著者

Miwa Morikawa Masahiro Shinoda Shinichiro Ohta Yuto Yoshida Takatomo Hirouchi Kanako Shinada Osamu Sasaki Takashi Sato Kenichi Kamachi Masaharu Shinkai

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.5528-20, (Released:2020-11-02)

参考文献数

23

被引用文献数

5

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Objective We aimed to clarify clinical and laboratory characteristics of coronavirus disease 2019 (COVID-19) patients, and further explore the features to detect COVID-19 pneumonia at the first visit to community-based hospitals. Methods Diagnoses of COVID-19 were based on positive results from real-time reverse-transcription polymerase chain reaction testing of nasopharyngeal-swab specimens. We retrospectively reviewed the medical records of patients showing positive results. The clinical characteristics and results of blood tests were compared between the patients with and without pneumonia. The risk factors associated with pneumonia were then evaluated by a multivariable analysis. Results The study cohort comprised 154 patients, including 117 patients (76.0%) with pneumonia at first visit. Significant differences were seen in age, the frequency of fever, tachycardia, desaturation (peripheral oxygen saturation ≤95%), any comorbidity, neutrocyte count and fraction, lymphocyte count and fraction, platelet count, lactate dehydrogenase (LDH), C-reactive protein (CRP), and fibrinogen between the patients with and without pneumonia. Using a multivariable analysis, CRP ≥0.3 mg/dL and fibrinogen >400 mg/dL were found to be associated with the presence of pneumonia. Conclusion Community-based settings for screening COVID-19 patients should perform chest X-ray and blood tests for white blood cell fractions, fibrinogen, LDH, and CRP. Of these, elevations in the CRP and fibrinogen levels could be critically associated with the presence of COVID-19 pneumonia.

著者

Masafumi Nakayama Takashi Uchiyama Nobuhiro Tanaka Takaaki Ohkawauchi Shunsuke Miwa Nobuhiro Hijikata Yuichi Kobori Hitoshi Matsuo Kiyotaka Iwasaki

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.11, pp.665-673, 2020-11-10 (Released:2020-11-10)

参考文献数

38

被引用文献数

2

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Background:We hypothesized that the intracoronary-electrocardiogram (IC-ECG)-based pressure index would be more stable and precise than the instantaneous flow reserve (iFR). We investigated the usefulness of the IC-ECG-based pressure index for diagnosing myocardial ischemia.Methods and Results:Thirty-seven consecutive patients with coronary stenosis requiring physiological assessment were enrolled in the study. iFR was measured at rest and under hyperemia in 51 and 40 lesions, respectively. The IC-ECG-triggered distal pressure (Pd)/aortic pressure (Pa) ratio (ICE-T) was defined as the mean Pd/Pa ratio in the period corresponding to the isoelectric line. The ICE-T was significantly lower than the iFR both at rest and during hyperemia (P<0.00001 for both). Fluctuations in the ICE-T pressure parameters (Pd/Pa, Pa, and Pd) were significantly smaller than those of iFR both at rest and during hyperemia. The diagnostic accuracy of predicting a fractional flow reserve (FFR) ≤0.80 of the ICE-T at rest was significantly higher than that of iFR (P=0.008). Receiver operating characteristic curve analyses showed that the ICE-T predicts FFR ≤0.80 more accurately than the iFR (area under curve 0.897 vs. 0.810 for ICE-T and iFR, respectively).Conclusions:We identified the period in the IC-ECG in which resting Pd/Pa was low and constant. The IC-ECG-based algorithm may improve the accuracy of diagnosing myocardial ischemia, without increasing invasiveness, compared with pressure-dependent indices.

著者

KIKUCHI Mumi SUZUKI Miwa UEDA Keiichi MIYAHARA Hirokazu UCHIDA Senzo

雑誌

Fisheries science : FS (ISSN:09199268)

巻号頁・発行日

vol.77, no.5, pp.795-798, 2011-09-01

著者

田口 聡志 上枝 正幸 三輪 一統 Satoshi Taguchi Masayuki Ueeda Kazunori Miwa タグチ サトシ ウエエダ マサユキ ミワ カズノリ

出版者

同志社大学商学会

雑誌

同志社商学 (ISSN:03872858)

