著者

藤原 綾乃 第2調査研究グループ

出版者

科学技術・学術政策研究所

巻号頁・発行日

2017-03 (Released:2017-04-11)

著者

Takeshi Yamauchi Yasuhiko Sakata Masanobu Miura Takeo Onose Kanako Tsuji Ruri Abe Takuya Oikawa Shintaro Kasahara Masayuki Sato Kotaro Nochioka Takashi Shiroto Jun Takahashi Satoshi Miyata Hiroaki Shimokawa on behalf of the CHART-2 Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0759, (Released:2017-01-14)

参考文献数

52

被引用文献数

19

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Background:The prognostic impact of atrial fibrillation (AF) among patients at high risk for heart failure (HF) remains unclear. In addition, there is no risk estimation model for AF development in these patients.Methods and Results:The present study included 5,382 consecutive patients at high risk of HF enrolled in the CHART-2 Study (n=10,219). At enrollment, 1,217 (22.6%) had AF, and were characterized, as compared with non-AF patients, by higher age, lower estimated glomerular filtration rate, higher B-type natriuretic peptide (BNP) level and lower left ventricular ejection fraction. A total of 116 non-AF patients (2.8%) newly developed AF (new AF) during the median 3.1-year follow-up. AF at enrollment was associated with worse prognosis for both all-cause death and HF hospitalization (adjusted hazard ratio (aHR) 1.31, P=0.027 and aHR 1.74, P=0.001, for all-cause death and HF hospitalization, respectively) and new AF was associated with HF hospitalization (aHR 4.54, P<0.001). We developed a risk score with higher age, smoking, pulse pressure, lower eGFR, higher BNP, aortic valvular regurgitation, LV hypertrophy, and left atrial and ventricular dilatation on echocardiography, which effectively stratified the risk of AF development with excellent accuracy (AUC 0.76).Conclusions:These results indicated that AF is associated with worse prognosis in patients at high risk of HF, and our new risk score may be useful to identify patients at high risk for AF onset.

著者

1. 松尾 豊 2. 西田 豊明 3. 堀 浩一 4. 武田 英明 5. 長谷 敏司 6. 塩野 誠 7. 服部 宏充

雑誌

人工知能

巻号頁・発行日

vol.30, no.3, pp.358-364, 2015-05-01

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訂正:p.364 長谷敏司氏の著者紹介における受賞作は正しくは「My Humanity」です.

著者

報告者:児玉直美 村上義昭 田中万理 (1.日本大学 2.大阪商業大学 3.一橋大学) 討論者:植杉威一郎 (一橋大学)

雑誌

日本経済学会2020年度秋季大会

巻号頁・発行日

2020-07-21

著者

荒川 政彦 和田 浩二 はやぶさ2 SCI/DCAM3 チーム

出版者

日本惑星科学会

雑誌

日本惑星科学会誌遊星人 (ISSN:0918273X)

巻号頁・発行日

vol.22, no.3, pp.152-158, 2013-09-25 (Released:2017-08-25)

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はやぶさ2には小型の衝突装置(SCI)が搭載されており,これは秒速2kmで小惑星表面に衝突してクレーターを形成する.このクレーターは小惑星内部を覗くための小窓であり,リモートセンシング観測やサンプル回収から,小惑星表面の宇宙風化や浅内部構造に関する知見を得る.一方, SCIが衝突する様子は分離カメラ(DCAM3)により撮影され,イジェクタカーテンの拡大する様子や小惑星周囲を飛び交うダストを観察する. SCIによる小惑星への衝突は宇宙衝突実験ともいえる.我々はこの世界で最初の小惑星における宇宙衝突実験の機会を利用して,微小重力下における「本物の小惑星物質」のクレーター形成過程を明らかにする.

