0947, (Released:2021-04-15)

参考文献数

35

被引用文献数

56

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Background:With aging population, the prevalence and incidence of heart failure (HF) have been increasing worldwide. However, the characteristics and outcomes of patients with HF in an era of aging are not well established in Japan.Methods and Results:The Japanese Registry Of Acute Decompensated Heart Failure (JROADHF), a retrospective, multicenter, nationwide registry, was designed to study the clinical characteristics and outcomes of patients hospitalized with HF throughout Japan in 2013. One-hundred and twenty-eight hospitals were selected by cluster random sampling and 13,238 hospitalized patients with HF were identified by medical record review. Demographics, medical history, severity, treatment, and in-hospital and long-term outcome data were collected from the Diagnostic Procedure Combination and medical charts. Data were analyzed using univariate and multivariate logistic regression analysis. The mean age of registered patients was 78.0±12.5 years and 52.8% were male. Elderly patients (age >75 years) accounted for 68.9%, and HF with preserved ejection fraction (HFpEF) accounted for 45.1%. Median length of hospital stay was 18 days and in-hospital mortality was 7.7%. The median follow-up period was 4.3 years, and the incidence rates for cardiovascular death and rehospitalization for HF were 7.1 and 21.1 per 100 person-years, respectively.Conclusions:A contemporary nationwide registry demonstrated that hospitalized HF patients were very elderly, HFpEF was common, and their prognosis was still poor in Japan.

著者

Mari Ishida Chisa Matsumoto Keisuke Kida Memori Fukuda Nobuyuki Kagiyama Kenya Kusunose Shingo Matsumoto Seitaro Nomura Takahiro Okumura Yasutsugu Shiono Tatsunori Taniguchi Atsushi Mizuno Takuya Kishi Koichi Node Issei Komuro Ken-ichi Hirata Directors of the Japanese Circulation Society

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.12, pp.2248-2251, 2021-11-25 (Released:2021-11-25)

参考文献数

8

著者

Noriko Saito-Tarashima Akiho Murai Noriaki Minakawa

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.70, no.5, pp.310-315, 2022-05-01 (Released:2022-05-01)

参考文献数

59

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DNA and RNA are ubiquitous molecules responsible for storage and transmission of genetic information and together comprise the central dogma of molecular biology. However, the recent emergence of synthetic genetic polymers is providing an opportunity to challenge the fundamental principles of life. Herein, we describe the ongoing attempts to rewrite the central dogma with 4′-thioDNA and 4′-thioRNA, which feature a sulfur instead of an oxygen atom in the furanose ring moiety. Using reconstituted Escherichia coli gene expression machinery, studies have shown that the genetic information conserved in 4′-thioDNA can be transcribed to 4′-thioRNA and eventually translated into protein, mirroring the processes that occur in nature. Such studies underscore the feasibility of controlling life by substances other than DNA and RNA.

著者

藤津 裕亮 山本 真行 Fujitsu Hiroaki Yamamoto Masa-yuki

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

平成28年度宇宙科学に関する室内実験シンポジウム 講演集 = Proceedings of 2017 Symposium on Laboratory Experiment for Space Science

巻号頁・発行日

2017-02

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平成28年度宇宙科学に関する室内実験シンポジウム (2017年2月27日-28日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県

著者

Je-myung Shim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.24, no.12, pp.1251-1253, 2012 (Released:2013-01-17)

参考文献数

9

被引用文献数

16 21

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[Purpose] The purpose of this study was to examine changes in the carpal tunnels and median nerves appearing due to frequent movements of fingers by ultrasonography in young adults who frequently use smartphones. [Subjects] The subjects of this study were 20 young male and female adults who had no limitation in the range of movement of neck, shoulder, and arm joints, musculoskeletal disorder of the arm, or neurological symptoms such as paraesthesia and agreed to participate in the study. [Methods] The subjects who agreed to participate in this study were asked to use a smartphone for 30 minutes while maintaining comfortable sitting postures on a chair. They were asked to maintain the position of their shoulders comfortably while maintaining an angle of around 90° at the elbow. Some values measured before and after the experiment using a smartphone for 30 minutes were compared. The carpal tunnel was measured using ultrasonography. [Results] There were significant differences in median nerve circumference length, area of the median nerve area, distance between the highest point of the median nerve to the lunate, and distance between the bottom point of the median nerve to the lunate between before and after the experiment(p

