著者

Thatchai Kampitak Stephen D Betschel

出版者

(公社)日本産業衛生学会

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

pp.16-0053-CS, (Released:2016-06-06)

被引用文献数

8

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Introduction Occupational allergy to rodents among laboratory animal workers is common. Most patients generally experience allergic symptoms after the first few years of work. Associated symptoms are usually mild, such as rhinoconjunctivits, urticaria, and asthma. Anaphylaxis, although rare, could be severe and life threatening. Methods We have described in this study two cases of laboratory workers that developed skin and respiratory reactions following laboratory rat and mouse bites, consistent with anaphylaxis. Results Skin testing was found positive for rat epithelium in the patient with anaphylaxis due to rat bite. Elevated levels of specific IgE antibodies against rat and mouse epitheliums were also detected in both the patients. Conclusion These cases illustrate a severe hypersensitivity reaction that could potentially occur in occupational workers that are in close contact with rodents. Reduction of allergen exposure, regular screening, and job modification could be beneficial for affected individuals. Health care workers should be made aware that anaphylaxis could be a serious consequence of laboratory animal bites, particularly in those already sensitized.

著者

ケレイドジン D・シーリン(錫莉)

出版者

内陸アジア史学会

雑誌

内陸アジア史研究 (ISSN:09118993)

巻号頁・発行日

no.26, pp.109-131, 2011-03-31

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This paper examines the scribes' training functions in the banner and league offices in the eastern two leagues-Tusiyetu qan ayimav and Cecen qan ayimav-in Outer Mongolia under the Qing rule as well as the scribes' school established at the minister-office of Yeke Kuriy-e in the late Qing period. Based mainly on historical official documents, the author sheds light on dating the time when the scribes' training was started at the league and banner offices, the methods and contents of education there and, furthermore, clarifies various details related to the scribes' training school of the late Qing period, such as the school management, contents of education and regulations. The conducted research attests to the significance the scribes' training system, established in Outer Mongolia under the Qing rule, had on Mongolian history. This system played an important role in accomplishing the document-based administration in Outer Mongolia. It was also a significant factor in promoting Mongolian culture through spreading Mongolian letters and improving the literacy rate in Mongolian society.

著者

edited by John D. Langlois Jr. contributors Hok-lam Chan ...

出版者

Princeton University Press

巻号頁・発行日

1981

著者

Tonegawa S Kasahara S Fukuda T Sugimoto K Yasuda N Tsuruhara Y Watanabe D Mizukami Y Haga Y Matsuda T D Yamamoto E Onuki Y Ikeda H Matsuda Y Shibauchi T

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-06-19

被引用文献数

57

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直接観測された物質物理学の謎「隠れた秩序」. 京都大学プレスリリース. 2014-06-19.

著者

Kelcy Shepherd Bradley D. Westbrook Lee Mandell 他 村井 しのぶ[訳者]

出版者

大学図書館研究編集委員会

雑誌

大学図書館研究 (ISSN:03860507)

巻号頁・発行日

vol.77, pp.35-40, 2006-08

被引用文献数

1

著者

Valtcho D. Zheljazkov Charles L. Cantrell Tess Astatkie Ekaterina Jeliazkova

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.62, no.4, pp.195-199, 2013 (Released:2013-03-28)

参考文献数

23

被引用文献数

7 70

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Lavender (Lavandula angustifolia Mill.) is one of the most widely grown essential oil crops in the world. Commercial extraction of lavender oil is done using steam distillation. The objective of this study was to evaluate the effect of the length of the distillation time (DT) on lavender essential oil yield and composition when extracted from dried flowers. Therefore, the following distillation times (DT) were tested in this experiment: 1.5 min, 3 min, 3.75 min, 7.5 min, 15 min, 30 min, 60 min, 90 min, 120 min, 150 min, 180 min, and 240 min. The essential oil yield (range 0.5-6.8%) reached a maximum at 60 min DT. The concentrations of cineole (range 6.4-35%) and fenchol (range 1.7-2.9%) were highest at the 1.5 min DT and decreased with increasing length of the DT. The concentration of camphor (range 6.6-9.2%) reached a maximum at 7.5-15 min DT, while the concentration of linalool acetate (range 15-38%) reached a maximum at 30 min DT. Results suggest that lavender essential oil yield may not increase after 60 min DT. The change in essential oil yield, and the concentrations of cineole, fenchol and linalool acetate as DT changes were modeled very well by the asymptotic nonlinear regression model. DT may be used to modify the chemical profile of lavender oil and to obtain oils with differential chemical profiles from the same lavender flowers. DT must be taken into consideration when citing or comparing reports on lavender essential oil yield and composition.