著者

富澤 宏之 林 隆之 山下 泰弘 近藤 正幸 第2研究グループ

出版者

科学技術政策研究所

雑誌

調査資料 (Research Material)

巻号頁・発行日

vol.122,

著者

Hirotoshi Watanabe Takeshi Morimoto Ko Yamamoto Yuki Obayashi Masahiro Natsuaki Kyohei Yamaji Manabu Ogita Satoru Suwa Tsuyoshi Isawa Takenori Domei Kenji Ando Shojiro Tatsushima Hiroki Watanabe Masanobu Oya Kazushige Kadota Hideo Tokuyama Tomohisa Tada Hiroki Sakamoto Hiroyoshi Mori Hiroshi Suzuki Tenjin Nishikura Kohei Wakabayashi Takeshi Kimura for the STOPDAPT-2 ACS Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.87, no.5, pp.657-668, 2023-04-25 (Released:2023-04-25)

参考文献数

28

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Background: The REAL-CAD trial, reported in 2017, demonstrated a significant reduction in cardiovascular events with high-intensity statins in patients with chronic coronary syndrome. However, data are scarce on the use of high-intensity statins in Japanese patients with acute coronary syndrome (ACS).Methods and Results: In STOPDAPT-2 ACS, which exclusively enrolled ACS patients between March 2018 and June 2020, 1,321 (44.2%) patients received high-intensity statins at discharge, whereas of the remaining 1,667 patients, 96.0% were treated with low-dose statins. High-intensity statins were defined as the maximum approved doses of strong statins in Japan. The incidence of the cardiovascular composite endpoint (cardiovascular death, myocardial infarction, definite stent thrombosis, stroke) was significantly lower in patients with than without high-intensity statins (1.44% vs. 2.69% [log-rank P=0.025]; adjusted hazard ratio [aHR] 0.48, 95% confidence interval [CI] 0.24–0.94, P=0.03) and the effect was evident beyond 60 days after the index percutaneous coronary intervention (log-rank P=0.01; aHR 0.38, 95% CI 0.17–0.86, P=0.02). As for the bleeding endpoint, there was no significant difference between the 2 groups (0.99% vs. 0.73% [log-rank P=0.43]; aHR 0.96, 95% CI 0.35–2.60, P=0.93).Conclusions: The prevalence of high-intensity statins has increased substantially in Japan. The use of the higher doses of statins in ACS patients recommended in the guidelines was associated with a significantly lower risk of the primary cardiovascular composite endpoint compared with lower-dose statins.

著者

市川三升<市川団十郎(2世 1688生)>//〔編〕,英一蜂<英一蜂(1世 1691生)>,小川破笠//〔画〕

巻号頁・発行日

vol.甲, 1830

著者

中村 隆史 今井 寛 渡辺 政隆 第2調査研究グループ

出版者

科学技術政策研究所

雑誌

調査資料 (Research Material)

巻号頁・発行日

vol.129,

著者

大沼 清仁 植木 勉 平野 千博 今井 寛 第2調査研究グループ

出版者

科学技術政策研究所

雑誌

調査資料 (Research Material)

巻号頁・発行日

vol.097,

著者

meta2編集

出版者

meta2

巻号頁・発行日

2015

著者

Hirotoshi Watanabe Takeshi Morimoto Ko Yamamoto Yuki Obayashi Masahiro Natsuaki Kyohei Yamaji Manabu Ogita Satoru Suwa Tsuyoshi Isawa Takenori Domei Kenji Ando Shojiro Tatsushima Hiroki Watanabe Masanobu Oya Kazushige Kadota Hideo Tokuyama Tomohisa Tada Hiroki Sakamoto Hiroyoshi Mori Hiroshi Suzuki Tenjin Nishikura Kohei Wakabayashi Takeshi Kimura for the STOPDAPT-2 ACS Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0650, (Released:2022-12-08)

