著者

小金 一恵 二神 幸次郎 岡崎 昌利 谷口 律子 荒木 博陽 五味田 裕

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.599-604, 2002-12-10 (Released:2011-03-04)

参考文献数

6

被引用文献数

2 1

---

We have recently instituted an audit system with the goal of maintaining and improving quality in pharmaceutical management and counseling services, i.e., pharmaceutical care practices. This system was created to improve the quality of record keeping for counseling services. The audit system is composed of 5 supervising pharmacists. A meeting is held once a month, and an audit is carried out concerning the patient compliance instruction documents, medication history and practice records of 2 clinical departments. In addition, methods for improving business efficiency are also discussed. We herein report on the specific guidance given to the supervising pharmacists of each clinical department, based on a total of 12 audit conferences. As a result, four problems were identified : (1) fundamental description issues, (2) record keeping modes, (3) insurance demands, (4) pharmaceutical perspective. The following improvements were instituted after notifying the relevant pharmacists and all other pharmacy staff of these problems : a reduction in the leakage of specific items, corrections of the records explaining the pharmacological effects, establishment of a drug interaction checklist, simplification of laboratory data records, simplification of the format, utilization of a problem list field, and other issues. The role of this audit system in maintaining and improving the quality of pharmaceutical management and counseling services has become increasingly important because as the counseling services for patients continue to expand.

著者

田上 直美 高野 佐知子 本田 義輝 〓田 聡 谷崎 正典 吉原 博幸 中野 眞汎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.583-589, 2002-12-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

4 2

---

Recently, pharmaceutical care is increasing in importance. Pharmacists must provide pharmaceutical counseling services that can satisfy all patients. However, there are limitations in manpower and a lot of effort has to put devoted to using such manpower as effectively as possible. With this in mind, we developed a medication consultation support system for pharmacists to achieve an improved medical quality. As a result, labor saving results were obtained in document preparation of medication histories, laboratory test histories, and medication instruction records. Furthermore, the total work need to create medication instruction daily reports, monthly reports, etc. also decreased. As a result, the time and work pressure experienced by pharmacists decreased while the overall quality of this system was maintained.

著者

井藤 達也

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.511-520, 2002-12-10 (Released:2011-03-04)

参考文献数

26

被引用文献数

1 2

---

The purpose of this study was to evaluate the distribution of CPT-11 and its active metabolite, SN-38, in both pleural and pericardial fluid after intravenous administration.Two patients with lung cancer were intravenously treated with 60mg/m2 CPT-11 on days 1, 8, and 15. The CPT-11 was detected in the pleural fluid 1.5 hrs after the start of intravenous infusion, and its level reached a maximum 24 hrs later. Similarly, the active metabolite SN-38 was detected in the pleural fluid 1.5 hrs after the start of intravenous infusion. In addition, the SN-38 concentration in the pleural fluid was almost as high as that in the plasma 24 hrs later. These results suggest that intravenously administered CPT-11 may penetrate into the thoracic cavity and therefore be metabolized into SN-38 there. The maximum concentrations of CPT-11 and SN-38 in the pleural fluid to the corresponding plasma levels were 20. 4 % and 28. 5%, respectively. In addition, the AUCs of the lactone form of SN-38 were much lower than that of the carboxyl form in the pleural fluid.CPT-11, SN-38 and SN-38 glucronide all showed similar pharmacokinetics in the pericardium to that in plasma.

