著者

NAOTO KUNITOMO TAKU YAMAMOTO

出版者

JAPANESE ECONOMIC ASSOCIATION

雑誌

The Economic Studies Quarterly (ISSN:0557109X)

巻号頁・発行日

vol.41, no.1, pp.15-33, 1990-03-20 (Released:2008-02-28)

参考文献数

27

---

The method of testing the cross-equation restrictions under the rational expectation (RE) hypothesis based upon the fitted vector autoregressive (VAR) time series models has been used. It has been applied to test the cross-equation restrictions implied by the expectation hypothesis for the term structure of interest rates, the present value relation in the stock market, and the efficiency hypothesis without risk premium in forward exchange rate market.We point out that two conventional econometric practices of the prefiltering (or differencing) and the use of law of iterated projection are often inconsistent with the restrictions imposed by the RE hypothesis. We explore the general relation between this inconsistency problem and the cointegrated stochastic processes. New sufficient conditions for logical consistency to test the restrictions imposed by the RE hypothesis are given. We show that some cointegrated filter can be used as a possible solution in some cases. Further, we propose a necessary and sufficient condition for testing the cross-equation constraints imposed by the RE hypothesis based upon the vector autoregressive moving average (VARMA) models, which can be useful as a solution to the difficulty caused by an improper use of the law of iterated projection.

著者

山本 茂美 Shigemi Yamamoto

出版者

金城学院大学

雑誌

金城学院大学論集. 人文科学編 = Treatises and studies by the Faculty of Kinjo Gakuin College (ISSN:04538862)

巻号頁・発行日

vol.8, no.2, pp.155-162, 2012

著者

石黒 洋 山本 明子 中莖 みゆき 衣 蘭娟 石黒 真理子 山口 誠 近藤 志保 持丸 由香 Ishiguro Hiroshi Yamamoto Akiko Nakakuki Miyuki Yi Lanjuan Ishiguro Mariko Yamaguchi Makoto Kondo Shiho Mochimaru Yuka

出版者

名古屋大学総合保健体育科学センター

雑誌

総合保健体育科学 (ISSN:02895412)

巻号頁・発行日

vol.35, no.1, pp.9-15, 2012-03-30

---

Excretion of hypotonic sweat by eccrine sweat gland is achieved by re-absorption of NaCl by sweat duct which is an important function to prevent the salt loss and heat prostration. The Cl– transport by sweat duct is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. CFTR is the causative gene for cystic fibrosis, an autosomal recessive genetic disease. CFTR functions as a cAMP-dependent anion channel localized in the apical membrane of various epithelia. Loss of function due to severe mutations in both alleles causes typical cystic fibrosis characterized by dehydrated, thick, and viscous luminal fluid/mucus in the respiratory and gastrointestinal tract, pancreatic duct, and vas deferens. Cystic fibrosis is the most common genetic disease in Caucasians (1 per ~3,000 births) but it is rare in the Asian population including Japanese (1 per ~1.5 million). A compound heterozygote of mutations/polymorphisms (causing a mild dysfunction of CFTR) involves a risk of developing CFTR-related diseases (or atypical cystic fibrosis) such as chronic pancreatitis and male infertility due to congenital bilateral absence of the vas deferens (CBAVD). Recent studies suggest that CFTR mutations/polymorphisms are frequently found in Japanese patients with chronic pancreatitis, CBAVD and diffuse panbronchiolitis. Cl– concentration in the sweat is a useful measure of CFTR function in human. The sweat [Cl–] in healthy subjects is correlated with ages. High levels (>60 mM) of sweat [Cl–] suggest the dysfunction of CFTR.

著者

池永 満生 吉川 勲 古城 台 加藤 由美子 綾木 歳一 梁 治子 石崎 寛治 加藤 友久 山本 華子 原 隆二郎 Ikenaga Mitsuo Yoshikawa Isao Kojo Moto Kato Yumiko Ayaki Toshikazu Ryo Haruko Ishizaki Kanji Kato Tomohisa Yamamoto Hanako Hara Ryujiro

出版者

宇宙開発事業団

雑誌

宇宙開発事業団技術報告 = NASDA Technical Memorandum (ISSN:13457888)

