著者

Shin Miura Kiyoshi Kume Kazuhiro Kikuta Shin Hamada Tetsuya Takikawa Naoki Yoshida Seiji Hongo Yu Tanaka Ryotaro Matsumoto Takanori Sano Mio Ikeda Toru Furukawa Masahiro Iseki Michiaki Unno Atsushi Masamune

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.252, no.1, pp.63-71, 2020 (Released:2020-09-03)

参考文献数

28

被引用文献数

9 15

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Pancreatic cancer is one of the most dangerous solid tumors, but its early diagnosis is difficult. The abnormality of the main pancreatic duct (MPD), such as a single localized stricture and upstream dilatation, might be useful in the early detection of pancreatic cancer. However, these findings are often observed in benign inflammatory cases. This study aimed to clarify whether early pancreatic cancer presenting MPD abnormalities has characteristic features different from those of benign cases. This is a single-center, retrospective study. We analyzed 20 patients who underwent pancreatectomy presenting with a single, localized MPD stricture without identifiable masses on imaging: 10 patients with pancreatic ductal adenocarcinoma (cancer group; 6 with stage 0 and 4 with stage I) and 10 patients with benign strictures (benign group; 8 with inflammation and 2 with low-grade pancreatic intraepithelial neoplasms). Pancreatectomy was performed in these benign cases because high-grade intraepithelial neoplasm was suspected. Although the proportion of patients with diabetes mellitus tended to be higher in the cancer group (6/10) than that in the benign group (1/10) (P = 0.058), other clinical characteristics were not different between the groups. Preoperative cytological malignancies were detected in four patients in the cancer group (4/10) but not in the benign group (P = 0.09). Focal parenchymal atrophy and fat replacement were more frequently detected on computed tomography in the cancer group (7/10) than in the benign group (1/10) (P = 0.02). In conclusion, focal parenchymal atrophy and fat replacement may provide clues for the early diagnosis of pancreatic cancer.

著者

Makiko Sekiyama Shin Yamazaki Takehiro Michikawa Shoji F. Nakayama Hiroshi Nitta Yu Taniguchi Eiko Suda Tomohiko Isobe Yayoi Kobayashi Miyuki Iwai-Shimada Masaji Ono Kenji Tamura Junzo Yonemoto Toshihiro Kawamoto Michihiro Kamijima the Japan Environment and Children’s Study Group

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.5, pp.228-236, 2022-05-05 (Released:2022-05-05)

参考文献数

18

被引用文献数

8 24

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Background: The Japan Environment and Children’s Study (JECS) is a nationwide birth cohort study investigating environmental effects on children’s health and development. A Sub-Cohort Study has begun, conducting extended exposure and outcome measurements by targeting a subgroup randomly selected from the JECS Main Study. We report the Sub-Cohort Study methodology and participants’ baseline profiles.Methods: Of 100,148 children in the JECS Main Study, children born after April 1, 2013 who met eligibility criteria ([1] all questionnaire and medical record data from children and their mothers collected from the first trimester to 6 months of age, [2] biospecimens [except umbilical cord blood] from children and their mothers collected at first to second/third trimester and delivery) were randomly selected for each Regional Centre at regular intervals. Face-to-face assessment of neuropsychiatric development, body measurement, paediatrician’s examination, blood/urine collection for clinical testing and chemical analysis, and home visits (ambient and indoor air measurement and dust collection) are conducted. Participants are followed up at 1.5 and 3 years old for home visits, and 2, 4, 6, and 8 years old for developmental/medical examination. The details of protocols after age 10 are under discussion.Results: Of 10,302 selected children, 5,017 participated. The profiles of the participating mothers, fathers and children did not substantially differ between the Main Study and Sub-Cohort Study.Conclusion: The JECS Sub-Cohort Study offers a platform for investigating associations between environmental exposure and outcomes.

