著者

長谷美 達雄 馬場 邦彦

出版者

The Japanese Society of Snow and Ice

雑誌

雪氷 (ISSN:03731006)

巻号頁・発行日

vol.56, no.2, pp.119-126, 1994-06-15 (Released:2009-08-07)

参考文献数

12

被引用文献数

1 1

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関東地方では,南岸低気圧の通過の際に低気圧による暖かな東寄りの気流とこれとは相対的に冷たい北西部からの気流との間に局地前線が形成される.発達した低気圧の場合には東寄りの気流が強く内陸深くまでおよび,はじめ房総半島に見られた局地前線は内陸に進行する.一方,地上付近の北西風は関東西部の山地と前線との間に収束される.前線の西側で湿雪が降り,送電線着雪の発達条件となる.過去の大きな着雪事故はこの地域内で発生している.この地域性は関東の地形に起因し,また低気圧による局地的な前線と関連が深いと考えられるので,局地的な前線の成因と着雪発生との関わりについて考察した.

著者

関谷 忠雄

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.66, no.6, pp.693-694, 1973 (Released:2011-11-04)

著者

Folashade OLAIFA Joseph Olusegun AYO Suleiman Folorunsho AMBALI Peter Ibrahim REKWOT

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0038, (Released:2012-11-16)

被引用文献数

7

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Experiments were performed to investigate the effect of ascorbic acid in reducing haemato-biochemical changes in pack donkeys during the cold-dry (harmattan) season. Six experimental donkeys administered orally with ascorbic acid (200 mg/kg), and six control donkeys, not administered with ascorbic acid, were subjected to packing. Blood samples were collected from all donkeys for haematological and biochemical analyses. In the control donkeys, packed cell volume (PCV), erythrocyte count and haemoglobin concentration (Hb) decreased significantly (P<0.05) at the end of packing. In the experimental donkeys, there was no significant difference between the pre- and post-packing values of PCV, erythrocyte count and Hb. In the control donkeys, the neutrophil and neutrophil:lymphocyte ratio increased significantly (P<0.05) post-packing, but in the experimental donkeys, the pre- and post-packing values were not significantly different. Eosinophil count increased significantly (P<0.05) in experimental and control donkeys post-packing. In conclusion, packing exerted significant adverse effects on the haematological parameters, ameliorated by AA administration. AA may modulate neutrophilia and induce a considerable alteration of erythroid markers in donkeys subjected to packing during the harmattan season.

著者

Shigiko TAKEI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0405, (Released:2012-11-16)

被引用文献数

3

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Veterinary x-ray photography and examinations of synovial fluid, blood and urine were conducted on a Cynomolgus Monkey from China (5 years old) which exhibited macroscopically visible systemic joint swelling after the quarantine period. The presence of inflammatory cells in the synovial fluid obtained by arthrocentesis, high counts of neutrophils, monocytes and large unstained cells and the elevated serum CRP level suggested that the lesions in this animal were due to polyarthritis.

著者

Hideaki INAGAKI Yuji MORI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0388, (Released:2012-11-16)

被引用文献数

3

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It is known that long-term post-weaning individual housing significantly reduces emissions of 22-kHz calls in male rats. In this study, we assessed post-weaning successive changes in 22-kHz calls emitted by male rats under two different types of post-weaning housing conditions (individually and socially). In addition, we evaluated the critical point at which a significant reduction in 22-kHz calls could be observed in male rats housed individually after weaning. Significantly fewer 22-kHz calls were emitted by individually housed rats compared to socially housed rats at 16 weeks of age, indicating that 13 weeks after weaning may be a critical point for the reduction of 22-kHz calls caused by post-weaning individual housing.

著者

浅田 昭司

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.2, pp.115-122, 2012 (Released:2012-05-01)

著者

太田 成男 石橋 佳朋

出版者

一般社団法人 日本小児神経学会

雑誌

脳と発達 (ISSN:00290831)

巻号頁・発行日

vol.31, no.2, pp.122-128, 1999-03-01 (Released:2011-08-10)

参考文献数

14

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アポトーシスは細胞が縮小していく細胞死として発見され, それが遺伝子のプログラムによって能動的に進行する.アポトーシスは生体制御や生体防御機構として働き, 個体の維持には必須なプロセスである.アポトーシスのシグナルの伝達, 制御, 実行について関与する因子が同定され, その分子機構も詳細に論じられるようになった.アポトーシスのシグナル伝達には蛋白問の相互作用によって伝えられる機構とミトコンドリアシグナルが発せられる機構がある.Bc1-2ファミリー蛋白はアポトーシスを制御する.最終的にアポトーシスを実行するのはカスパーゼファミリーという蛋白切断酵素群であり, カスパーゼ自身も前駆体が切断され活性化される.

