著者

山田 理恵

出版者

一般社団法人 日本体育学会

雑誌

日本体育学会大会予稿集 第63回(2012) (ISSN:24241946)

巻号頁・発行日

pp.85, 2012-08-22 (Released:2017-04-06)

著者

金子 一夫 KANEKO Kazuo

出版者

茨城大学教育学部

雑誌

茨城大学教育学部紀要. 教育科学

巻号頁・発行日

vol.63, pp.23-42, 2014

著者

平畑 富次郎

出版者

京都帝国大学

巻号頁・発行日

1946

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博士論文

出版者

日本映画テレビ技術協会

巻号頁・発行日

no.322, 1979-06

出版者

写

巻号頁・発行日

vol.[203] 三分冊ノ二 東叡山赦帳之内書抜(天保十年)、御赦帳例書、東叡山赦帳之内書抜(天保十年)、御両名もの例書(天保十年),

著者

国竹 泰夫

出版者

日本航空宇宙学会

雑誌

スカイスポーツシンポジウム講演集 = Sky Sports Symposium

巻号頁・発行日

vol.21, pp.21-24, 2015

著者

大島 博幸 酒井 邦彦 高木 健太郎 池上 茂

出版者

社団法人 日本泌尿器科学会

雑誌

日本泌尿器科學會雑誌 (ISSN:00215287)

巻号頁・発行日

vol.65, no.11, pp.732-740, 1974-11-20 (Released:2010-07-23)

参考文献数

44

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Eleven cases of true hermaphrodites were investigated with special reference to the relationship between differentiation of gonads and development of sexual duct systems. On most of them were performed studies of the sex chromatin, fluorescent body and chromosomal analysis. Also, reported cases in Japan as well as in foreign countries were collected and reviewed.Chromosomal analysis on 9 cases revealed chromosomal constitutions of 46, XX in 3 cases, 46, XY in 4 and 46, XX/46, XY in 2.Four cases out of 5 patients with a testis at one side and an ovary at the opposite showed Y-bearing chromosomal constitutions. Most of reported cases with a similar type of gonadal developement as the above mentioned were proved to have Y chromosome in their stem cells.Analysis of chromosomes in myelocytes and lymphocytes from a patient with 46, XX/46, XY revealed an interesting result. Twenty-one myelocytes out of 24 had chromosomal constitution of 46, XY and only 3 had 46, XX, whereas almost all of lymphocytes investigated after culture of peripheral blood had 46, XX constitution. It may be suggested from the above finding that cell populations are different from one tissue to another and may influence the differentiation of the primordial gonad toward a testis or ovary. It was another interesting finding that the fluorescent body was observed in 19% of lymphocytes from the patient mentioned above. The observation indicates the importance of examining Barr body as well as fluorescent body on more than two kinds of tissues, because native cells without cell-culture can be utilized for the examinations.Six true hermaphrodites investigated for both Barr and fluorescent bodies consisted of two of 46, XX, 46, XY and 46, XX/46, XY, respectively. Both bodies were positive in each case with mosaicism 46, XX/ 46, XY, although their frequencies were at lower percentage than normal female or male. On the other hand, only a few Barr or fluorescent bodies were recognized in each case of 46, XY or 46, XX, respectively. It is difficult to decide whether the above results were caused by an unrecognized mosaicism or not.From the observations of true hermaphrodites and XX-males, there has been raised an assumption that a sex-determining factor may locate on one of autosomes to which Y chromosome may affect as a regulating factor. This assumption, however, appears not sufficient to explain the differentiation of the ovarian tissue in the case of 46, XY.Testes in the foetus stimulate the differentiation and development of the Wolflian duct and suppress the Mullerian duct. The former function appears to be controlled by one of androgens secreted from the foetal testis. From the observation of clinical cases and animal experiments, the latter function seems to be closely related to the chromosomal constitution of cells composing the ductal tissue, while this function must be mediated by a chemical messenger produced from the foetal testis.

