著者

寺田 久仁子 岩本 佳代子 小林 睦 辻野 政司 寺岡 文雄 荒川 行生 恩田 光子 前田 頼伸

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.35, no.2, pp.96-102, 2009 (Released:2010-02-07)

参考文献数

21

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Bone cements have been widely used to fill the dead space of bone tissues in orthopaedic surgeries.Loaded with antibiotics,these materials are also administered for the prevention and treatment of infections,infectious osteomyelitis for example.We made polymethylmethacrylate cement preparations of five commercial vancomycin (VCM) products and compared the in vitro dissolution profiles of the VCM in them and mechanical strengths of the cements.When immersed in phosphate buffer (PB) for 30 days,dissolved amounts of VCM ranged between just 5 and 19% of the calculated contents and after immersion in PB for 40 days mechanical strengths were significantly decreased (50-75% of the control without VCM).Further,on testing a cement preparation containing pharmaceutical additives as well as VCM,the amount of antibiotic released was significantly larger than that for other preparations and the release was more rapid as well.This cement preparation also had the lowest strength among those studied.By doing this,we showed that pharmaceutical additives could have marked effect on the dissolution of the antibiotic and mechanical strength for antibiotic-laden bone cements for the first time,though these were in vitro findings.The present study clearly demonstrated that the antibiotic products used can cause functional differences in antibioticladen bone cements and also suggested that pharmaceutical additives influence cement functions.It is therefore necessary to pay attention to both the antibiotic content of commercial VCM products and types of pharmaceutical additive in the preparation of such cements.

著者

髙橋 良平 今井 浩一 菅井 沙知 吉田 栄充 中村 益美 浜野 晋一郎 岩﨑 文男

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.12, pp.741-750, 2012-12-10 (Released:2013-12-10)

参考文献数

28

被引用文献数

1

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We evaluated ARCHITECT®・iCarbamazepine using chemiluminescent immunoassay (CLIA) with carbamazepine (CBZ) concentration in the serum of patients with epilepsy. The intra- and inter-assay coefficients of variation were 0.87-1.34% and 2.20-6.06%, respectively. Cross-reactivity of CBZ analogs by CLIA varied from 7.00-9.26% with carbamazepine-10,11-epoxide lower than that evaluated by fluorescence polarization immunoassay (FPIA), and 2.09-2.51% with 10-monohydroxycarbazepine higher than that evaluated by FPIA. Oxcarbazepine was not detected. In addition, we observed a correlation between the values obtained by CLIA method and the high performance liquid chromatography (HPLC) method (y = 1.07x - 0.09, r = 0.98), and FPIA method and HPLC method (y = 0.95x - 0.22, r = 0.97). Our results suggest that ARCHITECT®・iCarbamazepine measured the CBZ concentration in serum lower than that measured by FPIA. However we conclude that ARCHITECT®・iCarbamazepine can be used for routine monitoring of CBZ for the reason that ARCHITECT®・iCarbamazepine showed low cross-reactivity with CBZE by classification of CBZE/CBZ ratio.

著者

中山 季昭 塩月 篤史 春山 修一 須藤 欣三 辻 佳紀

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.39, no.5, pp.276-285, 2013-05-10 (Released:2014-05-10)

参考文献数

12

被引用文献数

3

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The preparation of anticancer drugs necessitates careful work because it can involve the handling of hazardous drugs. In actual clinical settings, liquid leakage can occur if the same rubber stopper is penetrated with injection needles multiple times; special attention should be paid to the fact that the first penetration mark can serve as a site of leakage to increase risk.Hence, we conducted a confirmatory study to detect air leakage, which can be detected with greater sensitivity than liquid leakage, using a number of methods of penetration with a focus on the viscoelasticity of rubber stoppers. In the second penetration, when the bevel was oriented perpendicularly to the first penetration (AB method), a leakage rate of 100% (30/30) was obtained with an 18 G regular-bevel needle penetrating the rubber stopper at a short depth of 0.5 mm from the first penetration mark. When the bevel orientation was changed under otherwise the same conditions (CB method), the leakage rate decreased to 37% (11/30). When the bevel orientation was completely aligned to the orientation of the first penetration (BB method), the leakage rate further decreased to 0% (0/30). Another important factor was the depth of penetration; under all conditions examined, lower leakage rates were obtained with a 1.0 mm depth than with 0.5 mm.As a result, in clinical settings involving two occurrences of penetration, two distinct cases were revealed depending on needle bevel positioning: spills and other forms of leakage prevented by the viscoelasticity of the rubber stopper and those promoted by the same.

