著者

板倉 秀 斎藤 きくゑ

出版者

日本音声言語医学会

雑誌

音声言語医学 (ISSN:00302813)

巻号頁・発行日

vol.17, no.2, pp.43-47, 1976-07-25 (Released:2010-06-22)

参考文献数

6

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A case of mutism with sudden onset was reported. A 5 year-old boy developed mutism while looking at TV screen. No definite cause was disclosed though psychogenic origin was strongly suggested. The patient became able to talk in whisper after speech training and play therapy for 2 years. A discussion on the course and training was made based on the clinical observation.

著者

Aya Nakamura Masami Watanabe Morito Sugimoto Tomoko Sako Sabina Mahmood Haruki Kaku Yasutomo Nasu Kazushi Ishii Atsushi Nagai Hiromi Kumon

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.60, no.3, pp.275-281, 2013 (Released:2013-03-31)

参考文献数

11

被引用文献数

7 73

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Gender identity disorder (GID) is a conflict between a person’s actual physical gender and the one they identify him or herself with. Testosterone is the key agent in the medical treatment of female to male GID patients. We conducted a dose-response analysis of testosterone replacement therapy (TRT) in 138 patients to determine the onset of the therapeutic effects. The TRT consisted of intramuscular injection of testosterone enanthate and patients were divided into three groups; 250 mg every two weeks, 250 mg every three weeks and 125 mg every two weeks. The onset of deepening of voice, increase in facial hair and cessation of menses was evaluated in each group. At one month after the start of TRT, the onset of these physical changes was more prevalent in the group receiving the higher dose of testosterone, and there were dose-dependent effects observed between the three treatment groups. On the other hand, at six months after the start of TRT, most of the patients had achieved treatment responses and there were no dose-dependent effects with regard to the percentage of patients with therapeutic effects. No significant side effects were observed in any of the treatment groups. We demonstrated that the early onset of the treatment effects of TRT is dose-dependent, but within six months of starting TRT, all three doses were highly effective. Current study provides useful information to determine the initial dose of TRT and to suggest possible changes that should be made in the continuous dosage for long term TRT.

著者

廣間 文彦 安田 雄司

出版者

特定非営利活動法人 日本呼吸器外科学会

雑誌

日本呼吸器外科学会雑誌 (ISSN:09190945)

巻号頁・発行日

vol.22, no.5, pp.818-822, 2008-07-15 (Released:2009-02-02)

参考文献数

7

被引用文献数

1

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症例は26歳男性で右自然気胸にて入院となった.胸腔鏡下に手術を施行したところ,右第4肋骨より発生した骨軟骨腫を認め,これに対面する右中葉肺胸膜面に圧迫が原因と思われる瘢痕とブラを認めた.これが気胸の原因と判断し,骨軟骨腫と右中葉のブラを切除した.肋骨に発生する骨軟骨腫は稀で,これが原因で気胸が発症した症例は自験例を含めて本邦で4例と極めて稀な症例であった.

著者

芝口 浩智 山本 知佳 黒木 政秀 二神 幸次郎

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.7, pp.977-982, 2010 (Released:2010-07-01)

参考文献数

13

被引用文献数

1 4

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Cytomegalovirus (CMV) remains the most important pathogen following solid organ transplantation and is the major cause of recipient morbidity and mortality during the first 6 months posttransplantation. To prevent CMV infection and/or to prevent symptomatic CMV disease, immunoglobulin (Ig) G including hyperimmune CMV IgG are used alone or in combination with antiviral medications. The CMV IgG titer, however, has a wide range and frequently depends on the company supplying the Ig preparation even if the preparations come from the plasma pool of a national blood donation agency. In the present study, we therefore simultaneously measured and evaluated the CMV IgG titers in various Ig preparations using two common methods: the neutralizing antibody (NT) and enzyme immunoassay (EIA). The CMV IgG titer in the present study indicated different values using both methods among Ig preparations that were made from the plasma pool of a national blood donation agency (about 3.5- or about 1.7-fold difference using the NT or EIA methods, respectively). Furthermore, there were no correlations in the CMV IgG titer between our findings and published data from the manufacturers, or between the two methods tested here. These findings suggest the importance and necessity of a standard method and/or sample for the measurement and assessment of CMV IgG in Ig preparations.

