著者

森本 耕三 土方 美奈子 Guo Tz-Chun 宮林 亜希子 山田 博之 慶長 直人

出版者

COSMIC

雑誌

呼吸臨床 (ISSN:24333778)

巻号頁・発行日

vol.4, no.6, pp.e00103, 2020 (Released:2022-10-22)

参考文献数

10

---

原発性線毛機能不全症候群(PCD)は主に常染色体潜性またはX連鎖性遺伝形式をとる先天性疾患の1つで,気道上皮細胞などに存在する運動性線毛や精子鞭毛の機能的障害を来し,臨床的には副鼻腔気管支症候群の特徴や不妊症,内臓逆位など呈する症候群をいう。気道クリアランスの障害により進行例では気管支拡張の進展により呼吸不全を来す。原因遺伝子はこれまでに40以上が知られており,近年新たな遺伝子異常の報告が続いているが,推測される全遺伝子異常の70%までしかカバーできていないとされている。診断には電子顕微鏡(electron microscopy:EM)検査や鼻腔NO測定など専門的な検査を必要とするため,診断が難しく,多くの患者が未診断の状態にあると考えられている。システマティックレビューから本邦ではこれまで主にEMのみを用いた診断が行われており,その解釈も欧米とは異なることが明らかとなった。われわれはPCD専門外来を開設した。これまでにびまん性汎細気管支炎でマクロライド療法不応例とされていた症例にDRC1の広範囲欠失をもつPCDが存在していることを報告した。アジア人に最適化した遺伝子パネルの開発を含め診断体制の確立により本邦の実態を明らかとし,患者支援活動に繋げることが望まれる。

著者

Shuhei IZAWA Nanako NAKAMURA-TAIRA Chihiro MORIISHI Toru YOSHIKAWA Rie AKAMATSU Hiroki IKEDA Tomohide KUBO

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.2023-0068, (Released:2023-09-15)

---

Mental health problems are prevalent among the working population and must be resolved. We conducted a web-based large-scale study of workers, including a baseline survey and two follow-up surveys, to investigate the associations between self-care behaviors in daily life (e.g., stress coping, sleep, diet, and exercise), work environment improvements, and mental health among Japanese employees from various industries. In this protocol, we demonstrate the study design and demographic data of the participants in the baseline survey. Invitations to participate in this study were sent to 421,825 internet monitor registrants in February 2022. Overall, 20,000 registrants who met the inclusion criteria participated in the survey. There were large variations in occupations and working styles (e.g., physical work, night work, and teleworking) among the participants, and we also found significant differences between male and female participants in the demographic data. An overview of the survey data suggests that the demographic characteristics of the participants in this study are comparable to those reported in previous studies on Japanese employees. We plan to use these survey data in the future to examine the associations of daily lifestyles and work environments with the mental health of Japanese employees.

著者

Ha Thi Le Nguyen Shizuka Suetsugu Yuna Nakamura Zita Demeter Shao-Hui Zheng Daisuke Fujita

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.73, no.4, pp.365-372, 2023 (Released:2023-10-03)

参考文献数

34

---

A large vascular bundle number (VBN) in the panicle neck in rice (Oryza sativa L.) is related to the ability to transport assimilates from stem and leaf to reproductive organs during seed maturation. Several quantitative trait loci (QTLs) for VBN have been identified by using segregating populations derived from a cross between indica and japonica rice cultivars. However, the detailed location, effect, and interaction of QTLs for VBN were not understood well. Here, to elucidate the genetic basis of VBN, we identified three stable QTLs for VBN—qVBN5, qVBN6 and qVBN11—by using 71 recombinant inbred lines derived from a cross between indica ‘IR24’ and japonica ‘Asominori’. We confirmed their positions and characterized their effects by using chromosome segment substitution lines (CSSLs) with an ‘IR24’ genetic background. qVBN6 had the most substantial effect on VBN, followed by qVBN11 and qVBN5. We developed pyramided lines carrying two QTLs for VBN to estimate their interaction. The combination of qVBN6 and qVBN11 accumulated VBN negatively in the pyramided lines owing to the independent actions of each QTL. The QTLs detected for VBN will enhance our understanding of genetic mechanisms of VBN and can be used in rice breeding.