著者

濃沼 政美 西澤 光代 瀬尾 誠 高瀬 知永 平野 公晟 伊藤 克敏 荒川 秀俊 前田 昌子

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.541-550, 2002-12-10 (Released:2011-03-04)

参考文献数

5

---

The most important aspect of an indwelling inter vascular catheters is to maintain the patency of the catheter. We recently developed a Heparin Lock Flush Solution Kit for use with center vein catheters (only in use at our Hospital). The kit consists of a syringe filled with 9 mL of normal saline (NS) and 1 mL of heparin (1000 IU/mL). We performed the following tests to evaluate the stability, sterility, seal, and dust identification in the preparation. The stability and sterility data indicated that heparin maintained its potency and had no bacterial contamination for 3 months. Testing the seal of the syringe indicated that the seal remained patent at a temperature range of 5°C to 60°C. We also found that even if we sterilized a syringe made of polypropylene using ethylene oxide gas (EOG), no toxins (i.e., ethylene oxide, ethylene chlorohydrin, ethylene glycol) were produced. Next, we examined the preparation time and cost to evaluate the practical benefit of developing the kit. According to our results, the estimated preparation time and cost were 43% and 29% less than for previous methods, respectively. Finally, we put a label on the medicine kit to prevent any misuse by the medical staff.

著者

寺町 ひとみ 畠山 裕充 松下 良 今井 幸夫 宮本 謙一 辻 彰

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.530-540, 2002-12-10 (Released:2011-03-04)

参考文献数

17

被引用文献数

7 7

---

The department of pharmacy which is a member of the Infection Control Committee in Kouseiren Chu-nou Hospital provided a systematic program of vancomycin (VCM) therapeutic drug monitoring (TDM) and consultations regarding the suitable dose and administration interval etc. of VCM for both patients and physicians. However, in many cases the initial dosage and dose interval were empirically decided by the physician.In the present study, we retrospectively examined three nomogrames that were recommended as the rough standard for determining the initial dosage and dose interval, in comparison to the Bayesian method, based on our hospital data collected from adult MRSA patients. We also compared our findings with the Moellering's method, Matzke's method, Maeda's method and the Population mean methods.Maeda's method did not predict the serum trough and peak levels that reach poisonous ranges. Maeda's method was found to be a safe method. In addition, Maeda's method was found to reach the therapeutic ranges the most frequently of the four methods. Furthermore, the calculations for Maeda's method were simpler than the other three methods. Accordingly, it is possible to easily calculate the initial dosage and dose interval in the clinical field. The serum VCM concentrations should thus be measured for each patient, as soon as possible, to correct the dosage using the Bayesian forecasting technique, because the therapeutic ranges sometimes deviate from the predicted range.

著者

寺岡 麗子 松田 芳久 杉本 功

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.521-529, 2002-12-10 (Released:2011-03-04)

参考文献数

9

被引用文献数

1 2

---

Guanidine hydrochloride, which is known to be effective in the treatment of Lambert-Eaton myasthenic syndrome, is very hygroscopic. Therefore, the mixture of the drug and lactose dispensed at hospital pharmacies tends to easily liquefy even under ordinary storage conditions because of poor compatibility. In this study the physicochemical and chemical stabilities of commercially available guanidine salts, namely hydrochloride, nitrate, carbonate, and sulfate, were investigated at various relative humidity levels. The critical relative humidity of the hydrochloride salt was significantly lower than the others and it was also more hygroscopic than the other three salts, however, nitrate was found to be sufficiently stable regarding humidity. The powder maintained a good flowability after long storage periods. The optimal diluent was selected to use in powders consisting of guanidine hydrochloride in order to stabilize the physicochemical and chemical properties. No solidification or change in appearance were observed in the mixture of the drug and magnesium aluminometasilicate (Neusilin® US2) as diluent and moisture adsorbent. The flow property (angle of repose) of this mixture was also investigated.

著者

前田 剛司 坂田 洋

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.495-501, 2002-10-10 (Released:2011-03-04)

参考文献数

10

被引用文献数

1 2

---

The injection auto ample dispensing equipment, combined with an ordering system, was established at the Kasugai Municipal Hospital. This equipment enabled us to give a patient one injection per prescription unit out of approximately 400 different prescriptions. In the hospital, this is now available in every ward except in the ICU. This system has been functioning favorably since its installation : it accurately produces prescriptions for injections, written instructions for injections, and labels for infusion bottles. Due to these traits, the people who work in the wards think highly of this system.A safety control system to prevent medical mishaps has been established because drug duplications and interactions with all types of medications can be checked with the injection auto ample dispensing equipment before administering injections to patients. However, we still have some problems to solve : namely, we still have to check the incompatibility and maintain the stability in mixing injection drugs.

