著者

和歌山県立図書館 編

出版者

和歌山県立図書館

巻号頁・発行日

vol.第1号, 1923

著者

新潟県刈羽郡立図書館 [編]

出版者

新潟県刈羽郡立図書館

巻号頁・発行日

vol.分冊 第2, 1921

出版者

市立名古屋図書館

巻号頁・発行日

vol.第14号, 1926

著者

京都府立京都図書館 編

出版者

京都府立京都図書館

巻号頁・発行日

vol.叢書事業之部, 1925

著者

京都府立京都図書館 編

出版者

京都府立京都図書館

巻号頁・発行日

vol.宗教神道之部, 1925

著者

巌手県立図書館 [編]

出版者

巌手県立図書館

巻号頁・発行日

vol.和漢書之部, 1923

出版者

市立名古屋図書館

巻号頁・発行日

vol.第13号, 1926

著者

小山 慶太

出版者

早稲田大学社会科学部学会

雑誌

早稻田人文自然科學研究 = The Waseda journal of general science (ISSN:02861275)

巻号頁・発行日

vol.28, pp.73-92, 1985-10 (Released:2016-11-24)

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論文

著者

佐藤 宏道 勝山 成美

出版者

公益社団法人 日本視能訓練士協会

雑誌

日本視能訓練士協会誌 (ISSN:03875172)

巻号頁・発行日

vol.21, pp.154-160, 1993-12-31 (Released:2009-10-29)

参考文献数

30

被引用文献数

1

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サルの大脳皮質一次視覚野(V1)の機能と構造の関連を理解する枠組を概説するとともに,V1が視覚中枢の中でどのように位置付けられるのかを最近の知見を交えて概説した.V1の機能構築を理解するには,網膜部位再現,層分化,ニューロン活動の刺激特異性,機能円柱などについて知ることが重要である.また視覚情報の流れとV1の役割を機能面および構造面から理解するのには,視覚刺激の運動や立体視の情報を運ぶ大細胞系(magnocellular system)と,形態や色などの情報を運ぶ小細胞系(parvocellular system)というV1にいたるまで並列な2つの経路の違いを知ることが助けとなる.両系によってV1に入力された情報は,それぞれの刺激特徴を専門に処理する並列な計算モジュールである機能円柱内で層間の階層的な処理を経た後,高次視覚野に分配出力される.視野の一点の情報を処理している各々のV1ニューロンの活動が,視野全体の再構築のためにどのように統合されているかについては不明の点が多いが,光学的計測法など新技術を導入した研究によってこの問題について新たな発展が期待される.

著者

大泉 光一

出版者

第一法規

雑誌

大学と学生 (ISSN:02864657)

巻号頁・発行日

no.24, pp.14-23, 2006-02

著者

石嶺 行男 仲田 栄二 仲間 操

出版者

琉球大学

雑誌

琉球大学農学部学術報告 (ISSN:03704246)

巻号頁・発行日

vol.30, pp.621-631, 1983-11-19

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1本研究は琉球列島におけるサトウキビ畑の雑草群落を植物社会学的方法によって分類することを目的とし, 本報はその一環として沖縄本島北部地区の調査結果をまとめたものである。2沖縄本島北部地区のサトウキビ畑から37個の植生調査資料が得られた。これらの資料をチューリッヒ・モンペリエー学派の方法で表操作した結果, 次の植生単位が明らかになった。ハマクワガタールリハコベ群集Aホシダ亜群集a.典型変群集b.タイワンコモチシダ変群集B典型亜群集Cヤブジラミ亜群集i.ヘビイチゴファシースDヒエガエリ亜群集c.典型変群集d.ヤナキタデ変群集e.ハマヒエガエリ変群集3ホシダ亜群集は株出畑に, ヒエガエリ亜群集は新植畑に生育する。また, ヤブジラミ亜群集と典型亜群集は両方の畑に生育している。

出版者

日経BP社

雑誌

日経コンストラクション (ISSN:09153470)

巻号頁・発行日

no.396, pp.120-121, 2006-03-24

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南太平洋の孤島に造る国際救助隊「サンダーバード」の基地の建設工事を,基地で使用する機材と共に一式で受注したら——。三菱重工業は,そんなシミュレーション映像を目玉に据えた就職イベント「MHI Jobcon 2006」を開催した。 対象は,2007年に卒業予定の大学生と大学院生。2月15日から3月2日まで,東京をはじめとする6都市の会場で同イベントを開いた。

出版者

日経BP社

雑誌

日経ビジネス (ISSN:00290491)