著者

岸川 禮子 宗 信夫 井上 定三 上村 正行 家守 千鶴子 河田 賢治 栗田 建一 城崎 拓郎 竹田 和夫 野上 兼一郎 三橋 勝彦 宿久 修 山田 篤伸 奥村 康 西間 三馨 石川 哮

出版者

日本補完代替医療学会

雑誌

日本補完代替医療学会誌 (ISSN:13487922)

巻号頁・発行日

vol.4, no.3, pp.127-136, 2007

被引用文献数

1

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通常の薬物治療を行っているスギ花粉症患者を対象に,カテキンより強力な抗アレルギー性を有すると報告されているメチル化カテキン含有品種べにふうき茶の飲用効果を,やぶきた茶飲用群と花粉飛散時期に比較検討した.<br> 福岡県内 12 施設の耳鼻咽喉科医院を受診したスギ花粉症患者 486 例に,単盲検法に準じてべにふうき茶飲用群(A 群)とやぶきた茶飲用群(B 群)に分けて 2005 年 2 月 1 日から毎日,スギ,ヒノキ科花粉飛散終了まで飲用させた.症状の重症度,薬剤使用量および QOL 障害度をスコア化して 2 群間内で比較した.<br> A 群と B 群との間で眼・鼻症状の日毎推移・QOL 障害度に差はなかった.しかし,スギ花粉飛散時期において合計薬剤スコアが A 群において低く,とくに飛散ピーク時期以降 A 群が B 群より低く推移する傾向が得られた (p < 0.1).<br> 花粉飛散時期に通常量のべにふうき茶を飲用することで,スギ花粉症増悪時に薬剤使用量が対照茶より少なく経過する傾向が得られたことから,補完的治療対策の 1 つの選択肢となる可能性が示唆された.<br>

著者

紫式部

出版者

林和泉掾

巻号頁・発行日

vol.[24], 1660

著者

阿部 三樹夫

出版者

早稲田大学史学会

雑誌

史観 (ISSN:03869350)

巻号頁・発行日

no.119, pp.p42-55, 1988-09

著者

小笹 美子 前堂 沙也加 當山 裕子

出版者

日本看護協会出版会

雑誌

日本看護学会論文集. 老年看護 (ISSN:13478249)

巻号頁・発行日

vol.43, pp.94-97, 2013

出版者

写

巻号頁・発行日

vol.中,

著者

北條 礼子 松崎 邦守

出版者

小学校英語教育学会

雑誌

小学校英語教育学会紀要 (ISSN:24330787)

巻号頁・発行日

vol.3, pp.39-45, 2003 (Released:2017-10-05)

著者

松本 直樹 Naoki Matsumoto 松山大学経済学部 Matsuyama UniversityCollege of Ecomomics

雑誌

松山大学論集 = Matsuyama University review (ISSN:09163298)

巻号頁・発行日

vol.16, no.4, pp.77-98, 2004-10-01

著者

川村 邦夫 阿部 寛

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.4, no.2, pp.134-140, 2002 (Released:2006-07-18)

参考文献数

7

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It is no doubt that media fill (simulation) test is the best method to evaluate aseptic processing. However, there are some problems concerning the acceptable criteria of “a contamination rate of less than 0.1% with 95% confidence limit”, which is specified in official compendia, such as JP,USP, EU GMP, WHO GMP, and ISO 13408 part 1 (General). In performing the media fill test, critical issues in performing media fills are the number of fills. Statistical validity of the observed contamination rate for the process has not been well explained hitherto. Problems associated with the “number” of criteria may not necessarily be treated with statistics, and personnel training and operation are sometimes major factors to cause contamination. However, dogma of “a contamination rate of less than 0.1% with 95% confidence limit” should be discussed further. Operation characteristic curves, which show the relationship between percent defectives and acceptance probability, clearly indicate that the more the number of fills, the higher the acceptable probability of contaminated units becomes in the range of contamination rate less than 0.1%. This means that the larger number of fills accept the worse average quality at the range of percent defectives less than 0.1%. According to a table of ISO 13408-1 (1998), which shows the relationship between the number of fills and the number of acceptable contaminated units, 10 positive units are accepted by 16970 fills' as the rate of contaminated units are less than 0.1% with a 95% confidence limit. However, the 95% confidential range of 4 positive units in 16970 fills is calculated to be 1/1970-6/16970. This means that zero (0) positive unit in 16970 fills, that is sterile prduct, is out-of control with a 95% confidence level. Even though the product meets the requirement of “less than 0.1% with a 95% confidence limit”, zero contamination unit in 16970 fills or asepsis must be very rare case. It means that sterile products become out-of-control according to the existing criteria. It is recommended that the dogmatic criteria such as less than 0.1% with 95% confidence limit should be revised. An example of a proposed new criteria is expressed as follows: “The result of media fill should show that the aseptic processing is consistently within the control limit (with a confidence limit of 95%) by using 3000 or more fills, and show the asepsis of the process or the validity of sterility of the product” in stead of “less than 0.1% with a 95% confidence limit.”