著者

高柳 理早 山田 安彦 河野 真理子 中村 均 佐藤 均 伊賀 立二

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.489-494, 2002-10-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

1 1

---

The new Good Clinical Practice (GCP) guidelines, which were based on ICH-GCP, were enforced in Japan in April 1997. These guidelines recommend that pharmacists play the role of managers of investigational drugs and also as cooperators (clinical research coordinator) in the performance of clinical trials. In this study, we carried out a survey of the attitude of the new graduate pharmacists (the group of graduates in the 1998 fiscal year and a group of graduates in the 1999 fiscal year) on clinical trials. After the first questionnaire, we lectured the students on GCP and performed clinical trials, and then the second questionnaire was conducted two months later. The group of graduates in the 1999 fiscal year had more opportunities to come in contact with information on clinical trials than the group in the 1998 fiscal year. Both groups knew that new GCP guidelines had been established, but they did not understand the details. Some of them had a negative impression concerning clinical trials. The lectures improved their knowledge and impression on the practice of clinical trials. After the lecture, over 90% of them thought that pharmacists should manage investigational drugs and provide information on these drugs for the rational practice of clinical trials. Furthermore, in 60% or more of the students, an improvement in the consciousness of evaluating the safety and efficacy of investigational drugs regarding the pharmacist's role was found.

著者

湯元 良子 高野 幹久

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.484-488, 2002-10-10 (Released:2011-03-04)

参考文献数

7

---

Clinical research as well as basic research is one of the important aspects for the development of clinical pharmacy. In clinical pharmacy research, like research in medicine, it is desirable to find and investigate problems on clinical pharmacotherapy and to utilize the findings of such results in the therapy. In order to promote such clinical pharmacy research, collaboration between hospital or community pharmacies and pharmaceutical universities is very important, because the former usually does not have enough space, equipment, or pharmacists to do the research, and the latter usually does not have chance to find the problems in clinical pharmaco-therapy. In the present study, we carried out a questionnaire survey concerning clinical pharmacy research, in order to clarify the present situations and needs in hospital or community pharmacy in Hiroshima prefecture. The results indicated that many pharmacists in hospital as well as community pharmacy feel that it is necessary to do clinical pharmacy research to understand and clarify the problems they found in clinical pharmacotherapy. In addition, though many of them are either not doing or can not do clinical pharmacy research under the present situation, they are interested in collaborating with pharmaceutical universities. These results offer important information in promoting clinical pharmacy research based on the collaboration between hospital or community pharmacies and pharmaceutical universities.

著者

平井 みどり 八木 敬子 木口 敏子 長嶺 幸子 冨田 尚子 上田 久美子 平井 由華 加藤 史恵 寺岡 麗子 大塚 誠 岩川 精吾 松田 芳久

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.461-467, 2002-10-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

5 5

---

Effective communication is central to patient-centered care in the successful practice of pharmacy. As well as communication skills, a pharmacist should acquire an effective presentation technique to establish interpersonal communication at a more than purely on a verbal level. Most undergraduates of Kobe Pharmaceutical University undergo practical training in hospitals or community pharmacies. It is essential for students to acquire communication skills in order to derive the full benefit from the practical training. We introduced a presentation and communication program at the pre-practical training stage. In the presentation component, students were asked to make a presentation on eight different aspects of a certain drug; in the communication component, students took part in a session where they learned and discussed interview skills, non-verbal communication, open-ended questioning and effective communication. Questionnaires answered by the undergraduates suggested that this training course had made a strong impression on them and had served as a useful guide to acquiring the presentation and communication skills essential in pharmaceutical care.