巻号頁・発行日

vol.67, no.4, pp.469-495, 2016-03

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瀧田輝己教授退職記念号

著者

三輪 和久 寺井 仁 Kazuhisa Miwa Hitoshi Terai

雑誌

人工知能学会誌 = Journal of Japanese Society for Artificial Intelligence (ISSN:09128085)

巻号頁・発行日

vol.18, no.3, pp.275-282, 2003-05-01

著者

Shohei Kusakabe Nahoko Higasitani Takakazu Kaneko Michiko Yasuda Hiroki Miwa Shin Okazaki Kazuhiko Saeki Atsushi Higashitani Shusei Sato

出版者

Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.35, no.1, pp.ME19141, 2020 (Released:2020-02-20)

参考文献数

65

被引用文献数

21

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Bradyrhizobium elkanii, a rhizobium with a relatively wide host range, possesses a functional type III secretion system (T3SS) that is involved in symbiotic incompatibility against Rj4-genotype soybean (Glycine max) and some accessions of mung bean (Vigna radiata). To expand our knowledge on the T3SS-mediated partner selection mechanism in the symbiotic legume-rhizobia association, we inoculated three Lotus experimental accessions with wild-type and T3SS-mutant strains of B. elkanii USDA61. Different responses were induced by T3SS in a host genotype-dependent manner. Lotus japonicus Gifu inhibited infection; L. burttii allowed infection, but inhibited nodule maturation at the post-infection stage; and L. burttii and L. japonicus MG-20 both displayed a nodule early senescence-like response. By conducting inoculation tests with mutants of previously reported and newly identified effector protein genes of B. elkanii USDA61, we identified NopF as the effector protein triggering the inhibition of infection, and NopM as the effector protein triggering the nodule early senescence–like response. Consistent with these results, the B. elkanii USDA61 gene for NopF introduced into the Lotus symbiont Mesorhizobium japonicum induced infection inhibition in L. japonicus Gifu, but did not induce any response in L. burttii or L. japonicus MG-20. These results suggest that Lotus accessions possess at least three checkpoints to eliminate unfavorable symbionts, including the post-infection stage, by recognizing different T3SS effector proteins at each checkpoint.

著者

Miwa Yamaguchi Yosuke Inoue Tomohiro Shinozaki Masashige Saito Daisuke Takagi Katsunori Kondo Naoki Kondo

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.29, no.10, pp.363-369, 2019-10-05 (Released:2019-10-05)

参考文献数

46

被引用文献数

40

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Background: This study aimed to examine the contextual effects of community-level social capital on the onset of depressive symptoms using a longitudinal study design.Methods: We used questionnaire data from the 2010 and 2013 waves of the Japan Gerontological Evaluation Study that included 14,465 men and 14,600 women aged over 65 years from 295 communities. We also used data of a three-wave panel (2006–2010–2013) to test the robustness of the findings (n = 7,424). Using sex-stratified multilevel logistic regression, we investigated the lagged associations between three scales of baseline community social capital and the development of depressive symptoms.Results: Community civic participation was inversely associated with the onset of depressive symptoms (men: adjusted odds ratio [AOR] 0.93; 95% confidence interval [CI], 0.88–0.99 and women: AOR 0.94; 95% CI, 0.88–0.997 per 1 standard deviation unit change in the score), while no such association was found in relation to the other two scales on social cohesion and reciprocity. This association was attenuated by the adjustment of individual responses to the civic participation component. Individual-level scores corresponding to all three community social capital components were significantly associated with lower risks for depressive symptoms. The results using the three-wave data set showed statistically less clear but similar associations.Conclusions: Promoting environment and services enhancing to community group participation might help mitigate the impact of late-life depression in an aging society.

著者

佐々木 美和 Sasaki Miwa ササキ ミワ

出版者

「宗教と社会貢献」研究会

雑誌

宗教と社会貢献 (ISSN:21856869)