著者

Saw Bo Day Shar Cuong Dinh Nguyen Sachiyo Sanada-Morimura Hideshi Yasui Shao-Hui Zheng Daisuke Fujita

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.73, no.4, pp.382-392, 2023 (Released:2023-10-03)

参考文献数

56

---

The brown planthopper (BPH: Nilaparvata lugens Stål) is one of the most destructive insects in rice production. The use of host plant resistance has potential to reduce damage caused by BPH. The heat tolerance japonica rice ‘Sagabiyori’, with superior grain quality and high soluble starch in the stem, is highly susceptible to damage by BPH. Here, to enhance its BPH resistance, we developed seven near-isogenic lines (NILs) carrying BPH2, BPH17-ptb, BPH32, BPH3, BPH17, BPH20, and BPH21 through marker-assisted selection and evaluated resistance to two BPH populations. Most lines were more resistant to the Hadano-1966 BPH population than Sagabiyori but were less effective against the highly virulent Koshi-2013 population. Nevertheless, in antixenosis tests, Koshi-2013 settled less on all NILs than on Sagabiyori. In addition, adult mortality and the percentage of fresh weight loss of lines carrying BPH17 and BPH3 indicated that these lines have higher resistance to Koshi-2013 than Sagabiyori. Current study revealed that BPH resistance of Sagabiyori became stronger by transferring BPH3 and BPH17 genes. Thus, BPH3 and BPH17 might be valuable for breeding programs to enhance BPH resistance of high grain quality rice varieties with heat tolerance.

著者

Katsuhiro Matsui Takayuki Tamura Keito Nishizawa Akiko Ohara-Takada

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.73, no.4, pp.408-414, 2023 (Released:2023-10-03)

参考文献数

20

---

Job’s tears (Coix lacryma-jobi L.) is grown widely in Asian countries and a crop that can fertilize with own pollen and pistils. The grains are used not only for food but also for medicinal purposes. The grain of many cultivars contains glutinous endosperm; only grains with this glutinous endosperm are suitable for use as medicine in Japan. Many wild types have non-glutinous endosperm and can easily cross with cultivar under natural environmental conditions. Because the non-glutinous endosperm trait is dominant to that of glutinous endosperm, F1 seeds produced by crosses between a cultivar and a wild type have non-glutinous endosperm. To reduce the rate of unwanted crosses, we investigated the pollen dispersal distance by using a red leaf sheath as a morphological marker. When plants were cultivated in rows 70 cm apart, the crossing rate was about 25%–35%. As the distance increased, the crossing rate decreased at a rate that could be fitted to a power approximation in fields without intervening plants and to an exponential equation in fields with intervening plants. Our data could be used as guidelines for preventing unwanted crossing with wild types when growing cultivars.

著者

YING-YAN KUO

出版者

Mathematical Institute, Tohoku University

雑誌

Tohoku Mathematical Journal, Second Series (ISSN:00408735)

巻号頁・発行日

vol.22, no.3, pp.325-332, 1970 (Released:2010-03-19)

参考文献数

11

被引用文献数

63

著者

Chien-Yu HSIAO Yi-Ming CHEN Yi-Ju HSU Chi-Chang HUANG Hsin-Ching SUNG Sheng-Shih CHEN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.6, pp.1110-1119, 2017 (Released:2017-06-29)