著者

Jae Yeon LEE Myung Cheol KIM

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0062, (Released:2013-10-09)

被引用文献数

5 35

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The present study evaluated and compared the oxidative stress status of dogs undergoing laparoscopic or open ovariectomy. Twelve healthy female dogs were divided into two groups according to the type of the surgical procedure, laparoscopic or open ovariectomy. Plasma total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels for the evaluation of oxidative stress were determined. Increases in plasma TOS and OSI levels and decreases in TAS levels were observed in both groups after surgery. The TOS level was significantly lower in the laparoscopic ovariectomy group compared with the open surgery group. Laparoscopic ovariectomy is a safe and beneficial surgical alternative to traditional ovariectomy with respect to oxidative stress status in dogs.

著者

Shoji Matsune

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.79, no.3, pp.170-175, 2012 (Released:2012-07-05)

参考文献数

28

被引用文献数

6 13

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Vascular endothelial growth factor (VEGF) was identified in 1980s as a protein that increases vascular permeability and induces endothelial cell-specific mitosis. VEGF plays an important role in angiogenesis during the embryonic stage and in angiogenesis and in increasing vascular permeability during postnatal life, both physiologically and pathologically. Great progress has been made in studies of VEGF, mainly in the field of oncology, and VEGF-targeted therapy has been successfully used to treat patients with cancer. In research related to chronic inflammation, several reports concerning rheumatoid arthritis or retinopathy and VEGF have been published. In the lower respiratory tract, increased levels of VEGF have been detected in biological samples from patients with asthma. However, VEGF has not been studied in detail in upper-airway diseases, such as rhinosinusitis. This review article focuses on VEGF and allergic rhinitis to advance studies of VEGF in chronic inflammation of the upper respiratory tract. VEGF levels in nasal secretions and nasal lavage fluid were higher in perennial allergic rhinitis than in nonallergic rhinosinusitis, after, rather than before, the antigen provocation test. The major VEGF isoforms were confirmed to be VEGF121 and VEGF165 in allergic rhinitis. Expression of VEGF mRNA was higher in serous versus mucous acini. In allergic rhinitis, serous acini produced significant quantities of VEGF, which was hypersecreted after antigen provocation. VEGF seems to play an important role in the pathophysiology of allergic rhinitis. Modulation of VEGF function seems to contribute to the successful treatment of conditions with airway inflammation such as allergic rhinitis.

著者

山田 千夏 朱宮 哲明 山口 剛 山田 慎吾 白石 真弓 柳田 勝康 中村 崇仁 梅田 巧 伊藤 美香利 尾崎 隆男

出版者

一般社団法人 日本農村医学会

雑誌

日本農村医学会雑誌 (ISSN:04682513)

巻号頁・発行日

vol.62, no.2, pp.106-111, 2013 (Released:2013-10-09)

参考文献数

6

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当院では2010年に,がん化学療法中の入院患者の給食として8日間サイクルの化学療法食を導入し,現在までに258名に提供した。今回,2011年10月~2012年3月の6か月間に化学療法食を提供した23名 (肺癌8名,急性骨髄性白血病5名,悪性リンパ腫3名等) に食事のアンケート調査を行ない,その結果を基に幾つかの改善を行なった。 食べ易さに対する回答では,96%の患者が食べ易いと評価した。食事量については,朝食について29%の患者が少ないと回答し,昼食と夕食については83%の患者がちょうどいいと回答した。食べ難かった料理では,「冷たい茶碗蒸し」と回答した患者が7名と最も多く,その他の料理では魚料理が食べ難い傾向がみられた。 アンケート結果を基に,朝食量を増量すると共に,「冷たい茶碗蒸し」の献立を「温かい茶碗蒸し」に変更した。また,魚の臭いを抑えるために「煮付け」と「蒸魚」の献立を「蒲焼き」と「あんかけ」に変更した。今後も調査を継続し,より多くの患者に対応できる化学療法食を目指したい。

著者

宿久 修 小宗 静男 君付 隆 川口 博 平川 直也 小宮山 荘太郎

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.43, no.5, pp.584-589, 1997-09-20 (Released:2013-05-10)

