著者

Maya Adachi Mai Watanabe Yasutaka Kurata Yumiko Inoue Tomomi Notsu Kenshiro Yamamoto Hiromu Horie Shogo Tanno Maki Morita Junichiro Miake Toshihiro Hamada Masanari Kuwabara Naoe Nakasone Haruaki Ninomiya Motokazu Tsuneto Yasuaki Shirayoshi Akio Yoshida Motonobu Nishimura Kazuhiro Yamamoto Ichiro Hisatome

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0261, (Released:2019-09-13)

参考文献数

39

被引用文献数

5

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Background:Treatment of myocardial infarction (MI) includes inhibition of the sympathetic nervous system (SNS). Cell-based therapy using adipose-derived stem cells (ASCs) has emerged as a novel therapeutic approach to treat heart failure in MI. The purpose of this study was to determine whether a combination of ASC transplantation and SNS inhibition synergistically improves cardiac functions after MI.Methods and Results:ASCs were isolated from fat tissues of Lewis rats. In in vitro studies using cultured ASC cells, mRNA levels of angiogenic factors under normoxia or hypoxia, and the effects of norepinephrine and a β-blocker, carvedilol, on the mRNA levels were determined. Hypoxia increased vascular endothelial growth factor (VEGF) mRNA in ASCs. Norepinephrine further increased VEGF mRNA; this effect was unaffected by carvedilol. VEGF promoted VEGF receptor phosphorylation and tube formation of human umbilical vein endothelial cells, which were inhibited by carvedilol. In in vivo studies using a rat MI model, transplanted ASC sheets improved contractile functions of MI hearts; they also facilitated neovascularization and suppressed fibrosis after MI. These beneficial effects of ASC sheets were abolished by carvedilol. The effects of ASC sheets and carvedilol on MI heart functions were confirmed by Langendorff perfusion experiments using isolated hearts.Conclusions:ASC sheets prevented cardiac dysfunctions and remodeling after MI in a rat model via VEGF secretion. Inhibition of VEGF effects by carvedilol abolished their beneficial effects.

著者

谷 由美子 山本 命子 深谷 幸子 青木 みか タニ ヤマモト フカヤ アオキ Y. TANI N. YAMAMOTO S. FUKAYA M. AOKI

雑誌

名古屋女子大学紀要 = Journal of the Nagoya Women's College

巻号頁・発行日

vol.24, pp.93-102, 1978-03-15

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"1.リノール酸またはコーンオイル添食による脂肪酸の生体内における挙動 リノール酸5g摂取によって血清のリノール酸は低下しアラキドン酸が4倍以上に増加した.しかしコーンオイル60g摂取によって,血清脂肪酸組成はアラキドン酸がやや減少しステアリン酸とオレイン酸は増加した.この相違については今後検討するつもりである.皮膚分泌物の脂肪酸組成は,リノール酸またはコーンオイル添食によっていずれもほとんど変動なく,パルミテン酸が30~40%をしめ次にステアリン酸,アラキドン酸が多く,いずれの場合も血清には不飽和脂肪酸が多く皮膚分泌物は大部分飽和脂肪酸よりなっていた.即ち血清成分がそのまま皮膚に浸透して分泌されるのではなく,汗腺,皮脂腺などで選択されて分泌されると考えられる.尿中脂肪酸組成はオレイン酸,ステアリン酸,パルミチン酸が多く,バルミトレイン酸は個体差が大きかった.必須脂肪酸は血清に比べて少く,コーンオイル摂取によって血清中の必須脂肪酸はほとんど変動しなかったが,尿中多価不飽和脂肪酸は増加した.2.リノール酸またはコーンオイル添食による血清脂質成分の変動 CHはいずれの場合も減少し,特にコーンオイル添食で著しく,従来血中のCHを低下させる因子の1つとして高度不飽和脂肪酸を含む植物油がよいとされている事実を裏付けた.CHを約48%含むβ-LPも同様に食後減少がみられた.TGは食後3時問に有意に増加した.これらの現象はリノール酸5g摂取よりもコーンオイル60g摂取の場合の方がその影響は顕著であった."