参考文献数

44

被引用文献数

15 16

---

Hualian No. 4 wild bitter gourd (WBG) is a specific vegetable cultivated by the Hualien District Agricultural Research and Extension Station in Taiwan. WBG is commonly consumed as a vegetable and used as a popular folk medicine. However, few studies have demonstrated the effects of WBG supplementation on exercise performance, physical fatigue and the biochemical profile. The purpose of this study was to evaluate the potential beneficial effects of WBG extract on fatigue and ergogenic functions following physiological challenge. Three groups of male ICR mice (n=8 per group) were orally administered 0, 1 or 2.5 g/kg/day of WBG for 4 weeks. They were respectively designated the vehicle, WBG-1X and WBG-2.5X groups. WBG significantly decreased body weight (BW) and epididymal fat pad (EFP) weight. Concerning physical performance, WBG supplementation dose-dependently increased grip strength and endurance swimming time. Concerning anti-fatigue activity, WBG decreased levels of serum lactate, ammonia, creatine kinase and blood urea nitrogen, and economized glucose metabolism after acute exercise challenge. Glycogen in the liver and gastrocnemius muscle dose-dependently increased with WBG treatment. Concerning the biochemical profile, WBG treatment significantly decreased alanine aminotransferase (ALT), blood urea nitrogen (BUN) and urea acid (UA), and increased total protein (TP). Therefore, 4-week supplementation with WBG may decrease white adipose weight, enhance energy economy, increase glycogen storage to enhance exercise performance and reduce fatigue.

著者

Daisuke KOJIMA Chun-Ho PARK Yusuke SATOH Satoshi INOUE Akira NOGUCHI Toshifumi OYAMAD

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.71, no.3, pp.319-324, 2009 (Released:2009-04-04)

参考文献数

31

被引用文献数

20 27

---

Fixed rabies viruses (CVS-11 strain) were inoculated intramuscularly to C57BL/6J mice, and the pathomorphological changes of the spinal cord including dorsal root spinal ganglion cells were investigated. At 4 days postinoculation (PI), viral antigens were first detected in the spinal neurons and dorsal root spinal ganglion cells without producing morphological changes. At 5 days PI, mild infiltration of lymphocytes was observed around the central canal, small blood vessels and leptomeninges. Cells positive to anti-Iba1 and anti-GFAP antibodies increased significantly from 3 to 5 days PI, respectively. Microglia changed their morphological forms to be ramified or amoeboid, and astroglia extended their cytoplasm from the leptomeninges to the parenchyma. At 7 days PI, apoptotic cells were found in the spinal cord and dorsal root spinal ganglion using TUNEL. We confirmed that most of T lymphocytes and a minority of microglial cells underwent apoptosis, using a combination of TUNEL and immunostaining with antibodies to viral phosphoprotein, CD3, Iba1 and GFAP. On the other hand, astroglial cells and virus-infected nerve cells were negative against TUNEL and cleaved caspase-3 antibody. These findings indicate that T lymphocytes and microglial cells died by apoptosis, whereas virus-infected nerve cells died by necrosis. This was accompanied by increased numbers and morphological changes of glial cells associated with the pathogenesis of CVS-11 in the C57BL/6J mouse.

著者

Lin-jiao Wang Wei Xi Xiao-lan Yuan Xiao-hua Yang

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

pp.c22-00843, (Released:2023-10-03)

参考文献数

31

---

Dapagliflozin (DAPA), sodium-glucose co-transporter 2 (SGLT-2) inhibitor, is used to treat Type 2 diabetes. In this study, a highly sensitive and selective analytical method based on ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) was established and validated for the determination of DAPA in rat plasma. The separation of DAPA and internal standard (DAPA-d5) were performed on a reversed-phase ACQUITY UPLC® BEH C18 column (100×3.0 mm, 1.7 µm). The mobile phase is composed of 0.1% formic acid in water (solvent A) and methanol (solvent B) in gradient elution. Under the negative ion mode, full MS/dd-MS2 was adopted to collect data via Q-Orbitrap. DAPA was effectively separated from matrix backgrounds within 10 min, and DAPA in plasma showed a good linear relationship in the range of 10-10000 µg/L. The determination coefficient (R2) was 0.9987, and the lower limit of quantification (LLOQ) was 10 µg/L. The precision and accuracy were all less than 10%, and the extraction recovery of DAPA was 86.16%-96.06% from plasma. This study offered an efficient separation and quantification method for DAPA. The improved and validated method succeeded in evaluating the pharmacokinetics of DAPA in rat plasma samples after a single oral administration of 1 mg/kg.