著者

Pandian Ganesh N Taniguchi Junichi Junetha Syed Sato Shinsuke Han Le Saha Abhijit Anandhakumar Chandran Bando Toshikazu Nagase Hiroki Vaijayanthi Thangavel Taylor Rhys D Sugiyama Hiroshi

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-01-24

被引用文献数

61

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人工スイッチを使った遺伝子コントロールに成功 -治療に役立つ可能性も- 京都大学プレスリリース. 2014-01-24.

著者

GRESHAM D

雑誌

Am J Hum Genet

巻号頁・発行日

vol.69, pp.1314-1331, 2001

被引用文献数

2 168

著者

Kent R. Walters Jr. S. Indu Rupassara R.J. Cody Markelz Andrew D.B. Leakey William M. Muir Barry R. Pittendrigh

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.37, no.4, pp.773-790, 2012-08-01 (Released:2012-08-01)

参考文献数

55

被引用文献数

1 9 1

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Methamphetamine (MA) appears to produce neurotoxic effects, in part, through disruptions of energy metabolism. A recent study of the whole-body proteome of Drosophila melanogaster showed many changes in energy metabolism-related proteins, leading us to hypothesize that MA toxicity may cause whole-body disruptions of energy metabolism. To test this, we monitored the response of energy reserves and other metabolites to MA-exposure with and without the addition of dietary glucose. We also monitored changes in feeding behavior, locomotor activity and respiration rates associated with MA-exposure to investigate how MA affects energy balance. We observed that glycogen and triglyceride levels decreased dramatically within 48 hr of MA-exposure, indicating a strongly negative caloric balance. Behavioral assays revealed that MA-treated flies decreased food consumption by 60-80% and exhibited a 2-fold increase in locomotion. Caloric expenditure decreased with MA-exposure, apparently due to a compensatory decrease in resting metabolism, showing that anorexia was the primary driver of the negative caloric balance. Additionally, we observed that glucose supplementation of MA-containing diet increased glycogen reserves by 44% at 48 hr, leading to a commensurate increase in survivorship. We conclude that dietary sugar supplementation enhances survivorship by partially compensating for decreased caloric intake resulting from MA-induced anorexia. The observation that MA produces similar behavioral changes in Drosophila and humans, i.e. increased locomotor activity and anorexia, further supports the use of Drosophila as a model organism for the study of the effects of MA.

著者

Toshiro SARUWATARI Masamitsu IWATA Yoshitaka YABUMOTO Frensley D. HUKOM Teguh PERISTIWADY Yoshitaka ABE

出版者

Kitakyushu Museum of Natural History and Human History

雑誌

北九州市立自然史・歴史博物館研究報告A類(自然史) (ISSN:13482653)

巻号頁・発行日

vol.17, pp.67-80, 2019-03-31 (Released:2020-09-15)

参考文献数

11

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Seventh specimen of Indonesian coelacanth, Latimeria menadoensis POUYAUD et al., 1999 was caught off Sulawesi, Indonesia on November 5, 2014. This specimen is a female, 1276 mm in standard length. Counts and measurements on the external morphology of the specimen was carried out by a team of Japanese and Indonesian researchers, providing the most comprehensive data on the morphology of this species. All available data on morphology of L. menadonesis is compiled together to provide insights into the biology and taxonomy of extant coelacanths.

著者

平野 弥生 C. D. Trowbridge 平野 義明

出版者

日本貝類学会

雑誌

Venus (Journal of the Malacological Society of Japan) (ISSN:13482955)

巻号頁・発行日

vol.71, no.3-4, pp.212-216, 2013-10-31 (Released:2016-05-31)

参考文献数

19

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餌海藻の細胞内に入り,内側から摂餌を行う嚢舌目ウミウシが少なくとも3種,沖縄に生息している。すべてアリモウミウシ属 Ercolaniaに分類され,1種はオーストラリアやグアムから報告されているE. kencolesi Grzymbowski et al., 2007と同定されたが,他の2種は未記載種であると思われる。これら3種には,海藻の細胞内に侵入するための独特な穴開け行動が共通して見られ,藻体内食は固有の行動適応を伴う新しい摂餌様式と見なすことができる。

著者

Peiming Wu Masayuki Hara Hironori Fudeyasu Manabu D. Yamanaka Jun Matsumoto Fadli Syamsudin Reni Sulistyowati Yusuf S. Djajadihardja

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.3, pp.93-96, 2007 (Released:2007-09-13)

参考文献数

10

被引用文献数

38 67

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Torrential rains that repeatedly occurred over Java Island causing widespread floods in late January and early February 2007 coincided with a strong and persistent trans-equatorial monsoon flow from the Northern Hemisphere. While convections develop frequently over the island’s mountainous areas in the afternoon, convections over the northern plains are active during the night and morning hours. The strong trans-equatorial monsoon flow with an upper southeasterly wind produces a strong low-level vertical shear of wind and dry mid-level environment over the island. These conditions allow the severe convections to occur repeatedly for days and to sustain for an extended period of time. The results suggest that the trans-equatorial monsoon flow plays a principal role in the formation of the repeated torrential rains. The probability of occurrence of a strong and persistent trans-equatorial monsoon flow that causes torrential rains and widespread floods over Java Island is estimated to be once every 5-10 years.