著者

岸田 真 Shin KISHIDA

雑誌

桜美林論考. 人文研究 = The journal of J. F. Oberlin University. Studies in humanities (ISSN:21850690)

巻号頁・発行日

vol.4, pp.143-157, 2013-03-01

著者

SHIGEAKI AOYAGI SATORU TOBINAGA KUMIKO WADA SHIN-ICHI NATA HIROSHI YASUNAGA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.67, no.2.3, pp.131-135, 2020-09-30 (Released:2022-11-16)

参考文献数

8

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Summary: Anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva is known as a cause of sudden cardiac death. However, it is often asymptomatic and incidentally diagnosed during evaluation for other cardiac diseases. We report a case of anomalous aortic origin of the right coronary artery (RCA) from the left sinus of Valsalva (ARCA) detected incidentally in a patient with degenerative mitral regurgitation (MR). A 47-year-old man, who had no history of myocardial ischemic symptoms on exertion, was admitted for sudden orthopnea. ECG revealed no ischemic changes and arrhythmias. Echocardiography demonstrated MR due to torn chordae of the posterior mitral leaflet. Computed tomography (CT) revealed the RCA arising from the left sinus of Valsalva at an acute angle and taking an interarterial course between the great arteries. The proximal RCA showed a circular shaped cross-section on CT, suggesting no presence of an intramural segment. Considering refractory heart failure and no history of myocardial ischemic symptoms on exertion as well as the findings of the CT angiography, urgent mitral valve repair was undertaken without surgical intervention for the anomalous RCA, and without evaluating myocardial ischemia. The patient recovered uneventfully. Postoperatively, myocardial perfusion scintigraphy demonstrated no exercise-induced myocardial ischemia. Patients with ARCA who are asymptomatic and whose coronary course is not intramural can be managed without surgical intervention for an anomalous coronary artery.

著者

Eunjin Shin Kyeong-Mi Choi Hwan-Soo Yoo Chong-Kil Lee Bang Yeon Hwang Mi Kyeong Lee

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.33, no.9, pp.1610-1614, 2010-09-01 (Released:2010-09-01)

参考文献数

25

被引用文献数

56 66

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In the course of screening anti-adipogenic activity of natural products employing the preadipocyte cell line, 3T3-L1 as an in vitro assay system, the EtOAc fraction of the stem barks of Fraxinus rhynchophylla DENCE (Oleaceae) showed significant inhibitory activity on adipocyte differentiation as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of six coumarins such as esculetin (1), scopoletin (2), fraxetin (3), fraxidin (4) esculin (5) and fraxin (6). Among the six coumarins isolated, esculetin (1) showed the most potent inhibitory activity on adipocyte differentiation, followed by fraxetin (3). Further studies with interval treatment demonstrated that esculetin (1) exerted inhibitory activity on adipocyte differentiation when treated within 2 d (days 0—2) after differentiation induction. We further investigated the effect of esculetin (1) on peroxisome proliferator activated receptor γ (PPARγ), one of the early adipogenic transcription factors. Esculetin (1) significantly blocked the induction of PPARγ protein expression and inhibited adipocyte differentiation induced by troglitazone, a PPARγ agonist. Taken together, these results suggest that esculetin (1), an active compound from F. rhynchophylla, inhibited early stage of adipogenic differentiation, in part, via inhibition of PPARγ-dependent pathway.

著者

Shin-ichi Momomura Hiroyuki Tsutsui Yoshitaka Sugawara Makoto Ito Takeshi Mitsuhashi Seiji Fukamizu Mahito Noro Naoki Matsumoto Tomoyuki Tejima Kaoru Sugi for the MOMIJI Study Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.8, pp.1911-1919, 2012 (Released:2012-07-25)

