著者

Naoki Sakane Yoko Asano Tomoko Kawamura Tomohiro Takatani Yasuhiro Kohama Kazutake Tsujikawa Hiroshi Yamamoto

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.27, no.12, pp.2014-2020, 2004 (Released:2004-12-01)

参考文献数

29

被引用文献数

1 2 3

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Fetal liver (FL) hematopoiesis is thought to be important for expanding the cell number during ontogeny. In order to investigate the cellular interaction molecules among FL stromal and hematopoietic cells, we established a monoclonal antibody, Ndk-10, that reacts with FL stromal cells but not with dish non-adherent cells. When Ndk-10 was added to an FL stromal and hematopoietic cell-coculture, it inhibited the survival of c-kit+ cells. The inhibitory activity of Ndk-10 was also observed in the fetal liver organ culture. The Ndk-10 recognized a 150 kD molecule in the adherent cells of FL and kidney, and the N-terminal amino acid sequence was identical to that of mouse aminopeptidase N/CD13. The peptidase activity of CD13 was inhibited by Ndk-10, and addition of its specific inhibitor resulted in the same inhibitory activity as Ndk-10. We propose that aminopeptidase N/CD13 is a critical molecule that regulates the survival of c-kit+ cells in the FL microenvironment.

著者

Mari Maeda-Yamamoto Kaori Ema Manami Monobe Ikuo Shibuichi Yuki Shinoda Tomohiro Yamamoto Takao Fujisawa

出版者

一般社団法人日本アレルギー学会

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.58, no.3, pp.437-444, 2009 (Released:2009-09-11)

参考文献数

20

被引用文献数

28

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Background: We previously reported that 'benifuuki' green tea containing O-methylated catechin significantly relieved the symptoms of perennial or seasonal rhinitis compared with a placebo green tea that did not contain O-methylated catechin in randomized double-blind clinical trials. In this study we assessed the effects of 'benifuuki' green tea on clinical symptoms of seasonal allergic rhinitis. Methods: An open-label, single-dose, randomized, parallel-group study was performed on 38 subjects with Japanese cedar pollinosis. The subjects were randomly assigned to long-term (December 27, 2006 - April 8, 2007, 1.5 months before pollen exposure) or short-term (February 15, 2007: after cedar pollen dispersal - April 8, 2007) drinking of a 'benifuuki' tea drink containing 34mg O-methylated catechin per day. Each subject recorded their daily symptom scores in a diary. The primary efficacy variable was the mean weekly nasal symptom medication score during the study period. Results: The nasal symptom medication score in the long-term intake group was significantly lower than that of the short-term intake group at the peak of pollen dispersal. The symptom scores for throat pain, nose-blowing, tears, and hindrance to activities of daily living were significantly better in the long-term group than the short-term group. In particular, the differences in the symptom scores for throat pain and nose-blowing between the 2 groups were marked. Conclusions: We conclude that drinking 'benifuuki' tea for 1.5 months prior to the cedar pollen season is effective in reducing symptom scores for Japanese cedar pollinosis.

著者

ホドシチェク ボル Hodoscek Bor 山元 啓史 Yamamoto Hilofumi

雑誌

第19回シンポジウム「人文科学とデータベース」

巻号頁・発行日

vol.19, pp.17, 2013-11 (Released:2014-01-15)

著者

尾崎 仁美 山本 惠子 オザキ ヒトミ ヤマモト ケイコ Ozaki Hitomi Yamamoto Keiko

出版者

大阪大学大学院人間科学研究科教育学系

雑誌

大阪大学教育学年報 (ISSN:13419595)

巻号頁・発行日

vol.2, pp.173-184, 1997-03

著者

translated into the English by K. Yamamoto

出版者

Niwa

巻号頁・発行日

1873

著者

山本 健太郎 Kentaro Yamamoto

出版者

関西学院大学法政学会

雑誌

法と政治 (ISSN:02880709)

巻号頁・発行日

vol.64, no.2, pp.586-554, 2013-07

著者

Yoji Urabe Hideya Yamamoto Toshiro Kitagawa Hiroto Utsunomiya Hiroshi Tsushima Fuminari Tatsugami Kazuo Awai Yasuki Kihara

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-13-0257, (Released:2013-07-18)

