著者
Yusuke Yamamoto Eiichiro Iwata Hideki Shigematsu Hiroshi Nakajima Masato Tanaka Akinori Okuda Yasuhiko Morimoto Keisuke Masuda Munehisa Koizumi Yasuhito Tanaka
出版者
The Japanese Society for Spine Surgery and Related Research
雑誌
Spine Surgery and Related Research (ISSN:2432261X)
巻号頁・発行日
pp.2017-0052, (Released:2018-02-28)
被引用文献数
6

Introduction To identify the temporal comparison of biochemical markers for early detection of surgical site infection (SSI) following instrumented spinal fusion that are not affected by operative factors.Materials and methods We reviewed data on C-reactive protein level and total white blood cell count and differential count before instrumented spinal fusion and at 1, 4, and 7 days postoperatively. The 141 patients in our sample were divided into an SSI group (patients who developed deep SSI) and a non-SSI group. We investigated the peak or nadir value day and identified those not affected by operative circumstances (operating time, intraoperative blood loss, and number of fusion segments) in the non-SSI group. If there was a significant difference between the peak or nadir value day and the next survey day, we considered the temporal comparison between these unaffected markers as an indicator of SSI and examined the usefulness of these indicators by calculating sensitivity and specificity. Furthermore, we investigated the usefulness of the combination of these markers (if even each one marker was recognized, we considered it positive).Results Four biochemical markers of SSI were selected: neutrophil percentage at postoperative day 4 more than day 1 (sensitivity 36%, specificity 95%), neutrophil count at postoperative day 4 more than day 1 (sensitivity 46%, specificity 93%), lymphocyte percentage at postoperative day 4 less than day 1 (sensitivity 36%, specificity 90%), and lymphocyte count at postoperative day 4 less than day 1 (sensitivity 36%, specificity 90%). The combination of these markers showed sensitivity 100%, specificity 80%, respectively.Conclusions Four markers are reliable indicators for early detection of SSI following spinal instrumented fusion because they are not affected by operative factor. The combination of each indicator had both high sensitivity and specificity. Therefore, it is reliable and much useful for early detection of SSI.
著者
Yoshiaki Yamamoto Yuki Kawamura Yuki Yamazaki Tatsuro Kijima Toshiya Morikawa Yoshimune Nonomura
出版者
公益社団法人 日本油化学会
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
vol.64, no.3, pp.283-288, 2015 (Released:2015-03-01)
参考文献数
30
被引用文献数
2 22

Palmitoleic acid is a promising bactericidal agent for cleansing products with alternative bactericidal abilities. In this study, we focus on the physical and biological activity of palmitoleic acid calcium salt (C16:1 fatty acid Ca salt) because it forms via an ion-exchange reaction between palmitoleic acid and Ca ions in tap water, and remains on the skin surface during the cleansing process. Here, we prepared C16:1 fatty acid Ca salt to investigate its crystal structure and physical and bactericidal properties. The Ca salt was a plate-shaped lamellar crystalline powder with a particle diameter of several micrometers to several tens of micrometers; it exhibited significant lubricity and alternative bactericidal activity against Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes). We also examined other fatty acid Ca salts prepared from lauric acid (C12:0 fatty acid), palmitic acid (C16:0 fatty acid), and oleic acid (C18:1 fatty acid). The bactericidal activities and lubricity of the fatty acid Ca salts changed with the alkyl chain length and the degree of unsaturation. The C16:1 fatty acid Ca salt exhibited the strongest selective bactericidal ability among the four investigated fatty acid Ca salts. These findings suggest that C16:1 fatty acid and its Ca salt have potential applications in cleansing and cosmetic products.
著者
山本 捷子 Shoko YAMAMOTO 日本赤十字秋田短期大学看護学科 THE JAPANESE RED CROSS JUNIOR COLLEGE OF AKITA
雑誌
日本赤十字秋田短期大学紀要 = Bulletin of the Japanese Red Cross Junior College of Akita (ISSN:13430033)
巻号頁・発行日
no.2, pp.17-23, 1998-03-31

