出版者

写

巻号頁・発行日

vol.右隻,

著者

KAZUO OGAWA TADAFUMI TERADA YOSHIYUKI MURANAKA TOSHIHIRO HAMAKAWA SETSURO FUJII

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.10, pp.4130-4136, 1987-10-25 (Released:2009-10-19)

参考文献数

13

被引用文献数

3 4

---

2- (1, t- and c-4-Dialkylcyclohex-r-1-yl) -2-oxoethyl arenesulfonates, 2- (4, 4-dialkylcyclohex-1-yl) -2-oxoethyl arenesulfonates and related compounds were synthesized and evaluated for esteraseand chymotrypsin-inhibitory activities in vitro and for hypolipidemic effect in vivo. The transisomers of 2- (1, 4-dialkylcyclohex-1-yl) -2-oxoethyl arenesulfonates showed much more potent esterase-inhibitory action (about 13 to 6200 times) than the cis-isomers as well as more potent hypolipidemic action (about 1.5 to 10 times) but the chymotrypsin-inhibitory actions of the two isomers were similarly low. On the other hand, the 2-oxoethyl arenesulfonates having a 4, 4- disubstituted cyclohexane ring mostly exhibited potent esterase-inhibitory action (order of IC50; 10-8 to 10-9M) and marked hypolipidemic effect (78% to 95% reductions of plasma triglyceride).

著者

KAZUO OGAWA TADAFUMI TERADA YOSHIYUKI MURANAKA TOSHIHIRO HAMAKAWA SHUNSAKU OHTA MASAO OKAMOTO SETSURO FUJII

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.8, pp.3276-3283, 1987-08-25 (Released:2009-10-19)

参考文献数

19

被引用文献数

5 8

---

trans-and cis-2-Diazo-1- (4-alkylcyclohexyl) -1-ethanones were reacted with arenesulfonic acids to afford the corresponding 2- (4-alkylcyclohexyl) -2-oxoethyl arenesulfonates. The esteraseinhibitory activity and hypolipidemic effect of the arenesulfonates were examined, and it was found that in most cases, the trans-isomers were more active than the corresponding cis-isomers.Stereoselective syntheses of several biologically potent trans-isomers (trans-3) were also developed.

著者

KAZUO OGAWA TADAFUMI TERADA YOSHIYUKI MURANAKA TOSHIHIRO HAMAKAWA SETSURO FUJII

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.6, pp.2426-2436, 1987-06-25 (Released:2009-10-19)

参考文献数

22

被引用文献数

2 4

---

Various ω-cycloalkyl-2-oxoalkyl arenesulfonates were synthesized and evaluated for esterase-and chymotrypsin-inhibitory activities and hypolipidemic activity. Among the tested compounds, 2-oxoalkyl arenesulfonates (4, 8 and 13) having a cyclohexyl substituent at the terminus of the alkyl chain exhibited considerable esterase-inhibitory activity, and several compounds among 4 and 8 also exhibited potent hypolipidemic action. The structure-activity relationships of these compounds are discussed.

著者

小川 和男 寺田 忠史 村中 義幸 浜川 寿博 橋本 貞夫 藤井 節郎

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.8, pp.3252-3266, 1986-08-25 (Released:2008-03-31)

参考文献数

34

被引用文献数

3 7

---

Many 2-oxoalkyl arenesulfonate derivatives having straight or branched alkyl chains of different lengths, 2-oxoalkyl bis-arenesulfonate derivatives, and alkyl arenesulfonate derivatives having a ketal moiety at the 2-position on the alkyl chain were synthesized, and their esterase-inhibitory activities, as well as hypolipidemic activities, were evaluated.Among these compounds, 1-(2, 4, 6-trimethylbenzenesulfonyloxy)-2-dodecanone (III-1u), and 1-(2, 3, 4, 6-tetramethylbenzenesulfonyloxy)-2-hexanone (III-1w), -2-octanone (III-1x) and -2-decanone (III-1y) exhibited potent esterase-inhibitory activities (IC50=3×10-10, 2×10-10, 2×10<-10> and 3×<-11>M, respectively). However, the sulfonate (XV) having a ketal moiety on the alkyl chain and the bis-sulfonate (XVI) exhibited low inhibitory activities toward esterase in comparison with III and XII. Most of the compounds III and some of the compounds XII exhibited potent hypolipidemic activities corresponding to more than 50% lipid-lowering effect (plasma triglyceride and cholesterol ester) in vivo. The structure-activity relatioinships of these compounds are discussed.

