著者

Yusuke Fukazawa Naoki Yamamoto Takashi Hamatani Keiichi Ochiai Akira Uchiyama Ken Ohta

出版者

Information Processing Society of Japan

雑誌

Journal of Information Processing (ISSN:18826652)

巻号頁・発行日

vol.28, pp.16-30, 2020 (Released:2020-01-15)

参考文献数

114

被引用文献数

6

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Monitoring mental health has received considerable attention as a countermeasure against the increasing occurrence of mental illness worldwide. However, current monitoring services incur costs because users are required to attach wearable devices or answer questions. To reduce such costs, many studies have used smartphone-based passive sensing technology to capture a user's mental state. This paper reviews those studies from the perspective of machine learning and statistical analysis. Forty-four studies published since 2011 have been reviewed and summarized from three perspectives: designed features, machine learning algorithm, and evaluation method. The features considered include location and mobility, activity, speech, sleep, phone usage, and context features. Tasks are classified as correlation analysis, regression tasks, and classification tasks. The machine learning algorithm used for each task is summarized. Evaluation metrics and cross validation methods are also summarized. For those who are not necessarily machine learning experts, we aim to provide information on typical machine learning framework for smartphone-based mental state estimation. For experts in the field, we hope this review will be a helpful tool to check for potential omissions.

著者

菅野 博之 大塚 英志 泉 政文 山本 忠宏 本多 マークアントニー 大内 克哉 Hiroyuki KANNO Eiji OHTSUKA Masafumi IZUMI Tadahiro YAMAMOTO Mark Anthony HONDA Katsuya OUCHI

出版者

神戸芸術工科大学

雑誌

芸術工学2012

巻号頁・発行日

2012-11-30

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WEB上にまんが表現が移行するということは、「単行本」や「雑誌」がWEBの環境下で新たな適応を求められることを意味する。現在のまんが表現は「コマ」を映画の1カットに見立て「モンタージュ」的に接続する一方、2頁単位の「見開き」に「構成」として配置するものであるが、そのような方法はWEB上では一度解体する。本研究では「横スクロール」形式によってiPadなどのタブレット上に帯状に描かれたまんがを表示する技法において、紙のまんがに替わる新しい文法形式を検証するため、中世の絵巻物「信貴山縁起」の手法の解析を行った。その結果、画面を上下二分割する中心軸上で読者の視線を上下させる技法を確認し、それがiPad対応の横スクロールまんがにも用いることができることを確認した。その他「異時間図法」など、絵巻の技法は応用可能であることが確認できた。「絵巻」と「横スクロール形式のWEBコミック」の方法上の互換性は高く、そこに「紙のまんが」や「アニメーションの技法」をどのようにあらためて導入するかが次の重要な課題である。

著者

Katsuhiko Yamamoto Toshio Irino Toshie Matsui Shoko Araki Keisuke Kinoshita Tomohiro Nakatani

出版者

ACOUSTICAL SOCIETY OF JAPAN

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.40, no.2, pp.84-92, 2019-03-01 (Released:2019-03-01)

参考文献数

27

被引用文献数

2

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The speech-based envelope power spectrum model (sEPSM) was developed to predict the speech intelligibility of sounds produced by nonlinear speech enhancement algorithms such as spectral subtraction. It is a linear model with a linear, level-independent gammatone (GT) filterbank as the front-end. Therefore, it seems difficult to evaluate speech sounds with low and high sound pressure levels (SPLs) consistently because the intelligibility of the speech is dependent on the SPL as well as the signal-to-noise ratio. In this study, the sEPSM was extended with the dynamic compressive gammachirp (dcGC) auditory filterbank and a ``common'' normalization factor of the modulation power spectrum component to improve the predictability of the model. For evaluating the proposed model, we performed subjective experiments on the intelligibility of speech sounds enhanced by spectral subtraction and a Wiener filter algorithm. We compared the subjective speech intelligibility scores with the objective scores predicted by the proposed dcGC-sEPSM, original GT-sEPSM, and other well-known conventional methods such as the short-time objective intelligibility measure (STOI), coherence speech intelligibility index (CSII), and hearing aid speech perception index (HASPI). The result shows that the proposed dcGC-sEPSM predicted the subjective results better did than the other methods.