現在でも,戦前の日本赤十字社の救護看護婦の活動を讃えている人々がいるが,それはなぜかという問題意識から,戦前の日赤看護婦にはどのような思想が期待されたか,ならびにそれが社会の思想,特に女子教育とどのように関連しているかを検討した。日赤看護婦の活動を支えた思想は,俗に「不撓不屈の日赤看護婦精神」といわれるものである。それは日赤の初代社長佐野常民の訓示や救護員十訓という徳目の教化や,直接的間接的な皇室崇拝の教化によって培われ,日赤看護婦に期待される「尽忠報国」や「奉仕,忍耐,献身」の思想が形成されたといえる。日赤看護婦思想形成の背景には,明治中期以後の教育勅語教育体制や女性観として良妻賢母思想の教育が存在し,学校教育と日赤看護婦の思想形成の教育方法は,儀式や旗,歌など情緒的注入方法の点で共通することを明らかにした。Why, even now, do people give such high praise to the Relief Nurse of the Japanese Red Cross of pre-World War II? This study is an investigation of what kind of spirit was expected of Japanese Red Cross Nurse in pre World War II times. The relation of this spirit to the stream of social thought and women's education at that time was clarified. The nurse's spirit of the Japanese Red Cross was called "Sacrificial" and "Inflexicible", and these endurance qualities supported their hard taskls and sufferings.
著者
Takehiro Hashimoto Satoshi Kutsuna Takahiro Maeki Shigeru Tajima Saho Takaya Yuichi Katanami Kei Yamamoto Nozomi Takeshita Kayoko Hayakawa Yasuyuki Kato Shuzo Kanagawa Norio Ohmagari
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2017.181, (Released:2017-09-11)
参考文献数
14
被引用文献数
4

Dengue fever remains underreported in Africa due to lack of awareness among healthcare providers, the presence of other febrile illnesses, and insufficient laboratory testing. We present a case of imported dengue fever from Burkina Faso to Japan, where an outbreak of dengue was reported on October 18, 2016. The phylogenetic analysis revealed that the isolate from our patient belonged to a distinct of sylvatic dengue viruses, suggesting that dengue viruses have been maintained in the mosquitoes and human cycles in Burkina Faso for more than 30 years.
著者
Yukihiko Ito Aya Mizukuchi Mitsuo Kise Hiromichi Aoto Shigeru Yamamoto Rie Yoshihara Jyunichi Yokoyama
出版者
徳島大学医学部
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.52, no.3,4, pp.159-164, 2005 (Released:2005-09-20)
参考文献数
28
被引用文献数
31 75

Effects of pre-germinated brown rice (PGBR) on postprandial blood glucose and insulin concentrations were compared with brown rice (BR) and white rice (WR) in two studies. In the first study, we investigated the time course of postprandial blood glucose and insulin concentrations after ingesting 25% (W/V) glucose solution, PGBR, BR or WR in 19 healthy young subjects. In the second study, dose-dependent effect of PGBR on the time course of postprandial blood glucose concentrations was compared among 4 different mixtures of PGBR and WR in 13 healthy young subjects. They were solely PGBR, 2/3 PGBR (PGBR: WR=2: 1), 1/3 PGBR (PGBR: WR=1: 2) and solely WR. Each sample was studied on a different day. The samples were selected randomly by the subjects. All the rice samples contained 50g of available carbohydrates. The previous day the subjects ate the assigned dinner by 9:00 pm and then were allowed only water until the examination. The next morning, they ingested each test rice sample with 150ml of water in 5-10 min. Blood was collected into capillary tubes from finger at 0, 30, 60, 90 and 120 min after the ingestion. The incremental areas under the curve (IAUC) of blood glucose concentrations (IAUC-Glc) for 120 min after the administration of PGBR and BR were lower than those after WR. In contrast the IAUC-Glc of BR and PGBR were not different (Study 1). The higher the ratio of PGBR/WR, the lower the glycemic index became (Study 2). These results suggest that intake of PGBR instead of WR is effective for the control of postprandial blood glucose concentration without increasing the insulin secretion. J. Med. Invest. 52: 159-164, August, 2005
著者
山元 恵理子 ヤマモト エリコ Eriko YAMAMOTO
雑誌
東洋英和大学院紀要
巻号頁・発行日
vol.4, pp.67-80, 2008