著者

池田透編著

出版者

北海道大学出版会

巻号頁・発行日

2013

著者

小川 和男 寺田 忠史 村中 義幸 浜川 寿博 橋本 貞夫 藤井 節郎

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.3, pp.1118-1127, 1986-03-25 (Released:2008-03-31)

参考文献数

43

被引用文献数

7 7

---

Many 1-substituted 2-alkanone derivatives were synthesized and their inhibitory activities toward pancreatic lipase and esterase were examined in order to obtain hypolipidemic agents. 1-Benzenesulfonyloxy-2-pentanone (VI-2a) and 1-(2, 4, 6-trimethylbenzenesulfonyloxy)-2-pentanone (VI-2q) exhibited not only potent and selective esterase inhibitions (IC50 : 9.0×10-7M and 1.0×10-6M, respectively), but also potent hypolipidemic action (90 and 92% reductions of plasma triglyceride, and 53 and 90% reductions of plasma total cholesterol, respectively). A novel working hypothesis is presented to account for the lowering of the plasma lipids level, i.e., that inhibition of esterase and lipase activities in the small intestinal lumen may be responsible for the decrease in the plasma lipids level.

著者

小川 和男 山田 省三 寺田 忠史 山崎 富生 本邦 隆次

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.33, no.6, pp.2256-2265, 1985-06-25 (Released:2008-03-31)

参考文献数

21

被引用文献数

1 6

---

2-Aklylidene-4-arylidene-1, 3-oxathiolan-5-one (III-1a-m) and 2, 4-diarylidene-1, 3-oxathiolan-5-one (III-2a-i) derivatives were synthesized by treating β-aryl-α-mercaptoacrylic acids (I) with alkanoic acid anhydrides (II) or by treating α-acylthio-β-arylacrylic acids (V) with thionyl chloride in dimethylformamide. Basic hydrolysis and methanolysis of III-1 and III-2 in the presence of lithium hydroxide easily occurred to give the corresponding ring-cleaved products, the carboxylic acid (I and II) and the ester (VII and VIII), respectively. The catalytic hydrogenation of the two olefinic bonds of III-2 in the presence of 10% palladium charcoal proceeded easily without ring cleavage to give 1, 3-oxathiolan-5-one (IXa-e) derivatives. The oxidation of III-1 and III-2 with m-chloroperbenzoic acid afforded the corresponding 1, 3-oxathiolan-5-one S-oxide (Xa, b) derivatives.

著者

小川 和男 寺田 忠史 本那 隆次

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.32, no.3, pp.930-939, 1984-03-25 (Released:2008-03-31)

参考文献数

16

被引用文献数

5 13

---

As a part of our search for new potent analgesic agents, novel fused pyrazole derivatives were synthesized. The reaction of 2-substituted-5-hydroxypyrazole (I) with ethyl 2-substituted (for example COCH3 or CO2C2H5) acylacetates (II) gave mainly pyrazolo [1, 2-a] pyrazole-1, 5 (1H, 5H)-diones (III). On the other hand, similar reaction of I with diethyl benzoylmalonate gave mainly pyrazolo [5, 1-b] [1, 3] oxazin-5 (5H)-one (V) but did not give III at all. Thermal and photochemical isomerization of III gave V. Methanolysis of IIIa in the presence of LiOH occurred with retention of the 4-ethoxycarbonyl-5-pyrazolone ring and similar products (VIa and VIf) were obtained by methanolysis of Va and Vf, respectively. Analgesic activities of the present new compounds were all inferior to that of aminopyrine.

