著者

土井 輝生

出版者

早稲田大学法学会

雑誌

早稲田法学 (ISSN:03890546)

巻号頁・発行日

vol.52, no.1-2, pp.77-99, 1977-03-25

著者

Hoshi Shu-ling Kondo Masahide Okubo Ichiro

出版者

Elsevier

雑誌

Vaccine (ISSN:0264410X)

巻号頁・発行日

vol.31, no.25, pp.2762-2771, 2013-06

被引用文献数

18 2

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Japan is now preparing to incorporate PCV-7 into the national childhood immunisation programme. Our recently published economic evaluation of using PCV-7 to the birth cohort suggests that the cost to gain one QALY is lower than the WHO's cost-effectiveness criterion for intervention. However, many countries have started to introduce PCV-13 into their national immunisation schedule replacing PCV-7 for preventing pneumococcal diseases among young children. These raise the need to appraise the ‘value for money’ of replacing PCV-7 with PCV-13 vaccination programme in Japan.We conducted a cost-effectiveness analysis with Markov model and calculated incremental cost effectiveness ratios (ICERs). Our base-case analyses, which assumed both PCVs have no net indirect effect and set the cost of PCV-7/PCV-13 per shot at ¥10,000 (US$125)/¥13,000 (US$163).The results show that in Base-case A (assumed PCV-13 has no additional protection against AOM compared to PCV-7), replacing PCV-7 with PCV-13 will cost ¥37,722,901 (US$471,536) or ¥35,584,455 (US$444,850) per QALY when the caregiver's productivity loss is not included or is included, respectively. While in Base-case B (assumed PCV-13 has additional protection against AOM compared to PCV-7), ¥343,830 (US$4298) per QALY or more QALY is gained by saving money without or with caregiver's productivity loss, respectively.We also find that, in Base-case B if cost per PCV-13 shot is equal to or less than that ¥17,000, then a PCV-13 vaccination programme offered to the birth cohort in Japan is likely to be a socially acceptable option compared to the current PCV-7 vaccination programme. Furthermore, if cost per PCV-13 shot is equal to or less than ¥12,000, replacing PCV-7 with PCV-13 will save money and gain more QALYs. While in Base-case A, the replacement can only be socially acceptable if cost per PCV-13 shot is equal to or less than ¥11,000.

著者

小関 隆

出版者

京都大学人文科学研究所

雑誌

人文學報 = The Zinbun Gakuhō : Journal of Humanities (ISSN:04490274)

巻号頁・発行日

vol.89, pp.45-96, 2003-12

著者

高村 学人

出版者

早稲田大学法学会

雑誌

早稲田法学会誌 = The Waseda Law Journal (Waseda Hougakukaishi) (ISSN:05111951)

巻号頁・発行日

vol.48, pp.105-160, 1998-03-25

著者

小島 廣光

出版者

北海道大学經濟學部 = HOKKAIDO UNIVERSITY SAPPORO,JAPAN

雑誌

經濟學研究 (ISSN:04516265)

巻号頁・発行日

vol.38, no.2, pp.23-31, 1988-09

著者

松井 雄志

巻号頁・発行日

2012

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筑波大学博士 (工学) 学位論文・平成24年3月23日授与 (甲第6032号)

著者

中山 留美子 長濱 文与 中島 誠 中西 良文 南 学

出版者

京都大学高等教育研究開発推進センター

雑誌

京都大学高等教育研究 (ISSN:13414836)

巻号頁・発行日

vol.16, pp.37-48, 2010-12-01

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In 2009, a First-Year-Experience (FYE) course of Mie University was introduced as an endeavor to transform students into active learners by having them acquire the university's educational goals. Mie University established this program to allow the students acquire generic skills broadly categorized into four abilities: to appreciate (kanjiru), to analyze (kangaeru), to communicate, and to integrate those skills in various practical situations (ikiru). The course consisted of 16 sessions. The first five sessions emphasized communication practices to enable the students to brush up their discussion skills. In the next seven workshops, the students were assigned a group project to complete. The last four sessions included presentation, evaluation of the projects, and reflection of their achievements. The student's responses were measured by a scholastic achievement evaluation, which was administered in September. To clarify the effect of the FYE course, we compared the evaluation of students enrolled in 2008 with 2009. ANOVA revealed significant differences in the evaluations. Their expectancy to acquire the four abilities was not as low as those who did not take this course. In addition, the majority of the students felt that their communication and practical skills had improved. Among all freshman in 2009, the evaluations for students who took the FYE course showed a similar trend. This course was evaluated as successful in transforming the students into active learners.

著者

宮﨑 隆志 日置 真世

出版者

北海道大学大学院教育学研究院附属子ども発達臨床研究センター = Research and Clinical Center for Child Development, Faculty of Education, Hokkaido University

雑誌

子ども発達臨床研究 (ISSN:18821707)

巻号頁・発行日

vol.4, pp.11-20, 2010-03-25

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社会的に排除された若者の自立支援にコミュニティ・エンパワメントの視点から接近する意義と課題を検討した。具体的な事例に即して、共時的移行の困難と自己の構造化の困難との関連を確認した上で、コミュニティ・エンパワメント型支援実践の構造を解明した。最後に、そのようなタイプの実践がもたらす自己の構造変化を、協働的な自己再構成の過程として抽出し、協働的活動システムの構築による支援実践や教育実践の可能性を導いた。

著者

山村 高淑

巻号頁・発行日

2011-11-20

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NPO法人グランド12事務局主催講演会(主催:NPO法人グランド12事務局). 2011年11月20日. 熊本城数寄屋丸二階御広間, 熊本市.

