著者

有賀, 長伯

出版者

村上勘兵衛[ほか8名]

巻号頁・発行日

vol.[3],

著者

澤野 宏 松本 拓也

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集 (ISSN:21879761)

巻号頁・発行日

vol.83, no.855, pp.17-00127-17-00127, 2017 (Released:2017-11-25)

参考文献数

9

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Demands for machining of three-dimensional (3D) complex geometries over a large area with nanometer scale accuracy have recently increased in the various industrial sectors. In order to meet such requirements, it is necessary to realize not only a machine tool with nanometer scale machining accuracy, but also a coordinate measuring machine with a nanometer scale measuring resolution for evaluating the machined parts profile. A scanning tunneling microscopy (STM) and atomic force microscope (AFM) probes have a high measuring resolution. However, in the STM, the specimen to be measured needs to have conductivity, and the AFM cannot measure a step shape or a slope. It is thought that the application of the profile measurement by the AFM probe can be expanded, by development the AFM probe suitable for the measurement of the slope shape. Therefore, this study proposed a novel AFM probe suitable for measuring the slope shape by using a low rigidity spring. In addition, the basic characteristics of the proposed AFM probe was experimentally investigated. Investigation results confirmed that the proposed AFM probe can detect atomic forces acting between the specimen and the probe.

著者

編集委員会

出版者

日本宗教学会

雑誌

宗教研究 (ISSN:03873293)

巻号頁・発行日

vol.91, no.2, pp.1-2, 2017-09-30 (Released:2017-12-30)

出版者

写

巻号頁・発行日

vol.第265冊,

著者

ジョン・ロック 著

出版者

東西出版社

巻号頁・発行日

1948

著者

明胡廣等奉敕撰

巻号頁・発行日

vol.[21], 1653

著者

寺島良安尚順 編

巻号頁・発行日

vol.[73], 1600

著者

松本 俊輔

出版者

相模女子大学

雑誌

相模女子大学紀要 (ISSN:21891842)

巻号頁・発行日

vol.79, 2015

著者

芳年

出版者

綱島亀吉

雑誌

風俗三十二相

巻号頁・発行日

1888

著者

梅田 素博

出版者

基礎造形学会

雑誌

基礎造形 (ISSN:09188908)

巻号頁・発行日

no.10, pp.1-8, 2001

著者

宋李〓等奉敕輯

巻号頁・発行日

vol.[8], 1567

著者

旦 慎吾

出版者

東京大学

巻号頁・発行日

1999

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博士論文

著者

田村元雄

出版者

写

巻号頁・発行日

vol.[3],

著者

大谷 敏夫

出版者

大阪府立大学

巻号頁・発行日

1990

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博士論文

著者

吉田 健一郎 東 龍太郎 佐伯 真由子 南 慶典 大谷 敏夫

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集 35 (ISSN:24331856)

巻号頁・発行日

pp.250-257, 1993-09-10 (Released:2017-08-18)

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Antibiotic C-1027, a novel antitumor chromoprotein isolated from the broth filtrate of Streptomyces globisporus C-1027, shows extremely potent cytotoxicity against KB carcinoma cells (IC_<50> 0.1ng/ml) in vitro and antitumor activity toward tumor-bearing mice in vivo. These activities are correlated with the ability of the antibiotic to cause DNA double-strand scission. The antibiotic consists of an apoprotein and a labile chromophore (C-1027-Chr) that is responsible for the biological activity of C-1027. The chromophore is readily separated from its apo-protein by extraction, but the exceeding instability in the protein-free state hampered the structure elucidation. The similar situation has been also observed in the other chromoprotein antibiotics of this family such as neocarzinostatin (NCS), macromomycin, auromomycin (AUR), actinoxanthin and kedarcidin. Among them, NCS is the only one whose chromophore structure has been elucidated, and very recently, the structural novelty of kedarcidin chromophore has been disclosed by the Bristol-Myers Squibb group. We have characterized an inactive but more stable reaction product (2) of C-1027-Chr, which was prepared by treatment of C-1027-Chr in ethanol. It possesses a macrocyclic structure together with oxazolinate and aminosugar moieties as side chains. Its benzodihydropentalene core structure suggested to us the presence of an enediyne in the native C-1027-Chr. We disclose herein the novel structure of C-1027-Chr (1) and the cycloaromatization mechanism leading to product (2), which would explain its extreme potency in terms of cytotoxicity and ability to cause DNA double-strand scission.

著者

柳澤 桂子

出版者

岩波書店

雑誌

図書

巻号頁・発行日

no.823, pp.2-7, 2017-08

著者

鎌田 真由美

出版者

京都大学

巻号頁・発行日

2013

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博士論文

著者

[中原]師郷 [著]

巻号頁・発行日

vol.[12], 1000

著者

奥野 恭史

出版者

京都大学

巻号頁・発行日

2000

---

論薬博第635号

著者

Kahori Naito Tomo Suzuki Masaki Kyoso Masayuki Ishijima

出版者

The Society of Life Support Engineering

雑誌

Journal of Life Support Engineering (ISSN:13419455)

巻号頁・発行日

vol.16, no.Supplement, pp.213-214, 2004 (Released:2010-07-21)

参考文献数

3