著者

廣谷 芳彦 八十 永理 的場 俊哉 池田 賢二 恩田 光子 川瀬 雅也 名徳 倫明

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.6, pp.371-378, 2012-06-10 (Released:2013-06-12)

参考文献数

6

被引用文献数

5 11

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To clarify the issues involved in the promotion of pharmacists’ participation in home medical care, we performed a questionnaire survey on the implementation situation of home medical care and pharmacists’ attitudes and opinions in community pharmacies. We mailed a questionnaire to 715 community pharmacies in July 2010. The pharmacists’ attitudes and opinions were validated through text mining. 78.3% of community pharmacies were requested to visit a patient’s home and provide a pharmaceutical service, but only 53.0% of these visits were made. In many pharmacies, an average of 2.3 pharmacists provided care to within 5 patients and visited the patient’s homes twice a month. Meanwhile, 27.7% of the pharmacies delivered prescription medicines to nursing facilities, and of these, only 19.8% of the pharmacies provided instructions regarding pharmaceutical care. Only 9.1% of the pharmacists participated in training workshops related to home medical care. 48.4% of the pharmacists recognized that they had to provide pharmaceutical care visits for patients coming to their pharmacies. Only 3.7% of the pharmacists participated in joint directions at the time of hospital discharge. Results of text mining showed the need for pharmaceutical care visits for patients with poor compliance, those who found it difficult to go to the pharmacy or had dementia, and the elderly living alone. Also, the patients and other homecare staff felt the necessity for pharmacists to provide pharmaceutical care in the patient’s home. In conclusion, in order to promote home medical care, inhibitory factors such as lack of pharmacists’ manpower and cooperation with home care staff, and insufficient provision of training workshops for home medical care need to be tackled.

著者

大山 勝宏 清水 万紀子 山崎 浩史

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.5, pp.310-316, 2014-05-10 (Released:2015-05-10)

参考文献数

18

被引用文献数

1 1

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A retrospective survey of a database containing patient backgrounds and prescribed drugs was conducted to elucidate the detailed characteristics and risk factors of adverse effects caused by topical dermatological formulations of diclofenac. A total of 145,478 patients who had been dispensed topical dermatological formulations of diclofenac at 466 community pharmacies belonging to Nihon Chouzai were included in the study. Of these, 580 patients had adverse effects. The incidence of adverse effects was significantly higher in the elderly (more than 65 years old) and in female patients. A variety of systemic adverse effects were evident in 19 patients. Approximately half of these adverse effects were related to the respiratory system, eg, asthma, but the other adverse effects (eg, edema, decreases in urinary volume, tremor and others) were not described in the drug package inserts. Data from patients with systemic adverse effects, and an age- and gender-matched control group of patients underwent multivariate logistic regression analysis. Asthma (odds ratio: 13.3, 95% confidence interval: 2.40 - 95.5, P = 0.004) and the number of co-administered drugs (odds ratio: 1.25, 95% confidence interval: 1.02 - 1.55, P = 0.035) were identified as risk factors for systemic adverse effects of topical dermatological formulations of diclofenac. Moreover, many of the co-administered drugs affected P450 enzymes other than P450 2C9, the main metabolizer of diclofenac. Therefore, to manage the risk of adverse events, it was concluded that various characteristics of concomitant medications and patient's medical history should be evaluated properly before topical dermatological formulations of diclofenac are prescribed.

著者

有吉 範高

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.39, no.2, pp.61-76, 2013-02-10 (Released:2014-02-10)

参考文献数

39

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Utilization of genetic information to achieve more appropriate use of drugs has not yet progressed, although a number of studies on the association between genetic polymorphisms and responses to drugs have been performed. Comparison among groups possessing different genotypes may give a significant difference in median responses to drugs, but little answer to the wide variation of drug response in patients sharing the same genotype. In fact, genetic information alone cannot accurately predict response to drugs in each individual.However, application of genetic information is often extremely useful to correct drug therapy to a more appropriate form in certain cases. Since pharmacists have to take responsibility for drug therapy in each patient, they should use all tools available including genotyping that may achieve better treatment. Nevertheless, since genetic information alone is insufficient to design better drug therapy in most cases at present, it is important to clarify factors, which should be considered together with genetic information. Clinical researches are indispensable to identify these factors.A simple genotyping method is a powerful tool to solve problems of drug therapy encountered at hospitals and/or to provide evidence through clinical studies on usefulness to apply genetic information to improve current drug therapy. The increase in the number of pharmacists, who are interested in not only drugs but also the genetic character of patients, is expected to contribute to better drug therapy in the future.