著者

松元 美香 大谷 道輝 馬島 裕子 並木 路広 假家 悟 内野 克喜

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.450-455, 2002-10-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

2 1

---

It is important that laboratory data to be constantly checked according to described package inserts during usage of medicines. However, many hepatic and renal disorders were reported to have strong adverse reactions for prescription drugs. We investigated the necessity of hepatic and renal function checks in package inserts for 3300 prescription drugs. As a result, the number of drugs which recommended checks on hepatic and renal functions were 240 (7.3%) and 209 (6.3%) respectively. The described expression or place regarding checks of hepatic and renal functions on package inserts were various types of unclear information to doctors and pharmacists. We thus found that the present style of package inserts unapprehensive to the necessity of hepatic and neral function checks. So, in our hospital, we decided to provide a list of drugs that required hepatic and renal function checks during administration of drugs.These findings suggest that the need of hepatic and renal functions monitoring during the administration of drugs by the establishment of a new Clinical Checks item in the package inserts is therefore necessary.

著者

影山 恵美子 古岩 清子 木村 りつ子 折井 孝男 伊賀 立二

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.435-442, 2002-10-10 (Released:2011-03-04)

参考文献数

3

---

The Ministry of Health and Welfare (the present, Ministry of Health, Labour and Welfare) has begun to report the recall information of medical supplies (in short, recall information) on the home page of the pharmaceutical information provision by the Organization for Pharmaceutical Safety and Research since April 1 st, 2001. However, all recall information on the home page appears the day after the official publication. In case of medical devices in comparison to pharmaceuticals, it takes a longer time to be reported on the home page. However, such recall information is valuable, because it is the only information source, which medical institutions can obtain up-to-date information spontaneously.At Uwajima City Hospital, from May 2001, the pharmacists have participated in a safety management program regarding new medical devices or medical materials.In order to keep all medical materials safe, pharmacists check the recall information regularly and provide them to the clinical site for risk management. Not only the medical institutions but also the dealers have begun to make practical use of such recall information. However, no system for using such information has yet been established among them. According to the regulations of recall information, a contact system from the maker to the dealer has been established. However, the first information of medical devices is always obtained through the home page. The way to obtain the information has been changing.Needless to say, the “Internet” is nowadays the main media for the communications all over the world. Accurate information must be speedy and reliable. The rational use of such information on the Internet is therefore urgently needed.

著者

後藤 伸之 吉村 直人 萱野 勇一郎 渡辺 享平 林 美由 青池 美穂 白波瀬 正樹 脇屋 義文 政田 幹夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.4, pp.401-406, 2002-08-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

1

---

A heparin lock is technique performed in order to prevent blood coagulation in the needle detained in the vessel, or a catheter. In Japan, when we perform a heparin lock, a heparin injection is diluted with physiological salt solution before use. We need to use prefilled syringes with diluted heparin. We received a sample of this product. We investigated the user-friendliness of the product. From our results, the prefilled syringe with the diluted heparin was found to be useful. Furthermore, when we use the prefilled syringe with diluted heparin, patient safety is increased.

著者

伊藤 雄大 髙田 麻季 飯田 真之 宇田 篤史 住吉 霞美 秋山 恵里 丸上 奈穂 丹田 雅明 野間 千尋 山本 和宏 五百蔵 武士 木村 丈司 西岡 達也 久米 学 槇本 博雄 矢野 育子

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.44, no.5, pp.236-243, 2018-05-10 (Released:2019-05-10)