出版者

法政大学

巻号頁・発行日

2017

著者

緒方 由美 進藤 穣 木村 郁夫

出版者

公益社団法人 日本水産学会

雑誌

日本水産学会誌 (ISSN:00215392)

巻号頁・発行日

vol.78, no.3, pp.461-467, 2012 (Released:2012-06-15)

参考文献数

19

被引用文献数

5 15

---

高鮮度水産物を凍結処理した場合,その品質は非常に良い状態で保たれる。しかしながら,高鮮度水産物で凍結耐性が高いことに関する科学的な研究はほとんど行われていない。本研究では高鮮度魚肉中に存在する ATP に着目し,ATP の筋肉タンパク質冷凍変性に及ぼす作用について検討した。ATP 濃度を維持できる筋原線維溶液モデル系を構築し,各濃度の ATP 存在下での冷凍変性速度を測定した結果,ATP による筋原線維タンパク質の冷凍変性抑制効果を確認した。その効果は,ATP 濃度と凍結貯蔵温度に依存し魚種差を示した。

著者

平野 砂峰旅

出版者

一般社団法人情報処理学会

雑誌

情報処理学会研究報告音楽情報科学(MUS) (ISSN:09196072)

巻号頁・発行日

vol.1996, no.19, pp.43-48, 1996-02-24

参考文献数

2

被引用文献数

5

---

大域結合カオスのアルゴリズムを用いて制作された、2つの作品"Emergination","Ping?Bang"を紹介することによって、作品に共通して使われている大域結合カオスのコンピュータミュージックへの応用例を示す。また、その他の応用の可能性について考察する。Chaos elements which is connected by "globally coupled map" (=GCM) are used in my computer music works "Emergination" and "Ping-Bang". This paper introduces GCM itself. Next it explains how to use GCM for the two works. And we discuss about possibility of the other GCM application for music.

出版者

写

巻号頁・発行日

vol.[173],

著者

中村 武恒 竹内 活徳 高村 豊 岡田 奈々 雨宮 尚之 中尾 公一 和泉 輝郎

出版者

低温工学・超伝導学会

雑誌

低温工学・超電導学会講演概要集 = Meetings of Cryogenics and Superconductivity (ISSN:09195998)

巻号頁・発行日

vol.81, 2009-11-18

参考文献数

1

著者

中山 毅

出版者

一般社団法人 日本温泉気候物理医学会

雑誌

日本温泉気候物理医学会雑誌 (ISSN:00290343)

巻号頁・発行日

vol.77, no.3, pp.250-256, 2014-05-30 (Released:2014-10-01)

参考文献数

20

---

入浴習慣は国や文化により大きく異なるが、一方で時代による変遷もあり、近年ではシャワー浴が普及する等の変化が現れている。そこで、現代の妊婦の入浴習慣について調査すると同時に、妊娠経過に及ぼす影響につき検討した。  2011年4月1日より2012年2月29日までに当院で出産をし、1ヶ月健診をおこなった褥婦204名を対象とし、無記名アンケートを実施した。アンケートは、入浴習慣、温泉浴に関する多肢選択法および自由記入法からなる。これらの結果と、妊娠経過中に起こったイベントにつき、後方視的に関連性を検討した。  204名の妊婦の内訳は、初産婦が99名、1経産が76名、2経産以上が29名であった。産科合併症としては、切迫流産が12名、切迫早産が35名、早産が15例、妊娠高血圧症候群が7名、微弱陣痛が10名、前期破水が26名に認めた。一方で妊娠中の入浴習慣については、全例毎日入浴習慣があったが、内訳として、毎日シャワー浴を行う妊婦(シャワー浴群)が38名(19%)、週に1~3回の湯浴が45名(22%)、週4日以上の湯浴を行う妊婦(湯浴群)が121名(59%)であった。産科合併症を比較したところ、湯浴群において、妊娠高血圧症候群の頻度が高く、一方で微弱陣痛に関しては、シャワー浴群の方が多い傾向にあった。  さらに、入浴習慣が外陰部の保清に影響するか、また細菌性腟症の原因や助長因子となるかについては、科学的根拠が乏しいが、本検討より湯浴を日常とする生活習慣が、腟内細菌叢やpHに影響を及ぼす可能性が示唆された。