Japan and Russia are in dispute over the Northern Territories (Etorofu, Kunashiri, Shikotan, and the Habomai Shoto) in the Chishima Archipelago held by Russia since 1945. Although this issue will be solved by the governments of both Japan and Russia, there has also been since 1992 a system of so-called "Interchange without Passports / Visas", or unofficial diplomacy by citizens of Japan and Russia in the Northern Territories. This system has been crowned with great success, especially after the Hokkaido Tohooki Earthquake occurred in 1994. The first group to deliver necessities of life to Russians in Shikotan was not the Russian government, but the group of Japanese former residents. Since that time, the Russian residents have changed their sentiment and now say that they may be able to live a life together there. We can say that this "Interchange without Passports / Visas" has helped to improve their mental infrastructure. This thesis is not only makes use of the academic analysis of the former research, but it is also based on original interviews of former residents, diplomats, Russian residents, and Japanese teachers. Moreover, it reflects the author's own inspection, conducted through participation in the "Interchange without Passports / Visas" in 2005 and 2006.
著者
Yasuyuki Kano Yuta Hashimoto Ichiro Nakanishi Junzo Ohmura Tama Amano Tomoyo Kuba Haruno Sakai Kazuyuki Ito Yoko Odagi Makiko Nishikawa Haruo Horikawa Kazuya Mizushima Ryoichi Yasukuni Munehisa Yamamoto
出版者
日本地震学会学, 日本測地学会学長
雑誌
IAG-IASPEI 2017
巻号頁・発行日
2017-07-11

We have launched Web-based transcription project “Minna de Honkoku" in January, 2017. The URL is https://honkoku.org/. “Minna de Honkoku" is also the name for Web application to realize this online transcription project. The study of historical earthquake is based on historical documents. In Japan, almost all of the documents are written in Kuzushi-ji. Kujzushi-ji is writing style used before ~1900. Since the style is different from that of modern Japanese, transcription is necessary to use the historical documents as data for earthquake research. Catalogs of historical records such as "New collection of materials for the history of Japanese earthquakes" has been published and used for earthquake research. Although huge number of historical documents survives, the majority of the documents left untranscribed. We loaded 114 historical documents included in the Ishimoto correction in Earthquake Research Institute Library, the University of Tokyo. We planned to start the transcription project with historical document describing past earthquakes on "Minna de Honkoku," although the application can be used for any type of historical document. "Minna de Honkoku" consists of viewer of document image and vertical (Japanese-style) editor for transcription. Users can input transcribed texts viewing its image. The ranking of words transcribed is displayed to keep motivation of users. The edit history and online bulletin board are implemented to enhance communication between users. The application is inked to Kuzushi-ji Learning Application, KuLA developed by Osaka University. Transcription has been completed for 29 documents out of total 114 documents in 3 weeks. Total number of inputted character is about 700,000. To finish the transcription of 114 earthquake-related historical document is the main goal of the project. In addition, the Web-based project may attract people who are not interested in local earthquake history and natural disaster.
著者
Michihito TAGAWA Yuhei YAMAMOTO Genya SHIMBO Aiko IGUCHI Xuenan XUAN Mizuki TOMIHARI Kazuro MIYAHARA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.79, no.5, pp.871-875, 2017 (Released:2017-05-18)
参考文献数
22
被引用文献数
2