巻号頁・発行日

vol.8, no.1, pp.129-162, 2018-04

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論文本稿は大阪の複数のプロテスタント教会において行った防災活動のアクションリサーチを事例として扱い、日本におけるプロテスタント福音派の社会貢献活動を考察したものである。分析・考察では稲場圭信[2009]の社会貢献活動の構成要素と、高瀬顕功[2015]の社会貢献活動の独立性の指標、また村田充八[2017]のプロテスタントのエートスの概念を援用した。結論として、社会貢献活動の促進と停滞に影響を及ぼしているのは(1)独立性の高さと、(2)現場のキリスト者の持つエートスとしての「召命」意識と新たな「宣教」観である、と考えられた。The purpose of this study is to identify what kinds of circumstance or motivation influence the progression or stagnation of social contributions by religious people. To determine this, the study examines the case of disaster risk reduction (DRR) activities as a social contribution activity done specifically by evangelical Christians in Japan. The action-research was conducted at protestant churches in Osaka. To analyze the data, the study utilized the perspective of "independence"(Takase2015) and "social contribution activity elements" (Inaba2009), along with the concept of Protestants'"ethos"(Murata2017). The DDR was shown to have resources largely independent from the church itself. Having the ethos of a "calling" can influence the progress of social contribution activities by evangelical Christians.

著者

Makoto NAKATA Yasutsugu MIWA James K. CHAMBERS Tsubasa SAITO Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.8, pp.1325-1328, 2018 (Released:2018-08-30)

参考文献数

17

被引用文献数

7

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A 14-month-old, female mini rex was referred for a detailed examination because of exercise intolerance with associated dyspnea. The thoracic radiograph demonstrated severe cardiac enlargement and elevation of the trachea. The echocardiography revealed dilatations of the right-side heart and pulmonary artery, and the color flow Doppler echocardiography demonstrated an atrial septum defect with left to right shunt, resulting in a disturbed flow. The rabbit died 19 days after the initial presentation, and a necropsy was performed. At the necropsy, a defect, 5 mm in diameter, was detected in the atrial septum. Based on the location of the defect, an ostium secundum type atrial septal defect was diagnosed. This is the first clinical report of atrial septal defect in rabbits.

著者

Takuya E. KISHIMOTO James K. CHAMBERS Kouki MIYAMA Nguyen V. SON Mun Keong KOK Mizuho UNEYAMA Yasutsugu MIWA Hiroyuki NAKAYAMA Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.10, pp.1511-1514, 2018 (Released:2018-10-10)

参考文献数

15

被引用文献数

1

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A hard palate mass was surgically removed from an Australian green tree frog (Litoria caerulea) and examined pathologically. The tumor consisted of sheets of small cells arranged in a tubular structure and cords or rosettes with fibrovascular stroma. Immunohistochemically, neoplastic cells were diffusely positive for cytokeratin and neuron-specific enolase and partially positive for S-100 and doublecortin. These findings indicate that the tumor originated from the neuroectodermal tissue. Based on these findings, the tumor was classified as a neuromastoma (neuroepithelioma). Sensory cells located in the hard palate of the frog were considered to be the origin of the tumor. The frog died after going through 3 surgeries and experiencing difficulties closing its mouth.

著者

土井 康孝 辻田 美和 辻田 忠弘 Yasutaka Doi Miwa Tsujita Tadahiro Tsujita

出版者

甲南大学

雑誌

甲南大学紀要. 理工学編 = Memoirs of Konan University. Science and engineering series (ISSN:13480383)

巻号頁・発行日

vol.50, no.1, pp.1-26, 2003-07-31

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東洲斎写楽の現存する浮世絵版画141点のうち、第一期作28点は写楽の作品で最も人気があり、それらすべてが役者絵である。役者絵なので女性の絵もすべて男性が演じているものである。写楽は女性の絵画を1点も残していないとされている。しかしその女性絵画は男性が演じているにもかかわらず女性の特徴を持つ。そこで写楽の浮世絵版画の第一期作の役者絵を男女に分けて目に焦点を当てて分析をおこなった。ある男役の順に男女12種類の目を当てはめたものを作り、被験者10人に対して男性の目か女性の目かという判断を行った。その際、女性の目を男性の顔に当てはめても明らかに違和感があるものはなかったが、女性の目を男性の目と区別できる人が多かった。そこで判別分析を用いて目の形状から男女の目の判別を行った。その結果、F_x=4.713Z_1-2.804Z_2+2.274Z_3-2.788という線形判別関数で男女の目を判別することができた。そして男女の目の判別において目の交差角が最も影響を与えることがわかった。次に上で求めた線形判別関数に実際の数値を代入し結果を求めた。その結果、男性の目でありながら女性の目であると判別されたものは1点だけであった。この目は女性の目であると判断されることが多かった目であった。すなわち、すべて男性でありながら男役と女役ではそれぞれの目を用いて男女の区別を行い、役者の特徴を出していることがわかった。目の交差角の分布をもとに6グループに分類し各グループから1つずつ目を選び男女の順に当てはめたものを作った。それらを画面に一度に表示し、30ペア60種類の感情表現を表示し最も当てはまると思われる絵画を被験者に選んでもらうことから男女の目をいろいろと変えることによって、目だけを変えた役者からどのようなイメージをうけるかという実験結果を得た。その結果、男女どちらの場合であっても男役の目を当てはめたほうが多くのプラスイメージの感情表現を得ることができ、女役の目を当てはめたときにはマイナスイメージの感情表現を得た。また、ディスプレイ上に絵画を一枚ずつ表示し対になる感情表現を与えSD (Semantic Differential)法を用いて分析を行っても、女性の目を当てはめたときのほうがマイナスイメージを与えるということがわかった。