参考文献数

7

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両側の耳硬化症と診断した42歳女性に右アブミ骨手術を行つた. 興味深いことに, すべての耳小骨は固着し, 病理学的に硬化病変が証明された. 初回のアブミ骨手術の際には, ツチ骨頭部・キヌタ骨短脚を上鼓室より剥離し, テフロンピストンをキヌタ骨長脚と卵円窓に留置した. しかし, 聴力の改善がなかつた. 2回目の手術でツチ骨頭部. キヌタ骨を摘出し, テフロンピストンを鼓索神経にかけ卵円窓に留置したところ, 聴力は改善した.

著者

有本 卓

出版者

一般社団法人 電子情報通信学会

雑誌

電子情報通信学会 基礎・境界ソサイエティ Fundamentals Review (ISSN:18820875)

巻号頁・発行日

vol.2, no.4, pp.4_4-4_8, 2009-04-01 (Released:2011-05-01)

参考文献数

31

著者

伊藤 祐紀子

出版者

公益社団法人 日本看護科学学会

雑誌

日本看護科学会誌 (ISSN:02875330)

巻号頁・発行日

vol.31, no.3, pp.3_50-3_60, 2011-09-20 (Released:2011-10-25)

参考文献数

15

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患者への気がかりをもとに看護していくプロセスを看護師の身体のあり様に着目して探究することを研究目的とした.修正版グラウンデッド・セオリー・アプローチにより,看護師32名の半構成的面接データを分析した.結果として,36概念,8サブカテゴリー,5カテゴリーが生成された.看護師は,患者に抱いた気がかりをもとに【身体感覚からの察知】に【持ち前の判断と手立ての駆使】によって,患者に生じている変化を看護師の【内に取り込んでわかる】ようになる.ここから,2つのプロセスが生じていた.わかることで患者に馴染むことで【押し出される行為】に至るプロセスと,わかることから新たなわからなさが明らかになり,それを探索し続けるプロセスである.これらは同時に進行し,【関わりから得た手ごたえと方向性のリレー】によって帰結していた.この帰結は,次に関わる患者との相互作用の基軸になっていた.

著者

Yuki YAMAMOTO Tatsuya YAMAMOTO Natsuki YUTO Thomas B. HILDEBRANDT Imke LUEDERS Gudrun WIBBELT Osamu SHIINA Yasushi MOURI Keisuke SUGIMURA Sayuri SAKAMOTO Saroch KAEWMANEE Kentaro NAGAOKA Gen WATANABE Kazuyoshi TAYA

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.1111070413-1111070413, (Released:2011-11-11)

被引用文献数

2 13

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The objective of the present study was to define the secretion of prolactin (PRL) in pregnant African and Asian elephants. Levels of immunoreactive (ir-) PRL in serum and placental homogenates were measured by a heterologous radioimmunoassay (RIA) based on an ovine and human RIA system, and the localization of immunoreactive (ir-) PRL in the placenta was detected by immunohistochemistry using anti-human PRL. Circulating ir-prolactin clearly showed a biphasic pattern during pregnancy in African and Asian elephants. Serum levels of ir-PRL started to increase from the 4-6th month of gestation and reached the first peak level around the 11-14th month. A second peak of circulating ir-PRL levels was observed around the 18-20th month of gestation followed by an abrupt decline after parturition. In contrast, in a case of abortion of an African elephant, the second peak of ir-PRL was not observed, and the levels remained low for about four months until parturition. The weight of the fetus delivered at the 17th month of gestation was 23.5 kg, which was quite small compared with normal fetuses in previous reports. Ir-PRL was detected in placental homogenates, and immunolocalization was observed in trophoblasts in both the African and Asian elephants, indicating that the placenta is the source of ir-PRL during pregnancy in elephants. The present results clearly demonstrated that circulating ir-PRL shows a biphasic pattern during normal pregnancy and that the placenta appears to be an important source of circulating ir-PRL during pregnancy in both African and Asian elephants.

