著者
Hiroyuki Matsuoka Gen-ichiro Sano Ryuta Hattori Hiroyuki Tomita Daisuke S. Yamamoto Makoto Hirai
出版者
Japanese Society of Tropical Medicine
雑誌
Tropical Medicine and Health (ISSN:13488945)
巻号頁・発行日
vol.40, no.2, pp.47-53, 2012 (Released:2012-10-05)
参考文献数
20
被引用文献数
1 4

It has been proposed that transgenic mosquitoes can be used as a “flying syringe” for infectious disease control. We succeeded in generating a transgenic (TG) mosquito, Anopheles stephensi, excreting and discharging DsRed in saliva. DsRed was deposited on the membrane where the TG mosquito probed with its proboscis. Repeated feeding by the TG mosquitoes induced anti-DeRed as well as anti-SG antibodies in mice. This indicates that the TG mosquitoes can immunize the animal. Moreover, in this report, we employed a pre-immunization method before exposing mice to the TG mosquitoes. We injected DsRed to mice to prepare memory B cells and exposed the mice to bites by the TG mosquitoes excreting DsRed. The mice produced a higher titer of antibody to DsRed, suggesting that the bites from TG mosquitoes act as a booster and that primary immunization with a vaccine protein and exposure to TG mosquitoes excreting the vaccine protein in the saliva produces a synergistic effect.
著者
Etsuji Suzuki Michio Yamamoto Eiji Yamamoto
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20210352, (Released:2022-01-22)
参考文献数
26

Background: The counterfactual definition of confounding is often explained in the context of exchangeability between the exposed and unexposed groups. One recent approach is to examine whether the measures of association (e.g., associational risk difference) are exchangeable when exposure status is flipped in the population of interest. We discuss the meaning and utility of this approach, showing their relationships with the concept of confounding in the counterfactual framework.Methods: Three hypothetical cohort studies are used, in which the target population is the total population. After providing an overview of the notions of confounding in distribution and in measure, we discuss the approach from the perspective of exchangeability of measures of association (e.g., factual associational risk difference vs. counterfactual associational risk difference).Results: In general, if the measures of association are non-exchangeable when exposure status is flipped, confounding in distribution is always present, although confounding in measure may or may not be present. Even if the measures of association are exchangeable when exposure status is flipped, there could be confounding both in distribution and in measure. When we use risk difference or risk ratio as a measure of interest and the exposure prevalence in the population is 0.5, testing the exchangeability of measures of association is equivalent to testing the absence of confounding in the corresponding measures.Conclusions: The approach based on exchangeability of measures of association essentially does not provide a definition of confounding in the counterfactual framework. Subtly differing notions of confounding should be distinguished carefully.
著者
Shin-ichi Momomura Yoshihiko Saito Yoshio Yasumura Kazuhiro Yamamoto Yasushi Sakata Masao Daimon Koichiro Kinugawa Hiroshi Okamoto Naoki Dohi Issei Komuro
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-17-0532, (Released:2017-08-02)
参考文献数
10
被引用文献数
5 8

Background:TY-0201 (TY) is a transdermal formulation of bisoprolol that is the free base of bisoprolol fumarate (BO), a drug widely used to treat chronic heart failure (CHF). The objectives of this phase II study were to evaluate the efficacy and safety of TY when switching from oral BO to TY in patients with CHF whose drug therapy was optimized, and to determine the dose conversion rate of BO to TY.Methods and Results:The efficacy and safety of once daily TY patch use for 16 weeks was investigated in 40 patients with CHF who were stabilized with an optimized drug treatment, including BO, after switching from BO to TY at the dose conversion rate of 5:8. The pre-switch left ventricular ejection fraction was 50.13±11.09% (mean±SD). The post-switch value was 50.87±10.79% after 16 weeks, which was not significantly different, with similar results for other efficacy and safety parameters. The 16-week study was continued for all patients without changing doses after switching to TY. No cardiovascular deaths, hospitalizations for worsening HF, or significant safety concerns were observed.Conclusions:Efficacy was maintained without significant safety concerns in patients with CHF who were stabilized with BO treatment after switching to TY, suggesting the appropriateness of the dose conversion rate.
著者
Huan Hu Ami Fukunaga Toshitaka Yokoya Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Toshiaki Miyamoto Naoko Sasaki Takayuki Ogasawara Naoki Gonmori Kenya Yamamoto Ai Hori Kentaro Tomita Satsue Nagahama Maki Konishi Nobumi Katayama Hisayoshi Morioka Isamu Kabe Tetsuya Mizoue Seitaro Dohi for the Japan Epidemiology Collaboration on Occupational Health Study Group
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
pp.63118, (Released:2021-10-23)
参考文献数
32
被引用文献数
5