著者

Meng-Yuan HE Ling-Yun JIANG

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Communications (ISSN:09168516)

巻号頁・発行日

vol.E106-B, no.10, pp.881-890, 2023-10-01

---

In the current heterogeneous wireless communication system, the sharp rise in energy consumption and the emergence of new service types pose great challenges to nowadays radio access network selection algorithms which do not take care of these new trends. So the proposed energy efficiency based multi-service heterogeneous access network selection algorithm-ESRS (Energy Saving Radio access network Selection) is intended to reduce the energy consumption caused by the traffic in the mobile network system composed of Base Stations (BSs) and Access Points (APs). This algorithm models the access network selection problem as a Multiple-Attribute Decision-Making (MADM) problem. To solve this problem, lots of methods are combined, including analytic Hierarchy Process (AHP), weighted grey relational analysis (GRA), entropy theory, simple additive weight (SAW), and utility function theory. There are two main steps in this algorithm. At first, the proposed algorithm gets the result of the user QoS of each network by dealing with the related QoS parameters, in which entropy theory and AHP are used to determine the QoS comprehensive weight, and the SAW is used to get each network's QoS. In addition to user QoS, parameters including user throughput, energy consumption utility and cost utility are also calculated in this step. In the second step, the fuzzy theory is used to define the weight of decision attributes, and weighted grey relational analysis (GRA) is used to calculate the network score, which determines the final choice. Because the fuzzy weight has a preference for the low energy consumption, the energy consumption of the traffic will be saved by choosing the network with the least energy consumption as much as possible. The simulation parts compared the performance of ESRS, ABE and MSNS algorithms. The numerical results show that ESRS algorithm can select the appropriate network based on the service demands and network parameters. Besides, it can effectively reduce the system energy consumption and overall cost while still maintaining a high overall QoS value and a high system throughput, when compared with the other two algorithms.

著者

Jin-Ho Park

出版者

ARCHITECTURAL INSTITUTE OF JAPAN (AIJ), ARCHITECTURAL INSTITUTE OF KOREA (AIK), ARCHITECTURAL SOCIETY OF CHINA (ASC)

雑誌

Journal of Asian Architecture and Building Engineering (ISSN:13467581)

巻号頁・発行日

vol.4, no.1, pp.25-30, 2005 (Released:2005-07-30)

参考文献数

18

被引用文献数

4

---

This paper first discusses the fundamental notion of shape morphing and morphing techniques. Then it sets out to introduce early applications of the notion in architecture. Antoni Gaudi′s Sagrada Familia Cathedral in Spain and Le Corbusier′s Firminy Chapel in France are examined with regard to shape morphing. The examination seeks to cast new light on the significance of the two designs whose morphing method has become the legacy of an innovative characteristic of considerable contemporary architecture.

著者

Jun Miyata Hirotomo Yamanashi Shin-Ya Kawashiri Sakiko Soutome Kazuhiko Arima Mami Tamai Fumiaki Nonaka Yukiko Honda Masayasu Kitamura Koji Yoshida Yuji Shimizu Naomi Hayashida Shigeru Kawakami Noboru Takamura Takashi Sawase Atsutoshi Yoshimura Yasuhiro Nagata Mayumi Ohnishi Kiyoshi Aoyagi Atsushi Kawakami Toshiyuki Saito Takahiro Maeda

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230079, (Released:2023-07-29)