巻号頁・発行日

no.1030, pp.54-56, 2000-02-28

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文化放送ブレーンが2001年3月に卒業予定の大学生10万人を対象に実施した就職人気企業ランキング調査(有効回答者数3040人)の結果、1位は前年に続いてソニーとなった。 得票数は866票。2位のNTTドコモ(前年3位)の342票を2倍以上も上回る圧倒的な人気である。

著者

大和 隆志 杉山 亨 須賀 亮 大塚 雅巳 大野 雅二

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.48, no.3, pp.194-205, 1990-03-01 (Released:2009-11-13)

参考文献数

31

被引用文献数

1

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Bleomycins (BLMs) are antitumor antibiotics of unusual glycopeptide structure. The potent activity of BLM is attributed to the oxygen activation and the DNA cleavage by the formation of iron-chelate of the peptide moiety. erythro-β-Hydroxy-L-histidine, a pivotal amino acid for the oxygen activation, is prepared enantioselectively by aldol reaction of (R) -3-bromoacetyl-4-isopropyl-1, 3-oxazolidin-2-one with 1-triphenylmethylimidazole-4-carbaldehyde. Model ligands for the metal binding site of BLM with 4-methoxypyridine (PYML-6) and 4-dimethylaminopyridine (PYML-8) show oxygen activation up to 97% and 125% of that of BLM, respectively. cis-β-Methylstyrene is oxidized either with Fe (III) -H2O2 or Fe (II) -O2 complex systems of BLM and PYML-6 to give the corresponding optically active epoxide. The DNA binding region of BLM is combined with PYML-6 to give the first man-designed BLM, PYML (6) -bleomycin, which shows nucleotide cleavage mode remarkably similar to that of BLM. On the other hand, PYML-6 moiety and distamycin are coupled to afford PYML (6) - (4R-APA) -distamycin which shows dramatically altered AT specific mode in the DNA scission.

著者

神戸 敏江 土屋 香誉子 堀 誠 浴本 久雄 高橋 良和 竹内 富雄

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.17, no.4, pp.527-530, 1994-04-15 (Released:2008-04-10)

参考文献数

5

被引用文献数

1

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Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as flattened cell morphology, anchorage dependent cell growth, etc. (referred to as anti-ras activity). The study elucidated relationships between the chemical structure of anthracyclines and the anti-ras activity. The human tumor cell line T24, which has a mutated H-ras gene, responded to the anthracyclines, as did K- or H-ras 3T3 cells, in respect to the phenotypic alterations. Pirarubicin was more than 4 times as active as aclarubicin in inhibiting the growth of solid tumors of K-ras 3T3 cells in nude mice, possibly reflecting a difference in anti-ras activity between the two antibiotics.

著者

KATSUTOSHI TAKAHASHI HISAO EKIMOTO SHOKO AOYAGI AKIKO KOYU HIROSHI KURAMOCHI OSAMU YOSHIOKA AKIRA MATSUDA AKIO FUJII HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.32, no.1, pp.36-42, 1979 (Released:2006-04-12)

参考文献数

12

被引用文献数

30 31

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Pepleomycin (PEP), 3-[(S)-1'-phenylethylamino]propylaminobleomycin has potent activity and is less pulmonary toxic than bleomycin (BLM). Biological activity and toxicity of the following degradation products of PEP have been studied in detail: the product of carbamoyl migration (ISO), the product of decarbamylation (DC), the product of ring closure of the side chain on the pyrimidine moiety (RC), the depyruvamide product (DP) and the product of an enzymatic inactivation (DA). These degradation products showed much lower activity than PEP in vitro: antimicrobial and anti-HeLa activities, inhibition of DNA synthesis in AH66 cells and the DNA strand cleavage. Acute toxicity and pulmonary toxicity were tested in mice. Results indicated much lower acute toxicity corresponding to the decreased in vitro activity when compared to PEP. DP and RC did not cause lung fibrosis in mice, while ISO and DC showed 1/2.6 and 1/5.7 degree of pulmonary toxicity, respectively, in comparison with PEP.