著者

Mari Ishida Chisa Matsumoto Keisuke Kida Memori Fukuda Nobuyuki Kagiyama Kenya Kusunose Shingo Matsumoto Seitaro Nomura Takahiro Okumura Yasutsugu Shiono Tatsunori Taniguchi Atsushi Mizuno Takuya Kishi Koichi Node Issei Komuro Ken-ichi Hirata Directors of the Japanese Circulation Society

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0822, (Released:2021-10-22)

参考文献数

8

著者

Akihiko Nogami Takashi Kurita Haruhiko Abe Kenji Ando Toshiyuki Ishikawa Katsuhiko Imai Akihiko Usui Kaoru Okishige Kengo Kusano Koichiro Kumagai Masahiko Goya Yoshinori Kobayashi Akihiko Shimizu Wataru Shimizu Morio Shoda Naokata Sumitomo Yoshihiro Seo Atsushi Takahashi Hiroshi Tada Shigeto Naito Yuji Nakazato Takashi Nishimura Takashi Nitta Shinichi Niwano Nobuhisa Hagiwara Yuji Murakawa Teiichi Yamane Takeshi Aiba Koichi Inoue Yuki Iwasaki Yasuya Inden Kikuya Uno Michio Ogano Masaomi Kimura Shun-ichiro Sakamoto Shingo Sasaki Kazuhiro Satomi Tsuyoshi Shiga Tsugutoshi Suzuki Yukio Sekiguchi Kyoko Soejima Masahiko Takagi Masaomi Chinushi Nobuhiro Nishi Takashi Noda Hitoshi Hachiya Masataka Mitsuno Takeshi Mitsuhashi Yasushi Miyauchi Aya Miyazaki Tomoshige Morimoto Hiro Yamasaki Yoshifusa Aizawa Tohru Ohe Takeshi Kimura Kazuo Tanemoto Hiroyuki Tsutsui Hideo Mitamura on behalf of the JCS/JHRS Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0637, (Released:2021-06-01)

参考文献数

1350

被引用文献数

75

著者

Takehiro Suzuki Hiroaki Yamaguchi Motoi Kikusato Tetsuro Matsuhashi Akihiro Matsuo Takeya Sato Yuki Oba Shun Watanabe Daichi Minaki Daisuke Saigusa Hiroko Shimbo Nobuyoshi Mori Eikan Mishima Hisato Shima Yasutoshi Akiyama Yoichi Takeuchi Akinori Yuri Koichi Kikuchi Takafumi Toyohara Chitose Suzuki Masahiro Kohzuki Jun-ichi Anzai Nariyasu Mano Shigeo Kure Teruyuki Yanagisawa Yoshihisa Tomioka Masaaki Toyomizu Sadayoshi Ito Hitoshi Osaka Ken-ichiro Hayashi Takaaki Abe

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.236, no.3, pp.225-232, 2015 (Released:2015-06-26)

参考文献数

27

被引用文献数

2 34

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Mitochondria are key organelles implicated in a variety of processes related to energy and free radical generation, the regulation of apoptosis, and various signaling pathways. Mitochondrial dysfunction increases cellular oxidative stress and depletes ATP in a variety of inherited mitochondrial diseases and also in many other metabolic and neurodegenerative diseases. Mitochondrial diseases are characterized by the dysfunction of the mitochondrial respiratory chain, caused by mutations in the genes encoded by either nuclear DNA or mitochondrial DNA. We have hypothesized that chemicals that increase the cellular ATP levels may ameliorate the mitochondrial dysfunction seen in mitochondrial diseases. To search for the potential drugs for mitochondrial diseases, we screened an in-house chemical library of indole-3-acetic-acid analogs by measuring the cellular ATP levels in Hep3B human hepatocellular carcinoma cells. We have thus identified mitochonic acid 5 (MA-5), 4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid, as a potential drug for enhancing ATP production. MA-5 is a newly synthesized derivative of the plant hormone, indole-3-acetic acid. Importantly, MA-5 improved the survival of fibroblasts established from patients with mitochondrial diseases under the stress-induced condition, including Leigh syndrome, MELAS (myopathy encephalopathy lactic acidosis and stroke-like episodes), Leber’s hereditary optic neuropathy, and Kearns-Sayre syndrome. The improved survival was associated with the increased cellular ATP levels. Moreover, MA-5 increased the survival of mitochondrial disease fibroblasts even under the inhibition of the oxidative phosphorylation or the electron transport chain. These data suggest that MA-5 could be a therapeutic drug for mitochondrial diseases that exerts its effect in a manner different from anti-oxidant therapy.