著者

三宅 泰雄 田島 英三

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.3, no.2, pp.8-18, 1954-12-31 (Released:2010-07-21)

著者

藤巻 裕蔵

出版者

Yamashina Institute for Ornitology

雑誌

山階鳥類研究所研究報告 (ISSN:00440183)

巻号頁・発行日

vol.34, no.1, pp.73-79, 2002-10-25 (Released:2008-11-10)

参考文献数

21

被引用文献数

1 3

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北海道のエゾライチョウBonasa bonasiaの食性について,237例のそ嚢内容物にもとづいて調べた。得られたそ嚢数は,狩猟期の1994/95年と1995/96年の10月~1月の216例,非狩猟期の1996年2~9月の21例である。そ嚢内容物の湿重量を計測した後,各食物項目に区分して乾燥し,各食物項目ごとに乾重量を計測した。各食物項目について月ごとに出現頻度と乾重量で示した。調べたそ嚢内容物237例のうち,35例(15%)は空であった。そ嚢内容物の湿重量は0~49.4g,平均(±標準偏差,以下同様)5.3±6.7g(n=237),乾重量は0~22.5g,平均1.88±3.02gであった。例数の多かった10月~1月についてみると,湿重量,乾重量とも10,11月より12,1月で有意に大きかった。出現頻度の高かった食物は,6,7月には草本類の葉,種子,節足動物,8,9月には葉,種子,果実,節足動物,10月には落葉広葉樹の冬芽,ヤマブドウとサルナシの果実,11,12月には冬芽,葉,果実,1,2月には冬芽であった。これらのうち,同定できたのは,冬芽では,ヤナギ類,カンバ類,ハンノキ類,ホオノキ,サクラ類,ナナカマド類,イヌエンジュ,ニシキギ類カエデ類,ツツジ類,トネリコ類であった。葉では,イチイ,トドマツ,カタバミ類,シロツメクサであった。種子では,ウルシ,トウヒ類,トドマツ,カンバ類,ハンノキ類,キイチゴ類,シソ類,カタバミ類,スゲ類,スミレ類であった。果実では,7,8月にはニワトコ,10月以降にはヤマブドウ,サルナシ,マタタビ,フッキソウ,ツルウメモドキ,ナナカマドであった。動物では,カタツムリ類,クモ類,カゲロウ類,カワゲラ類ハサミムシ類,バッタ類,カメムシ類,アワフキムシ類,鱗翅類,甲虫類,アリ類であった。乾重量でみた主要な食物は,6,7月には種子,8~9月には葉,種子,果実,10~12月には冬芽,葉,種子,果実,1~2月には冬芽と果実であった。北海道における食性をヨーロッパと比べると,どちらも植物食である点では基本的に同じであるが,北海道では樹種の多さを反映して多くの落葉広葉樹の冬芽を利用し,ヤマブドウやサルナシといった蔓植物の果実を秋から地表が雪で覆われる厳冬期までよく食べていた。

著者

弘瀬 冬樹 中村 綾子 長谷川 昭

出版者

公益社団法人 日本地震学会

雑誌

地震 第2輯 (ISSN:00371114)

巻号頁・発行日

vol.55, no.3, pp.249-260, 2002-12-15 (Released:2010-03-09)

参考文献数

27

被引用文献数

11

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We found a clear b-value variation associated with the rupture of asperities based on investigations of spatial and temporal distributions of frequency-magnitude relation for earthquakes in the northeastern (NE) Japan subduction zone. We used the Tohoku-University earthquake catalogue in the period from January 1, 1981 to October 3, 2001 after correcting artificial magnitude shift and removing artificial events. Spatial distribution of b-value is compared with the locations of asperities estimated on the plate boundary east off NE Japan. Estimated b-value decreases with increasing depth. Anomalously high b-values are observed in two areas off-Iwate and off-Fukushima regions, and asperities do not intrude into them. Temporal variation of b-value for presently analysed six asperities shows a remarkable increase in b-value after the rupture of each asperity. Then the b-value decreases gradually. These observations suggest that b-value reflects the stress change occurring in the vicinity of the asperities.