著者

山村 高淑

出版者

北海道大学大学院国際広報メディア・観光学院観光創造専攻文化資源マネジメント研究室

雑誌

北海道大学文化資源マネジメント論集

巻号頁・発行日

vol.5, pp.1-5, 2009-01-05

著者

川本 思心 浅羽 雅晴 大石 麻美 武山 智博 関島 恒夫 島谷 幸宏 西條 美紀

出版者

北海道大学科学技術コミュニケーター養成ユニット

雑誌

科学技術コミュニケーション (ISSN:18818390)

巻号頁・発行日

vol.5, pp.19-40, 2009-03

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Dialogues with community constituents are indispensable for scientists whose research fields and applications are closely related with communities throughout the research processes of consensus building on executions of research projects, making decisions on research policies, sharing the products of the projects, corrections. What kind of guidance is required for scientists to maintain a dialogue with the society? Using mailing list and web portfolio, we recorded a process of planning and executing a science cafe with two researchers who research for reintroduction of Crested Ibis (Toki) into Sado Island. Additionally, to understand the reality of the research, we observed the field research by the scientists in Sado Island. This record and analysis about difficulty and the solution of the science cafe serves scientists as a effectively guidance.

著者

西村 泰一

巻号頁・発行日

2013

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平成の年号の発案者は安岡正篤であるということを総理大臣経験者の竹下登が示唆しているが、安岡正篤を有名にしたのは,彼が1922年に東京大学の卒業記念に出版した”王陽明研究”である。吉田茂、池田隼人、佐藤栄作、福田赳夫、大平正芳を始めとする多くの政治家が彼を師と仰いでいた。皇室とも関係が深く、終戦の折の玉音放送の原稿の作成には、全面的に協力している。東洋思想に造詣が深く、”学問修養とは、優游自適である”の名文句を残している。ここではその”優游自適”を絵にして見た。ご笑覧いただければ、幸いである。なお埼玉県菅谷の金鶏神社の傍には安岡正篤記念館があるので、時間と興味のある方は一度尋ねてみられるといい。

著者

Isozaki Hiroshi

出版者

日本数学会

雑誌

數學 (ISSN:0039470X)

巻号頁・発行日

vol.59, no.2, pp.113-130, 2007-04

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量子力学における3体問題と境界値逆問題に関する最近の話題について解説する. 3体問題の連続スペクトルに対応する固有函数展開定理と, 双曲幾何学の境界値逆問題への応用が主題である.

出版者

筑波大学学生新聞会

雑誌

筑波學生新聞

巻号頁・発行日

no.197, 2004-01-10

出版者

筑波大学学生新聞会

雑誌

筑波學生新聞

巻号頁・発行日

no.29, 1984-11-10

著者

古田 武 寺川 眞穂 小林 敏男 フルタ タケシ テラカワ マホ コバヤシ トシオ Furuta Takeshi Terakawa Maho Kobayashi Toshio

出版者

大阪大学経済学会

雑誌

大阪大学経済学 (ISSN:4734548)

巻号頁・発行日

vol.58, no.3, pp.1-19, 2008-12

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We suggest a framework of the global niche market which would enable a company to create and develop a new business. A global niche market is a small market which has particular and differentiated needs. There are two advantages to this framework. First, it makes the customers’ needs clear and thus companies are able to conform more closely to the particular needs. Second, competition with big companies can be avoided by selecting the appropriate market and business that match with the scale of the company (e.g. smaller scale venture businesses). The company would then be able to sustain its business by using the resources currently available. Here, we illustrate this process of new business creation step by step through a case study.

著者

Mohamed Nabawy Hassab El-Naby Ahmed

巻号頁・発行日

2008

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Thesis (Ph. D. in International Political Economy)--University of Tsukuba, (A), no. 4830, 2008.7.25

著者

福武 剛

出版者

京都大学

巻号頁・発行日

1981-05-23

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新制・論文博士

著者

Ebina Manato Tsuruta Fuminori Katoh Megumi C. Kigoshi Yu Someya Akie Chiba Tomoki

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.6, pp.e65285, 2013-06

被引用文献数

14 3

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Nucleolus is a dynamic structure that controls biogenesis of ribosomal RNA and senses cellular stresses. Nucleolus contains a number of proteins including ribosomal proteins that conduct cellular stresses to downstream signaling such as p53 pathway. Recently, it has been reported that modification by a ubiquitin-like molecule, Nedd8, regulates subnuclear localization of ribosomal protein L11. Most of L11 is normally localized and neddylated in nucleolus. However, cellular stress triggers deneddylation and redistribution of L11, and subsequent activation of p53. Although Nedd8 modification is thought to be important for L11 localization, the mechanism of how neddylation of L11 is regulated remains largely unknown. Here, we show that Myeloma overexpressed 2 (Myeov2) controls L11 localization through down-regulation of Nedd8 modification. Expression of Myeov2 reduced neddylation of proteins including L11. We also found that Myeov2 associates with L11 and withholds L11 in nucleoplasm. Although Myeov2 interacted with a Nedd8 deconjugation enzyme COP9 signalosome, L11 deneddylation was mediated by another deneddylase Nedp1, independently of Myeov2. Finally, p53 transcriptional activity is upregulated by Myeov2 expression. These data demonstrate that Myeov2 hampers L11 neddylation through their interactions and confines L11 to nucleoplasm to modulate nucleolar integrity. Our findings provide a novel link between oncogenic stress and p53 pathway and may shed light on the protective mechanism against cancer.

著者

菊川美代子

出版者

現代キリスト教思想研究会

雑誌

アジア・キリスト教・多元性

巻号頁・発行日

vol.9, pp.17-30, 2011-03