Aims: We aimed to investigate the association between non-high-density lipoprotein cholesterol (non-HDL-C) levels and the risk of cardiovascular disease (CVD) and its subtypes. Methods: In this contemporary cohort study, we analyzed the data of 63,814 Japanese employees aged ≥ 30 years, without known CVD in 2012 and who were followed up for up to 8 years. The non-HDL-C level was divided into 5 groups: <110, 110-129, 130-149, 150-169, and ≥ 170 mg/dL. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for CVD and its subtypes associated with each non-HDL-C group, considering 130-149 mg/dL as the reference group. Results: During the study period, 271 participants developed CVD, including 78 myocardial infarctions and 193 strokes (102 ischemic strokes, 89 hemorrhagic strokes, and 2 unknowns). A U-shaped association between non-HDL-C and stroke was observed. In the analysis of stroke subtypes, the multivariable-adjusted HR (95% CI) for hemorrhagic stroke was 2.61 (1.19–5.72), 2.02 (0.95–4.29), 2.10 (1.01–4.36), and 1.98 (0.96-4.08), while that for ischemic stroke was 1.54 (0.77-3.07), 0.91 (0.46-1.80), 0.73 (0.38-1.41), and 1.50 (0.87-2.56) in the <110, 110-129, 150-169, and ≥ 170 mg/dL groups, respectively. Individuals with elevated non-HDL-C levels had a higher risk of myocardial infarction. Conclusions: High non-HDL-C levels were associated with an increased risk of myocardial infarction. Moreover, high and low non-HDL-C levels were associated with a high risk of stroke and its subtypes among Japanese workers.
著者
Hikaru Horii Manaho Matsubara Kenji Sasaoka Takahiro Yamamoto
出版者
The Japan Society of Vacuum and Surface Science
雑誌
e-Journal of Surface Science and Nanotechnology (ISSN:13480391)
巻号頁・発行日
vol.19, pp.125-130, 2021-12-23 (Released:2021-12-23)
参考文献数
40
被引用文献数
1

The thermoelectric response of bilayer graphene over a wide temperature range (0 < T ≤ 400 K) was theoretically investigated using linear response theory combined with a Green's function technique. We found that the power factor PF for a fixed chemical potential μ exhibits a maximum at a certain T. On the other hand, we found that the PF for a fixed T exhibits a maximum (PFmax) at an optimal μ [or optimal carrier concentration (nopt)]. In addition, we clarified the T dependence of nopt and PFmax and explained the existence of nopt in terms of the thermal excitation of electrons between the valence and conduction bands, which cannot be predicted by the conventional Mott formula.
著者
山本 博史 Yamamoto Hiroshi
出版者
神奈川大学経済学会
雑誌
商経論叢 (ISSN:02868342)
巻号頁・発行日
vol.51, no.4, pp.85-106, 2016-07-31

論説
著者
Ko NAKASUMI Naoki YAMAMOTO Taro TAKAMI Harumichi ITOH Kazuhito ITAMOTO Hiro HORIKIRIZONO Toshie ISERI Munekazu NAKAICHI Yuki NEMOTO Hiroshi SUNAHARA Kenji TANI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.21-0396, (Released:2021-12-06)
被引用文献数
3