著者

Masayoshi Yamamoto Yoshihiro Seo Tomoko Ishizu Isao Nishi Yoshie Hamada-Harimura Tomoko Machino-Ohtsuka Kimi Sato Seika Sai Akinori Sugano Kenichi Obara Kazutaka Aonuma

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0240, (Released:2017-06-06)

参考文献数

27

被引用文献数

9

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Background:Although experimental animal studies report many pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP-4i), their prognostic value has not been demonstrated in clinical trials.Methods and Results:Among 838 prospectively enrolled heart failure (HF) patients hospitalized for acute decompensated HF, 79 treated with DPP-4i were compared with 79 propensity score-matched non-DPP-4i diabetes mellitus (DM) patients. The primary endpoint was all-cause mortality; the secondary endpoint was a composite of cardiovascular death and hospitalization. During follow-up (423±260 days), 8 patients (10.1%) in the DPP-4i group and 13 (16.5%) in the non-DPP-4i group died (log-rank, P=0.283). The DPP-4i group did not have a significantly higher rate of all-cause mortality (log-rank, P=0.283), or cardiovascular death or hospitalization (log-rank, P=0.425). In a subgroup analysis of HF with preserved ejection fraction (HFpEF; n=75), the DPP-4i group had a significantly better prognosis than the non-DPP-4i group regarding the primary endpoint (log-rank, P=0.021) and a tendency to have better prognosis regarding the secondary endpoint (log-rank, P=0.119). In patients with HF with reduced EF (n=83), DPP-4i did not result in better prognosis.Conclusions:DPP-4i did not increase the risk of adverse clinical outcomes in patients with DM and HF. DPP-4i may be beneficial in HFpEF.

著者

Mafumi Owa Kazunori Aizawa Nobuyuki Urasawa Hiroyuki Ichinose Kazuya Yamamoto Koji Karasawa Mitsuru Kagoshima Jun Koyama Shu-ichi Ikeda

出版者

日本循環器学会

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.65, no.4, pp.349-352, 2001 (Released:2001-06-01)

参考文献数

13

被引用文献数

66 105

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Four patients had the clinical features of `ampulla cardiomyopathy', consisting of acute-onset transient left ventricular apical akinesis with basal normokinesis, normal coronary angiogram, ST-segment elevation and subsequent giant T wave inversion, which mimicked acute coronary syndrome, the onset of which occurred shortly after extreme mental stress. Myocardial necrosis was minimal, although 2 patients showed elevated serum catecholamine levels in the acute phase. Each patient underwent serial cardiac radionuclide single-photon emission computed tomography of myocardial functional sympathetic innervation, fatty acid metabolism and perfusion using I-123-metaiodobenzyl-guanidine (MIBG), I-123-β-metyl-iodophenyl pentadecanoic acid (BMIPP) and thallium-201 (201Tl), respectively. In the acute phase, MIBG and BMIPP imaging showed an uptake defect in the apical region, whereas 201Tl uptake was mildly decreased. When assessed semi-quantitatively, the MIBG images had higher defect scores from the acute phase throughout the year of observation compared with BMIPP, and 201Tl. These observations suggest that the primary cause of ampulla cardiomyopathy is related to a disturbance of the cardiac sympathetic innervation. (Jpn Circ J 2001; 65: 349 - 352)

著者

Tsutsumi Naotaka Kimura Takeshi Arita Kyohei Ariyoshi Mariko Ohnishi Hidenori Yamamoto Takahiro Zuo Xiaobing Maenaka Katsumi Park Enoch Y Kondo Naomi Shirakawa Masahiro Tochio Hidehito Kato Zenichiro

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-12-15

被引用文献数

92

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免疫・神経難治疾患の治療薬開発を促進するインターロイキン18複合体立体構造を解明. 京都大学プレスリリース. 2014-12-16.

著者

Ban Hiroshi Yamamoto Hiroki Hanakawa Takashi Urayama Shin-Ichi Aso Toshihiko Fukuyama Hidenao Ejima Yoshimichi

出版者

The Society for Neuroscience

雑誌

The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:02706474)

巻号頁・発行日

vol.33, no.43, pp.16992-17007, 2013-10-23

被引用文献数

35

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モノの背後を見る脳の仕組みを解明 -視対象の部分像から全体像を復元する第1次視覚野の活動をfMRIで観察-. 京都大学プレスリリース. 2013-10-23.