参考文献数

18

被引用文献数

2

---

Team-based learning (TBL) is an active learning method which has been designed to help students solve problems both by themselves and as a team. In this study, TBL was introduced in the journal club (gathering to read and discuss medical papers) for pharmacists, and its effectiveness was compared with that of a traditional lecture. The subjects, 29 pharmacists at Kobe University Hospital, were randomly allocated to the lecture group and TBL group. The pre-test was conducted two months before the journal club, and the post-tests were conducted immediately and one month after the journal club. There was no significant difference in the background data of the pharmacists between the lecture group and the TBL group. The score differences between the pre-test and the post-test immediately after the journal club were not significant (11.4 ± 2.3 points (mean ± SD) in the TBL group, 8.8 ± 4.2 points in the lecture group, P = 0.14). The post-test scores immediately after the journal club in the TBL group (19.6 ± 0.5 points) were significantly higher compared with those in the lecture group (17.8 ± 1.5 points) (P < 0.01), and the learning effect provided by TBL tended to be maintained one month after the TBL. In conclusion, TBL was an alternative method of the ordinal lecture and may be a useful learning method for pharmacists to read medical papers critically compared with the ordinal lecture.

著者

石田 和久 中尾 承司 佐多 照正 岩下 佳敬 本田 香奈恵 山下 カオリ 黒木 久知 田辺 元 山崎 芳人 上田 勝

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.3, pp.259-262, 2002-06-10 (Released:2011-03-04)

参考文献数

8

被引用文献数

2 2

---

In order to examine the fungistatic action of TPN fluids against Candida abicans, which was clinically isolated and chosen as a model fungus because of its high risk of infection, we attempted to compare the TPN products commonly used at our hospital. Furthermore, we also investigated the effects of pH and sodium bisulfite (NaHSO3) on this action. Under the respective conditions of a lower pH or higher concentration of NaHSO3, the fungistatic action was weakly recognized, however, under the both conditions (lower pH and higher concentration of NaHSO3), a remarkable fungistatic action was observed.

著者

菅原 満 荻野 修 宮崎 勝巳

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.3, pp.256-258, 2002-06-10 (Released:2011-03-04)

参考文献数

4

被引用文献数

2 1

---

Zyvox® (linezolid), an oxazolidinone-class synthetic antibacterial agent, has been approved for the treatment of vancomycin-resistant Enterococcus faecium infections. Although there are three forms of this drug, including injection, tablets and oral suspension, presently available overseas, only injection and tablets have so far been approved in Japan. It is possible to use ground tablets as an oral suspension. However, the quality including the stability of linezolid in such a suspension has not yet been studied. In this study, we therefore, examined the stability of linezolid in a suspension of ground tablets and the characteristics of such a suspension. The solubility of linezolid was low, and approximately 85% of linezolid was suspended in a solid phase. Linezolid was stable in the suspension, and there were no differences in the pH for up to 24 hours. However, precipitation occurred rapidly after the ground tablets had been suspended. The concentration of linezolid in the upper layer of the suspension decreased to half of the initial concentration in 15 min.In conclusion, Zyvox® was found to be stable and therefore is considered suitable to be ground and used in an oral suspension. Such suspensions should be re-suspended just before use, especially when the suspension is pre-constituted.

著者

高橋 昌也 新井 克明 本間 真人 鈴木 勝 佐藤 信一 幸田 幸直

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.2, pp.172-175, 2002-04-10 (Released:2011-03-04)

参考文献数

9

被引用文献数

2 1

---

To investigate the description of the expiration date and manufacturing number on the drug packages, “pillow” packages and “heat-seal” packages, the questionnairing was carried out to pharmaceutical companies. Fifty-six drugs consisting of three hundred thirty-seven items, with sales of over 10 billion yen in 1998, were investigated at the corresponding 26 companies. The recovery rate of the questionnaire from the company was 100%, and the answer for all questions was also perfect. Three hundred fourteen items (93%) have had description regarding the manufacturing number and/or the expiration date on the heat-sealed packages. The manufacturing number took precedence over the expiration date. Of 269 pillow packages, 69 items (26%) have had description of manufacturing number and/or expiration date on the pillow package. There were 41 products (12%) that the company did not guarantee an expiration date being described on the box container when the packages were taken out from the box container.As a result, the description of the manufacturing number and expiration date on the packages, “pillow” and “heat-seal”, is still not complete even though the companies guarantee the expiration date when the drugs were stored with these packages. Since the information of the expiration date is necessary for the appropriate management of tablet and capsule products, it is required to describe manufacturing number and expiration date on every drug package including “pillow” and “heat-seal” packages.