著者

武隈 洋 岩井 美和子 藤原 俊恵 川岸 亨 熊井 正貴 松浦 麻耶 馬渕 朋美 須田 範行 宮本 剛典 荻野 修 菅原 満 宮崎 勝巳

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.7, pp.575-584, 2005-07-10

被引用文献数

5 6

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The results of cancer chemotherapy have been improved remarkably by the development of new drugs and combining drugs in treatment. However, cancer chemotherapy protocols are complicated and the adverse effects are more severe than those of other pharmacotherapies. It was therefore felt important to create a database of protocols for the preparation and dispensing of drugs used in cancer chemotherapy. Using Microsoft Access, we have created a database from 320 protocols we have collected so far from 12 clinical departments and developed operating programs for it. The database has enabled us to search for a protocol using keywords-names of drugs, diseases and clinical departments-and most of the operations can be carried out by the click of a mouse. With our database, pharmacists are able to access protocols quickly and check prescriptions of anticancer drugs even if they are unfamiliar with computers, and we consider it to be a useful tool for this purpose.

著者

剱田 侑希 門田 佳子 鈴木 小夜 青森 達 小林 典子 高木 彰紀 手塚 淑人 大谷 壽一 中村 智徳

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.2, pp.117-123, 2014-02-10 (Released:2015-02-10)

参考文献数

23

被引用文献数

1 2

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In advanced pharmacy practice experiences (APPE) in community pharmacies in Japan, students are not always satisfied with over-the-counter (OTC) counseling practice. Aiming to improve the quality of such practice, we conducted a questionnaire survey of 167 students after their APPE to assess student satisfaction and the current status and problems they experienced with OTC counseling practice. The results revealed that opportunities for practice differed among sites. While 27.8% of students had experienced selling OTC drugs to patients, 11.4% of students carried out no selling, shadowing or role play (RP). The difference arose also in student satisfaction. As expected, most students who experienced selling OTC drugs to patients rated the practice most favorably, especially students who had experienced consultation sales obtained higher satisfaction. On the other hand, most students who experienced both shadowing and RP but not the opportunity to sell OTC drugs also rated the practice quite positively; in particular, students who had more than six opportunities for shadowing and RP rated the practice favorably. In conclusion, although OTC counseling is not well practiced during APPE, mainly because of limited opportunities to sell OTC drugs, student satisfaction may be improved by introducing and increasing opportunities for shadowing and RP.

著者

三好 淳子 井門 敬子 松岡 綾 武市 佳己 山口 巧 岡本 千恵 末丸 克矢 荒木 博陽

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.3, pp.233-237, 2005-03-10

被引用文献数

10 14

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At the Division of Pharmacy in Ehime University Hospital, we conduct drug counseling training for undergraduate students and graduate students aimed at helping them acquire communication skills as well as clinical knowledge. The program relies largely on case-based learning (CBL) procedures and role-play practice using video tape recordings. In the following, we describe the drug counseling training program and report the results of a student evaluation of the program. The training program consists of the following : 1. Explanation of the procedure of the practical training; 2. Presentation of a mock case file-including a patient profile, diagnosis, clinical history, laboratory data and prescription; 3. Explanation of how to collect drug information; 4. Study of individual cases by students, 5. Role-play in providing drug counseling and recording this on video (with a student in the counseling role and a pharmacist in the patient role) and 6. Discussion and review by students and clinical pharmacists (including the person who played the patient role) after watching the video recording. After the training, we conducted a survey of the participating students by questionnaire regarding their opinions of the training program. Almost all of the students considered the practical training to be useful because it enabled them to evaluate their performance in drug counseling and communication skills objectively. They also felt that the guidance they had received from clinical pharmacists had been useful. Our training program on drug counseling using CBL procedures and video recordings is thus a simple method of training students which enables them to improve both their communication skills and clinical knowledge.