著者

榎並 鈴子 齋藤 泉

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.4, no.2, pp.127-133, 2002 (Released:2006-07-18)

参考文献数

9

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For decreasing particulate matter in sterile products, it is important to find the cause of the particulate contamination by containers as well as drugs. Particulate matter in laminated aluminum film, which is one of the multiple materials to be useful for the container of drugs, was investigated by various methods. It was found that the number of particles in the water increased with time by the particle counter when water was filled in a bag of laminated aluminum film. The number of the generated particles from the bag left for several hours exceeded that of the bag shaken sixty times. Besides, many white particles were detected under the microscope by filtrating water. The white particles weren't observed from the polyethylene film alone before lamination. And white particles was observed irrespective of treatment of heat-seal. Therefore, it was supposed lamination process was the cause of the particle formation. The number of particles in heat-sealed bag increased about twice as many as the number of particles in non-heat-seal bag (sealed by adhesive tape). Therefore, the treatment of heat-seal was also cause of the particle formation. In either case, film was held under high temperature and high pressure. Moreover, analyses of white particles showed that main ingredient in particles was same with an ingredient in polyethylene film which was soluble in ethanol. Therefore, it was presumed that the condition of high temperature and pressure caused the particle formation from an impurity in polyethylene, and particles appeared in water.

著者

曲田 純二

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.4, no.2, pp.121-126, 2002 (Released:2006-07-18)

参考文献数

5

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Regulatory agencies in Japan, US and EU have been requiring validation for sterilizing filtration as part of aseptic processing to pharmaceutical industry. ISO 13408 offers guidance to filter users concerning general requirements for set up, validation and routine operation of a sterilizing filtration process, to be used for aseptic processing of health care products. ISO/TC 198/WG9 has been working for definition of requirements for filter selection, fluid specific selection criteria, filtration process, system design, routine process, documentation, maintenance &change control and operator training. At present, it is a step of Draft International Standard.

著者

蒲川 拓治

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.4, no.2, pp.99-106, 2002 (Released:2006-07-18)

参考文献数

27

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In the development or validation of sterilization process for terminally sterilized parenteral drugs, biological indicators (BIs) are used to evaluate the effectiveness of sterilization. Accurately determining the heat resistance of BIs (D value) in parenrteral solution is extremely important because the D value varies due to variations in the chemical composition of parenteral solutions. The steam BIER vessel can rigidly control the process variables such as exposure temperature and time and provide reproducible physical test conditions. It is possible to heat the BI suspension in capillary tube or small container with short time for come-up and cool-down by using the steam BIER vessel. Because of this advantage, the steam BIER vessel is useful for determination of the D value in parenteral solution. The steam BIER vessel can solve the problem concerning accuracy and procedures of determining the D value in parenteral solution and contribute to perform the high level sterilization process validation for parenteral drugs.

著者

表 真美

出版者

日本家庭科教育学会

雑誌

日本家庭科教育学会誌 (ISSN:03862666)

巻号頁・発行日

vol.47, no.2, pp.136-146, 2004-07-01 (Released:2017-11-22)

参考文献数

15

被引用文献数

1

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Home economics schoolbooks and supplementary textbooks for Finnish comprehensive schools were investigated. The findings were follows: 1. Three kinds of schoolbooks and 12 kinds of supplementary textbooks for home economics are published from 3 companies in Finland. 2. The home economics teacher decides whether or not to adopt these books. The schoolbooks and the supplementary textbooks that they adopt are distributed to all students for free of charge. 3. The schoolbooks were composed of contents about family relationships, food, washing and cleaning, consumer education, and environmental education. 4. The pages with content about food are 68〜74%. Especially, the recipes for many kinds of dishes, such as bread, and cake are included in these schoolbooks. 5. The contents of the schoolbooks are concrete and practical. 6. Most of the supplementary textbooks are about food. 7. The schoolbooks and supplementary textbooks of home economics for Finnish Comprehensive schools correspond to the purpose of Finnish basic education and also to the framework curriculum for the comprehensive schools in 1994.

著者

清陳春輯

出版者

陳氏湖海樓刊

巻号頁・発行日

vol.第4册, 1819