参考文献数

38

被引用文献数

11 16

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Background: Intensive lipid-lowering therapy with statins reduces cardiovascular events, but residual cardiovascular risks remain. Intake of n-3 polyunsaturated fatty acids (PUFAs) has been associated with cardiovascular events. We examined the relationships between serum n-3 PUFAs and coronary atherosclerotic findings on computed tomography angiography (CTA) in patients undergoing statin treatment. Methods and Results: We enrolled 172 subjects (mean age: 68.2 years; 64% men) prior to statin treatment for 6 months. Serum PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, were measured. When the patients were divided into 2 groups according to the median EPA level (61.3μg/ml), the low-EPA group showed higher incidences of 3-vessel plaque involvement (62% vs. 43%, P=0.015), noncalcified plaques (NCPs) (74% vs. 52%, P=0.0016), extensive NCPs (≥2 segments) (56% vs. 34%, P=0.0036), and high-risk plaques (minimum CT density <39HU and remodeling index >1.05) (43% vs. 22%, P=0.0034). Multivariate analyses revealed that low EPA levels were an independent factor for these coronary plaque findings. The DHA levels were not independently associated with these findings. Conclusions: Low serum EPA level, but not serum DHA, is associated with the presence and extent of NCPs and high-risk plaques detected by coronary CTA in patients undergoing lipid-lowering therapy with statins.

著者

Hidenori Arai Akira Yamamoto Yuji Matsuzawa Yasushi Saito Nobuhiro Yamada Shinichi Oikawa Hiroshi Mabuchi Tamio Teramoto Jun Sasaki Noriaki Nakaya Hiroshige Itakura Yuichi Ishikawa Yasuyoshi Ouchi Hiroshi Horibe Tohru Egashira Hiroaki Hattori Nobuo Shirahashi Toru Kita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.12, no.5, pp.240-250, 2005 (Released:2005-10-05)

参考文献数

53

被引用文献数

27 31

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We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G → A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (−514 → CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.

著者

Miyako Yuasa-Kawase Daisaku Masuda Taiji Yamashita Ryota Kawase Hajime Nakaoka Miwako Inagaki Kazuhiro Nakatani Kazumi Tsubakio-Yamamoto Tohru Ohama Akifumi Matsuyama Makoto Nishida Masato Ishigami Toshiharu Kawamoto Issei Komuro Shizuya Yamashita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.20, no.5, pp.514-515, 2013 (Released:2013-05-29)

参考文献数

48

著者

Fujita Mari Sasanuma Hiroyuki Yamamoto Kimiyo N. Harada Hiroshi Kurosawa Aya Adachi Noritaka Omura Masato Hiraoka Masahiro Takeda Shunichi Hirota Kouji

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.4, 2013-04-03

被引用文献数

19

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DNAが切れていないのに発生する染色体断裂の発見 -ヒトの被爆線量を測定する手法に異議あり-. 京都大学プレスリリース. 2013-04-04.

著者

Yamamoto Shinya Humle Tatyana Tanaka Masayuki

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.1, 2013-01-30

被引用文献数

56

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技を盗むチンパンジー : 効率のよい道具使用テクニックを他者から見て学ぶ--ヒト特有と考えられている累積進化文化の認知的基盤--. 京都大学プレスリリース. 2013-01-31.

著者

Yamamoto Shinya Humle Tatyana Tanaka Masayuki

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)

巻号頁・発行日

2012-02-06

被引用文献数

151

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相手の状況に合わせたチンパンジーの手助け行動. 京都大学プレスリリース. 2012-02-07.

著者

Masafumi Seki Naruhiko Ikari Seigo Yamamoto Yuhki Yamagata Kosuke Kosai Katsunori Yanagihara Tomoyuki Kakugawa Shintaro Kurihara Koichi Izumikawa Yoshitsugu Miyazaki Yasuhito Higashiyama Yoichi Hirakata Takayoshi Tashiro Shigeru Kohno

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.45, no.22, pp.1323-1326, 2006 (Released:2006-12-15)

参考文献数

22

被引用文献数

11 24 11

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A 77 years old woman who had a bite with eschar on her left arm, was admitted to emergency ward in our hospital, because of high fever, severe malaise, skin eruption, and consciousness disturbance beginning 5 days previously. She was diagnosed as Japanese spotted fever by seropositive of Rickettsia japonica (R. japonica) antibody, and successfully treated with fluoroquinolone, after minocycline hydrochloride had been proven ineffective. R. japonica-specific DNA was detected by PCR from the tick: Haemaphysalis hystricis larvae collected from a mountainous location in Fukuoka, Japan where the patient had been bitten.