著者

宮崎 靖則 谷古宇 秀 浅山 亨 河野 博充 櫻井 正太郎 柳川 忠二

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.34, no.12, pp.1077-1085, 2008 (Released:2010-02-07)

参考文献数

13

被引用文献数

4 3

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We compared the in vitro performance of brand-name and generic spherical carbon absorbents by studying their physicochemical and adsorptive properties.There was no correlation between specific surface area and adsorption rate for pigment substances.The adsorption removal rates for pigment substances and uremic toxins were almost the same for Kremezin and Kyucal but the adsorption removal rates of some substances were lower for Merckmezin than those for Kremezin.In addition,the adsorption rates for digestive enzymes,important in vivo substances that should not be adsorbed,were high for Kremezin but low for Kyucal and Merckmezin.We found that Kremezin and Kyucal were comparable as regards the adsorption removal rate of indole in the presence of pepsin and sodium cholate,in vivo substances,but with Merckmezin,the adsorption removal rate for indole was lower.In our findings,we noted that the adsorption performance of the generic product Kyucal for most substances was equivalent to that of Kremezin while the adsorption performance of Merckmezin for some substances was lower than that of Kremezin.As a particular conclusion,the lower adsorption removal rate of Merckmezin for indole in the presence of vivo substances needs to be taken into consideration as this will affect clinical results.

著者

中島 由紀 高尾 斎昭 前川 理沙 寺田 さとみ 椎尾 康 大谷 道輝 杉浦 宗敏 山村 喜一 内野 克喜

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.5, pp.323-325, 2011 (Released:2012-08-02)

参考文献数

7

被引用文献数

1 1

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We prepared dried thyroid rectal suppositories for the treatment of thyroid papillary adenocarcinoma in patients with hypothyroidism in response to clinicians’ requests. The suppositories had a content of 50 mg or 100 mg and were prepared using dried thyroid powder and hard fat. The initial daily dose of 100 mg, which was given as a single dose in the morning, could be increased on the basis of thyroid stimulating hormone (TSH) levels, as required. In addition, an oral dose of levothyroxine sodium hydrate 150 μg could be switched to a dose of 300 mg of dried thyroid rectal suppositories in this patient.These results suggested that the dose of dried thyroid rectal suppositories for the treatment of hypothyroidism should be titrated for individual patients based on TSH levels.

著者

石塚 良子 深津 祥央 丸山 志穂子 中桐 真樹子 尾崎 淳子 石津 雅弘 乾 賢一 篠山 重威

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.1, pp.57-62, 2001-02-10 (Released:2011-03-04)

参考文献数

11

被引用文献数

1 1

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Pharmacists play various roles other than merely dispensing test drugs at our hospital for the appropriate performance of clinical trials in accordance with the new GCP guidelines : e.g. do a preliminary review, function as the office of the Institutional Review Board, prepare for monitoring and auditing by the sponsor, conduct the follow-up of patients involved in clinical trials, check for inclusion/exclusion criteria on enrollment. Pharmacists thus contributed to the successful completion of 93 cases from July 1997 to January 2000. The items of management were as follows : 1) the prevention of protocol deviations (46 cases), 2) the follow-up of subjects (22 cases), 3) managing the financial affairs and payments to subjects (14 cases), 4) corresponding to adverse events in subjects (9 cases) etc. Especially, 18 cases of protocol deviation occurred at the time of enrollment, and most of them were a contravention of exclusion criteria such as medication using prohibited combinations. Supports for the appropriate enrollment of patients into clinical trials was thus suggested to be important to ensure the safety of patients. Based on the above information, pharmacists should therefore play an active roll in clinical drug trials since their professional knowledge and skill are often of vital importance.

著者

尾田 一貴

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.6, pp.335-344, 2011 (Released:2012-08-25)

参考文献数

33

被引用文献数

2 8

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In order to contribute to antimicrobial stewardship, it is extremely important for pharmacists to apply PK / PD theory (combination of pharamacokinetics (PK) and pharmacodynamics (PD)) as well as the montecarlo simulation. However, very little useful PK / PD simulation software incorporating the montecarlo simulation is available for the clinical setting. We therefore developed easy-to-use software for this purpose based on Microsoft® Office Excel.With it, drug clearance, volume of distribution, and PK / PD parameters are easily calculated using correlation equations derived from patient parameters, such as serum creatinine level and body weight, based on population pharmacokinetic parameters reported by various researchers. The montecarlo simulation is performed by generating pseudorandom numbers based on antibiograms, or interindividual coefficients of variation for each population pharmacokinetic parameter. We found that population pharmacokinetic parameters reported as following a 2-compartment model could be used as a 1-compartment model in the montecarlo simulation and report for the first time that the RN method (consisting of the RAND function and NORMSINV function in Microsoft® Office Excel) can be utilized as a pseudorandom number generator in the same manner as the MB method (consisting of Mersenne-Twister method and Box-Muller method).Adoption of this software in the clinical setting will enable us to evaluate individual patient PK / PD parameter values and contribute to providing useful evidence for PK / PD theory.