著者

Masaki Ohya Yuko Iwashita Satoko Kunimoto Shuto Yamamoto Toru Mima Shigeo Negi Takashi Shigematsu

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.58, no.18, pp.2595-2603, 2019-09-15 (Released:2019-09-15)

参考文献数

28

被引用文献数

7

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Objective This follow-up survey report describes medication adherence and patient preferences, beliefs, and expectations of maintenance hemodialysis treatment in Japan. Methods This patient-reported questionnaire-based survey was conducted in six regions in Japan from September 2016 to November 2016. Patients The questionnaire was provided to 700 patients (50-79 years old) on maintenance hemodialysis for >3 years who were members of the Japan Association of Kidney Disease Patients. Patients were randomly selected by a stratified sampling method based on patient distribution observed from the Japanese Society for Dialysis Therapy Renal Data Registry. Results A total of 524 (74.9%) complete patient questionnaires were evaluated; the mean (SD) age was 66.6 (7.2) years (men, 63.4%) with a dialysis vintage of 16.9 (9.1) years. Adherence was high for all types of medications: between 76.7% for phosphate binders and 95.7% for antidiabetic medications. The most common reason for a missed dose was forgetting to take medication [52.5% (117/223)]. Patient preference for oral medication was as low as 0.9% (1/110), 9% (31/345), and 2.9% (2/69) for patients who felt mental burden, felt no mental burden, and neither, respectively, with their current treatment regimen. In addition, 37.8% (198/524) of patients responded that the elimination of 1 medication (1 tablet) would reduce their mental burden. Conclusion The results of this survey show that overall medication adherence is high in Japanese patients on maintenance hemodialysis. While many patients perceive an absence of mental burden, they still prefer to avoid oral medication when possible.

著者

Masaharu Kataoka Toru Satoh Hiromi Matsubara Koji Yamamoto Tsukasa Inada Kazunari Umezawa Tomohiko Takahashi Atsushi Nakano Keiichi Fukuda

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.6, pp.268-275, 2019-06-10 (Released:2019-06-10)

参考文献数

15

被引用文献数

2

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Background:This retrospective study was conducted to evaluate the safety and efficacy of ambrisentan combination therapy with phosphodiesterase type 5 (PDE5) inhibitors in Japanese patients with pulmonary arterial hypertension (PAH).Methods and Results:PAH patients who received ambrisentan for the first time in combination with a PDE5 inhibitor between January 2013 and the end of August 2015 were included in this study. Adverse drug reaction (ADR) safety analysis, as well as the efficacy analysis focusing on changes in clinical parameters, were investigated for overall cases and cases stratified by patient background. Forty-eight consecutive patients (n=21, 43.8% with idiopathic PAH; male/female, 18/30; average age, 43.3±17.4 years; World Health Organization functional class III/IV, n=22, 45.8%) who were treated with ambrisentan and a PDE5 inhibitor in Japan underwent the safety analysis. A total of 14 ADR occurred in 10 patients (20.8%). ADR included headache (8.3%), face edema (4.2%), angina pectoris (2.1%), hyperemia (2.1%), dyspnea (2.1%), pulmonary hypertension (i.e., worsening of PAH, 2.1%), nausea (2.1%), hepatic function abnormal (2.1%), edema (2.1%), and sudden death (2.1%). On analysis of hemodynamics parameters, there was a significant improvement in the mean pulmonary arterial pressure (−13.5 mmHg, P=0.0001) and pulmonary vascular resistance (−563.53 dyn·s·cm−5, P=0.0033).Conclusions:Ambrisentan combination therapy is safe and effective in hemodynamics improvement.

著者

Sho YOSHIMOTO Daiki KATO Satoshi KAMOTO Kie YAMAMOTO Masaya TSUBOI Masahiro SHINADA Namiko IKEDA Yuiko TANAKA Ryohei YOSHITAKE Shotaro ETO Kohei SAEKI James Kenn CHAMBERS Ryohei KINOSHITA Kazuyuki UCHIDA Ryohei NISHIMURA Takayuki NAKAGAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0019, (Released:2019-05-29)