参考文献数

28

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Background: The REAL-CAD trial, reported in 2017, demonstrated a significant reduction in cardiovascular events with high-intensity statins in patients with chronic coronary syndrome. However, data are scarce on the use of high-intensity statins in Japanese patients with acute coronary syndrome (ACS).Methods and Results: In STOPDAPT-2 ACS, which exclusively enrolled ACS patients between March 2018 and June 2020, 1,321 (44.2%) patients received high-intensity statins at discharge, whereas of the remaining 1,667 patients, 96.0% were treated with low-dose statins. High-intensity statins were defined as the maximum approved doses of strong statins in Japan. The incidence of the cardiovascular composite endpoint (cardiovascular death, myocardial infarction, definite stent thrombosis, stroke) was significantly lower in patients with than without high-intensity statins (1.44% vs. 2.69% [log-rank P=0.025]; adjusted hazard ratio [aHR] 0.48, 95% confidence interval [CI] 0.24–0.94, P=0.03) and the effect was evident beyond 60 days after the index percutaneous coronary intervention (log-rank P=0.01; aHR 0.38, 95% CI 0.17–0.86, P=0.02). As for the bleeding endpoint, there was no significant difference between the 2 groups (0.99% vs. 0.73% [log-rank P=0.43]; aHR 0.96, 95% CI 0.35–2.60, P=0.93).Conclusions: The prevalence of high-intensity statins has increased substantially in Japan. The use of the higher doses of statins in ACS patients recommended in the guidelines was associated with a significantly lower risk of the primary cardiovascular composite endpoint compared with lower-dose statins.

著者

元橋 一之 小柴 等 池内 健太 科学技術・学術政策研究所第2調査研究グループ

出版者

科学技術・学術政策研究所

雑誌

DISCUSSION PAPER

巻号頁・発行日

vol.192,

著者

司会:三谷羊平(京都大学)1.オンラインサーベイ実験のフロンティア 三谷羊平(京都大学)2.オンライン実験のフロンティア 竹内あい(立命館大学)3.ラボ実験とオンライン実験の比較 花木伸行(大阪大学)4.経済学における実験・調査のベストプラクティス 北村周平(大阪大学)5.パネル討論

雑誌

日本経済学会2023年度春季大会

巻号頁・発行日

2023-04-11

著者

S. TACHIBANA M. ABE M. ARAKAWA M. FUJIMOTO Y. IIJIMA M. ISHIGURO K. KITAZATO N. KOBAYASHI N. NAMIKI T. OKADA R. OKAZAKI H. SAWADA S. SUGITA Y. TAKANO S. TANAKA S. WATANABE M. YOSHIKAWA H. KUNINAKA THE HAYABUSA2 PROJECT TEAM

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.48, no.6, pp.571-587, 2014-11-20 (Released:2014-12-19)

参考文献数

99

被引用文献数

59 103

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Hayabusa2 is an asteroid exploration mission to return surface samples of a near-Earth C-type asteroid (162173) 1999 JU3. Because asteroids are the evolved remnants of planetesimals that were the building blocks of planets, detailed observation by a spacecraft and analysis of the returned samples will provide direct evidence regarding planet formation and the dynamic evolution of the solar system. Moreover, C-type asteroids are expected to preserve the most pristine materials in the solar system, a mixture of minerals, ice, and organic matter that interact with each other. Space missions are the only way to obtain such pristine materials with geologic context and without terrestrial contamination. Hayabusa2 will launch off in 2014, arrive at 1999 JU3 in mid-2018, and fully investigate and sample the asteroid at three different locations during its 18-month stay. The concept and design of the Hayabusa2 sampler are basically the same as that on-board Hayabusa, and impact sampling with a 5-g Ta bullet will be made at three locations of the asteroid. The sample container has three separate chambers inside to store samples obtained at different locations separately. The spacecraft will return to Earth with samples in December 2020. Returned samples will be investigated by state-of-the-art analytical techniques in 2020 to understand the evolutionary history of the solar system from 4.56 Gyr ago to the present by combining results from laboratory examinations of the returned samples with remote-sensing datasets and comparing all results of observations of meteorites, interplanetary dust particles, and future returned samples.