Cytotoxic T lymphocyte associated gene-4 (CTLA-4) is a costimulatory molecule, expressed on the surface of activated T cells that negatively regulates T cell activation. In humans, alternative splicing of the CTLA-4 gene generates two major isoforms of mRNA, and a soluble form of CTLA-4 (sCTLA-4) was detected in normal human serum. We describe alternatively spliced mRNA expressed in peripheral blood mononuclear cells obtained from a healthy dog lacking the transmembrane domain coded by exon 3 of the CTLA-4 gene. Immunoprecipitation and western blotting of dog serum revealed a band of approximately 23-kDa, which is consistent with the predicted size, based on the amino acid sequence of the canine sCTLA-4 obtained in this study.
著者
Emile Mehanna Hiram G. Bezerra David Prabhu Eric Brandt Daniel Chamié Hirosada Yamamoto Guilherme F. Attizzani Satoko Tahara Nienke Van Ditzhuijzen Yusuke Fujino Tomoaki Kanaya Gregory Stefano Wei Wang Madhusudhana Gargesha David Wilson Marco A. Costa
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.77, no.9, pp.2334-2340, 2013 (Released:2013-08-23)
参考文献数
23
被引用文献数
15 67

Background: Coronary artery calcification (CAC) presents unique challenges for percutaneous coronary intervention. Calcium appears as a signal-poor region with well-defined borders by frequency-domain optical coherence tomography (FD-OCT). The objective of this study was to demonstrate the accuracy of intravascular FD-OCT to determine the distribution of CAC. Methods and Results: Cadaveric coronary arteries were imaged using FD-OCT at 100-μm frame interval. Arteries were subsequently frozen, sectioned and imaged at 20-μm intervals using the Case Cryo-Imaging automated systemTM. Full volumetric co-registration between FD-OCT and cryo-imaging was performed. Calcium area, calcium-lumen distance (depth) and calcium angle were traced on every cross-section; volumetric quantification was performed offline. In total, 30 left anterior descending arteries were imaged: 13 vessels had a total of 55 plaques with calcification by cryo-imaging; FD-OCT identified 47 (85%) of these plaques. A total of 1,285 cryo-images were analyzed and compared with corresponding co-registered 257 FD-OCT images. Calcium distribution, represented by the mean depth and the mean calcium angle, was similar, with excellent correlation between FD-OCT and cryo-imaging respectively (mean depth: 0.25±0.09 vs. 0.26±0.12mm, P=0.742; R=0.90), (mean angle: 35.33±21.86° vs. 39.68±26.61°, P=0.207; R=0.90). Calcium volume was underestimated in large calcifications (3.11±2.14 vs. 4.58±3.39mm3, P=0.001) in OCT vs. cryo respectively. Conclusions: Intravascular FD-OCT can accurately characterize CAC distribution. OCT can quantify absolute calcium volume, but may underestimate calcium burden in large plaques with poorly defined abluminal borders.  (Circ J 2013; 77: 2334–2340)
著者
Shinji Okayasu Kiyoyuki Kitaichi Akina Hori Tetsuya Suwa Yukio Horikawa Mayumi Yamamoto Jun Takeda Yoshinori Itoh
出版者
公益社団法人日本薬学会
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.35, no.6, pp.933-937, 2012-06-01 (Released:2012-06-01)
参考文献数
26
被引用文献数
6 35

Metformin is a drug to improve glycemic control by reducing insulin resistance and is currently considered to be one of the first-choice drugs for type 2 diabetes mellitus (T2DM). However, during metformin use, adverse drug reactions (ADRs) including gastrointestinal adverse events were frequently observed. Thus, in the present study, we investigated the incidence of ADRs induced by metformin and further analyzed risk factors for ADRs in Japanese patients with type 2 diabetes mellitus who initially administered metformin (500–750 mg). One hundred and one hospitalized patients receiving metformin during September 1, 2009 and August 31, 2010 were studied. The incidence of ADRs and changes in laboratory data including hemoglobin A1c (HbA1c) were monitored retrospectively. The anti-glycemic effect of metformin was successfully observed as indicated by decreased HbA1c. Among ADRs, diarrhea was most frequently occurred during metformin use (26.7% of patients) although the symptom of diarrhea was mild in most cases and disappeared within 3 d after the initial use. A logistic regression analysis showed the existence of six risk factors, including initial dose (750 mg), female, age (≦65), body mass index (≧25), aspartate aminotransferase (≧30 IU/L) and alkaline phosphatase (≧270 IU/L). The incidence of diarrhea increased linearly as the number of risk factors increased. In conclusion, in order to avoid ADRs, especially diarrhea, subsequently improving the quality of life during metformin use, the optimization of the dose of metformin by considering risk factors would be beneficial for patients with T2DM.
著者
LEE Suni MATSUZAKI Hidenori KUMAGA-TAKEI Naoko YAMAMOTO Shoko HATAYAMA Tamayo YOSHITOME Kei NISHIMURA Yasumitsu OTSUKI Takemi
出版者
川崎医科大学
雑誌
Kawasaki medical journal (ISSN:03850234)
巻号頁・発行日
vol.42, no.1, pp.15-24, 2016