著者

Shinji C. Nagasaki Tomonori D. Fukuda Mayumi Yamada Yusuke III Suzuki Ryo Kakutani Adam T. Guy Itaru Imayoshi

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

pp.22074, (Released:2022-12-16)

被引用文献数

1

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The Gal4/UAS system is a versatile tool to manipulate exogenous gene expression of cells spatially and temporally in many model organisms. Many variations of light-controllable Gal4/UAS system are now available, following the development of photo-activatable (PA) molecular switches and integration of these tools. However, many PA-Gal4 transcription factors have undesired background transcription activities even in dark conditions, and this severely attenuates reliable light-controlled gene expression. Therefore, it is important to develop reliable PA-Gal4 transcription factors with robust light-induced gene expression and limited background activity. By optimization of synthetic PA-Gal4 transcription factors, we have validated configurations of Gal4 DNA biding domain, transcription activation domain and blue light-dependent dimer formation molecule Vivid (VVD), and applied types of transcription activation domains to develop a new PA-Gal4 transcription factor we have named eGAV (enhanced Gal4-VVD transcription factor). Background activity of eGAV in dark conditions was significantly lower than that of hGAVPO, a commonly used PA-Gal4 transcription factor, and maximum light-induced gene expression levels were also improved. Light-controlled gene expression was verified in cultured HEK293T cells with plasmid-transient transfections, and in mouse EpH4 cells with lentivirus vector-mediated transduction. Furthermore, light-controlled eGAV-mediated transcription was confirmed in transfected neural stem cells and progenitors in developing and adult mouse brain and chick spinal cord, and in adult mouse hepatocytes, demonstrating that eGAV can be applied to a wide range of experimental systems and model organisms.Key words: optogenetics, Gal4/UAS system, transcription, gene expression, Vivid

著者

Kazunori D YAMADA Samy BALADRAM Fangzhou LIN

出版者

The Editorial Committee of the Interdisciplinary Information Sciences

雑誌

Interdisciplinary Information Sciences (ISSN:13409050)

巻号頁・発行日

vol.28, no.1, pp.95-105, 2022 (Released:2022-07-31)

参考文献数

40

被引用文献数

1

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Thus far, we have experienced three artificial intelligence (AI) booms. In the third one, we succeeded in developing AI that partially surpassed human capabilities. However, we are yet to develop AI that, like humans, can perform a series of cognitive processes. Consciousness built into devices is called machine consciousness. Related research has been conducted from two perspectives: studying machine consciousness as a tool to elucidate human consciousness and achieving the technological goal of furthering AI research with conscious AI. Herein, we survey the research conducted on machine consciousness from the second perspective. For AI to attain machine consciousness, its implementation must be evaluated. Therefore, we only surveyed attempts to implement consciousness as systems on devices. We collected research results in chronological order and found no breakthroughs that could deliver machine consciousness soon. Moreover, there is no method to evaluate whether an implemented machine consciousness system possesses consciousness, thus making it difficult to confirm the certainty of the implementation. This field of research is a new frontier. It is an exciting field with many discoveries expected in the future.

著者

高橋 静夫 ドムニング D. P. 斎藤 常正

出版者

PALAEONTOLOGICAL SOCIETY OF JAPAN

雑誌

日本古生物学會報告・紀事 新編 (ISSN:00310204)

巻号頁・発行日

vol.1986, no.141, pp.296-321, 1986-04-30 (Released:2010-05-25)