著者

古澤 陽子 枝村 一磨 吉岡(小林) 徹 高橋 真木子 隅藏 康一 科学技術・学術政策研究所第2 研究グループ

出版者

科学技術・学術政策研究所

雑誌

DISCUSSION PAPER

巻号頁・発行日

vol.179,

著者

Yasuaki Takeji Tomohiko Taniguchi Takeshi Morimoto Shinichi Shirai Takeshi Kitai Hiroyuki Tabata Kazuki Kitano Nobuhisa Ono Ryosuke Murai Kohei Osakada Koichiro Murata Masanao Nakai Hiroshi Tsuneyoshi Tomohisa Tada Masashi Amano Hiroki Shiomi Hirotoshi Watanabe Yusuke Yoshikawa Ko Yamamoto Mamoru Toyofuku Shojiro Tatsushima Norino Kanamori Makoto Miyake Hiroyuki Nakayama Kazuya Nagao Masayasu Izuhara Kenji Nakatsuma Moriaki Inoko Takanari Fujita Masahiro Kimura Mitsuru Ishii Shunsuke Usami Kenichiro Sawada Fumiko Nakazeki Marie Okabayashi Manabu Shirotani Yasutaka Inuzuka Tatsuhiko Komiya Kenji Minatoya Takeshi Kimura on behalf of the CURRENT AS Registry-2 Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-1062, (Released:2022-04-19)

参考文献数

29

被引用文献数

2

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Background: There is scarce data evaluating the current practice pattern and clinical outcomes for patients with severe aortic stenosis (AS), including both those who underwent surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) and those who were managed conservatively in the TAVI era.Methods and Results: The Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis (CURRENT AS) Registry-2 is a prospective, physician-initiated, multicenter registry enrolling consecutive patients who were diagnosed with severe AS between April 2018 and December 2020 among 21 centers in Japan. The rationale for the prospective enrollment was to standardize the assessment of symptomatic status, echocardiographic evaluation, and other recommended diagnostic examinations such as computed tomography and measurement of B-type natriuretic peptide. Moreover, the schedule of clinical and echocardiographic follow up was prospectively defined and strongly recommended for patients who were managed conservatively. The entire study population consisted of 3,394 patients (mean age: 81.6 years and women: 60%). Etiology of AS was degenerative in 90% of patients. AS-related symptoms were present in 60% of patients; these were most often heart failure symptoms. The prevalence of high- and low-gradient AS was 58% and 42%, respectively, with classical and paradoxical low-flow low-gradient AS in 4.5% and 6.7%, respectively.Conclusions: The CURRENT AS Registry-2 might be large and meticulous enough to determine the appropriate timing of intervention for patients with severe AS in contemporary clinical practice.

著者

LogergistK2

出版者

中央公論社

雑誌

自然 (ISSN:03870014)

巻号頁・発行日

vol.34, no.4, pp.p101-105, 1979-04

著者

科学技術・学術政策研究所第2 研究グループ 科学技術・学術政策研究所 第2 研究グループ

出版者

科学技術・学術政策研究所

雑誌

NISTEP REPORT

巻号頁・発行日

vol.186,

著者

Yuichi TSUDA Takanao SAIKI Fuyuto TERUI Satoru NAKAZAWA Makoto YOSHIKAWA Seiichiro WATANABE Hayabusa2 Project Team

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES (ISSN:05493811)

巻号頁・発行日

vol.63, no.4, pp.115-123, 2020 (Released:2020-07-04)

参考文献数

8

被引用文献数

2

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Hayabusa2 arrived at the asteroid Ryugu in June 2018, and as of April 2019, the mission succeeded in conducting two rovers landing, one lander landing, one spacecraft touchdown/sample collection and one kinetic impact operation. This paper describes the initial nine months of the asteroid proximity operation activity of the Hayabusa2 mission, and gives an overview of the achievements thus far. Some important engineering and scientific activities conducted synchronously with spacecraft operations in order to complete all planned operations in time against unexpectedly harsh environment of Ryugu are also described.