There are many environmental, occupational and medical substances that cause dysregulation of autoimmunity. Among these substances, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. Many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases such as rheumatoid arthritis (RA), systemic sclerosis (SSc), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasm antibody (ANCA)-related vasculitis. Although the importance of NALP3 inflammasome as the initial immune reaction against silica particles has been recognized, the processes that form the various autoimmune diseases in silica-exposed patients remain unclear. Silica can activate various immune cells and cause an unbalance of regulatory T cells, responder T cells and T helper 17 cells, which might be key factors in understanding the silica-induced autoimmune alteration. In contrast, asbestos exposure shows a smaller association with autoimmune diseases. However, interesting findings have been reported regarding anti-endothelial and mesothelial cell antibodies detected in asbestos-exposed patients. Further investigations may contribute to elucidation of the mechanisms involved in environmental factor-induced modification of autoimmunity.
著者
Choa AN Yumiko OKAMOTO Siyu XU Kyung Yeon EO Junpei KIMURA Naomichi YAMAMOTO
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.16-0472, (Released:2016-12-30)
被引用文献数
19

This study aimed at characterizing fecal microbiota of three captive carnivore species of leopard cats Prionailurus bengalensis, Eurasian otters Lutra lutra and raccoon dogs Nyctereutes procyonoides. We used DNA barcoding sequencing to analyze 16S rRNA genes of uncultured bacteria in the feces collected in the Seoul Zoo. The sequencing analyses revealed that: 1) Firmicutes was the most dominant phylum for all three animals; 2) bacterial genus-rank compositions were distinct across species of the animals; and 3) bacterial community memberships were different across species of the studied animals. We expect such baseline information is useful for better understanding of these endangered species and future management of their health in zoos.
著者
Keita Shibata Arisa Matsumoto Ayumi Nakagawa Keiko Akagawa Akihiro Nakamura Toshinori Yamamoto Naomi Kurata
出版者
公益社団法人日本薬学会
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.39, no.11, pp.1767-1773, 2016-11-01 (Released:2016-11-01)
参考文献数
19
被引用文献数
7

Community pharmacies in Japan have long been advocated as effective sources of nonprescription medicines and health-related advice. Consumers sometimes self-treat symptoms of minor illnesses without consulting a pharmacist because the benefits of such consultations are not adequately recognized. The aim of this study was to investigate the use and impact of pharmacist consultations before purchase of nonprescription laxatives. An online survey was conducted July 14–22, 2012 with 500 respondents (250 men, 250 women), ranging 20–60 years old. All participants had purchased nonprescription laxatives for constipation within the past year. Stratified analysis was used to compare responses in groups that had and had not consulted a pharmacist before purchase. Consulting a pharmacist appears to improve consumers’ awareness and makes them more likely to use appropriate medication. Those who consulted a pharmacist were better able to identify side effects and take appropriate action than the group that did not consult the pharmacist. Those who consulted a pharmacist were also significantly more likely to say that they would consult a pharmacist in the future. These results indicate that it is important for consumers to be able to consult with pharmacists, to improve consumers’ awareness of side effects and to self-medicate appropriately, and hence improve their quality of life. Pharmacists in community pharmacy could be more active in health promotion campaigns, such as drug safety, campaigns, to raise their public profile. Increased public awareness of what pharmacists in community pharmacy do will make it easier for patients to consult with them.
著者
Sho Yamamoto Tetsuri Kikuchi Yutaka Yamagiwa Takashi Handa
出版者
一般社団法人 園芸学会
雑誌
The Horticulture Journal (ISSN:21890102)
巻号頁・発行日
pp.OKD-006, (Released:2016-11-03)
被引用文献数
5