著者

Tetsuaki Shoji Hidenori Mizugaki Yasuyuki Ikezawa Megumi Furuta Yuta Takashima Hajime Kikuchi Houman Goudarzi Hajime Asahina Junko Kikuchi Eiki Kikuchi Jun Sakakibara-Konishi Naofumi Shinagawa Ichizo Tsujino Masaharu Nishimura

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.12, pp.1769-1772, 2018-06-15 (Released:2018-06-15)

参考文献数

17

被引用文献数

2

---

This report describes the case of a 66-year-old man with non-small cell lung cancer and venous thromboembolism (VTE). Unfractionated heparin (UFH) was initially used to control VTE before chemotherapy. However, switching UFH to warfarin or edoxaban, a novel oral anticoagulant (NOAC), failed. Chemotherapy was then administered to control the tumor which was thought to have been the main cause of VTE, which had been treated by UFH. After tumor shrinkage was achieved by chemotherapy, we were able to successfully switch from UFH to edoxaban. Controlling the tumor size and activity enabled the use of edoxaban as maintenance therapy for VTE.

著者

小林 雅也 谷本 典子 岡田 奈々

出版者

日本看護協会出版会

雑誌

日本看護学会論文集 2 成人看護 (ISSN:13478206)

巻号頁・発行日

vol.37, pp.183-185, 2006

著者

Haruhi Yamada Yukiko Katsumori Miki Kawano Shumpei Mori Ryo Takeshige Jun Mukai Hiroshi Imada Hiroyuki Shimoura Hachidai Takahashi Tadasu Horai Yutaka Okita Ken-ichi Hirata

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.12, pp.1763-1767, 2018-06-15 (Released:2018-06-15)

参考文献数

12

被引用文献数

5

---

A 73-year-old man, with congestive heart failure due to combined valvar disease, underwent curative surgery. Although the surgery was successful, his clinical course was eventful because of pulmonary complications, and he began to deteriorate mentally. Quetiapine was prescribed, which appeared to effectively settle his mental status. Following the administration of quetiapine, however, he developed acute kidney injury (AKI) that required continuous hemodiafiltration. Subsequent to discontinuation of quetiapine, his renal function gradually improved. Atypical antipsychotic drugs, including quetiapine, are frequently used to treat delirium in elderly patients in the intensive-care setting. This case highlights a potential risk of quetiapine-related AKI.

著者

Yutaka Shimada Makoto Fujimoto Tatsuya Nogami Hidetoshi Watari Hideyuki Kitahara Hiroki Misawa Yoshiyuki Kimbara Kei-ichiro Kita

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.12, pp.1733-1740, 2018-06-15 (Released:2018-06-15)

参考文献数

26

被引用文献数

11

---

A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.

著者

角山 浩三 今中 誠 古川 九州男 岸田 朗 山田 恭裕

出版者

The Iron and Steel Institute of Japan

雑誌

鉄と鋼 (ISSN:00211575)

巻号頁・発行日

vol.75, no.11, pp.2090-2097, 1989-11-01 (Released:2009-06-19)

参考文献数

5

被引用文献数

4 4

---

The influence of base metal surface roughness parameters on the clarity of painted automotive cold rolled sheet steels was investigated. The sheet steels were dull finished by shot blasting, electro-discharge texturing or laser dull texturing. It was found that the painted clarity improved with decreasing of Ra, while it scarcely depended on PPI. Characteristic of the surface profiles of base metal was the waviness with wavelength of hundreds micron. Whose trace remained after coating and deteriorated the clarity. In shot blasting, the dendritic microstructure and the statistical fluctuation of grit collision generated the waviness and made it difficult to control its wavelength. And, in electro-discharge texturing, it is suggested, controlling the waviness is difficult similarly. In laser dull texturing, it was possible to reduce the wavelength of waviness to less than hundreds micron and then to improve the clarity without deteriorating the press formability. A larger fraction of flat portion in laser dull texture was also responsible for the improvement of clarity.