Transcatheter arterial embolization (TAE) and transcatheter arterial chemoembolization (TACE) are standard treatments for advanced hepatocellular carcinoma (HCC) and particularly for unresectable tumors or liver metastases in humans. However, reports on TACE used in veterinary medicine are few. This study aimed to evaluate the feasibility and safety of drug-eluting bead transarterial chemoembolization (DEB-TACE). We performed DEB-TACE in four clinically normal dogs and pharmacokinetically compared the results against hepatic arterial infusion (HAI) of cisplatin in two dogs. Drug-eluting beads (DEB) loaded with cisplatin were injected through a microcatheter for selective embolization of the left hepatic artery. After embolization, computed tomography (CT) images and histological examination findings were obtained during a 4-week observation period. Serum platinum concentrations were measured to evaluate cisplatin after each procedure. Biochemical analysis was performed during a 12-week observation period. Embolization was successful in all dogs, and there were no clinically apparent abnormalities. Embolization was confirmed up to 4 weeks after DEB-TACE in two of the four dogs and up to 1 week in the other two dogs using postoperative CT images. Cisplatin was not detected in peripheral veins in all dogs after DEB-TACE, but it was detected in trace amounts after HAI. DEB-TACE using cisplatin was safe and well tolerated by normal dogs. DEB-TACE may be useful in terms of determining systemic toxicity and drug concentration within tumors.
著者
Kenichi Ozawa Susumu Yamamoto Kazuhiko Mase Iwao Matsuda
出版者
The Japan Society of Vacuum and Surface Science
雑誌
e-Journal of Surface Science and Nanotechnology (ISSN:13480391)
巻号頁・発行日
vol.17, pp.130-147, 2019-09-07 (Released:2019-09-07)
参考文献数
89
被引用文献数
10

Establishing an accurate view of the photocatalytic mechanism of titanium dioxide (TiO2) has been a challenging task since the discovery of the Honda-Fujishima effect. Despite the great success of catalytic studies in elucidating the chemical and physical aspects of photocatalysis, many questions remain. A surface science approach, which is characterized by the use of atomically well-defined surfaces in precisely controlled environments, is a powerful tool to shed light on the fundamental mechanism, especially the dynamics of photoexcited carriers. In the present contribution, recent progress in photocatalytic research that correlates photocatalytic activity and carrier dynamics on rutile and anatase TiO2 is reviewed. A special focus is placed on the lifetime of photoexcited carriers. We present a method to determine the carrier lifetime; pump-probe time-resolved soft X-ray photoelectron spectroscopy, utilizing an ultraviolet laser as a pump light and a synchrotron radiation as a probe light. The carrier lifetime is found to be linearly correlated with the photocatalytic decomposition/desorption rate of acetic acid adsorbed on single-crystal TiO2 surfaces. The important role of a potential barrier on the TiO2 surface, which influences the carrier lifetime and the photocatalytic activity, is discussed.
著者
Yasuhisa FUJII Kazumasa YAMAMOTO Seiichi NAKAGAWA
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE Transactions on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E95.D, no.4, pp.1101-1111, 2012-04-01 (Released:2012-04-01)
参考文献数
30
被引用文献数
2