巻号頁・発行日

pp.306-338, 1994-10-20

---

HZE(高エネルギー重荷電粒子)および宇宙放射線の遺伝的影響を調べるため、ショウジョウバエ(Drosophila melanogaster)の成虫雄と幼虫をスペースシャトル/エンデバー号(STS-47)に搭載し、雄の生殖細胞(精子やその元となる精原細胞など)に起こる伴性劣性致死突然変異と、幼虫の翅原基体細胞に起こる染色体のつなぎかえによる突然変異を調べた。用いた系統は、標準的な野生株(Canton-S)と放射線高感受性株(mei-41)である。各系統で、成虫雄は200匹ずつ、幼虫は約6000匹ずつを搭載し宇宙環境に曝すとともに、ほぼ同数を地上対照群として、宇宙飛行群と同じ環境条件(温度と湿度)で飼育した。宇宙飛行は約8日間であった。帰還した雄のハエは、伴性劣性致死突然変異を調べるため、検出用系統の処女雌に交配し、次々世代で致死遺伝子を保有しているX染色体を検出した。宇宙飛行群の致死遺伝子をもった染色体頻度は、地上対照群の頻度に比べて、野生株では2倍、放射線高感受性株では3倍高かった。幼虫は、帰還時にほとんどが蛹になっており、翌日より徐々に羽化が始まった。羽化した成虫は、順次70%アルコールで貯蔵し、後に翅標本を作成して、染色体突然変異由来の翅毛変異スポットを調べた。野生株では、宇宙飛行群と地上対照群の頻度は、ほぼ同じであった。放射線高感受性株から分離してくるMuller-5個体における頻度は、地上対照群に比べて宇宙飛行群では、1.5倍高かった。しかし、放射線高感受性個体における宇宙飛行群の頻度は、地上対照群に比べて有意に低い頻度を示した。地上対照群に比べて、宇宙飛行群の劣性致死突然変異の高頻度は、生殖細胞において、放射線と微小重力の突然変異誘発作用への相乗効果を示唆している。しかし、この相乗効果は、体細胞の染色体突然変異誘発作用に対しては観察されなかった。

著者

Keiichi Ozono Toshimi Michigami Noriyuki Namba Shigeo Nakajima Takehisa Yamamoto

出版者

The Japanese Society for Pediatric Endocrinology

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.15, no.4, pp.129-135, 2006 (Released:2006-11-03)

参考文献数

45

被引用文献数

3 3

---

Serum phosphate levels are regulated in both calcium-dependent and -independent fashions. Active vitamin D increases while PTH decreases serum phosphate levels in association with the elevation of serum calcium. On the other hand, a calcium-independent phosphaturic factor, historically called phosphatonin is believed to exert a physiological function based on findings in hereditary and tumor-induced diseases characterized by hypophosphatemia with normocalcemia. Among them, autosomal dominant hypophosphatemic rickets (ADHR) has contributed greatly to its elucidation because the gene responsible for ADHR encodes fibroblast growth factor 23 (FGF23) that has been found to have a phosphaturic effect. In addition, FGF23 has been proved to be involved in most cases of oncogenic osteomalacia and X-linked hypophosphatemic rickets that are also characterized by hypophosphatemia and normocalcemia. Moreover, familial tumoral calcinosis, which represents the metabolic mirror image of hypophosphatemic conditions, is caused by a loss-of-function mutation in the FGF23 gene in some patients. Very recently, hereditary hypophosphatemic rickets with hypercalciuria has been found to be caused by mutations in the SLC34A1 gene which encodes a type of sodium phosphate cotransporter. These findings may provide new strategies for treating patients with abnormal phosphate metabolism.

著者

山本 隆基 Yamamoto Takaki

出版者

福岡大学研究推進部

雑誌

福岡大学法学論叢 = Fukuoka University Review of Law (ISSN:04298411)

巻号頁・発行日

vol.55, no.2, pp.279-342, 2010-09

著者

Yusuke Kashihara Yuki Iwai Natsuo Ishiwata Nobuyuki Oyama Hidetoshi Matsuno Hiroyuki Horikoshi Koji Yamamoto Minoru Kuwabara

出版者

The Iron and Steel Institute of Japan

雑誌

ISIJ International (ISSN:09151559)

巻号頁・発行日

vol.57, no.4, pp.665-672, 2017-04-15 (Released:2017-04-19)

参考文献数

29

被引用文献数

4 6

---

Improved permeability and increased gas utilization have been desired in order to achieve low coke rate operation of blast furnaces. Coke mixed charging in the ore layer is one of the effective measures for realizing these improvements. A new charging technique for mixing small coke in the ore layer at a blast furnace with a center feed type bell-less top was developed and investigated in an experiment with a 1/18.8 scale model of an actual blast furnace at JFE Steel. By the new charging technique that small coke was charged in the determined port of the upper bunker before ore was charged in the upper bunker, the discharge pattern of the mixed small coke discharged from the bell-less top was improved, and the radial distribution of the mixed small coke ratio at the furnace top after the mixed materials were charged in the blast furnace was also improved. The new charging technique was applied to an actual blast furnace at JFE Steel, and improvement of gas permeability and a decrease in the coke rate were confirmed.