被引用文献数

12

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Canine anal sac gland carcinoma (ASGC) frequently occurs in the apocrine glands of the canine anal sac and shows aggressive biological behavior. The expression of human epidermal growth factor receptor 2 (HER2) has been reported in various human and canine tumors. HER2 is a promising therapeutic target of these tumors, and HER2-targeted drugs, such as trastuzumab and lapatinib, have improved the outcome of these patients. In this study, HER2 expression in ASGC was evaluated to investigate its potential as a therapeutic target for canine ASGC. HER2 mRNA expression in surgically resected ASGC tissues was significantly higher than that in normal anal sac tissue. To evaluate the expression of HER2 protein, paraffin-embedded ASGC tissues were immunohistochemically evaluated. Strong and broad staining of HER2 was detected in ASGC tissues, while HER2 was weakly to moderately stained in normal anal sac apocrine glands and squamous epithelia. The degree of HER2 expression in ASGC tissues was scored based on its intensity and positivity (score: 0–3+). Scoring of HER2 expression revealed 6 samples (24%) scored 3+, 14 (56%) scored 2+, and 5 (20%) scored 1+, with no samples scoring 0. In all, 80% of canine ASGC tissues were positive for HER2 (scored ≥2+). Furthermore, putative HER2-overexpressed cells in ASGC were detected with trastuzumab by flow cytometry. These preliminary data may lead to further evaluation of the role of HER2 in canine ASGC as a mechanism of malignancy and as a therapeutic target for HER2-targeted therapy.

著者

Jun YASUDA Takahiro YOSHIZAKI Kaori YAMAMOTO Masae YOSHINO Masako OTA Takashi KAWAHARA Akiko KAMEI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.65, no.2, pp.177-183, 2019-04-30 (Released:2019-04-30)

参考文献数

28

被引用文献数

10

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The purpose of the study was to examine the association of the frequencies of milk and dairy product consumption with subjective sleep quality during the training period in Japanese elite athletes. In this cross-sectional study, 682 Japanese elite athletes who were candidates for the 2016 Rio Olympic Games underwent medical evaluations at the medical center of The Japan Institute of Sports Sciences. Self-reported questionnaires were used to collect information on demographics and lifestyle (age, height, weight, sports, presence of milk allergy, smoking and drinking habits), subjective sleep quality (good, normal, or poor), bedtime, waking time, sleep duration, and frequencies of milk and dairy product consumption. Data from 679 athletes (379 men, 300 women) without milk allergy, were analyzed. Based on the frequencies of both milk and dairy product consumption, the athletes were divided into three groups: low (0-2 d/wk), middle (3-5 d/wk), and high (6-7 d/wk). Multiple logistic regression models showed that in comparison with the low milk consumption group, the middle [OR (95% CI): 0.48 (0.26-0.91)] and high groups [0.38 (0.21-0.71)] were significantly associated with a lower risk of decrease in subjective sleep quality (0: good, 1: normal or poor) only in women, after adjusting for possible confounders, such as smoking, drinking habits, and sleep duration. Accordingly, the present study elucidated that a greater frequency of milk consumption was significantly associated with a lower risk of decrease in subjective sleep quality, during training periods in women.

著者

Takamitsu Waki Masaharu Kodama Midori Akutsu Kiyoshi Namai Masayuki Iigo Takeshi Kurokura Toshiya Yamamoto Kenji Nashima Masayoshi Nakayama Masafumi Yagi

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-096, (Released:2017-09-29)

被引用文献数

1 13

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Double flower and hortensia (mophead) hydrangea (Hydrangea macrophylla (Thunb.) Ser.) traits are recessively inherited. Cross breeding of these traits in hydrangea is difficult because it takes about two years from crossing to flowering. In this study, we aimed to obtain DNA linkage markers that would allow accelerated selection of these traits. We used next-generation sequencing to comprehensively collect DNA sequences from the ‘Kirakiraboshi’ with a double flower and lacecap inflorescence and the ‘Frau Yoshimi’ with a single flower and hortensia inflorescence, and designed simple sequence repeat (SSR) primer pairs for map construction. We screened 768 SSR primer pairs in 93 F2 progeny derived from ‘Kirakiraboshi’ and ‘Frau Yoshimi’. We identified 147 loci, which were expanded to 18 linkage groups with a total map length of 980 cM. Linkage analysis identified that both the double flower trait from ‘Kirakiraboshi’ (dKira) and the hortensia trait from ‘Frau Yoshimi’ (hFrau) were located on linkage group KF_4. Detailed linkage analysis using 351 F2 progeny revealed a 34.8 cM map length between the two loci and identified two tightly linked SSR markers, STAB045 for dKira and HS071 for hFrau. Genetic analysis suggested that double flower and hortensia traits are each controlled by a single recessive gene. Together, the linkage map, SSR markers, and genetic information obtained in this study will be useful for future hydrangea breeding.