参考文献数

32

被引用文献数

21 16

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Background: Cardiac resynchronization therapy (CRT) is effective in reducing morbidity and mortality in systolic heart failure patients with cardiac dyssynchrony as demonstrated in studies with primarily Western populations. Although CRT devices with a defibrillator (CRT-D) became available in Japan since 2006, their efficacy remains uncertain in Japanese patients. In this prospective, multicenter study, the efficacy of CRT-D therapy in an all-Japanese population was compared with the study conducted in the US, Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE-ICD). Methods and Results: Ninety-three patients were evaluated according to the subject selection criteria of the MIRACLE-ICD study, and 80 patients were enrolled. Results at baseline and 6-month post-CRT-D implantation were compared in terms of composite clinical response (CCR) and other secondary endpoints. Quality of life (QOL) was assessed with a validated Japanese version of the Minnesota Living with Heart Failure questionnaire. CCR was improved in 55 patients (68.8%), unchanged in 14 (17.5%), and worsened in 11 patients (13.7%) (MIRACLE-ICD general phase: 62.0%, 13.4% and 24.6%, respectively). Non-inferiority was verified by 1-sided test with 10% equivalence margin. QOL score improved significantly (50.0±26.2 vs. 23.6±20.2, P<0.01). Conclusions: The MOMIJI study demonstrated that CRT-D effectiveness as assessed with CCR was non-inferior to the trials conducted outside Japan, thus suggesting that the benefits of CRT-D are similar between Japanese and non-Japanese patients.  (Circ J 2012; 76: 1911–1919)

著者

岸田 真 Shin KISHIDA

雑誌

桜美林論考. 人文研究 = The journal of J. F. Oberlin University. Studies in humanities (ISSN:21850690)

巻号頁・発行日

vol.3, pp.61-74, 2012-03-01

著者

Miyuki Yuda Shin Aizawa Isao Tsuboi Yoko Hirabayashi Tomonori Harada Hirotsugu Hino Shuichi Hirai

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.11, pp.1602-1608, 2022-11-01 (Released:2022-11-01)

参考文献数

28

被引用文献数

3

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Lipopolysaccharide (LPS) treatment induced hemophagocytic lymphohistiocytosis in senescence-accelerated mice (SAMP1/TA-1), but not in senescence-resistant control mice (SAMR1). SAMP1/TA-1 treated with LPS exhibited functional impairment of the hematopoietic microenvironment, which disrupted the dynamics of hematopoiesis. Macrophages are a major component of the bone marrow (BM) hematopoietic microenvironment, which regulates hematopoiesis. Qualitative and quantitative changes in activated macrophages in LPS-treated SAMP1/TA-1 are thought to contribute to the functional deterioration of the hematopoietic microenvironment. Thus, we examined the polarization of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages, and the dynamics of macrophage production in the BM of SAMP1/TA-1 and SAMR1 after LPS treatment. After LPS treatment, the proportions of M1 and M2 macrophages and the numbers of macrophage progenitor (CFU-M) cells increased in both SAMP1/TA-1 and SAMR1. However, compared to the SAMR1, the increase in the M1 macrophage proportion was prolonged, and the increase in the M2 macrophage proportion was delayed. The increase in the number of CFU-M cells was prolonged in SAMP1/TA-1 after LPS treatment. In addition, the levels of transcripts encoding an M1 macrophage-inducing cytokine (interferon-γ) and macrophage colony-stimulating factor were markedly increased, and the increases in the levels of transcripts encoding M2 macrophage-inducing cytokines (interleukin (IL)-4, IL-10, and IL-13) were delayed in SAMP1/TA-1 when compared to SAMR1. Our results suggest that LPS treatment led to the severely imbalanced polarization of activated M1/M2 macrophages accompanied by a prolonged increase in macrophage production in the BM of SAMP1/TA-1, which led to the impairment of the hematopoietic microenvironment, and disrupted the dynamics of hematopoiesis.

