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1 0 0 0 OA The Potential Inhibitory Effect of Revaprazan, an Acid Pump Antagonist, on Anticoagulation with Warfarin

著者: Jae-Woo Jung Hye-Ryun Kang Jae-Woo Kwon Tae-Eun Kim So-Hee Lee Kyoung Sup Hong Kyung-Sang Yu Sang-Heon Cho
出版者: 東北ジャーナル刊行会
雑誌: The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日: vol.224, no.4, pp.293-300, 2011 (Released:2011-07-29)
参考文献数: 28
被引用文献数: 4 5

Revaprazan is the first acid pump antagonist with a function similar to that of proton pump inhibitors (PPIs). It has a dual action, active suppression of gastric acid secretion and gastric mucosa protection. While PPIs are known to enhance the prolongation of prothrombin time by warfarin, no research has been done on the drug interaction between revaprazan and warfarin. This study was conducted in order to verify the potential drug interaction between revaprazan and warfarin. Omeprazole, a representative PPI, was used as the control for revaprazan. We searched for patients who were given either revaprazan or omeprazole along with warfarin using the medical record database of Seoul National University Hospital between July 2007 and June 2010. Among the 15 patients who took revaprazan and warfarin together, 73.3% (11/15) showed more than 30% reduction of anticoagulation effect by warfarin after revaprazan was added. The revaprazan group showed a significant shortening of prothrombin time during revaprazan administration compared to pre- and post-revaprazan medication (P < 0.05) while the omeprazole group did not show such difference. Revaprazan seems to have cumulative dose-dependent anti-warfarin or anti-coagulation effect, as judged from the fact that the longer medication with revaprazan showed correlation with the shortening of prothrombin time (R = −0.632, P < 0.05). This study shows a possible interaction between revaprazan and warfarin and suggests that revaprazan can cause shortening of prothrombin time. Therefore, when revaprazan is prescribed to patients on warfarin therapy, prothrombin time should be frequently monitored.

2012-05-11 15:06:00
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1 0 0 0 「未来のスラム」は存在しない(<連載>特集を読んで(2010年1月号[特集=未来のスラム]))

著者: 山形浩生
出版者: 日本建築学会
雑誌: 建築雑誌 (ISSN:00038555)
巻号頁・発行日: no.1615, 2011-03-20

2012-05-11 14:20:10
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https://ci.nii.ac.jp/naid/110008513509

1 0 0 0 OA 日本における原子力発電所の建設に伴う溶接の諸問題

著者: 橋本宇一木原博安藤良夫
出版者: 社団法人溶接学会
雑誌: 溶接学会誌 (ISSN:00214787)
巻号頁・発行日: vol.33, no.4, pp.357-363, 1964-04-25

The first nuclear power station in Japan (Advanced Calder Hall type, 166MW electric) is now under construction at Tokaimura. Construction of several new nuclear power stations will begin within a few years and also building project of the first nuclear powered ship (6500 G. T.) has been started in 1963. Al-killed steel plates 80&acd;94mm thick were manually welded for Tokai reactor pressure vessel and its steam raising units were constructed with 54&acd;74mm thick boiler plates using both submerged arc and manual welding. JPDR is a small BWR (12.5MW electric), and the inner surface of its pressure vessel was stainless steel cladded by submerged arc process. Researches on the welding of the nuclear reactor have been extensively carried out by Japan Welding Engineering Society and also each industrial plant is doing its own researches. The study on the effect of irradiation on the properties of materials has been just started.

2012-05-11 12:54:41
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1 0 0 0 IR イナゴの採集と調理活動 : 福島県中央部を事例として (立教大学史学会大会報告)

著者: 末永雅洋
出版者: 立教大学
雑誌: 史苑 (ISSN:03869318)
巻号頁・発行日: vol.72, no.2, pp.29-36, 2012-03

2012-05-11 11:34:11
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1 0 0 0 IR 新潟県内のせがい造りを持つ町家の系列に関する研究 : 信濃川・阿賀野川流域・日本海沿岸,各町のせがい造り形状の比較

著者: 小林勉西村伸也棒田恵渡辺恵樋口雅希
出版者: 一般社団法人日本建築学会
雑誌: 日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日: vol.73, no.634, pp.2557-2564, 2008-12-30

"Machiya" houses in the "segai-style", which is characterized by its use of cantilevers as the ceiling beams to hold the roof, can be seen all over Niigata Prefecture. "Machiya" houses in the Shinano and Agano river basins and on the Japan Sea coast were examined and house systems and their use of interior space investigated. "Segai-style" houses were consequently divided into four groups according to defferences in details: houses on Sado Island; houses downstream on the Shinano and Agano rivers; houses midstream on the Shinano river; houses upstream on the Shinano river and on the Japan Sea coast.