著者

Yoshiaki Kaneko Tadashi Nakajima Tadanobu Irie Masahiko Kurabayashi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.19, pp.2287-2288, 2013 (Released:2013-10-01)

参考文献数

2

被引用文献数

1

著者

Shiho USUI Yasushi MIZOGUCHI Hidemi YASUDA Nobuaki ARAI Yuzo KOKETSU

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0369, (Released:2013-10-08)

被引用文献数

1 10

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The objectives of this study were to set specific dog breed and sex standards for total cholesterol (T-Cho) and total triglyceride (T-TG) concentrations in dogs and to quantify the associations between dog age and concentrations of both lipids for different breeds. Increased age was associated with higher T-Cho and T-TG concentrations in all five breed groups (P<0.05); T-Cho concentrations increased by 62.5 mg/dL between 9 and 16 years of age, and T-TG concentrations increased by 4.8 mg/dL per year of age (P<0.05). Miniature Schnauzers had the highest T-Cho concentrations of the studied breeds, while Miniature Dachshunds had the lowest concentrations (P<0.05). Veterinarians should consider dog age and breed when they use the lipid concentrations for diagnostic purposes.

著者

Yusuke MURAHATA Asami YAMAMOTO Yuya MIKI Yoshiaki HIKASA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0398, (Released:2013-10-08)

被引用文献数

1 3

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This study aimed to investigate and compare the antagonistic effects of atipamezole, yohimbine and prazosin on medetomidine-induced diuresis in healthy cats. Five cats were repeatedly used in each of the 9 groups. One group was not medicated. Cats in the other groups received 40 µg/kg medetomidine intramuscularly and saline (as the control), 160 µg/kg prazosin, or 40, 160 or 480 µg/kg atipamezole or yohimbine intravenously 0.5 hr later. Volume, pH and specific gravity of urine; plasma arginine vasopressin (AVP) level; and creatinine, osmolality and electrolyte levels in both urine and plasma were measured. Both atipamezole and yohimbine, but not prazosin, antagonized medetomidine-induced diuresis. The antidiuretic effect of atipamezole was more potent than that of yohimbine, but was not dose dependent, in contrast to the effect of yohimbine at the tested doses. Both atipamezole and yohimbine reversed medetomidine-induced decreases in both urine specific gravity and osmolality and increases in plasma osmolality and free-water clearance. Antidiuresis of either atipamezole or yohimbine was not related to the area under the curve for AVP level, although the highest dose of both atipamezole and yohimbine initially and temporarily increased plasma AVP levels, suggesting that this may partly influence the antidiuretic effects of both agents. The diuretic effect of medetomidine in cats may be mediated by α2-adrenoceptors, but not α1-adrenoceptors. Atipamezole and yohimbine can be used as antagonistic agents against medetomidine-induced diuresis in healthy cats.

著者

Junji YOSHIDA Nobuyuki KAWAGOE Tomohiro KAWAMURA

出版者

一般社団法人 日本機械学会

雑誌

Journal of System Design and Dynamics (ISSN:18813046)

巻号頁・発行日

vol.7, no.3, pp.293-303, 2013 (Released:2013-09-30)

参考文献数

18

被引用文献数

2

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Bicycles are popular with the general public because of their low price and easy maintenance, and they will be an important vehicle in the future because of their low environmental load. Improving the comfort of the ride is one of the important factors that will lead to increased popularity. We attempted to increase comfort by reducing vibration, and evaluated the results with a subjective test. We determined that low frequency vibration of the seat greatly affected the comfort of the ride. We then performed a transfer path analysis (TPA) and a hammering test to investigate how the vibration characteristics of the bicycle affected the vibration of the seat. Through TPA, the rear of the bicycle frame was found to have a high influence on the seat vibration, and the vibration behavior was obtained by modal analysis. In order to reduce seat vibration, a spring was inserted in the front of the seat and, to increase the stiffness, a steel plate and bolts were attached to the rear of the frame. As a result, the seat vibration while riding was decreased by about 10 dB, and the comfort of the ride was greatly improved.

著者

小笠原 弘親

出版者

日本政治学会

雑誌

年報政治学 (ISSN:05494192)

巻号頁・発行日

vol.43, pp.1-17, 1992-12-22 (Released:2009-12-21)

著者

中村 安秀

出版者

日本国際保健医療学会

雑誌

国際保健医療 (ISSN:09176543)

巻号頁・発行日

vol.28, no.1, pp.27-27, 2013-03-20 (Released:2013-04-11)