著者

Hisao EKIMOTO Kimihiko TAKADA Takao OHNUKI Katsutoshi TAKAHASHI Akira MATSUDA Tomohisa TAKITA Hamao UMEZAWA

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.2, no.1, pp.25-31, 1987 (Released:2010-02-25)

参考文献数

26

被引用文献数

7 11

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Sensitivity to bleomycin-induced pulmonary fibrosis was tested in various strains of mice. Among the strains examined, ICR, C57BL/10(H-2b), and C3H/He(H-2k) mice were highly sensitive to the induced pulmonary fibrosis; C57BL/6(H-2b), DBA/2(H-2d), A/J(H-2a), B6C3F1 and BDF1 mice were moderately sensitive, and CBA/JN(H-2k), BALB/c(H-2d), CDF1 and CBF1 mice were less sensitive. In congenic mice, which differ from each other only in the H-2 locus, C57BL/10(H-2b) was highly sensitive; B10·D2(H-2d) was moderately sensitive; and B10·BR(H-2k) and B10·A(H-2a) were less sensitive. Thus, the sensitivity differed depending on the haplotype of the H-2 genes. Furthermore, non-H-2 genes also seemed to be involved in the sensitivity to the pulmonary fibrosis. There was no correlation between the sensitivity to pulmonary fibrosis and enzyme activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in the lung tissues, but the levels of reducing agents such as ascorbic acid and tocopherol in the lungs were inversely correlated with the sensitivity to the pulmonary fibrosis, except in the case of BALB/c and its F1 mice.

著者

HISAO EKIMOTO HIROSHI KURAMOCHI KATSUTOSHI TAKAHASHI AKIRA MATSUDA HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.33, no.4, pp.426-434, 1980 (Released:2006-04-12)

参考文献数

18

被引用文献数

21 22

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The kinetics of the reaction of BLM-Fe(II)-O2 with DNA in the absence or presence of 2-mercaptoethanol (2-ME) were studied. The total number of bases released by BLM-Fe(II)-O2 in the presence of 2-ME increased about 6.5 times more than that in the absence of 2-ME in the reaction of 6 hours at 37°C. The molar ratios of the released bases ware little affected by the reaction time, temperature or 2-ME. Among the four bases, thymine was preferentially released. On the basis of a reaction scheme of BLM-Fe(II)-O2 with DNA, the equations were derived by the steady-state method. In the absence of 2-ME, the release of bases from DNA was dependent on the concentration of BLM-Fe(II)-O2, but independent of the concentration of DNA. In the presence of 2-ME, a biphasic reaction was observed; the first one is due to BLM-Fe (II) which originally existed and the second one is due to BLM-Fe(II) produced by the reduction of BLM-Fe(III) with 2-ME. In the second reaction, the rate of the release of bases from DNA was proportional to the concentration of BLM-Fe(II) and 2-ME, but inversely proportional to the concentration of DNA. The rate-determining step in the reaction of BLM-Fe(II)-O2 with DNA in the presence of 2-ME was found to be the reduction of BLM-Fe(III) to BLM-Fe(II). By these kinetic studies, the reaction of BLM-Fe(II)-O2 with DNA in the presence of 2-ME was elucidated to proceed in a catalytic fashion. Furthermore, the maximum number of bases released by BLM from DNA was one base per twelve to thirteen bases.

著者

三島由紀夫著

出版者

東京創元社

巻号頁・発行日

1957

著者

埜渡 裕義 黒田 泰男 速水 宏 岡本 一也 浴本 久雄 高橋 克俊

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.37, no.9, pp.2406-2409, 1989-09-25 (Released:2008-03-31)

参考文献数

15

被引用文献数

14 18

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Novel alkyl-1, 4-butanediamine Pt(II) complexes having a seven-membered ring structure were synthesized and characterized by fast atom bombardment mass and infrared spectra and elemental analysis. Their antitumor activities in vivo toward lymphoid leukemia L1210 and LEwis lung carcinoma LL were studied in the case where the leaving group was either dichloride or cyclobutane-1, 1-dicarboxylate. 1, 4-Butanediamine Pt(II) complexes (seven-membered ring) showed higher antitumor activities than those of ethylenediamine Pt(II)(five-membered ring) and 1, 3-propanediamine Pt(II)(six-membered ring) complexes toward L1210 for both leaving groups. Alkyl-1, 4-butanediamine Pt(II) complexes showed high antitumor activities toward L1210, except for 1, 1-dimethyl-1, 4-butanediamine Pt(II) complexes. In particular, 2, 2-dimethyl-1, 4-butanediamine and 2, 3-dimethyl-1, 4-butanediamine Pt(II) complexes exhibited excellent antitumor activities with T/C% values higher than 300. None of the dichloro Pt(II) complexes showed antitumor activities toward LL, but the cyclobutane-1, 1-dicarboxylato Pt(II) complexes, which were moderately active toward L1210 with T/C% values aroung 200, also showed high antitumor activities toward LL with T/C% values of more than 200. Alkyl-1, 4-butanediamine Pt(II) complexes with a seven-membered ring structure were found to be stable and to have antitumor activities in vivo.