参考文献数

42

被引用文献数

1

---

In an aging society, it is important to visualize the conditions of people living with diseases or disabilities, such as frailty and sarcopenia, and determine the environmental and genetic factors underlying such conditions. Atherosclerosis and arterial stiffness are key conditions between these factors and noncommunicable diseases. In 2014, we launched a population-based prospective open-cohort study, the Nagasaki Islands Study (NaIS), which was conducted in Goto City, located in the remote islands of Nagasaki Prefecture, Japan, mostly involving middle-aged and older residents. We conducted our own health checkups along with the annual standardized checkups organized by the municipality; recruited study participants; and started to follow-up with them for vital status (death), migration, and occurrence of diseases such as myocardial infarction, stroke, fracture, and human T-cell leukemia virus type 1 (HTLV-1) -associated uveitis. Our checkups were conducted as baseline surveys in different areas of Goto City during the fiscal years 2014–2016, secondary surveys during 2017–2019, and tertiary surveys since 2021, consisting of medical interviews, physical examinations, blood and urine tests, body composition measurements, osteoporosis screening, arterial stiffness measurements, carotid ultrasonography, and dental examination. A total of 4,957 residents participated in either the baseline or secondary surveys and were followed-up; and 3,594 and 3,364 residents (aged 27–96 and 28–98 years) participated in the baseline and secondary surveys, respectively. In conclusion, the NaIS has been undertaken to reveal the influence of aging and risk factors of noncommunicable diseases and disabilities, with an aim to contribute towards better healthcare in the future.

著者

Ning Luo Gui-bing Chen Teng Zhang Jie Zhao Jing-nan Fu Ning Lu Tao Ma

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.2, pp.187-193, 2023-02-01 (Released:2023-02-01)

参考文献数

47

被引用文献数

1 3

---

Endoplasmic reticulum (ER) dysfunction is characterized by ER stress, which can be triggered by sepsis. Recent studies have reported that lessening ER stress is a promising therapeutic approach to improving the outcome of sepsis. Genipin is derived from gardenia fruit, which is a traditional Chinese medicinal herb for anti-inflammation. Here, mice were treated with genipin (2.5 mg/kg) intravenously to assess its biological effects and underlying mechanism against polymicrobial sepsis. Furthermore, the present study focused on detecting the levels of ER stress-related proteins, including protein kinase R-like ER kinase (PERK), glucose-regulated protein of 78 kDa (GRP78), phosphorylated-eukaryotic initiation factor 2α (p-eIF2α), and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP). The results demonstrated that genipin significantly decreased the serum concentrations of tumor necrosis factor-α and interleukin-6, alleviated histopathological damage to the lungs, livers and spleens, and even improved the survival rates of septic mice. Moreover, sepsis significantly upregulated the protein expression levels of splenic GRP78, PERK, p-eIF2α and CHOP, but their levels were significantly suppressed by genipin. Furthermore, genipin also significantly downregulated cleaved caspase-3 expression levels and reduced sepsis-induced splenocyte apoptosis. In conclusion, genipin potentially improved the survival rate of sepsis and attenuated sepsis-induced organ injury and an excessive inflammatory response in mice. The effects of genipin against sepsis were potentially associated with decreased splenocyte apoptosis via the attenuation of sepsis-induced ER stress to further inhibit ER stress-induced apoptosis.

著者

鈴木 高史 Alexander Egyir-Yawson

出版者

神戸常盤大学

雑誌

挑戦的萌芽研究

巻号頁・発行日

2014-04-01

---

アフリカトリパノソーマ症を媒介するツェツェバエの新たなコントロール法の構築を行うことを目的として、以下の解析を行った。ツェツェバエのコロニーを確立し麻酔システムの検討を行った。さらにGlossina palpalis defensin(GpDef)分子の抗アフリカトリパノソーマ原虫活性プロファイルを明らかにした。当初予定していた、貯精嚢へのインジェクションは困難であったため、アフリカトリパノソーマ原虫の動き、エキソソーム関連分子解析、ツェツェバエゲノム上のポリドナウイルス類似配列解析を行い、遺伝子組換えシステム構築の可能性検討を行った。