参考文献数

35

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1978年8月, 山形県西村山郡大江町を流れる最上川で, 異常渇水のため露出した河床に大型哺乳類の骨格が含まれているのを2名の小学生が発見した。河床の岩層は, 本郷層の橋上砂岩部層で, 初期後期中新世のDenticulopsis katayamae Zone (9-10.4 Ma)を指示する珪藻化石を産する。一節の長さ6~8センチ, 直径14~15センチの椎骨が140センチの長さに連なり, 長さ20~90センチの大きく湾曲した肋骨が26本程度数えられた。骨格前部には長さ51センチの頭骨が, 口蓋を上に頭頂を下にした状態で保存され, 長さ41センチの一対の肩甲骨も認められた。骨格を砂岩からとり出すにつれて, この標本は体前半部の骨格がほぼ完全に揃った, 極めて良く保存された大海牛の化石であることが明らかになった。指・掌骨を含む右前肢は, 絶滅した大海牛類の前肢の構造を示す, 現存する世界唯一の標本である。骨格の特徴により山形の化石は, カリフオルニアから記載されたDusisiren jordaniに近似するが, 歯の大きさがjordaniのものの3/4と小さく, しかも咬合面の模様が単純で, 歯が著るしい退化を示す点で大きく異なる。歯の退化は, 大海牛の進化系列のもっとも際立った形質変化で, 大型の歯を備えた先祖型のDusisiren属から, 歯が退化して失われたHydrodamalis属への進化系列が北太平洋地域で確立されている。歯の特徴および肩甲骨, 胸骨, 手根骨の性質から, 本骨格はD. jordaniとHydrodamalis cuestaeを結ぶ, これまで未記載の中間型の種であることが判明し, ここにDusisiren dewana(和名 : ヤマガタダイカイギュウ)という新種を提唱した。H. cuestaeは, ベーリング海で1768年に絶滅したステラー大海牛(H. gigas)の先祖なので, 本新種の設定により, 中期中新世のD. jordaniにさかのぼる四代の大海牛の進化系列が明らかになった。

著者

TP&Dフォーラム2021実行委員会 田窪 直規 小林 康隆 光富 健一 藤倉 恵一 今野 創祐

出版者

一般社団法人 情報科学技術協会

雑誌

情報の科学と技術 (ISSN:09133801)

巻号頁・発行日

vol.72, no.8, pp.310-315, 2022-08-01 (Released:2022-08-01)

著者

Paul D. Loprinzi

出版者

Active Aging Research Center

雑誌

Journal of Trainology (ISSN:21865264)

巻号頁・発行日

vol.11, no.1, pp.12-16, 2022-05-30 (Released:2022-06-15)

参考文献数

27

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Objective: To provide a brief overview of the literature evaluating the individual and combined effects of cognitive and physical (exercise) training on cognitive function. Design and Methods: An overview review approach was employed. Results: Cognitive and physical training, and their combination, can improve various cognitive outcomes (e.g., memory) in several adult populations (e.g., healthy older adults, older adults with mild cognitive impairment). These effects, howev er, are influenced by several factors, such as the setting in which the training occurs (e.g., supervised or home-based), the type of combined training (e.g., physical-cognitive, motor-cognitive, multi-domain), and the type of comparison/con trol group utilized. Conclusions: Combining cognitive and physical exercise together in a training program may yield improvements in cogni tive function.

著者

黒瀬 大介 古屋 成人 Djeddour D. H. Evans H. C. 對馬 誠也 土屋 健一

出版者

九州病害虫研究会

雑誌

九州病害虫研究会報 (ISSN:03856410)

巻号頁・発行日

vol.59, pp.31-37, 2013-11-29 (Released:2015-10-14)

参考文献数

22

被引用文献数

3 3

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Fallopia japonica(Japanese knotweed, Polygonaceae), native to Japan, has been a serious invasive perennial weed in North America and large parts of Europe, especially in the UK, where there is an urgent need for a classical biological control strategy. Surveys have confirmed the presence of specialized plant pathogens in the native range of Japan. The results of the surveys showed that three fungal diseases of two rusts and a leaf-spot disease were predominantly common and widespread in the field. These rusts were identified as Puccinia polygoni-amphibii var. tovariae and Aecidium polygoni-cuspidati. Furthermore, a leaf-spot fungus morphologically identified as Mycosphaerella polygoni-cuspidati is also distributed widely in Japan. In the field, P. polygoni-amphibii var. tovariae and M. polygonicuspidati were confirmed to have severe infectivity to F. japonica. Thus, it is suggested that these two pathogens have high potential to become classical biological control agents for F. japonica.

著者

by D'Arcy Wentworth Thompson

出版者

Oxford University Press

巻号頁・発行日

1947

著者

Thomson R Genovese G Canon C Kovacsics D Higgins MK Carrington M Winkler CA Kopp J Rotimi C Adeyemo A Doumatey A Ayodo G Alper SL Pollak MR Friedman DJ Raper J

出版者

一般社団法人 日本小児腎臓病学会

雑誌

日本小児腎臓病学会雑誌 (ISSN:09152245)

巻号頁・発行日

vol.27, no.2, pp.141-142, 2014 (Released:2015-05-11)