著者

Aad G. Abbott B. Abdallah J. Abdinov O. Abeloos B. Aben R. Abolins M. AbouZeid O. S. Abramowicz H. Abreu H. Abreu R. Abulaiti Y. Acharya B. S. Adamczyk L. Adams D. L. Adelman J. Adomeit S. Adye T. Affolder A. A. Agatonovic-Jovin T. Agricola J. Aguilar-Saavedra J. A. Ahlen S. P. Ahmadov F. Aielli G. Akerstedt H. Åkesson T. P A Akimov A. V. Alberghi G. L. Albert J. Albrand S. Alconada Verzini M. J. Aleksa M. Aleksandrov I. N. Alexa C. Alexander G. Alexopoulos T. Alhroob M. Alimonti G. Alison J. Alkire S. P. Allbrooke B. M M Allen B. W. Allport P. P. Aloisio A. Alonso A. Alonso F. Alpigiani C. Alvarez Gonzalez B. Álvarez Piqueras D. Alviggi M. G. Amadio B. T. Amako K. Amaral Coutinho Y. Amelung C. Amidei D. Amor Dos Santos S. P. Amorim A. Amoroso S. Amram N. Amundsen G. Anastopoulos C. Ancu L. S. Andari N. Andeen T. Anders C. F. Anders G. Anders J. K. Anderson K. J. Andreazza A. Andrei V. Angelidakis S. Angelozzi I. Anger P. Angerami A. Anghinolfi F. Anisenkov A. V. Anjos N. Annovi A. Antonelli M. Antonov A. Antos J. Anulli F. Aoki M. Aperio Bella L. Arabidze G. Arai Y. Araque J. P. Arce A. T H Arduh F. A. Arguin J. F. Argyropoulos S. Arik M. Armbruster A. J. Armitage L. J. Arnaez O. Arnold H. Arratia M. Arslan O. Artamonov A. Artoni G. Artz S. Asai S. Asbah N. Ashkenazi A. Åsman B. Asquith L. Assamagan K. Astalos R. Atkinson M. Atlay N. B. Augsten K. Avolio G. Axen B. Ayoub M. K. Azuelos G. Baak M. A. Baas A. E. Baca M. J. Bachacou H. Bachas K. Backes M. Backhaus M. Bagiacchi P. Bagnaia P. Bai Y. Baines J. T. Baker O. K. Baldin E. M. Balek P. Balestri T. Balli F. Balunas W. K. Banas E. Banerjee Sw Bannoura A. A E Barak L. Barberio E. L. Barberis D. Barbero M. Barillari T. Barisonzi M. Barklow T. Barlow N. Barnes S. L. Barnett B. M. Barnett R. M. Barnovska Z. Baroncelli A. Barone G. Barr A. J. Barranco Navarro L. Barreiro F. Barreiro Guimarães da Costa J. Bartoldus R. Barton A. E. Bartos P. Basalaev A. Bassalat A. Basye A. Bates R. L. Batista S. J. Batley J. R. Battaglia M. Bauce M. Bauer F. Bawa H. S. Beacham J. B. Beattie M. D. Beau T. Beauchemin P. H. Beccherle R. Bechtle P. Beck H. P. Becker K. Becker M. Beckingham M. Becot C. Beddall A. J. Beddall A. Bednyakov V. A. Bedognetti M. Bee C. P. Beemster L. J. Beermann T. A. Begel M. Behr J. K. Belanger-Champagne C. Bell A. S. Bell W. H. Bella G. Bellagamba L. Bellerive A. Bellomo M. Belotskiy K. Beltramello O. Belyaev N. L. Benary O. Benchekroun D. Bender M. Bendtz K. Benekos N. Benhammou Y. Benhar Noccioli E. Benitez J. Benitez