著者

Yamamoto Tetsuo Kinoshita Manabu Shinomiya Nariyoshi HIROI Sadayuki SUGASAWA Hidekazu MATSUSHITA Yoshitaro MAJIMA Takashi SAITOH Daizoh SEKI Shuhji

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.51, no.2, pp.145-156, 2010-03-16

被引用文献数

38

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While bone marrow or stem cell transplantation can rescue bone marrow aplasia in patients accidentally exposed to a lethal radiation dose, radiation-induced irreversible gastrointestinal damage (GI syndrome) is fatal. We investigated the effects of ascorbic acid on radiation-induced GI syndrome in mice. Ascorbic acid (150 mg/kg/day) was orally administered to mice for 3 days, and then the mice underwent whole body irradiation (WBI). Bone marrow transplantation (BMT) 24 h after irradiation rescued mice receiving a WBI dose of less than 12 Gy. No mice receiving 14 Gy-WBI survived, because of radiation-induced GI syndrome, even if they received BMT. However, pretreatment with ascorbic acid significantly suppressed radiation-induced DNA damage in the crypt cells and prevented denudation of intestinal mucosa; therefore, ascorbic acid in combination with BMT rescued mice after 14 Gy-WBI. DNA microarray analysis demonstrated that irradiation up-regulated expressions of apoptosis-related genes in the small intestine, including those related to the caspase-9-mediated intrinsic pathway as well as the caspase-8-mediated extrinsic pathway, and down-regulated expressions of these genes in ascorbic acid-pretreated mice. Thus, pretreatment with ascorbic acid may effectively prevent radiation-induced GI syndrome.

著者

Hideki ENDO Daishiro YAMAGIWA Kazuyoshi ARISHIMA Masako YAMAMOTO Motoki SASAKI Yoshihiro HAYASHI Toshio KAMIYA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.61, no.10, pp.1137-1141, 1999-10-25 (Released:2000-04-12)

参考文献数

16

被引用文献数

5 7

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The MRI examination was carried out in a formalin-fixed specimen of the Ganges River dolphin (Platanista gangetica), one of the evolutionary primitive species of cetaceans. We could morphologically elucidate the tracheobronchial ramification in the intact whole body. We demonstrated from the MRI sections that the characteristic tracheal bronchus branches from the trachea at the cranial portion. These findings suggest the phylogenetic relationships between cetaceans and artiodactyls. The left bronchus is obviously larger in diameter than the right one. We suggest that the right bronchus has smaller capacity of gas exchange than the left one, because the dolphin possesses the tracheal bronchus in the right lung. The MRI method will be important in the non-invasive study of the anatomy in endangered animal carcass as Ganges River dolphin.

著者

Mizuno Hideyuki Yamamoto Ryoichi

出版者

The American Physical Society

雑誌

Physical Review E (ISSN:15393755)

巻号頁・発行日

vol.82, no.3, 2010-09

被引用文献数

17

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We numerically examine dynamical heterogeneity in a highly supercooled three-dimensional liquid via molecular-dynamics simulations. To define the local dynamics, we consider two time intervals: τα and τngp. τα is the α relaxation time, and τngp is the time at which non-Gaussian parameter of the Van Hove self-correlation function is maximized. We determine the lifetimes of the heterogeneous dynamics in these two different time intervals, τhetero(τα) and τhetero(τngp), by calculating the time correlation function of the particle dynamics, i.e., the four-point correlation function. We find that the difference between τhetero(τα) and τhetero(τngp) increases with decreasing temperature. At low temperatures, τhetero(τα) is considerably larger than τα, while τhetero(τngp) remains comparable to τα. Thus, the lifetime of the heterogeneous dynamics depends strongly on the time interval.

著者

Shihoya Wataru Kashima Makoto Okada Naoi Yamamoto Takuya Murayama Tomo Takada Tomonori Maeda Yu-ki Okada Kazuya Kajita Ken Hashiya Fumitaka Mori Hitoshi Okada Takuya Sugiura Tasuku

出版者

iGEM Kyoto

巻号頁・発行日

2010-11-06

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iGEM 2010 Jamboree, Massachusetts Institute of Technology, USA Nov 6th - 8th, 2010.