著者

山本 野理子 Noriko Yamamoto

雑誌

人文論究 (ISSN:02886677)

巻号頁・発行日

vol.63, no.4, pp.51-75, 2014-02-10

著者

水野 基樹 川田 裕次郎 飯田 玲依 山本 真己 東 慎治 上野 朋子 山田 泰行 杉浦 幸 田中 純夫 Motoki Mizuno Yujiro Kawata Rei Iida masaki Yamamoto Shinji Higashi Tomoko Ueno Yasuyuki Yamada Miyuki Sgiura Sumio Tanaka 千葉経済大学短期大学部非常勤講師 CHIBA KEIZAI COLLEGE Part-time Lecturer

出版者

千葉経済大学短期大学部

雑誌

千葉経済大学短期大学部研究紀要 = Bulletin of Chiba Keizai College (ISSN:13498312)

巻号頁・発行日

no.4, pp.51-61,

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The psychology of motivation is a broad and loosely defined field. Furthermore, motivation is a basic psychological process. Few would deny that it is the most important focus of the micro organizational behavior. Traditionally, psychologists have not totally agreed on how to classify the various human motives, but they acknowledge that some motives are unlearned physiologically based. For that reason, it is difficult to comprehend a framework of motive concepts which can predict human behavior. Therefore, the purpose of this paper was to review the motive concept suggested by McClelland(1987), who is most closely associated with the study of achievement motive. Specifically, first we summarized up the measurement and concepts of motive, such as "measures of human motive dispositions", "achievement motive", "power needs", "affiliative motive" and "avoidance motive". In addition, we critically reviewed and discussed them in terms of the definitions of concepts. In conclusion, although we could grasp the implications of each motive concept, there were some ambiguities regarding McClelland's motive concepts. Thus, more elaborate conceptual regulation and detailed explanation of the connections to the concepts seem necessary in order to clarify the notion of motive concepts, because there are a number of motives which lie in a gray area from the viewpoint of human motivation described by McClelland.

著者

YUTAKA KUNIMATSU YOSHIHIRO SAWADA TETSUYA SAKAI MOTOTAKA SANEYOSHI HIDEO NAKAYA AYUMI YAMAMOTO MASATO NAKATSUKASA

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.125, no.2, pp.45-51, 2017 (Released:2017-09-21)

参考文献数

58

被引用文献数

2

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The African primate fossil record is very poor between the mid-Middle and mid-Late Miocene. Nakali (~10–9.8 Ma) is one of the rare African localities that have yielded primate fossils from this period, including a new genus of great ape, Nakalipithecus nakayamai, and another large-bodied hominoid species. The Nakali primate fauna also includes small-bodied ‘apes’ and Old World monkeys (mostly colobines). In this article, we describe a new specimen of a small-bodied ‘ape’ discovered from Nakali, which is assigned to nyanzapithecines. Nyanzapithecines are characterized by their derived dental morphology, and the previously known nyanzapithecines range in chronological age between the Late Oligocene and early Middle Miocene (~25–13.7 Ma). The new nyanzapithecine specimen from Nakali is therefore the latest occurrence of this group in the African fossil record, extending its chronological range by almost 4 million years younger.

著者

Yoshitsugu Higashi Shigeki Nakamura Yasuhiro Tsuji Chika Ogami Kaoru Matsumoto Koyomi Kawago Kotaro Tokui Ryuji Hayashi Ippei Sakamaki Yoshihiro Yamamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.2, pp.253-258, 2018-01-15 (Released:2018-01-15)

参考文献数

31

被引用文献数

18

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A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.

著者

山本 健太郎 Kentaro Yamamoto

出版者

関西学院大学法政学会

雑誌

法と政治 (ISSN:02880709)

巻号頁・発行日

vol.64, no.3, pp.972-945, 2013-11

著者

Ishikura Yukiko Yabuta Yukihiro Ohta Hiroshi Hayashi Katsuhiko Nakamura Tomonori Okamoto Ikuhiro Yamamoto Takuya Kurimoto Kazuki Shirane Kenjiro Sasaki Hiroyuki Saitou Mitinori

出版者

Elsevier B.V.

雑誌

Cell Reports (ISSN:22111247)

巻号頁・発行日

vol.17, no.10, pp.2789-2804, 2016-12-06

被引用文献数

134

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マウス多能性幹細胞から精子幹細胞を試験管内で誘導 : 精子形成全過程の試験管内誘導の基盤形成. 京都大学プレスリリース. 2016-12-07.