著者

Miyako Yuasa-Kawase Daisaku Masuda Taiji Yamashita Ryota Kawase Hajime Nakaoka Miwako Inagaki Kazuhiro Nakatani Kazumi Tsubakio-Yamamoto Tohru Ohama Akifumi Matsuyama Makoto Nishida Masato Ishigami Toshiharu Kawamoto Issei Komuro Shizuya Yamashita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.19, no.3, pp.263-275, 2012 (Released:2012-03-26)

参考文献数

48

被引用文献数

9 32

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Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients.Methods: By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of 123I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n =319) and healthy subjects (n =1,239) were underwent.Results: The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p <0.0001).Conclusion: The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic.

著者

Hikichi Takafusa Matoba Ryo Ikeda Takashi Watanabe Akira Yamamoto Takuya Yoshitake Satoko Tamura-Nakano Miwa Kimura Takayuki Kamon Masayoshi Shimura Mari Kawakami Koichi Okuda Akihiko Okochi Hitoshi Inoue Takafumi Suzuki Atsushi Masui Shinji

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)

巻号頁・発行日

2013-04-02

被引用文献数

31

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初期化を阻害する転写因子が分化を促進する. 京都大学プレスリリース. 2013-04-02.

著者

Hiroaki Kawano Nobu Yamamoto Hirokazu Kurohama Shinji Okano Masaya Kurobe Tomohiro Honda Ryohei Akashi Tsuyoshi Yonekura Satoshi Ikeda Koichi Izumikawa Koji Maemura

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.62, no.3, pp.411-417, 2023-02-01 (Released:2023-02-01)

参考文献数

37

被引用文献数

3

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A 19-year-old Japanese man was hospitalized for cardiogenic shock 28 days after receiving a second dose of the coronavirus disease 2019 (COVID-19) mRNA-1273 vaccine. He had had a high fever for three days with vomiting and abdominal pain before arriving at our hospital. The patient visited a local hospital and was diagnosed with heart failure and acute appendicitis. An endomyocardial biopsy specimen showed myocarditis. Thereafter, Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were initiated immediately along with inotropic support and steroid pulse therapy. Given these findings, he was finally diagnosed with multiple inflammatory syndrome and fulminant myocarditis.

著者

Akiko Masumoto Hiroyuki Yamamoto Nobuyuki Takahashi Tetsuari Onishi Tomofumi Takaya

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0089, (Released:2023-11-28)

著者

Kohei Tsuji Takuya Kobayakawa Takahiro Ishii Nobuyo Higashi-Kuwata Chika Azuma Kouki Shinohara Yutaro Miura Kenichi Yamamoto Soshi Nishimura Shin-ichiro Hattori Haydar Bulut Hiroaki Mitsuya Hirokazu Tamamura

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.71, no.12, pp.879-886, 2023-12-01 (Released:2023-12-01)

参考文献数

53

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In the development of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drugs, its main protease (Mpro), which is an essential enzyme for viral replication, is a promising target. To date, the Mpro inhibitors, nirmatrelvir and ensitrelvir, have been clinically developed by Pfizer Inc. and Shionogi & Co., Ltd., respectively, as orally administrable drugs to treat coronavirus disease of 2019 (COVID-19). We have also developed several potent inhibitors of SARS-CoV-2 Mpro that include compounds 4, 5, TKB245 (6), and TKB248 (7), which possesses a 4-fluorobenzothiazole ketone moiety as a reactive warhead. In compounds 5 and TKB248 (7) we have also found that replacement of the P1-P2 amide of compounds 4 and TKB245 (6) with the corresponding thioamide improved their pharmacokinetics (PK) profile in mice. Here, we report the design, synthesis and evaluation of SARS-CoV-2 Mpro inhibitors with replacement of a digestible amide bond by surrogates (9–11, 33, and 34) and introduction of fluorine atoms in a metabolically reactive methyl group on the indole moiety (8). As the results, these compounds showed comparable or less potency compared to the corresponding parent compounds, YH-53/5h (2) and 4. These results should provide useful information for further development of Mpro inhibitors.