著者

Kyohei MATSUI So TANABE Shuyi SUN Dung NGUYEN Takamasa KINOSHITA Yojiro YAMAMOTO Hiroshi SHIIGI

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.36, no.12, pp.1461-1465, 2020-12-10 (Released:2020-12-10)

参考文献数

31

被引用文献数

5

---

Enzyme-linked immunosorbent assay (ELISA) is a widespread analytical biochemistry assay. In this work, a direct ELISA method using a metallic nanoparticle (NP)-immobilized 96-well plate was developed for high-throughput, highly sensitive fluorescence analysis. Immobilization of metallic NPs on a 96-well plate effectively amplified fluorescence signals of the assay. The silver (Ag) NP-immobilized plate showed the best fluorescence enhancement effect of all the metal-immobilized plates tested. We used the Ag NP-immobilized plate to detect biomolecules and bacteria and found that both the fluorescence intensity and the limit of detection (LOD) were strongly enhanced by more than 100 times compared with those of the unmodified 96-well plates. Quantitative and qualitative considerations for target bacteria regarding the impact of autofluorescence on detection were successfully obtained for several strains. Our results demonstrate the potential of applying Ag NPs for enhancing the efficiency of direct and indirect ELISA assays.

著者

山本 二三丸 ヤマモト フミマル Fuminaru Yamamoto

雑誌

立教經濟學研究

巻号頁・発行日

vol.44, no.1, pp.69-97, 1990

著者

松原 仁 山本 和彦 Hitoshi Matsubara Kazuhiko Yamamoto

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会誌 = Journal of Japanese Society for Artificial Intelligence (ISSN:09128085)

巻号頁・発行日

vol.2, no.3, pp.266-272, 1987-09-01

被引用文献数

10

著者

Hidekazu Yoshida Koshi Yamamoto Toshiaki Ohe Nagayoshi Katsuta Yusuke Muramiya Richard Metcalfe

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.54, no.4, pp.233-242, 2020 (Released:2020-08-27)

参考文献数

35

被引用文献数

9

---

Spherical carbonate concretions are commonly observed in marine clayey sedimentary strata and often contain well preserved fossils. Previous studies revealed that the spherical concretions are formed by the very rapid reaction with decomposed organic matter from inside and Ca2+ ion of seawater. However, the detailed mass transport process during concretion formation has not been completely understood. Here two different size of spherical concretions, cm size of tusk-shell concretions and metre size of Moeraki boulders, are re-examined to understand the diffusion oriented formation process. Field observations, and detailed mineralogical (XRD) and geochemical analyses (SXAM, XRF, δ13C) revealed diffusive transport of HCO3− from decaying organic matter and Ca2+ from surrounding pore-water of marine origin led to solid carbonate precipitation reactions that progressed from the margin of a concretion. Based on the compositional gradients across the concretions, a diffusion based diagram has been applied to estimate the growth rates of the different size of spherical concretions. The process and rate estimation indicate that even gigantic spherical concretions can form quite rapidly in the muddy matrices under a diffusion-controlled transport regime.

著者

Yuji Yamamoto Yuko Ohara Ami Iwai Reina Hara Takanori Matsuki Kiyoharu Fukushima Yohei Oshitani Hiroyuki Kagawa Kazuyuki Tsujino Kenji Yoshimura Mari Miki Keisuke Miki Masahide Mori Hiroshi Kida

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.3991-19, (Released:2020-03-19)

参考文献数

15

被引用文献数

1 5

---

Influenza vaccination can trigger various adverse reactions, and thrombocytopenia is also rarely reported. Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred within one day of influenza vaccination and diffuse alveolar hemorrhage (DAH) leading to acute respiratory failure. The patient was treated with glucocorticoid pulse therapy, intravenous immunoglobulin, and temporary mechanical ventilation, and eventually he made a full recovery. Vaccine-related thrombocytopenia and DAH should be considered adverse reactions, even if they develop very soon after vaccination.