This paper presents a novel method for improving the readability of automatic speech recognition (ASR) results for classroom lectures. Because speech in a classroom is spontaneous and contains many ill-formed utterances with various disfluencies, the ASR result should be edited to improve the readability before presenting it to users, by applying some operations such as removing disfluencies, determining sentence boundaries, inserting punctuation marks and repairing dropped words. Owing to the presence of many kinds of domain-dependent words and casual styles, even state-of-the-art recognizers can only achieve a 30-50% word error rate for speech in classroom lectures. Therefore, a method for improving the readability of ASR results is needed to make it robust to recognition errors. We can use multiple hypotheses instead of the single-best hypothesis as a method to achieve a robust response to recognition errors. However, if the multiple hypotheses are represented by a lattice (or a confusion network), it is difficult to utilize sentence-level knowledge, such as chunking and dependency parsing, which are imperative for determining the discourse structure and therefore imperative for improving readability. In this paper, we propose a novel algorithm that infers clean, readable transcripts from spontaneous multiple hypotheses represented by a confusion network while integrating sentence-level knowledge. Automatic and manual evaluations showed that using multiple hypotheses and sentence-level knowledge is effective to improve the readability of ASR results, while preserving the understandability.
著者
Takahiro Sayama Ryoko Araki Kodai Yamamoto Apip
出版者
Japan Society of Hydrology and Water Resources (JSHWR) / Japanese Association of Groundwater Hydrology (JAGH) / Japanese Association of Hydrological Sciences (JAHS) / Japanese Society of Physical Hydrology (JSPH)
雑誌
Hydrological Research Letters (ISSN:18823416)
巻号頁・発行日
vol.15, no.2, pp.23-30, 2021 (Released:2021-04-15)
参考文献数
38
被引用文献数
2

Extensive deforestation in tropical regions may significantly influence the hydrological cycle. However, subsurface runoff processes in thick soil layers in humid tropical forests are poorly understood; thus, the impact of land-use changes in such regions remains unclear. To understand runoff generation mechanisms in the humid tropics, we monitored groundwater and soil moisture dynamics in a forested hillslope in Sumatra, Indonesia. We also conducted field and laboratory experiments to determine soil hydraulic characteristics and used the results to simulate vertical infiltration and groundwater recharge. Although the soil is categorized as silty clay loam, the high infiltrability and high water retention capacity of the soil enabled infiltration during storm events and recharge to groundwater. Within the 4–5 m thick soil layer at the foot of the hillslope, the shallow groundwater table quickly responded to rainfall and did not drop below a depth of 2–3 m, possibly due to continuous flow contributions from the upslope. Overall, this study demonstrates the importance of subsurface flow and vertical infiltration in thick soil layers in humid tropical regions.
著者
Ryohei Aoyagi Takahiro Yamamoto Yuuki Furukawa Makoto Arita
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.69, no.10, pp.953-961, 2021-10-01 (Released:2021-10-01)
参考文献数
99

Polyunsaturated fatty acids (PUFAs), esterified to phospholipids, are susceptible to oxidation. They form oxidized phospholipids (OxPLs) by oxygenases or reactive oxygen species (ROS), or both. These OxPLs are associated with various diseases, such as atherosclerosis, pulmonary injuries, neurodegenerative diseases, cancer, and diabetes. Since many types of OxPLs seem to be generated in vivo, precise determination of their structural diversity is required to understand their potential structure-specific functions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful method to quantitatively measure the structural diversity of OxPLs present in biological samples. This review outlines recent advances in analytical methods for OxPLs and their physiological relevance in health and diseases.
著者
Toshiaki Taira Yuki Ishizaki Shusei Yamamoto Kenichi Sakai Hideki Sakai Tomohiro Imura
出版者
Japan Oil Chemists' Society
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.68, no.12, pp.1223-1230, 2019 (Released:2019-12-01)
参考文献数
42
被引用文献数
1 1