著者

Shiho Kino Yudai Tamada Kenji Takeuchi Atsushi Nakagomi Koichiro Shiba Taro Kusama Takafumi Yamamoto Jun Aida

出版者

Japan Prosthodontic Society

雑誌

Journal of Prosthodontic Research (ISSN:18831958)

巻号頁・発行日

pp.JPR_D_23_00091, (Released:2023-08-11)

参考文献数

48

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Purpose: A growing body of evidence suggests that oral health is associated with a wide range of health outcomes; however, opinions tend to vary because of inconsistent findings. This study aimed to simultaneously examine the association between oral health status and multiple health and well-being indicators using outcome-wide epidemiology.Methods: Data were obtained from the Japan Gerontological Evaluation Study. Oral health status was categorized as: ≥20 teeth, 10-19 teeth with dental prosthesis, 0-9 teeth with prosthesis, 10-19 teeth without prosthesis, and 0-9 teeth without prosthesis. We examined the associations between oral health status in 2013 and 35 health and well-being outcomes in 2019, including physical/cognitive health, psychological distress, subjective health, social well-being, prosocial/altruistic behaviors, and health behaviors, using two databases (n=32,827 and 15,905).Results: Compared to individuals with ≥20 teeth, those with <20 teeth had a 10-33% higher risk of mortality and a 7-10% higher risk of functional disability six years later. Additionally, individuals with fewer than 20 teeth tended to go out less frequently and eat fewer vegetables and fruits. Furthermore, individuals with 0-9 teeth without a prosthesis were more likely to have severe functional disability (risk ratio (RR):1.17, 95% confidence interval (CI):1.05-1.31), engage in fewer intellectual activities (standardized difference: 0.17, 95% CI: 0.10-0.24), and feel more hopeless (RR: 1.21, 95% CI: 1.04-1.41).Conclusions: The prevention of tooth loss and prosthodontic treatment may be associated with reduced mortality and functional disability, as well as maintenance of intellectual ability, frequency of going out, and improvements in dietary lifestyle.

著者

Daisuke Nose Yuhei Shiga Ryou-u Takahashi Yuki Yamamoto Yasunori Suematsu Takashi Kuwano Makoto Sugihara Miyuki Kanda Hidetoshi Tahara Shin-ichiro Miura

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0038, (Released:2023-07-11)

参考文献数

52

被引用文献数

2

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Background: The utility of telomere G-tail length to predict coronary artery disease (CAD) remains controversial. CAD results from coronary artery narrowing due to cholesterol and lipid accumulation, augmented by inflammatory cells and other factors. This study explored the significance of telomere G-tail length in suspected CAD patients.Methods and Results: In all, 95 patients with suspected CAD or ≥1 cardiac risk factor underwent coronary computed tomography angiography (CCTA). We measured leukocyte telomere length and G-tail length using a hybrid protection method, and diagnosed the presence of CAD using CCTA. Associations between G-tail length and the presence of CAD, the number of stenosed coronary arteries, and brachial-ankle pulse wave velocity (baPWV) were analyzed. No significant difference was observed in G-tail length when comparing groups with or without CAD or statin treatment. However, in the non-statin group, G-tail length was significantly shorter in patients with 3-vessel disease compared with 1-vessel disease. Dividing the group using a baPWV of 1,300 cm/s, telomere G-tail length was significantly shorter in the high-risk (baPWV ≥1,300 cm/s) group.Conclusions: The clinical utility of telomere G-tail length as a CAD risk indicator seems limited. There was a trend for longer telomere G‐tail length in the statin‐treated group. Moreover, telomere G-tail length was reduced in patients at high-risk of cardiovascular events, aligning with the trend of a shortening in telomere G-tail length with CAD severity.