著者

山本 智章 佐藤 成登志 石川 知志 Yamamoto Noriaki Sato Naritoshi Ishikawa Tomoji

出版者

新潟医療福祉学会

雑誌

新潟医療福祉学会誌 (ISSN:13468774)

巻号頁・発行日

vol.8, no.2, pp.46-50, 2008-12

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We reported clinical results of the treatment of lumbar disk disorder patients by using active traction apparatus DRX-9000(Axiom Worldwide, Tampa, FL, USA). Fifty patients were received 30-minites sessions every week or 2 weeks, for 3 months. Pain as measured on visual analog scale rating significantly decreased at 4.91±0.93 to 2.69±1.02 (p<0.01), and 76% patients indicated satisfaction for treatment. . DRX-9000 spinal decompression is expected to improve discogenic low back pain producing negative pressure in intervertebral disc by different mechanism from conventional traction. Further studies are requires to demonstrate the evidence of effectiveness of DRX-9000 treatment on lumbar disc disorders.能動的牽引治療器DRX-9000による椎間板障害患者の治療を行い、76%の患者で疼痛の改善効果が得られた。これまでの牽引装置と異なるメカニズムで椎間板に陰圧を生じることにより除圧効果が期待される。本治療器の有効性の確立にはさらなる検討が必要であり、Randomized double blind trialを含めた研究の蓄積が求められる。

著者

山本 明歩 Akiho YAMAMOTO 京都文教大学総合社会学部 KYOTO BUNKYO UNIVERSITY Department of Social Relations

出版者

京都文教大学

雑誌

総合社会学部研究報告 = Reports from the Faculty of Social Relations (ISSN:21888981)

巻号頁・発行日

vol.15, pp.11-26, 2012

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Anabaptists, who reside in many countries throughout the world, include the Mennonites, the Amish, the Brethren and Hutterites. The customs in some of the old-order groups in Anabaptists are distinguishable in many ways from those of the society around them. This difference, along with their religiousness, makes them look fundamentalistic and conservative. In short, they are often viewed as groups of people who restrict personal freedom and resist any changes in lifestyle. In contrast to such observations, this paper argues that Anabaptists actually put emphasis on individual choice and that this leads to the diverse cultural traits and behavior which include what seems to be the resistance to assimilation or acculturation observed in traditional groups.

著者

山本 聡美 Satomi Yamamoto

出版者

[共立女子大学・共立女子短期大学総合文化研究所]

雑誌

共立女子大学・共立女子短期大学総合文化研究所紀要 = Bulletin of Center for Interdisciplinary Studies of Science and Culture, Kyoritsu Women's University & Junior College

巻号頁・発行日

no.22, pp.86-80, 2016

著者

Hajime Kasai Akane Matsumura Toshihiko Sugiura Ayako Shigeta Nobuhiro Tanabe Keiko Yamamoto Hideki Miwa Ryogo Ema Seiichiro Sakao Koichiro Tatsumi

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-1080, (Released:2016-03-11)

参考文献数

15

被引用文献数

2 8

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Background:Mean pulmonary arterial pressure (MPAP) is an important pulmonary hemodynamic parameter used in the management of patients with chronic thromboembolic pulmonary hypertension (CTEPH). We compared echocardiography-derived estimates of MPAP with right heart catheterization (RHC) to identify reliable noninvasive methods of estimating MPAP-derived RHC (MPAPRHC) in these patients.Methods and Results:Echocardiography and RHC were performed in 56 patients with CTEPH (60.5±12.0 years; 44 females). We measured the tricuspid regurgitation (TR) pressure gradient (TRPG) using echocardiography. The mean systolic right ventricular (RV)-right atrial (RA) gradient was calculated by tracing the TR time velocity flow. Systolic and mean pulmonary artery pressures (SPAPTRand MPAPTR) estimated from TRPG and mean systolic RV-RA gradient were calculated by adding RA pressure based on the inferior vena cava. MPAPChemlawas calculated using Chemla’s formula: 0.61×SPAPTR+2 mmHg. MPAPRHCand pulmonary vascular resistance were 35.9±11.3 mmHg and 6.6±3.6 Wood units, respectively. The mean difference from MPAPRHCand limits of agreement were −1.5 mmHg and −19.6 to 16.5 mmHg for MPAPTR, and −4.6 mmHg and −24.5 to 15.2 mmHg for MPAPChemla. Accuracy within 10 mmHg and 5 mmHg of MPAPRHCwas 80.4% and 46.4% for MPAPTR, and 71.4% and 48.2% for MPAPChemla, respectively.Conclusions:MPAPTRand MPAPChemlaare reliable estimates for MPAPRHCin patients with CTEPH.