著者

Shiga Takeki Suzuki Hiroyuki Yamamoto Ayumi YAMAMOTO Hiroaki YAMAMOTO Kazuo

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.51, no.4, pp.405-415, 2010-07-16

被引用文献数

1 12

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Previously, we have shown that phenyl hydroquinone, a hepatic metabolite of the Ames test-negative carcinogen <i>o</i>-phenylphenol, efficiently induced aneuploidy in <i>Saccharomyces cerevisiae</i> by arresting the cell cycle at the G2/M transition as a result of the activation of the Hog1 (p38 MAPK homolog)-Swe1 (Wee1 homolog) pathway. In this experiment, we examined the aneuploidy forming effects of hydroquinone, a benzene metabolite, since both phenyl hydroquinone and hydroquinone are Ames-test negative carcinogens and share similar molecular structures. As was seen in phenyl hydroquinone, hydroquinone induced aneuploidy in yeast by delaying the cell cycle at the G2/M transition. Deficiencies in <i>SWE1</i> and <i>HOG1</i> abolished the hydroquinone-induced delay at the G2/M transition and aneuploidy formation. Furthermore, Hog1 was phosphorylated by hydroquinone, which may stabilize Swe1. These data indicate that the hydroquinone-induced G2/M transition checkpoint, which is activated by the Hog1-Swe1 pathway, plays a role in the formation of aneuploidy.

著者

Kida Ikuhiro Yamamoto Toru

出版者

Elsevier B.V.

雑誌

Brain Research (ISSN:00068993)

巻号頁・発行日

vol.1317, pp.116-123, 2010-03-04

被引用文献数

5

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It is essential to elucidate the relationship between blood oxygenation level-dependent (BOLD) signals and neuronal activity for the interpretation of the functional magnetic resonance imaging (fMRI) signals; this relationship has been quantitatively investigated by animal studies measuring evoked potentials as indices of neuronal activity. Although most human fMRI studies employ the event-related task design, in which the stimulus duration is short, few studies have investigated the relationship between BOLD signals and evoked potentials at short stimulus durations. The present study investigated this relationship in the somatosensory cortex of anesthetized rats by using electrical forepaw stimulation at a short duration of 4 s and comprehensively analyzed it at different frequencies (1-10 Hz) and currents (0.5-2.0 mA). Somatosensory evoked potential (SEP) responses were measured at the scalp using silver ball electrodes. The sum of the peak-to-peak amplitude (ΣSEP) and average SEP (avg. SEP) responses were calculated. BOLD signals were obtained using a spin-echo echo-planar imaging sequence at 7 T. The relationship between the avg. SEP and BOLD signals varied with frequency, whereas that between ΣSEP and BOLD signals showed a significant correlation at varying frequencies and currents. In particular, the relationship between ΣSEP and ΣBOLD, which is the sum of the BOLD signals obtained at each time point reflecting the area under the BOLD response curves, mostly converged, irrespective of the frequency. Our results suggest that ΣBOLD obtained using a spin-echo sequence reflects the neural activity as quantified by ΣSEP, which was determined at different frequencies and currents.

著者

Hiroyuki Yamamoto Kyoko Yamamoto Katsumi Yoshida Chiyohiko Shindoh Kyoko Takeda Masami Monden Hiroko Izumo Hiroyuki Niinuma Yutaro Nishi Koichiro Niwa Yasuhiro Komatsu

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.237, no.3, pp.201-207, 2015 (Released:2015-10-24)

参考文献数

24

被引用文献数

2 2

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Chronic kidney disease (CKD) is a global public health issue, and strategies for its early detection and intervention are imperative. The latest Japanese CKD guideline recommends that patients without diabetes should be classified using the urine protein-to-creatinine ratio (PCR) instead of the urine albumin-to-creatinine ratio (ACR); however, no validation studies are available. This study aimed to validate the PCR-based CKD risk classification compared with the ACR-based classification and to explore more accurate classification methods. We analyzed two previously reported datasets that included diabetic and/or cardiovascular patients who were classified into early CKD stages. In total, 860 patients (131 diabetic patients and 729 cardiovascular patients, including 193 diabetic patients) were enrolled. We assessed the CKD risk classification of each patient according to the estimated glomerular filtration rate and the ACR-based or PCR-based classification. The use of the cut-off value recommended in the current guideline (PCR 0.15 g/g creatinine) resulted in risk misclassification rates of 26.0% and 16.6% for the two datasets. The misclassification was primarily caused by underestimation. Moderate to substantial agreement between each classification was achieved: Cohen’s kappa, 0.56 (95% confidence interval, 0.45-0.69) and 0.72 (0.67-0.76) in each dataset, respectively. To improve the accuracy, we tested various candidate PCR cut-off values, showing that a PCR cut-off value of 0.08-0.10 g/g creatinine resulted in improvement in the misclassification rates and kappa values. Modification of the PCR cut-off value would improve its efficacy to identify high-risk populations who will benefit from early intervention.