著者

Yasuhiro Nakano Tetsuya Matoba Mitsutaka Yamamoto Shunsuke Katsuki Yasuaki Koga Yasushi Mukai Shujiro Inoue Nobuhiro Suematsu Taiki Higo Masao Takemoto Kenji Miyata Makoto Usui Toshiaki Kadokami Hideki Tashiro Kunio Morishige Kiyoshi Hironaga Hiroyuki Tsutsui for the QcVIC Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0047, (Released:2023-06-06)

参考文献数

36

被引用文献数

1

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Background: Recent revisions of clinical guidelines by the Japanese Circulation Society, American Heart Association/American College of Cardiology, and European Society of Cardiology updated the management of antithrombotic strategies for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). However, the extent to which these guidelines have been implemented in real-world daily clinical practice is unclear.Methods and Results: We conducted surveys on the status of antithrombotic therapy for patients with AF undergoing PCI every 2 years from 2014 to 2022 in 14 cardiovascular centers in Japan. The primary use of drug-eluting stents increased from 10% in 2014 to 95–100% in 2018, and the use of direct oral anticoagulants increased from 15% in 2014 to 100% in 2018, in accordance with the revised practice guidelines. In patients with acute coronary syndrome, the duration of triple therapy within 1 month was approximately 10% until 2018, and increased to >70% from 2020. In patients with chronic coronary syndrome, the duration of triple therapy within 1 month was approximately 10% until 2016, and >75% from 2018. Since 2020, the most common timing of discontinuation of dual antiplatelet therapy to transition to anticoagulation monotherapy during the chronic phase of PCI has been 1 year after PCI.Conclusions: Japanese interventional cardiologists have updated their treatment strategies for patients with AF undergoing PCI according to revisions of clinical practice guidelines.

著者

Hiroyuki Yamamoto Takahiro Sawada Hirohisa Murakami Tomofumi Takaya

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0018, (Released:2023-05-31)

参考文献数

1

著者

Mashio Nakamura Satoshi Tamaru Shigeki Hirooka Atsushi Hirayama Akihiro Tsuji Mitsuhiro Hirata Mitsuru Munemasa Izumi Nakagawa Masahiro Toshima Hiroaki Shimokawa Yuki Nishimura Toru Ogura Takeshi Yamamoto Hirono Satokawa Toru Obayashi Norikazu Yamada on behalf of the AKAFUJI Study Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0158, (Released:2023-06-30)

参考文献数

16

被引用文献数

1

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Background: A large-scale prospective study of the efficacy and safety of warfarin for the treatment of venous thromboembolism (VTE) has not been conducted in Japan. Therefore, we conducted a real-world prospective multicenter observational cohort study (AKAFUJI Study; UMIN000014132) to investigate the efficacy and safety of warfarin for VTE.Methods and Results: Between May 2014 and March 2017, 352 patients (mean [±SD] age 67.7±14.8 years; 57% female) with acute symptomatic/asymptomatic VTE were enrolled; 284 were treated with warfarin. The cumulative incidence of recurrent symptomatic VTE was higher in patients without warfarin than in those treated with warfarin (8.7 vs. 2.2 per 100 person-years, respectively; P=0.018). The cumulative incidence of bleeding complications was not significantly different between the 2 groups. The mean prothrombin time-international normalized ratio (PT-INR) during warfarin on-treatment was <1.5 in 180 patients, 1.5–2.5 in 97 patients, and >2.5 in 6 patients. The incidence of bleeding complications was significantly higher in patients with PT-INR >2.5, whereas the incidence of recurrent VTE was not significantly different between the 3 PT-INR groups. The cumulative incidence of recurrent VTE and bleeding complications did not differ significantly among those in whom VTE was provoked by a transient risk factor, was unprovoked, or was associated with cancer.Conclusions: Warfarin therapy with an appropriate PT-INR according to Japanese guidelines is effective without increasing bleeding complications, regardless of patient characteristics.