Garcia J. A. Benjamin D. P. Bensinger J. R. Bentvelsen S. Beresford L. Beretta M. Berge D. Bergeaas Kuutmann E. Berger N. Berghaus F. Beringer J. Berlendis S. Bernard C. Bernard N. R. Bernius C. Bernlochner F. U. Berry T. Berta P. Bertella C. Bertoli G. Bertolucci F. Bertram I. A. Bertsche C. Bertsche D. Besjes G. J. Bessidskaia Bylund O. Bessner M. Besson N. Betancourt C. Bethke S. Bevan A. J. Bhimji W. Bianchi R. M. Bianchini L. Bianco M. Biebel O. Biedermann D. Bielski R. Biesuz N. V. Biglietti M. Bilbao De Mendizabal J. Bilokon H. Bindi M. Binet S. Bingul A. Bini C. Biondi S. Bjergaard D. M. Black C. W. Black J. E. Black K. M. Blackburn D. Blair R. E. Blanchard J. B. Blanco J. E. Blazek T. Bloch I. Blocker C. Blum W. Blumenschein U. Blunier S. Bobbink G. J. Bobrovnikov V. S. Bocchetta S. S. Bocci A. Bock C. Boehler M. Boerner D. Bogaerts J. A. Bogavac D. Bogdanchikov A. G. Bohm C. Boisvert V. Bold T. Boldea V. Boldyrev A. S. Bomben M. Bona M. Boonekamp M. Borisov A. Borissov G. Bortfeldt J. Bortoletto D. Bortolotto V. Bos K. Boscherini D. Bosman M. Bossio Sola J. D. Boudreau J. Bouffard J. Bouhova-Thacker E. V. Boumediene D. Bourdarios C. Bousson N. Boutle S. K. Boveia A. Boyd J. Boyko I. R. Bracinik J. Brandt A. Brandt G. Brandt O. Bratzler U. Brau B. Brau J. E. Braun H. M. Breaden Madden W. D. Brendlinger K. Brennan A. J. Brenner L. Brenner R. Bressler S. Bristow T. M. Britton D. Britzger D. Brochu F. M. Brock I. Brock R. Brooijmans G. Brooks T. Brooks W. K. Brosamer J. Brost E. Broughton J. H. Bruckman de Renstrom P. A. Bruncko D. Bruneliere R. Bruni A. Bruni G. Brunt B. H. Bruschi M. Bruscino N. Bryant P. Bryngemark L. Buanes T. Buat Q. Buchholz P. Buckley A. G. Budagov I. A. Buehrer F. Bugge M. K. Bulekov O. Bullock D. Burckhart H. Burdin S. Burgard C. D. Burghgrave B. Burka K. Burke S. Burmeister I. Busato E. Büscher D. Büscher V. Bussey P. Butler J. M. Butt A. I. Buttar C. M. Butterworth J. M. Butti P. Buttinger W. Buzatu A. Buzykaev A. R. Cabrera Urbán S. Caforio D. Cairo V. M. Cakir O. Calace N. Calafiura P. Calandri A. Calderini G. Calfayan P. Caloba L. P. Calvet D. Calvet S. Calvet T. P. Camacho Toro R. Camarda S. Camarri P. Cameron D. Caminal Armadans R. Camincher C. Campana S. Campanelli M. Campoverde A. Canale V. Canepa A. Cano Bret M. Cantero J. Cantrill R. Cao T. Capeans Garrido M. D M Caprini I. Caprini M. Capua M. Caputo R. Carbone R. M. Cardarelli R. Cardillo F. Carli T. Carlino G. Carminati L. 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出版者