Lilium auratum var. auratum Lindl. is distributed in the eastern part of Honshu, the main island of Japan. L. auratum var. platyphyllum Baker is endemic to the Izu archipelago, which consists of nine large islands located in south of Honshu’s Izu peninsula. Both varieties have been used as important parents of Oriental hybrid lily cultivars. They have large white flowers with yellow central stripes and colored spots on their tepals. L. auratum var. platyphyllum has larger flowers and wider leaves than L. auratum var. auratum. L. auratum var. platyphyllum has yellow spots, whereas L. auratum var. auratum has red or brown ones. Natural hybridization between these two taxa has been suggested on the basis of spot colors of populations in the Izu archipelago and the Izu peninsula. However, their genetic diversity and hybridity in nature have not been reported. We performed morphological analysis using 72 individuals of L. auratum var. auratum from seven populations and 72 individuals of L. auratum var. platyphyllum from six populations. We also performed simple sequence repeat (SSR) analysis using 102 individuals of L. auratum var. auratum from seven populations and 134 individuals of L. auratum var. platyphyllum from six populations. Both analyses revealed that L. auratum var. auratum and L. auratum var. platyphyllum are genetically different and that L. auratum var. platyphyllum has genetic diversity among populations in the archipelago.
著者
Osamu UCHIDA Masafumi KOSUGI Gaku ENDO Takamitsu FUNAYAMA Keisuke UTSU Sachi TAJIMA Makoto TOMITA Yoshitaka KAJITA Yoshiro YAMAMOTO
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)
巻号頁・発行日
vol.E99-A, no.8, pp.1551-1554, 2016-08-01

It is important to collect and spread accurate information quickly during disasters. Therefore, utilizing Twitter at the time of accidents has been gaining attention in recent year. In this paper, we propose a real-time information sharing system during disaster based on the utilization of Twitter. The proposed system consists of two sub-systems, a disaster information tweeting system that automatically attaches user's current geo-location information (address) and the hashtag of the form “#(municipality name) disaster,” and a disaster information mapping system that displays neighboring disaster-related tweets on a map.
著者
Kenji Nakatsuma Hiroki Shiomi Takeshi Morimoto Yutaka Furukawa Yoshihisa Nakagawa Kenji Ando Kazushige Kadota Takashi Yamamoto Satoru Suwa Minoru Horie Takeshi Kimura on behalf of the CREDO-Kyoto AMI investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-16-0204, (Released:2016-06-28)
参考文献数
24
被引用文献数
2 22

Background:Inter-facility transfer for primary percutaneous coronary intervention (PCI) from referring facilities to PCI centers causes a significant delay in treatment of ST-segment elevation acute myocardial infarction (STEMI) patients undergoing primary PCI. However, little is known about the clinical outcomes of STEMI patients undergoing inter-facility transfer in Japan.Methods and Results:In the CREDO-Kyoto acute myocardial infarction (AMI) registry that enrolled 5,429 consecutive AMI patients in 26 centers in Japan, the current study population consisted of 3,820 STEMI patients who underwent primary PCI within 24 h of symptom onset. We compared long-term clinical outcomes between inter-facility transfer patients and those directly admitted to PCI centers. The primary outcome measure was a composite of all-cause death or heart failure (HF) hospitalization. There were 1,725 (45.2%) inter-facility transfer patients, and 2,095 patients (54.8%) with direct admission to PCI centers. The cumulative 5-year incidence of death/HF hospitalization was significantly higher in the inter-facility transfer patients than in those with direct admission (26.9% vs. 22.2%; log-rank P<0.001). After adjusting for potential confounders, the risk for death/HF hospitalization was significantly higher (adjusted hazard ratio: 1.22, 95% confidence interval: 1.07–1.40, P<0.001) in the inter-facility transfer patients than in those directly admitted.Conclusions:Inter-facility transfer was associated with significantly worse long-term clinical outcomes for patients with STEMI undergoing primary PCI.