著者

SHIN,Kunio

出版者

English Literary Society of Japan

雑誌

Studies in English literature

巻号頁・発行日

no.55, 2014-03-01

著者

Eriko SATO Ikuko YANO Masahiro SHIMOMURA Satohiro MASUDA Toshiya KATSURA Shin-ichi MATSUMOTO Teru OKITSU Yasuhiro IWANAGA Shinji UEMOTO Ken-ichi INUI

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

Drug Metabolism and Pharmacokinetics (ISSN:13474367)

巻号頁・発行日

vol.24, no.2, pp.175-179, 2009 (Released:2009-05-10)

参考文献数

20

被引用文献数

3

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We attempted a switch of mammalian target of rapamycin (mTOR) inhibitors from sirolimus to everolimus, a derivative of sirolimus and now on the market in Japan, in two pancreatic islet transplant patients. Both patients were administered tacrolimus with sirolimus or everolimus. They had been administered 5 or 9 mg sirolimus once a day and had maintained a trough concentration of about 15 ng/mL as measured by high performance liquid chromatography with ultraviolet detection. After the switch from sirolimus to everolimus, they were given 10 or 12 mg/day of everolimus twice a day to maintain a trough concentration of 12-15 ng/mL as measured by a fluorescence polarization immunoassay (FPIA) method. Afterward, the blood concentrations of everolimus and sirolimus after the conversion were measured by high performance liquid chromatography with mass spectrometry and everolimus concentrations were found to be 5-10 ng/mL. These data show that a larger dosage is needed for everolimus than sirolimus to maintain the same trough blood concentration. Data obtained by the FPIA for everolimus should be carefully evaluated after switching from sirolimus to everolimus because of the cross-reactivity of the antibody with sirolimus.

著者

Keiji Wada Yukihisa Suzuki Akira Ushiyama Shin Ohtani Kenji Hattori Atsushi Saito Satoshi Nakasono Satoshi Miyawaki Takashi Yanagisawa Yoshiya Ohnuma

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Communications Express (ISSN:21870136)

巻号頁・発行日

vol.11, no.10, pp.661-666, 2022-10-01 (Released:2022-10-01)

参考文献数

7

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This letter presents development of a magnetic field generator to evaluation of biological effects. The magnetic field generator has a frequency bandwidth of 85 kHz because it is intended for wireless power supply for electric vehicles. Furthermore, the generator is designed to operate for only one second, and can produce the induced magnetic field of 10 times compared to basic restrictions of the ICNIRP. By applying the magnetic field generator, it is possible to conduct a evaluation and verification of biological effect depending on electromagnetic fields for WPT systems of electric vehicles.

著者

Shin TANAKA

出版者

Japanische Gesellschaft für Germanistik

雑誌

Neue Beiträge zur Germanistik (ISSN:24330906)

巻号頁・発行日

vol.112, pp.48-60, 2003 (Released:2018-03-31)

著者

Masahiro Endo Kei Fujiwara Syougo Hamada Satoshi Murata Shin-ichiro M Nomura

出版者

The Biophysical Society of Japan General Incorporated Association

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.52, no.supplement, pp.S107, 2012-08-15 (Released:2017-05-01)

著者

Yosuke Hata Osamu Iida Shin Okamoto Takayuki Ishihara Kiyonori Nanto Takuya Tsujimura Naoko Higashino Taku Toyoshima Ikurou Kitano Yoshihiko Tsuji Mitsuyoshi Takahara Toshiaki Mano

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63773, (Released:2022-08-27)