著者

Miwa Yamaguchi Masafumi Eguchi Shamima Akter Takeshi Kochi Huanhuan Hu Ikuko Kashino Keisuke Kuwahara Isamu Kabe Tetsuya Mizoue

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

pp.2017-0298-OA, (Released:2018-09-27)

被引用文献数

4

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Objective: To investigate associations of work-related stressors and their changes over time with the risk of developing metabolic syndrome (MetS) among Japanese manufacturing workers.Methods: Participants were 1,040 employees aged 19 to 68 years who were free from MetS at baseline and completed the three year-interval follow-up survey. MetS was defined according to the Joint Interim Statement. Work-related stressors (job strain, job demands, job control, and worksite social support) were assessed based on the Job Content Questionnaire and were split into two categories (low and high) by the median value at each survey. Multivariable logistic regression was performed to investigate the associations of baseline work-related stressors and their changes over time with the incidence of MetS.Results: Three years later, 61 workers developed MetS. Higher job demands at baseline were significantly associated with a lower risk of MetS (adjusted odds ratio 0.46, 95% confidential interval: 0.24, 0.89). In the analyses of the changes in stressors over time, those whose job demands changed from low to high showed significantly higher risk of MetS (adjusted odds ratio 3.27, 95% confidential interval: 1.46, 7.34), compared with those who reported low job demands in both surveys.Conclusions: Results suggest that an increase in job demands over time, but not higher job demands at baseline, is associated with increased risk of MetS.

著者

Natee Sirisit Daiki Kido Yuki Wakisaka Hiroko Ariga-Miwa Satoru Takakusagi Kiyotaka Asakura Oki Sekizawa Tomohiro Sakata Tomoya Uruga Yasuhiro Iwasawa

出版者

The Japan Society of Vacuum and Surface Science

雑誌

e-Journal of Surface Science and Nanotechnology (ISSN:13480391)

巻号頁・発行日

vol.16, pp.387-390, 2018-09-01 (Released:2018-09-01)

参考文献数

20

被引用文献数

3

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We have shown a possibility of multi-atom resonant X-ray Raman (MARX-Raman) spectroscopy by measuring the N K-edge loss spectrum of TaN at Ta L3-edge and C K-edge loss spectrum of Er(C5H5)3 at Er L1-edge. When the excitation X-ray energy was tuned to the Ta L3-edge and inelastic scattering spectra were recorded around 400 eV loss corresponding to the N K-edge Raman region, we found a clear enhancement of emission spectrum. The same enhancement was observed in C K-edge Raman region in Er(C5H5)3. These experimental results have indicated the possibility of MARX-Raman phenomenon which may lead to a new in situ and bond-specific XAFS spectroscopy for low Z elements. [DOI: 10.1380/ejssnt.2018.387]

著者

三輪 和久 石井 成郎 Kazuhisa Miwa Norio Ishii

雑誌

人工知能学会誌 = Journal of Japanese Society for Artificial Intelligence (ISSN:09128085)

巻号頁・発行日

vol.19, no.2, pp.196-204, 2004-03-01

著者

Nobuhiro Hara Takamichi Miyamoto Junji Yamaguchi Takamasa Iwai Sadahiro Hijikata Keita Watanabe Yuichiro Sagawa Ryo Masuda Ryoichi Miyazaki Naoyuki Miwa Masahiro Sekigawa Tetsuo Yamaguchi Yasutoshi Nagata Toshihiro Nozato Orie Kobayashi Satoshi Umezawa Toru Obayashi