We report the synthesis of amphiphilic dodecenyl phosphonic acid PC12 from vinylphosphonic acid, a reactive phosphonic acid intermediate. The trans-P-C=C moiety enabled PC12 to disperse well in water. Surface tension and dynamic light scattering measurements revealed that PC12 exhibited high surface activity and reduced the surface tension of water from 72.0 to 23.6 mN/m, thereby resulting in the spontaneous formation of aggregates even in a dilute aqueous solution (critical aggregation concentration (CAC) = 4.8 × 10–4 M). In contrast to modern lipids with double-tailed structures, the PC12 of simple singletailed structure spontaneously formed bilayered vesicles, without an external energy supply. Compared with the strength of hydrogen bonds formed by the long, saturated alkyl chain of dodecyl phosphonic acid (DPA), the strength of PC12 intermolecular hydrogen bonds was weaker. The melting point of PC12 was approximately 20°C lower than that of DPA. These results indicate that the trans-P-C=C moiety was considerably important for spontaneous vesicle formation in water. Preliminary modeling of the morphological transitions of the closed bilayer structures in the vesicles was then conducted, by varying the pH and adding an α-helical peptide scaffold.
著者
Athchaya SUWANSOONTORN Katsuhiro YAMAMOTO Shusaku NAGANO Jun MATSUI Yuki NAGAO
出版者
The Electrochemical Society of Japan
雑誌
Electrochemistry (ISSN:13443542)
巻号頁・発行日
pp.21-00042, (Released:2021-05-21)
参考文献数
47
被引用文献数
2

Investigation of interfacial proton transport is necessary to elucidate biological systems. As commonly found in biomaterials, the carboxylic acid group was proven to act as a proton-conducting group. This study investigated the influence of carboxylic acid concentration on both interfacial and internal proton transport. Several styrene-based polymers containing the carboxylic acid group were synthesized. The amount of carboxylic acid group in the polymer chain was varied to explore the effects of weak acid concentration on polymer thin films’ electrical properties. The IR p-polarized multiple-angle incidence resolution spectrometry (pMAIR) spectra show the higher ratio of the free carboxylic acid groups rather than cyclic dimers in polymers with a higher concentration of carboxylic acid group, facilitating the more hydrogen bonding networks in films. The water uptake results reveal the similar number of adsorbed water molecules per carboxylic acid group in all thin films. Remarkably, polymer thin films with high carboxylic acid concentration provide internal proton conduction because of the relative increase in the amount of the free carboxylic acid group. In contrast, interfacial proton conduction was found in low carboxylic acid concentration polymers because of the relatively large amount of cyclic dimer carboxylic acid group and poor amount of free carboxylic acid group. This study provides insight into interfacial proton transport behavior according to the weak acid concentration, which might explain proton transport in biological systems.
著者
YAMAJI Moeka KUBOTA Takuji YAMAMOTO Munehisa K.
出版者
Meteorological Society of Japan
雑誌
気象集誌. 第2輯 (ISSN:00261165)
巻号頁・発行日
pp.2021-033, (Released:2021-02-17)
被引用文献数
8

Reliability information of satellite precipitation products is required for various applications. This study describes and evaluates a reliability flag of the Global Satellite Mapping of Precipitation Near-Real-Time precipitation product (GSMaP_NRT). This flag was developed to characterize the reliability of GSMaP_NRT data simply and qualitatively by considering its algorithm characteristics. The reliability at each pixel is represented by any one of ten levels (10 being the best and 1 the worst) by considering three major factors: 1) “surface type reliability”—which takes into account that estimation of rainfall using passive microwave sensors is better over the oceans than over land and coastal areas; 2) “low-temperature reliability”—which takes into account the lower reliability due to surface snow cover in low-temperature conditions; and 3) “Moving Vector with Kalman Filter (MVK) propagation reliability”—which means that the reliability gets worse with the increase in time since the last overpass of the passive microwave sensor. To evaluate the utility of the reliability flag, statistical indices are calculated for each reliability level using gauge-calibrated ground radar data around Japan. It is found that the reliability flag represents the differences in GSMaP accuracy: the accuracy worsens as the reliability decreases. The GSMaP errors exhibit seasonal changes that are well represented by the ten levels of the reliability flag, indicating that the reliability flag can be used to catch seasonal variations in GSMaP accuracy due to changes in environmental factors. This study also raises the possibility of improving the reliability flag by using information related to heavy orographic rainfall. It is shown how the error features of heavy orographic rainfall differ from those of the total rainfall, and it is suggested that heavy orographic rainfall information can be utilized to further improve the reliability flag.
著者
Hiroaki Seito Takeo Hoshi Yusaku Yamamoto
出版者
The Japan Society for Industrial and Applied Mathematics
雑誌
JSIAM Letters (ISSN:18830609)
巻号頁・発行日
vol.11, pp.13-16, 2019 (Released:2019-03-05)
参考文献数
11