参考文献数

25

被引用文献数

1

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Aims: This study aimed to investigate the long-term impact of guideline-directed medical therapy (GDMT) on 10-year mortality in patients with chronic limb-threatening ischaemia (CLTI) after revascularization. Methods: We performed a retrospective multicentre study enrolle 459 patients with CLTI who underwent revascularization (396 endovascular therapy [EVT] and 63 bypass surgery [BSX] cases) between January 2007 and December 2011. The primary outcome measure was all-cause mortality. We additionally explored the predictors for all-cause mortality using Cox regression hazard models; the influence of GDMT, defined as prescription of antiplatelet agents, statins, and angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) in aggregate, on all-cause mortality, and the association between baseline characteristics using interaction effects. Results: During the 10-year follow-up after revascularization, 234 patients died. In Kaplan-Meier analysis, 10-year mortality was significantly lower in patients who received statins (p<.001) and ACE inhibitors or ARBs (p=.010) than those who did not. However, there were no differences in 10-year mortality between patients who received anti-platelet agents and those who did not (p=.62). Interaction analysis revealed that GDMT had a significantly different hazard ratio in patients who were and were not on hemodialysis and in those treated with EVT or BSX (p for interaction =.002 and .044, respectively). In the multivariate analysis, age >75 years, non-ambulatory status, hemodialysis, congestive heart failure, left ventricular ejection fraction <50%, and GDMT were significantly associated with all-cause mortality. Conclusions: Appropriate GDMT use was independently associated with 10-year mortality in patients with CLTI after revascularization.

著者

朔 啓二郎 三浦 伸一郎 瀬川 波子 野田 慶太 中嶋 恵美子 西尾 美登里 安永 晋一郎晋一郎 柳瀬 敏彦 SAKU Keijiro MIURA Shin-ichiro OGAWA Masahiro ZHANG Bo NODA Keita NAKASHIMA Emiko NISHIO Midori YASUNAGA Shin'ichiro YANASE Toshihiko

出版者

日本機能性食品医用学会

雑誌

機能性食品と薬理栄養 : 日本機能性食品医用学会認定誌 : Associate journal of Japanese Society for Medical Use of Functional Foods = 機能性食品と薬理栄養 : 日本機能性食品医用学会認定誌 : Associate journal of Japanese Society for Medical Use of Functional Foods (ISSN:13482564)

巻号頁・発行日

vol.10, no.1, pp.367-406, 2016

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第13回日本機能性食品医用学会総会会長講演

著者

森山 新 MORIYAMA Shin

出版者

お茶の水女子大学比較日本学教育研究センター

雑誌

お茶の水女子大学比較日本学教育研究センター研究年報

巻号頁・発行日

no.5, pp.147-153, 2009-03

著者

SeongHan SHIN Shota YAMADA Goichiro HANAOKA Yusuke ISHIDA Atsushi KUNII Junichi OKETANI Shimpei KUNII Kiyoshi TOMOMURA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E105-A, no.8, pp.1121-1133, 2022-08-01

被引用文献数

1

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AONT (All-or-Nothing Transform) is a kind of (n, n)-threshold secret sharing scheme that distributes a message m into a set of n shares such that the message m can be reconstructed if and only if n shares are collected. At CRYPTO 2000, Desai proposed a simple and faster AONT based on the CTR mode of encryption (called CTRT) and proved its security in the ideal cipher model. Though AES-128, whose key length k = 128 and block length l = 128, can be used in CTRT as a block cipher, AES-256 and AES-192 cannot be used due to its intrinsic restriction of k ≤ l. In this paper, we propose an extended CTRT (for short, XCTRT) suitable for AES-256. By thoroughly evaluating all the tricky cases, we prove that XCTRT is secure in the ideal cipher model under the same CTRT security definition. Also, we discuss the security result of XCTRT in concrete parameter settings. For more flexibility of key length, we propose a variant of XCTRT dealing with l<k ≤ 2l by slightly modifying the construction of the last block. After showing implementation details and performance evaluation of CTRT, XCTRT, and the variant, we can say that our XCTRT and its variant have high-speed encoding and decoding performance and are quite practical enough to be deployed in real-world applications.

著者

Yadab P. DHAKAL Wataru SUZUKI Takashi KUNUGI Shin AOI

出版者

JAPAN ASSOCIATION FOR EARTHQUAKE ENGINEERING

雑誌

日本地震工学会論文集 (ISSN:18846246)

巻号頁・発行日

vol.15, no.6, pp.6_91-6_111, 2015 (Released:2015-11-25)

参考文献数

37

被引用文献数

7 7

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We constructed ground motion prediction equation (GMPE) for absolute velocity response spectra in the period range of 1 to 10 s with the primary aim of providing early warning of long-period ground motions in Japan during moderate to large magnitude earthquakes. We found that the spatial variability of the observed long-period intensities can be reproduced in broad areas within a difference of one intensity by using the methodology proposed in this study that requires the magnitude and distance to be determined promptly.