著者

山本 吉章 家田 直幸 三島 信行 松田 一己 高橋 幸利 賀川 義之

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.7, pp.411-418, 2011 (Released:2012-08-30)

参考文献数

25

被引用文献数

1

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This study was designed to evaluate the persistence and safety of topiramate therapy in children and adults with epilepsy. It was a retrospective cohort study undertaken from October 2007 in which we analyzed the clinical records of 726 patients (216 children and 510 adults) who received topiramate for the treatment of epilepsy at the National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders. Factors associated with discontinuation of topiramate therapy determined from the results of the log-rank test (p<0.1) were subjected to multivariate Cox regression analysis in order to calculate hazard ratios and 95% confidence intervals (95% CI).Suspension (Discontinuation) or dose reduction of topiramate were necessary due to adverse effects in 85 children (39%), of which the major ones were drowsiness (16.2%), anorexia (10.7%), hypohidrosis (4.7%), and irritability (4.2%). There was a higher incidence of hypohidrosis and a lower incidence of speech disorders in children as compared with adults (both p < 0.05). According to Cox proportional hazards analysis, the adjusted hazard ratio for discontinuation of topiramate therapy in children was 0.92 (95% CI : 0.75-1.23 ; p=0.76). In conclusion, this comparative study showed that the persistence and safety of topiramate therapy were similar in children and adults.

著者

中川 直人 Leanne Lai 眞野 成康

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.39, no.1, pp.25-32, 2013-01-10 (Released:2014-01-10)

参考文献数

29

被引用文献数

1

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This article discusses pharmacy practice training in the US and Japan for the purpose of improving pharmacy practice training in Japan. The authors compare the Advanced Pharmacy Practice Experience (APPE) in Nova Southeastern University (NSU) Doctor of Pharmacy program with the pharmacy practice training in Japan. The NSU APPE inhospital focuses on clinical practice training. It does not provide dispensing and drug distribution practice training, which are important as basic practice in Japan. On the other hand, there is no difference in the community pharmacy training between the NSU APPE and the pharmacy practice training in Japan.The article also examines students' limits in the NSU APPE and pharmacy practice training in Japan, classifying participation as (A) students performance without preceptors with post-performance approval by preceptors and (B) students performance under direct preceptor's supervision. There is no difference in hospital training between the NSU APPE and pharmacy practice training in Japan. However, there are significant limits on dispensing practice training in community pharmacies in Japan.

著者

中野 玲子 武藤 達也 虎石 顕一 朝倉 俊成

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.34, no.7, pp.705-710, 2008-07-10

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To clarify the factors in preference for insulin injectors, 69 subjects (aged 20-49 years) were asked to select 1 of 4 different injectors and then to complete a questionnaire regarding 9 selection factors regarded as important, among them "ease of gripping" and "portability" , before and after instruction on operating the injectors. "Portability" was considered the most important factor for selecting injectors on first impression, i.e. before instruction, and the percentage of subjects choosing "simplicity of operation" increased after instruction. About half of the subjects selected a different injector before and after instruction, so there appeared to be a relationship between injector selection and the evaluation factors. From the results, we made a table which we thought would be helpful in selecting insulin injectors based on factors regarded as important when using them in practice.

著者

鹿角 昌平

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.10, pp.628-633, 2012-10-10 (Released:2013-10-10)

参考文献数

9

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Although the importance of generic medicines has been increasing in recent years, knowledge about related intellectual property rights disputes is scarce, so the purpose of this study is to analyze disputed cases of intellectual property rights as a supply risk of generic medicines. With 57 analyzed cases, the right to seek injunction was accepted in 4 cases, but provisional execution was not accepted. Furthermore the right to seek injunction was actually executed in only 1 case. Therefore, there were disputed cases of intellectual property rights as a supply risk of generic medicines, but it was suggested that the risk is restricted.