出版者

The Editorial Committee of Annals of Vascular Diseases

雑誌

Annals of Vascular Diseases (ISSN:1881641X)

巻号頁・発行日

vol.11, no.1, pp.106-111, 2018-03-25 (Released:2018-03-25)

参考文献数

27

被引用文献数

3

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Objective: Although deep vein thrombosis (DVT) followed by pulmonary thromboembolism (PE) is a critical complication during pregnancy, there have been few reports about its intrapartum management. We evaluated intrapartum management by using a temporary inferior vena cava filter (IVCF) in pregnant women with PE/DVT.Materials and Methods: Eleven women with PE/DVT during pregnancy between January 2004 and December 2016 were included. The patients were hospitalized for intravenous unfractionated heparin infusion after acute PE/DVT onset. Seven patients were discharged and continued treatment with subcutaneous injection of heparin at the outpatient unit. IVCF was implanted 1–3 days before delivery in 10 patients. Anticoagulant therapy was discontinued 6–12 h before delivery. We retrospectively analyzed rates of maternal or perinatal death, and recurrence of symptomatic PE/DVT.Results: One patient was diagnosed as having PE/DVT and 10 had DVT alone. One patient suffered hemorrhagic shock during delivery; however, maternal or perinatal death and recurrence of symptomatic PE/DVT did not occur in any patient.Conclusion: Maternal or perinatal death and recurrence of symptomatic PE/DVT was not seen in women diagnosed as having PE/DVT during pregnancy and treated with anticoagulant therapy and IVCF.

著者

Miwa NISHIDA Ayako HINO Kazushige MORI Takehisa MATSUMOTO Takashi YOSHIKUBO Hideo ISHITSUKA

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.19, no.11, pp.1407-1411, 1996-11-15 (Released:2008-04-10)

参考文献数

20

被引用文献数

87 100

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The antitumor activity of cytostatic 5'-deoxy-5-fluorouridine (5'-dFUrd) depends on its being converted to 5-fluorouracil (5-FUra) by the enzyme thymidine phosphorylase (dThdPase, EC 2.4.2.4). We prepared mouse anti-human dThdPase monoclonal antibodies to serve as tools for clinical studies with this drug. Partially purified dThdPase obtained from HCT116 human colon cancer cells grown in athymic mice was used as an antigen for the immunization of mice. Six hydridomas were cloned which produced anti-human dThdPase antibodies, as detected by Western blot analysis with human dThdPase. With these antibodies, we developed an ELISA method sensitive enough to measure dThdPase levels, even in tumor tissue samples weighing as little as 10 mg. In addition, one monoclonal antibody was suitable for immunologically staining the enzyme in tumor tissues. Thus, these anti-human dThdPase monoclonal antibodies could be used to measure levels of the enzyme in tumor cells, which is essential for the activation of 5'-dFUrd.

著者

Tetsuo Yamaguchi Masahiro Terashima Chisato Takamura Hironobu Sakurai Kiyotoshi Ooishi Tomoya Yoshizaki Junji Yamaguchi Sadahiro Hijikata Takamasa Iwai Yuichiro Sagawa Keita Watanabe Ryoichi Miyazaki Ryo Masuda Naoyuki Miwa Masahiro Sekigawa Nobuhiro Hara Yasutoshi Nagata Takamichi Miyamoto Toru Obayashi Toshihiro Nozato

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9605-17, (Released:2017-12-21)

参考文献数

11

被引用文献数

3

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A 55-year-old man presented with dyspnea, edema, and appetite loss. He had undergone coronary artery bypass grafting 8 years previously. He had jugular venous distention and Kussmaul's sign. Contrast-enhanced cardiac magnetic resonance imaging (CMRI) demonstrated an intrapericardial mass compressing the right ventricular (RV) cavity. T1- and T2-weighted black-blood images showed a mass with heterogeneous high signal intensity and a thick and dark rim. The mass was considered to be a chronic hematoma. After pericardiotomy with surgical removal of the hematoma, CMRI showed the marked improvement of the RV function. Late intrapericardial hematoma is rare and CMRI is useful for making a differential diagnosis.