We apply the shifted minimum residual method to a shifted linear system $(A+i\sigma I){\bf x}={\bf b}$ arising from quantum-mechanical wave packet simulation and discuss its advantages and disadvantages, comparing it with the widely used COCG method. Although the method requires more vector operations per iteration than the COCG method, it enjoys such nice properties as being free from breakdown, monotonic decrease of the residual norm and applicability to Hermitian-plus-shift systems, and can be a method of choice in some cases. Application of the method to the case of multiple shifts is also discussed.
著者
Yugo Yamashita Yuuki Maruyama Hirono Satokawa Yuji Nishimoto Ichizo Tsujino Hideki Sakashita Hiroko Nakata Yoshinori Okuno Yoshito Ogihara Sen Yachi Naoki Toya Masami Shingaki Satoshi Ikeda Naoto Yamamoto Shizu Aikawa Nobutaka Ikeda Hiroya Hayashi Shingo Ishiguro Eriko Iwata Michihisa Umetsu Akane Kondo Takehisa Iwai Takao Kobayashi Makoto Mo Norikazu Yamada on behalf of the Taskforce of VTE and COVID-19 in Japan Study
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-21-0169, (Released:2021-05-20)
参考文献数
33
被引用文献数
30

Background:Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.Methods and Results:The VTE and COVID-19 in Japan Study is a retrospective, multicenter cohort study enrolling hospitalized patients with COVID-19 who were evaluated with contrast-enhanced computed tomography (CT) examination at 22 centers in Japan between March 2020 and October 2020. Among 1,236 patients with COVID-19, 45 (3.6%) were evaluated with contrast-enhanced CT examination. VTE events occurred in 10 patients (22.2%), and the incidence of VTE in mild, moderate, and severe COVID-19 was 0%, 11.8%, and 40.0%, respectively. COVID-19 patients with VTE showed a higher body weight (81.6 vs. 64.0 kg, P=0.005) and body mass index (26.9 vs. 23.2 kg/m2, P=0.04), and a higher proportion had a severe status for COVID-19 compared with those without. There was no significant difference in the proportion of patients alive at discharge between patients with and without VTE (80.0% vs. 88.6%, P=0.48). Among 8 pulmonary embolism (PE) patients, all were low-risk PE.Conclusions:Among a relatively small number of patients undergoing contrast-enhanced CT examination in Japanese real-world clinical practice, there were no VTE patients among those with mild COVID-19, but the incidence of VTE seemed to be relatively high among severe COVID-19 patients, although all PE events were low-risk without significant effect on mortality risk.
著者
山本 佐和子 Sawako Yamamoto
出版者
同志社大学国文学会
雑誌
同志社国文学 = Doshisha Kokubungaku (ISSN:03898717)
巻号頁・発行日
no.92, pp.170-185, 2020-03-20

室町期に見られる「ゲナ」(例.「ヤレ杜鵑ハ、吾ガ心中ヲ知テ不如帰トナクゲナヨ」中華若木詩抄)が、モダリティのうち「本体把握」(大鹿薫久1995「本体把握―「らしい」の説―」)を表すことを手がかりに、形容動詞派生接辞「~ゲナリ」がモダリティ形式となる史的変化の過程を検証した。「~ゲナリ」は、中世前期に名詞に付く用法を生じており、活用語連体形を述部とする準体句に後接する過程を経て、モダリティ形式としての用法を獲得したと考えられる。廣田收教授退職記念号