著者

Naoki YONEDA Tadashi TAKADA Tetsushi HIRANO Shogo YANAI Anzu YAMAMOTO Youhei MANTANI Toshifumi YOKOYAMA Hiroshi KITAGAWA Yoshiaki TABUCHI Nobuhiko HOSHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.4, pp.634-637, 2018 (Released:2018-04-18)

参考文献数

21

被引用文献数

4 25

---

Although neonicotinoid pesticides are expected to have harmful influence on mammals, there is little animal experimental data to support the effect and mechanisms. Since acetylcholine causes the release of dopamine, neonicotinoids may confer a risk of developmental disorders via a disturbance in the monoamine systems. Male mice were peripubertally administered dinotefuran (DIN) referring to no observed effect level (NOEL) and performed behavioral and immunohistological analyses. In an open field test, the total locomotor activity was increased in a dose-dependent manner. The immunoreactivity of tyrosine hydroxylase in the substantia nigra was increased in DIN-exposed mice. These results suggest that exposure to DIN in peripubertal male mice causes hyperactivity and a disturbance of dopaminergic signaling.

著者

Hiroki Usuku Eiichiro Yamamoto Masato Nishi Takashi Komorita Masafumi Takae Taiki Nishihara Fumi Oike Masanobu Ishii Koichiro Fujisue Daisuke Sueta Satoshi Araki Seiji Takashio Seitaro Oda Yohei Misumi Mitsuharu Ueda Taishi Nakamura Hiroaki Kawano Hirofumi Soejima Kenji Sakamoto Koichi Kaikita Yukio Ando Hirotaka Matsui Kenichi Tsujita

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.12, pp.730-738, 2020-12-10 (Released:2020-12-10)

参考文献数

27

---

Background:Using transthoracic echocardiography, including 2D speckle tracking imaging (STI), this study examined cardiac function after domino liver transplantation (DLT) with liver grafts explanted from patients with hereditary amyloidogenic transthyretin amyloidosis.Methods and Results:In all, 14 patients who underwent DLT at Kumamoto University Hospital and for whom 2D STI information was available were enrolled in the study; time-dependent echocardiographic changes were evaluated in 7. Although left ventricular (LV) systolic and diastolic function did not differ between the pre- and post-DLT periods (mean [±SD] 5.4±1.0 years after DLT), there were significant (P<0.05 for all) increases in the post- vs. pre-DLT period in basal longitudinal strain (LS; −13.4±2.3 vs. −19.3±4.4), relative apical LS index (=apical LS/[basal LS+mid LS]; 0.75±0.20 vs. 0.58±0.08), and LV ejection fraction/global LS (3.91±0.58 vs. 3.06±0.44). Age at the time of DLT was significantly higher in the group with impaired (>−14%) than preserved basal LS (57.2±3.5 vs. 39.6±16.0 years; P<0.05). When control subjects (n=14) were added to the enrolled DLT recipients, multivariable logistic regression analysis revealed that a history of DLT was significantly associated with impaired basal LS (>−14%; odds ratio 28.39, 95% confidence interval 1.89–427.45, P<0.05).Conclusions:LV systolic and diastolic function was preserved in the long term after DLT. However, 2D STI revealed subtle cardiac dysfunction in DLT recipients, which may be an early manifestation of cardiac amyloidosis.

著者

YAMAMOTO Tadahiro

出版者

国際日本文化研究センタープロジェクト推進室

雑誌

Dōjin Journal : An academic journal on popular cultures established by the International Research Center for Japanese Studies (ISSN:24357901)

巻号頁・発行日

vol.1, pp.1-13, 2020-11-30

---

In the manga series Norakuro, author Tagawa Suihō employs a multifaceted, multilayered style of expression to depict a variety of scenes related to war. This manga series for children was published between 1931 and 1941 and centered on the military exploits of a stray dog called Norakuro. In the series, Tagawa effectively uses two-page spreads – one image across two pages – to convey both the expansive nature of the battlefield and the individual experiences of the characters involved in conflict. Over time, as the issues and themes of war appeared more frequently in children's manga, Tagawa's use of the two-page spread increased, and this form of expression became indivisible from the depiction of battlefields. In this paper, I will examine not only the ways in which the forms of expression employed in two-page spreads in Norakuro transformed as the lived realities of war influenced manga content, but also the ways in which Tagawa's own worldview and ideals informed his depictions.