著者

Yusuke Kawashima Natsumi Mori Norihito Kawashita Yu-Shi Tian Tatsuya Takagi

出版者

Chem-Bio Informatics Society

雑誌

Chem-Bio Informatics Journal (ISSN:13476297)

巻号頁・発行日

vol.21, pp.1-10, 2021-01-29 (Released:2021-01-29)

参考文献数

16

被引用文献数

1

---

Fragment molecular orbital (FMO) calculation is a useful ab initio method for analyzing protein–ligand interactions in the current structure-based drug design. When multiple ligands exist for one receptor, a post-FMO calculation tool is required because of large numbers of interaction energy decomposition terms calculated using this method. In this study, a method that combines self-organizing maps (SOM) and hierarchical clustering analysis (HCA) was proposed to analyze the results of the FMO energy components. This method could effectively compress the high-dimensional energy terms and is expected to be useful to analyze the interaction between protein and ligands. A case study of antitype 2 diabetes mellitus target DPP-IV and its inhibitors was analyzed to verify the feasibility of the proposed method. After performing dimensional compression using SOM and further grouping using HCA, we obtained superclasses of the inhibitors based on the dispersion energy (DI), which showed consistency with structural information, indicating that further analyses of detailed energies per superclass can be an effective approach for obtaining important ligand–protein interactions.

著者

Yu Odake Naoto Fukutani Kanako Shimoura Tappei Morino Natsuki Matsumura Niu Qian Yuki Shinohara Kohei Mukaiyama Momoko Nagai-Tanima Tomoki Aoyama

出版者

Japan Society for Occupational Health

雑誌

Environmental and Occupational Health Practice (ISSN:24344931)

巻号頁・発行日

vol.3, no.1, pp.2020-0024-OA, 2021 (Released:2021-06-25)

参考文献数

40

被引用文献数

1

---

Objectives: This study aimed to examine the factors for reducing monetary loss due to presenteeism by using a tailored healthcare web-application among office workers with chronic neck pain. Methods: The study was single-arm pre-post comparison study using secondary data of 130 Japanese office workers with chronic neck pain who used a tailored healthcare web-application (web-app) over 12 weeks. This data was obtained from BackTech Inc. (Kyoto, Japan), which manages the healthcare web-app. The primary outcome measure was the monetary loss due to presenteeism based on the quality and quantity method. Secondary outcome measures were intensity of physical symptoms measured by the Visual Analog Scale, frequency of web-app use obtained from the database, and the risk of depression score assessed by the Depression and Suicide Screen. Results: Eighty-six participants were included in the complete-case analysis. Monetary loss due to presenteeism and the risk of depression reduced, while physical symptoms improved significantly (p<0.01) after using the web-app. After covariate adjustment, decrease in neck pain intensity (β=0.25, confidence interval=2.34 to 32.66) and high frequency of web-app use (β=−0.24, confidence interval=−10.29 to −0.63) were significantly associated with a reduction in monetary loss due to presenteeism. Conclusion: Neck pain intensity and frequency of web-app use may be important factors for reducing monetary loss due to presenteeism among office workers with chronic neck pain who used a tailored health care web-app.

著者

Aman B Pulungan Carine de Beaufort Amajida F Ratnasari Helena A Puteri Laura Lewis-Watts Zulfiqar A Bhutta

出版者

The Japanese Society for Pediatric Endocrinology

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.32, no.3, pp.137-146, 2023 (Released:2023-06-24)