著者

Ryutaro Arita Rie Ono Natsumi Saito Satoko Suzuki Akiko Kikuchi Minoru Ohsawa Yasunori Tadano Tetsuya Akaishi Takeshi Kanno Michiaki Abe Ko Onodera Shin Takayama Tadashi Ishii

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.257, no.3, pp.241-249, 2022 (Released:2022-07-02)

参考文献数

49

被引用文献数

2

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Coronavirus disease 2019 (COVID-19) causes a variety of pain symptoms in the acute phase. Severe chest pain suddenly occurs even without abnormalities on examination and is sometimes refractory to analgesics. Such pain is a clinical concern in care facilities with limited resources, and this is the first report on the use of saikanto for its treatment. In Miyagi Prefecture, Japan, COVID-19 patients with mild symptoms were admitted to a hotel that operated as an isolation facility, and their symptoms were observed. In this article, we report four cases in which chest pain comorbid with mild to moderate COVID-19 was successfully treated with saikanto, a traditional Japanese (Kampo) medicine. The patients presented with chest pain and underwent medical examination at the facility. Two patients had severe chest pain refractory to acetaminophen. Critical cardiopulmonary diseases were ruled out in all the patients, and three patients had features of pneumonia on chest radiograph. Medications, including saikanto, were administered to the patients. The patients’ chest pain and other symptoms improved 1-4 days after the administration of saikanto, and they left the care facility without hospitalization. The cause of the chest pain experienced by these patients is unclear, but we speculate that it could be minimal pleural inflammation or neuropathy. Previous pharmacological studies have suggested anti-inflammatory and analgesic properties of the crude drugs that constitute saikanto. This case report suggests that saikanto could be a treatment option for chest pain refractory to analgesics in patients with mild to moderate COVID-19.

著者

Tomomi Masumitsu Takuro Kubozono Masaaki Miyata Hyuma Makizako Takayuki Tabira Toshihiro Takenaka Shin Kawasoe Akihiro Tokushige Sayoko Niwa Mitsuru Ohishi

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63594, (Released:2022-06-24)

参考文献数

35

被引用文献数

2

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Aim: This study aims to investigate the association of the Cardio-Ankle Vascular Index (CAVI) with self-reported sleep duration and sleep quality in community-dwelling older adults aged ≥ 65 years. Methods: The Tarumizu Study was a cohort of community-based health checkups conducted in the Tarumizu City, Japan, in 2018 and 2019. In total, 997 participants aged ≥ 65 years (median age, 74 years) were examined. We obtained the average sleep duration and sleep quality using self-reported questionnaires and classified them into three separate groups according to sleep duration (<6 h, 6–8 h, and ≥ 8 h) and sleep quality (good, medium, and poor). The arterial stiffness was measured using the CAVI. Results: As per our findings, the CAVI was significantly higher in the ≥ 8 h sleep group (CAVI=9.6±1.3) than in the <6 h (CAVI=9.1±1.1) or 6–8 h (CAVI=9.1±1.2) groups (p<0.001). After adjustment for age, sex, systolic blood pressure, current smoking status, body mass index, frequency of exercise, educational background, frailty, sleep medication, sleep quality, and nap duration, multivariable regression analysis demonstrated that the CAVI was significantly higher in the ≥ 8 h group than in the 6–8 h group (p=0.016). In contrast, multivariable regression analysis showed that there was no significant association between sleep quality and CAVI. Conclusions: A significant association was noted between long sleep duration (≥ 8 h) and elevated CAVI in community-dwelling older adults aged ≥ 65 years. We, therefore, suggest that long sleep duration, not sleep quality, is correlated with arterial stiffness in older adults.