著者

Kozo Amano Toshihide Miwa Yasunori Maeda

出版者

Japan Society of Civil Engineers

雑誌

PAPERS OF THE RESEARCH MEETING ON THE CIVIL ENGINEERING HISTORY IN JAPAN (ISSN:09134107)

巻号頁・発行日

vol.4, pp.107-113, 1984-06-25 (Released:2010-06-15)

参考文献数

9

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明治後期から大正前期にかけて、成長期を迎えた大阪市の常住人口は100万人を超えて、膨脹し続けた。路面電車が市内交通機関として、十分な機能を発揮するに至る明治41年頃以前は人力車・巡航船が大阪市の都市交通の中心的役目を果たし、さらに、一部臨港地域では渡船も重要な役割を果たしてきた。なかでも、わが国の独創的交通機関である人力車は、明治初年に出現して以来、着実に増加して、明治中期以後は大阪市民の足として重要役割を果たすようになり全盛期には2人乗りもあわせて2万台を超えていたが、巡航船や路面電車、大正中期以降の自動車の発達により衰退して行った。路面電車開業と同年の明治36年運航を開始した巡航船は、最盛期には2万人以上の乗客を運んでいたが、明治41年路面電車の路線拡張により、大正2年にその使命を終えた。本研究は明治期における交通手段の変遷について述べる。

著者

Isao MATSUMOTO James Kenn CHAMBERS Yasutsugu MIWA Hiroyuki NAKAYAMA Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.6, pp.979-983, 2017 (Released:2017-06-10)

参考文献数

10

被引用文献数

4

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Anaplastic large T-cell lymphoma (ALTCL) is rarely reported in domestic animals. Accordingly, the histopathological and immunohistochemical characteristics of ALTCL have not been well established in prairie dogs. The present report documents three cases in which prairie dogs were diagnosed with ALTCL arising in the subcutaneous tissue, oral mucosa or the mesenteric lymph nodes. Of the three cases, one was available for necropsy and the others were biopsy cases. Microscopically, moderate to large, pleomorphic neoplastic lymphocytes with ovoid to polygonal, bizarre-shaped nuclei, abundant cytoplasm and eosinophilic granules were seen in all cases. Immunohistochemical staining revealed membranous or cytoplasmic CD3 expression of the neoplastic lymphocytes. The neoplastic cells often had granzyme B-positive cytoplasmic granules. One of the prairie dogs with nodal ALTCL suffered systemic dissemination of the tumor and died suddenly. In the two biopsy cases, one animal died on the day of the biopsy examination and the other died six weeks after chemotherapy. ALTCL in prairie dogs displays a cytotoxic T cell phenotype and presumably carries a poor prognosis regardless of the anatomical type.

著者

Daisuke Sueta Koichi Kaikita Nobukazu Okamoto Soichiro Yamabe Masanobu Ishii Yuichiro Arima Miwa Ito Yu Oimatsu Tatsuro Mitsuse Satomi Iwashita Eiichi Nakamura Seiji Hokimoto Hiroshi Mizuta Hisao Ogawa Kenichi Tsujita for the ESCORT-TKA Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0612, (Released:2017-09-16)

参考文献数

50

被引用文献数

4

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Background:The pharmacological advantage of combining physiotherapy with anticoagulants for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) is not fully known. Herein we investigated the potential benefit of this combination therapy in patients undergoing TKA.Methods and Results:The 38 patients were randomly assigned to a physiotherapy group (n=19) or a physiotherapy plus 30 mg/day edoxaban group (n=19). The occurrence of VTE was evaluated, as were serial changes in parameters measured by the Total Thrombus-formation Analysis System, a novel system for quantitatively analyzing thrombus formation using microchips with thrombogenic surfaces (collagen plus tissue factor, atheroma [AR]-chip). Combination therapy significantly reduced the incidence of VTE after TKA compared with monotherapy (P=0.038). The area under the curve (AUC) of thrombus formation for the AR-chip (AR10-AUC30) was significantly lower in the combination group (P=0.001) on Day 7 after TKA than before TKA, but no significant change was observed with monotherapy (P=0.809). In 13 VTE-positive patients, AR10-AUC30was significantly lower in the combination group (n=3) than in the monotherapy group (n=10) on Day 7 (P=0.045).Conclusions:The combination of physiotherapy and edoxaban significantly reduced the incidence of VTE after TKA compared with physiotherapy alone. However, it is possible that VTE occurrence after TKA is not only associated with thrombogenicity, but also rheological factors.