参考文献数

35

被引用文献数

1

---

A decade since the discovery of insulin, the increasing prevalence of type 1 diabetes mellitus (T1DM) has underscored the prevailing inequalities in the provision of essential care for T1DM worldwide. However, the details on the availability of insulin types and associated medical devices remain unclear. A cross-sectional electronic survey was distributed across a global network of pediatric societies under the umbrella of the International Pediatric Association (IPA). Access to and availability of pediatric diabetes care were investigated using standardized questions. Responses from 25 of 132 pediatric societies across six regions were included. Pediatric endocrinologists typically manage T1DM together with pediatricians or adult endocrinologists. Nonetheless, 24% of the respondents reported pediatricians to be the sole healthcare professionals. According to the respondents, the patients were either partially or completely responsible for payments of insulin (40%), A1C (24%), C-peptide (28%), and antibody testing for diagnosis (28%). Government support is generally available for insulin, but this was merely 20% for insulin pumps and 12% for continuous glucose monitors. There are considerable disparities in the access, availability, and affordability of diabetes testing, medications, and support between countries with significant out-of-pocket payments for care. Country- and region-specific improvements to national programs are necessary to achieve optimal pediatric diabetes care globally.

著者

Satoshi Suzuki Ken-Ichi Kusumoto

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

pp.FSTR-D-23-00114, (Released:2023-09-26)

---

The regulation of enzyme activity in the production of various fermented foods using koji mold has been optimized in many ways, and few additional refinements are apparent. This study examined light as a modifiable factor with which to adjust the enzyme activities of koji. A previous study has shown improved saccharification of wheat bran with Aspergillus oryzae RIB40 under at least 8 h of darkness. In the work reported here, light exposure had no significant effect on the saccharification activity of A. oryzae RIB1187. However, light exposure for 8 h or more continuously decreased protease-specific activity in RIB1187, as was seen previously in RIB40. This information may help manufacturers to improve fungal enzyme production, processes, and facilities.

著者

四井 美月 Liang Kuo-ching 廣原 茉耶 北沢 桃子 吉村 道孝 江口 洋子 藤田 卓仙 岸本 泰士郎 榊原 康文

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会全国大会論文集 第32回 (2018) (ISSN:27587347)

巻号頁・発行日

pp.4C2OS27b02, 2018 (Released:2018-07-30)

---

精神疾患の診断は現在,問診に基づく医師の主観的判断によって行われている.このような現在の診断方法は医師の経験に強く依存するため,正確な診断を行うための客観的な診断方法を開発する必要があると言われている.したがって我々の目標は,デバイスによって記録されたデータからうつ病患者の重症度を客観的に計算する深層学習手法を構築することである. 本研究では,うつ病患者と健常者を音声データで分類する深層学習プログラムを開発する.

著者

Yusuke Kondo Tomoka Ogawa Emiri Kanno Masafumi Hirono Takako Kato-Minoura Ritsu Kamiya Toshiki Yagi

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

vol.48, no.2, pp.175-185, 2023 (Released:2023-09-23)

参考文献数

54

---

Ciliary outer-arm dynein (OAD) consists of heavy chains (HCs), intermediate chains (ICs), and light chains (LCs), of which HCs are the motor proteins that produce force. Studies using the green alga Chlamydomonas have revealed that ICs and LCs form a complex (IC/LC tower) at the base of the OAD tail and play a crucial role in anchoring OAD to specific sites on the microtubule. In this study, we isolated a novel slow-swimming Chlamydomonas mutant deficient in the IC2 protein. This mutation, E279K, is in the third of the seven WD repeat domains. No apparent abnormality was observed in electron microscope observations of axonemes or in SDS-PAGE analyses of dynein subunits. To explore the reason for the lowered motility in this mutant, in vitro microtubule sliding experiments were performed, which revealed that the motor activity of the mutant OAD was lowered. In particular, a large difference was observed between wild type (WT) and the mutant in the microtubule sliding velocity in microtubule bundles formed with the addition of OAD: ~35.3 μm/sec (WT) and ~4.3 μm/sec (mutant). From this and other results, we propose that IC2 in an OAD interacts with the β HC of the adjacent OAD, and that an OAD-OAD interaction is important for efficient beating of cilia and flagella.Key words: cilia, axoneme, dynein heavy chain, cooperativity