著者

山本 政儀 Yamamoto Masayoshi

出版者

金沢大学自然計測応用研究センター

雑誌

平成15(2003)年度科学研究費補助金 基盤研究(C) 研究成果報告書 = 2003 Fiscal Year Final Research Report

巻号頁・発行日

vol.2002-2003, pp.7p., 2004-03-01

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本研究は、陸上環境における放射性物質の最大のリザーバーである大地、すなわち土壌中でのPuのスピシエーション(存在状態、存在形態)を重点的に行なった。フィールドとして国内のPu汚染レベルの数〜数百倍高い旧ソ連核実験場セミパラチンスク内外の表層土壌を用いた。土壌の粒径分画、磁気分画とバイオイメージングアナライザー法を組み合わせて、種々の粒径の放射性物質を含む粒子Hot-particle(放射能の強い粒子)を定量的に探査する手法をまず確立し、それら粒子の特性を走査型電子顕微鏡(SEM)、エネルギー分散型蛍光X線分液装置(SEM-EDX)等で観察し、全体及び個々の粒子のPu測定も実施して、粒子特性とPuの関係、全体としての粒子Puの存在割合を明らかにする。また、微粒子に対しては、アルファー・トラック法を併用してPuの存在特性を考察することを目的に研究を進めてきた。 セミパラチンスク核実験場周辺のドロン村で採取した高濃度Pu汚染土壌を用いた。この地域の^<239,240>Pu及び^<137>Cs蓄積量はそれぞれ530-14,320Bq/m^2,790-10,310Bq/m^2であった。その後、試料をサイズ別に<0.45,0.45-32,32-88,88-125,125-250,250-500,500-2000μmに分画し、それぞれの分画中のPu濃度の測定を測定し、アルファー・トラック法でHot-particleの存在を確かめた。その結果、土壌の125μmを境にして<125μmで^<239,240>Pu濃度が高く更にHot-particle数が多いことが解り、土壌の再浮游からの吸入被曝経路の重要性が示唆された。Hot-particleの探査については、数-数十μmの勢多くのHot-particleの存在を確認(Pu由来)したが、定量的評価には更なる検討が必要で有り、顕微鏡下での自動測定を放医研の研究者と共同で研究を進めている。

著者

Yuki Inoue Reo Okiyama Yuuki Hagiwara Junji Yamamoto

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.57, no.2, pp.92-99, 2023 (Released:2023-04-14)

参考文献数

24

被引用文献数

1

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We measured the Raman spectra of CO2 fluid at 30 MPa and room temperature (19.1–21.3°C). The spectra showed peaks attributed to the CO2 combining various isotopes such as 12C16O2, 13C16O2, and 12C16O18O. The relative ratio of 12C16O2 to 12C16O18O peaks represents the oxygen isotope ratio of CO2. To evaluate the precision of the peak ratios, we measured the CO2 Raman spectra at different exposure times. We examined the standard deviation (1 σ) of the peak intensity ratios and area ones for 20 measurements at each exposure time. The standard deviations of the intensity ratios and area ones were 2.7 and 3.1%, respectively, at a maximum exposure time of 494 s, conversion to peak intensity of 12C16O2 yields about 2,000,000 counts. The uncertainties are 2.5–3 times greater than expected from the noise of a CCD camera and photon statistics. The oxygen isotope ratios (δ18O) of natural samples have a range of variation of about 16.6%. Compared to that value, the precision we obtained from this study is very small. Raman spectroscopy can be combined with microscopy to analyze areas as small as approx. 1 μm in diameter. Therefore, oxygen isotope measurement using Raman spectroscopy has potential for application to natural samples as a new method for small CO2 fluids such as fluid inclusions.

著者

山本 政人 Masato Yamamoto

出版者

学習院大学人文科学研究所

雑誌

人文 (ISSN:18817920)

巻号頁・発行日

no.9, pp.35-54, 2011-03-28

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本論文は日本におけるアタッチメント理論の受容とその後の研究の発展について検討したものである。Bowlby のアタッチメント理論は1970 年代に日本に紹介されたが、実証研究が盛んになったのは、1980 年代に入り、Strange Situation procedure(SSP)が導入されたことによってであった。しかし、SSP は日本の乳児に強いストレスを与えるため、Cタイプの出現を促進すると考えられた。また、アタッチメントのタイプと気質には明確な関連が見られなかったため、SSP による研究は衰退した。1990 年代に入り、内的ワーキングモデル概念が注目され、アタッチメント研究は再び盛んになった。特に、アタッチメントの世代間伝達に関する研究は活発に続けられてきた。世代間伝達だけでなく世代間の相互作用を明らかにすることや、児童虐待の防止につながる実践的研究を推進することが今日の重要な課題である。