Elsevier

雑誌

Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics (ISSN:03702693)

巻号頁・発行日

vol.756, pp.52-71, 2016-05-10

被引用文献数

12

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In the pp→tt process the angular distributions of top and anti-top quarks are expected to present a subtle difference, which could be enhanced by processes not included in the Standard Model. This Letter presents a measurement of the charge asymmetry in events where the top-quark pair is produced with a large invariant mass. The analysis is performed on 20.3 fb-1 of pp collision data at √s=8TeV collected by the ATLAS experiment at the LHC, using reconstruction techniques specifically designed for the decay topology of highly boosted top quarks. The charge asymmetry in a fiducial region with large invariant mass of the top-quark pair (mtt>0.75 TeV) and an absolute rapidity difference of the top and anti-top quark candidates within -2<|yt|-|yt|<2 is measured to be 4.2±3.2%, in agreement with the Standard Model prediction at next-to-leading order. A differential measurement in three tt- mass bins is also presented.

著者

渡邊 淳也 Watanabe Jun-ya

出版者

筑波大学文藝・言語学系

雑誌

文藝言語研究. 言語篇 (ISSN:03877515)

巻号頁・発行日

vol.54, pp.15-44, 2008-10-31

著者

Seiki TAKATSUKI Shingo MIURA Kazuo SUZUKI Kaori ITO-SAKAMOTO

出版者

The Mammal Society of Japan

雑誌

Journal of the Mammalogical Society of Japan (ISSN:09141855)

巻号頁・発行日

vol.15, no.2, pp.91-98, 1991 (Released:2010-08-25)

参考文献数

21

被引用文献数

1

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A mass mortality of sika deer (Cervus nippon) population occurred on Kinkazan Island in northern Japan in the spring of 1984, which followed an unusual cold winter. We collected a sample of 240 deer skulls. All deer were aged and sexed except some fawns. The sex ratio of >1 year old deer was 50: 50, but was skewed toward males compared with the sex ratio obtained in the population census in 1983. The oldest age at death was 12.5 years for males and 15.5 years for females. The frequency was low for young age classes. A relative cumulative frequency curve was constructed to examine the age-specific mortality pattern. The curves of both sexes suggested that mortality was relatively high for fawns and low for adult and prime-aged animals, and that mortality was higher and life span was shorter for males than for females.

著者

Mariko Harada-Shiba Takao Ohta Akira Ohtake Masatsune Ogura Kazushige Dobashi Atsushi Nohara Shizuya Yamashita Koutaro Yokote Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.CR002, (Released:2018-02-06)

参考文献数

49

被引用文献数

63

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This paper describes consensus statement by Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia (FH) in order to improve prognosis of FH.FH is a common genetic disease caused by mutations in genes related to low density lipoprotein (LDL) receptor pathway. Because patients with FH have high LDL cholesterol (LDL-C) levels from the birth, atherosclerosis begins and develops during childhood which determines the prognosis. Therefore, in order to reduce their lifetime risk for cardiovascular disease, patients with FH need to be diagnosed as early as possible and appropriate treatment should be started.Diagnosis of pediatric heterozygous FH patients is made by LDL-C ≥140 mg/dL, and family history of FH or premature CAD. When the diagnosis is made, they need to improve their lifestyle including diet and exercise which sometimes are not enough to reduce LDL-C levels. For pediatric FH aged ≥10 years, pharmacotherapy needs to be considered if the LDL-C level is persistently above 180 mg/dL. Statins are the first line drugs starting from the lowest dose and are increased if necessary. The target LDL-C level should ideally be <140 mg/dL. Assessment of atherosclerosis is mainly performed by noninvasive methods such as ultrasound.For homozygous FH patients, the diagnosis is made by existence of skin xanthomas or tendon xanthomas from infancy, and untreated LDL-C levels are approximately twice those of heterozygous FH parents. The responsiveness to pharmacotherapy should be ascertained promptly and if the effect of treatment is not enough, LDL apheresis needs to be immediately initiated.

著者

Yuko Wada Maki Kihara Mitsuru Nozawa Ken-ichi Shimokawa Fumiyoshi Ishii

出版者

バイオ&ソーシャル・サイエンス推進国際研究交流会

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

vol.9, no.3, pp.229-233, 2015 (Released:2015-07-17)

参考文献数

11

被引用文献数

11

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The physicochemical and pharmaceutical properties (pH, peel force, water-vapor permeability, and stretchability) of brand-name and generic ketoprofen products were evaluated and compared. The pHs of Mohrus as a brand-name product and Teikoku as a generic product were low (about 4). Among the other generic products, Patell and Nichi-Iko had a pH of about 4.3 while Frestol, Raynanon, BMD, and Touchron showed a pH of 4.6-5.2, which was in the pH range of normal healthy skin (4.5-6.5). The adhesive force was high (≥ 1.38) for Mohrus as a brand-name product as well as for Teikoku and Patell as generic products, but it was low (≤ 0.57) for the other 5 generic products. The water-vapor permeabilities of Mohrus as a brand-name product and Teikoku and Patell as generic products were low, being less than 1/6 of those for the other 5 generic products. Among the 5 generic products, BMD showed the highest water-vapor permeability (1,330 g/m2), and the other products also showed a value ≥ 1,100 g/m2. The elongatedness of Mohrus was the lowest (15.5 cm), and that of Raynanon was the highest (24.5 cm); the difference was 9 cm. In this study, the physiochemical and pharmaceutical properties of ketoprofen tapes were clarified, which will allow pharmacists to provide products according to the needs of each patient when a brand-name product is changed to a generic one.