著者

Masako Miyashita Masahiro Kikuya Chizuru Yamanaka Mami Ishikuro Taku Obara Yuki Sato Hirohito Metoki Naoki Nakaya Fuji Nagami Hiroaki Tomita Hideyasu Kiyomoto Junichi Sugawara Atsushi Hozawa Nobuo Fuse Yoichi Suzuki Ichiro Tsuji Shigeo Kure Nobuo Yaegashi Masayuki Yamamoto Shinichi Kuriyama

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.237, no.4, pp.297-305, 2015 (Released:2015-12-02)

参考文献数

32

被引用文献数

1 22

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After the Great East Japan Earthquake of 2011, there has been a concern about health problems among children. Therefore, we investigated the prevalence of wheeze and eczema symptoms and associated factors among children in areas primarily affected by the disaster. From 2012 to 2014, we distributed the parent-administered questionnaire to 25,198 children in all 233 public schools in the 13 municipalities of Miyagi Prefecture in northeast Japan. A total of 7,155 responses (mean age 10.5 ± 2.2 years) were received (response rate: 28.4%). The prevalence of allergic symptoms according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire in 2nd, 4th, 6th, and 8th graders was 12.4%, 9.9%, 9.3%, and 5.6% for wheeze, and 20.1%, 18.0%, 14.0%, and 12.4% for eczema. In multivariate logistic analysis, younger age, history of hospitalization, and difficulties in children’s daily lives as assessed by the Strengths and Difficulties Questionnaire (SDQ), were significantly and consistently associated with both allergic symptoms (both P < 0.05). Living in a coastal municipality was also associated with eczema symptoms (P = 0.0278). The prevalence of eczema symptoms in the 2nd (20.1%) and 8th (12.4%) grades was significantly higher than previously reported in Japan. Living in a coastal municipality was independently associated with eczema symptoms, and psychometric properties were also closely linked to allergic symptoms. These findings are clinically important for understanding the risks of allergic disorders after natural disasters.

著者

Tohru OKADA Tadashi KAMADA Hiroshi TSUJI Jun-etsu MIZOE Masayuki BABA Shingo KATO Shigeru YAMADA Shinji SUGAHARA Shigeo YASUDA Naoyoshi YAMAMOTO Reiko IMAI Azusa HASEGAWA Hiroshi IMADA Hiroki KIYOHARA Kenichi JINGU Makoto SHINOTO Hirohiko TSUJII

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.4, pp.355-364, 2010 (Released:2010-07-29)

参考文献数

49

被引用文献数

130

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In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the National Institute of Radiological Science (NIRS), Japan. Among several types of ion species, carbon ions were chosen for cancer therapy because they were judged to have the most optimal properties in terms of superior physical and biological characteristics. As of March 2010, 5,196 patients have been registered for carbon ion radiotherapy. Clinical results have shown that carbon ion radiotherapy has the potential to provide a sufficient radiation dose to the tumor, while having acceptable morbidity in the surrounding normal tissues. Tumors that appear to respond favorably to carbon ions include locally advanced tumors as well as histologically non-squamous cell tumor types such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma. By taking advantage of the unique properties of carbon ions, treatment with small fractions within a short treatment period has been successfully carried out for a variety of tumors. This means that carbon ion radiotherapy can offer treatment for larger numbers of patients than is possible with other modalities over the same time period.

著者

Xiaoxiong Xing Yoshinori Dobashi Tsuyoshi Yamamoto

雑誌

研究報告グラフィクスとCAD(CG)

巻号頁・発行日

vol.2012-CG-147, no.2, pp.1-6, 2012-06-15

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We present a real-time framework for rendering hair under environment lighting. We precompute the diffuse and specular irradiance environment maps for Kajiya-Kay model with a given environment map, thus reduce the runtime shading computation to simple texture lookups, and we simulate hair self-shadowing by using offline ambient occlusion. In addition, we further achieve runtime editing of the environment map by using spherical harmonic lighting to accelerate the computation of irradiance maps.