著者

中島 輝一 真野 泰成 大内 かおり 佐藤 大輔 岩田 杏子 樋口 安耶 江原 邦明 加藤 芳徳 廣澤 伊織 田島 正教 土屋 文人 山田 治美 小瀧 一 旭 満里子

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.9, pp.599-608, 2012-09-10 (Released:2013-09-12)

参考文献数

9

被引用文献数

4 17

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We established a pharmaceutical outpatient clinic at the International University of Health and Welfare Mita Hospital. In the clinic, pharmacists provide mainly pharmaceutical care for cancer outpatients based on prescriptions from a doctor, and then feed back the contents of medication counseling and information about patients to doctors.In this study, we evaluated the role of the pharmaceutical outpatient clinic. From April to July 2011, we investigated retrospectively the contents of feedback from pharmacists to doctors. The contents consisted of three types of information such as medication counseling, history of side effects and allergy, and uneasiness from patients. Most of this information was on side effects. Approximately 42% of uneasiness from patients was about the side effects of chemotherapy. Furthermore, we conducted a questionnaire survey in 62 cancer outpatients that gave informed consent during the period as mentioned above. The results showed that the degree of understanding of drugs on treatment and prevention of the onset of side effects after consultation was markedly improved compared with those before consulting. Many patients (50/62) felt “uneasiness about treatment" and “some uneasiness" before consultation. However, 88.0% (44/50) of them noted that their “anxiety was eased" after consultation. The degree of reduction in uneasiness in patients with stage Ⅰ and Ⅱ breast cancer was larger than that with stage Ⅲ and Ⅳ. In conclusion, it is suggested that the clinic may play a role which makes it possible to enable cancer outpatients to participate in medical treatment with ease, in addition to enabling support for doctors.

著者

粟屋 敏雄 大滝 康一 石原 昌司 小野 尚志 千葉 薫 板垣 祐一 山田 武宏 須野 学 早勢 伸正 田崎 嘉一 松原 和夫

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.6, pp.425-434, 2005-06-10

参考文献数

11

被引用文献数

1 5

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出版社版新規システム導入後のオーダシステム内の記録から,処方が試みられた併用禁忌の組み合わせなどを解析した.相互作用チェックは,その処方の投与期間内に重複しているすべての薬品を自処方内および他処方内の薬歴データファイルから抽出し,チェック対象薬剤が重複した場合,チェックメッセージを表示した.システム運用開始以降,13ヵ月間における処方せんおよび注射指示せんの枚数はそれぞれ290956枚,299017枚の計589973枚であった.調査期間内にチェックのかかった回数は299件であった.警告としたものを除く173件中,96件は処方が中止された.時間外の併用禁忌の処方の危険率は時間内に比べ実に4倍近くにも上った.オーダ別にみると,実に80%近くの併用禁忌の組み合わせは注射薬が関与するものであった.最もチェックのかかった頻度が高かった薬剤の組み合わせはトランサミン注とトロンビン細粒の組み合わせであった

著者

吉田 侑矢 辻 琢己 細田 敦規 河野 武幸 久保 貞也 佐竹 正人 難波 洋 瀬野 智美 前田 定秋

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.5, pp.288-298, 2012-05-10 (Released:2013-05-10)

参考文献数

3

被引用文献数

2 1

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In the future, over-the-counter (OTC) drugs for chronic diseases, such as diabetes mellitus, hypertension and hyperlipidemia, may partly replace prescription drugs, and pharmacists will be required to advise patients on the proper use of these drugs. At present, the curriculum unit “Learn over the counter” is a part of the model core curriculum of the pharmacy practice externship. However, there is a gap between the general instructional objective (GIO) of this unit and the occupational ability of current pharmacists. To fill the gap, it is necessary to create a new instructional program on campus as a part of the 6-year pharmacy education program. We have developed a new approach that includes specific behavioral objectives (SBOs) for OTC, supplements and health consultation. The effectiveness of this approach was evaluated by means of a questionnaire survey and a text-mining approach based on free description. The results indicated that pharmacy students realized the importance of self-medication. In addition, they understood the responsibility of pharmacists in relation to the prevention of disease onset, the provision of advice on appropriate OTC drugs, interaction with the patient and provision of drug information. We consider that our approach will be helpful to educate pharmacists about the need to promote effective self-medication.