著者

Mizuki Miura Masao Yamasaki Yukari Uemura Masatomo Yoshikawa Katsumi Miyauchi Hiroyuki Tanaka Hideki Miyachi Jun Yamashita Makoto Suzuki Takeshi Yamamoto Ken Nagao Issei Komuro Morimasa Takayama

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.2, pp.461-468, 2016-01-25 (Released:2016-01-25)

参考文献数

22

被引用文献数

14 18

---

Background:Previous trials have found that low low-density lipoprotein-cholesterol (LDL-C) on admission was associated with increased mortality in patients with acute myocardial infarction (AMI). There are few reports, however, on the effect of low LDL-C with or without in-hospital statin treatment on short-term prognosis in AMI patients.Methods and Results:A total of 9,032 AMI patients underwent primary PCI in 68 centers in the Tokyo CCU Network Registry during 2009–2012, in whom LDL-C was measured in 6,486. We divided them into 4 groups: statin-treated/LDL-C <100 mg/dl (n=1,236), statin-treated/LDL-C ≥100 mg/dl (n=3,671), statin-naïve/LDL-C <100 mg/dl (n=662), and statin-naïve/LDL-C ≥100 mg/dl (n=917). We assessed hospital mortality within 30 days. In-hospital all-cause mortality was significantly lower in the statin-treated/LDL-C ≥100-mg/dl group (3.2%, P<0.001). On multivariate Cox regression analysis, adjusted for age, gender, hypertension, diabetes mellitus, dyslipidemia and other clinical factors, the combination of statin treatment and LDL-C ≥100 mg/dl was an independent predictor of lower in-hospital mortality (adjusted HR, 0.211; 95% CI: 0.096–0.462; P<0.001). In the LDL-C <100-mg/dl patients, statin treatment also independently reduced in-hospital mortality (adjusted HR, 0.467; 95% CI: 0.223–0.976; P=0.043). Spontaneously low LDL-C was associated with increased short-term mortality.Conclusions:Statin treatment was associated with better short-term outcome in patients with AMI, even in patients with low LDL-C. (Circ J 2016; 80: 461–468)

著者

山本 通 Yamamoto Toru

出版者

神奈川大学

雑誌

商経論叢 (ISSN:02868342)

巻号頁・発行日

vol.32(1), pp.301-331, 1996-06-28

著者

Taishi TANABE Yurina FUKUDA Kazuhiko KAWASHIMA Satomi YAMAMOTO Takashige KASHIMOTO Hisaaki SATO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0182, (Released:2020-11-27)

---

Alpha-amanitin, one of the amatoxins in egg amanita, has a cyclic peptide structure, and was reported as having antiviral activity against several viruses. We investigated whether α-amanitin has antiviral activity against feline immunodeficiency virus (FIV). FL-4 cells persistently infected with FIV Petaluma were cultured with α-amanitin. Reverse transcriptase (RT) activity in the supernatant of FL-4 cells was significantly inhibited by α-amanitin. In addition, the production of FIV core protein in FL-4 cells was inhibited by α-amanitin when analyzed by western blotting. Furthermore, α-amanitin inhibited the transcription of FIV in real-time RT-PCR. These data suggested that α-amanitin showed anti-FIV activity by inhibiting the RNA transcription level.

著者

Takeo Shimasaki Satoko Yamamoto Tomiyasu Arisawa

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.41, no.9, pp.1311-1321, 2018-09-01 (Released:2018-09-01)

参考文献数

76

被引用文献数

3 19

---

In biological systems, extracellular vesicles including exosomes have recently been revealed to play a significant role in the communication between various cells, and the number of papers on this subject has dramatically increased. In current conventional exosome studies, the standard research method is to use liquid biopsies to analyze extracts of various disease exosomes. However, exosomes are only one of many key players in natural cellular interactions. Reproducing the phenomena occurring in vivo and investigating the interactions are required in order to examine their role fully. For exosome research, an alternative to the liquid biopsy method for observing natural interactions is the co-culturing technique. It does not require an exosome extraction procedure, and while the technique has been used in many studies thus far, its application to exosome research has been limited. However, the use of co-culturing technologies is necessary to examine the essential interactions of exosomes. An overview of exosome research methodologies and co-culturing systems is thus provided here.

著者

山本 禮子 ヤマモト レイコ Reiko Yamamoto

雑誌

和洋女子大学紀要. 文系編

巻号頁・発行日

vol.39, pp.51-67, 1999-03