著者

西山 祐美 北田 徳昭 関戸 聡子 小林 睦 渡 雅克 内田 享弘 松山 賢治 黒田 和夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.2, pp.184-191, 2002-04-10 (Released:2011-03-04)

参考文献数

10

被引用文献数

4 4

---

A four-week practical hospital training course for undergraduates at Takarazuka Municipal Hospital has been conducted since 1998. The curriculum at our hospital consists of three elements, i.e., lectures on hospital pharmacy, the dispensing service and the clinical pharmacy service. Regarding the clinical pharmacy service, a case study had token a long time for the purpose of learning the actual services. In this study, we compared the results of the new curriculum with those of previous curriculums to establish a more effective and practical curriculum for undergraduates. Our curriculum showed no significant difference with the findings of other reports. Next, we investigated the student' s awareness by questionnaire. The results showed that most students developed on increased awareness of the pharmacist' s daily practice by the end of the practical training course. However it also showed a tendency that their interests in pharmacy practice differed according to their future courses and the university they were studying.From these results, further progress therefore appears to still be obtainable by increasing the cooperation between pharmaceutical universities and hospital pharmacies. In addition, it was considered that our curriculum should be further improved by better meeting the needs of students during the practical training course.

著者

花輪 剛久 青木 歩 花輪 和己 手塚 春樹 荒井 千春 河田 圭司 鈴木 正彦 中島 新一郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.2, pp.176-183, 2002-04-10 (Released:2011-03-04)

参考文献数

11

被引用文献数

2 2

---

The stability of powdery dosage forms of drugs prepared by unsealing the packages was investigated. For 247 articles purchased by the Yamanashi Medical University Hospital, the variables related to the evaluation of stability after unsealing these packages and investigating the contents based of an “Interview Form”. A longterm preservation test was carried out on 153 items (94%), and the mean length of the test was about 36 months. The acceleration and the severity tests were carried out using 17 items (10.4%) and 114 items (69.9%), respectively. The mean conditions of the acceleration test was 40°C/6 months, which agreed with the guidelines proposed by the “Drug Manufacturing Guidelines”. On the other hand, for the severity test, certain conditions for the evaluation could not be arranged, and testing was carried out under various conditions. In order to improve the efficiency of dispensing and the quality of life for patients, a further increased standardization of the testing conditions is recommended.

著者

田中 睦子 河野 健治 花輪 剛久 鈴木 正彦 中島 新一郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.2, pp.152-156, 2002-04-10 (Released:2011-03-04)

参考文献数

12

---

Di-2-ethylhexyl Phthalate (DEHP) was reported to dissolve from a polyvinyl chloride (PVC) administration tube during the infusion of an injection fluid containing a solvilizing agent, soybean oil or lecithin, etc. This paper describes the behavior of DEHP dissolution from PVC tubes during enteral tube feeding. The DEHP concentration was determined using HPLC. After the passage the ENSURE LIQUID® (EL) solution through the PVC tube, DEHP was dissolved in the EL solution. The EL solution is one type of enteral nutrition. This dissolution pattern was similar to that of injection fluid containing a solvilizing agent, in which the DEHP concentration in the EL solution increased linearly over time at first and thereafter reached a plateau. 170 μg of the DEHP was dissolved after 200mL of the EL solution had passed through the PVC administration set (the drip conditions were 25°C, 100mL/hr, tube length 115cm and inner diameter 0.3cm). The amount of DEHP which dissolved into the solution depended on the temperature (25-40°C), and no clear difference was observed between the PVC tubes (administration tube, feeding tube). In addition, the amount of DEHP that dissolved into the solution varied depending on the type of enteral nutrition.