著者

Shintaro Yanagimoto Michiko Haida Matsunobu Suko

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.51, no.12, pp.1631-1634, 2012 (Released:2012-06-15)

参考文献数

23

被引用文献数

2

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People living in Japan were affected in various ways after the Great East Japan earthquake of March 11, 2011. A 52-year-old female asthma patient not directly affected by the disaster experienced a decrease in peak expiratory flow (PEF) immediately after the earthquake. Despite increasing the inhaled and oral corticosteroid doses, her PEF did not recover. One month later, her PEF level abruptly returned to normal with minimal medications, which were previously ineffective, and the asthma-related symptoms vanished. The stabilization of her state of mind and actual social state seemed to be a part of the reason for the patient's recovery.

著者

柴崎 一郎

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌E(センサ・マイクロマシン部門誌) (ISSN:13418939)

巻号頁・発行日

vol.119, no.8-9, pp.405-410, 1999-08-01 (Released:2008-12-19)

参考文献数

23

被引用文献数

2 5 8

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Hall elements as mass production magnetic sensors are new application area for thin film technology such as vacuum deposition and MB E. Highly sensitive InSb thin film Hall elements formed by vacuum deposition are often applied as magnetic sensors for DC brushless motors used in electronic equipment. InAs Hall elements developed and produced by MBE have high sensitivity and stability over a wide temperature range and have potential for the present and future applications required by many electronic systems. Here, we review the recent status of application, production and the good characteristics of thin film Hall elements for use as magnetic sensors.

著者

増山 幹高

出版者

公共選択学会

雑誌

公共選択の研究 (ISSN:02869624)

巻号頁・発行日

vol.2006, no.46, pp.45-53, 2006-07-01 (Released:2010-10-14)

参考文献数

17

著者

Kenichiro Yaita Takumitsu Suzuki Yukihiro Yoshimura Natsuo Tachikawa

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.51, no.22, pp.3231-3232, 2012 (Released:2012-11-15)

参考文献数

2

被引用文献数

2 2 2

著者

Akihiro OHNISHI Tomohiro OSAKI Yoshiharu MATAHIRA Takeshi TSUKA Tomohiro IMAGAWA Yoshiharu OKAMOTO Saburo MINAMI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0240, (Released:2012-11-15)

被引用文献数

3 24

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The aim of this study was to investigate the correlations of severity of osteoarthritis (OA) and serum biomarkers including keratan sulfate (KS), hyaluronic acid (HA), and chondroitin sulfate (CS) 846 epitope. We also investigated the effect of glucosamine and fish collagen peptide (FCP) on OA. OA was induced in 12 rabbits (12 weeks of age) by anterior cruciate ligament transection (ACLT). After the surgery, the rabbits were orally administered FCP (F group), glucosamine (G group), or FCP and glucosamine (FG group) for 4 weeks. The control group was provided water ad libitum (C group). Blood was collected before surgery (pre-ACLT) and before euthanasia (post-ACLT) for serum marker measurement. Biomarker levels were measured by using commercial kits. We evaluated OA severity both macroscopically and histologically. Macroscopic evaluation showed mildly eroded condylar surfaces in the C group. Histological findings were significantly different from the FG and other groups. There were no significant differences between each group at post-ACLT in serum KS, HA and CS 846. Histological assessment and serum biomarker measurements performed at post- ACLT showed a significant correlation between HA concentration and OA severity. Variations in the CS 846 concentration at pre- and post-ACLT were significantly correlated with OA severity. Administration of glucosamine and FCP had chondroprotective effects in the ACLT model. Serum biomarker concentrations were significantly correlated with cartilage injury. Serum biomarker measurement would be useful for monitoring articular cartilage damage in the clinical setting.

著者

Wirasak FUNGFUANG Nobuhiko NAKAO Tomoaki NAKADA Makoto YOKOSUKA Toru R. SAITO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0276, (Released:2012-11-15)

被引用文献数

3 5

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The puberty onset in mammals is tightly coupled to the animal’s nutritional and metabolic state. In present study, we evaluated the effects of high fat diet on leptin, adiponectin levels, leptin mRNA expression and puberty onset in female rats. On day 21, female rats were divided into 2 groups; Normal food (NF) and High fat food (HF). HF group shows significantly earlier (P<0.001) date of vaginal opening and lower body weight (P<0.001) than NF group. The rats with HF had a significantly heavier uterus (P<0.05) than NF, whereas serum leptin and adiponectin levels and leptin mRNA expression were not significant differences between NF and HF. We speculate that the fat-induced nutritional imbalance in young females may lead to neuroendocrine dysfunction during adolescence.

著者

Yukiko Takao Yoshiyuki Miyazaki Fumitake Onishi Hideaki Kumihashi Yasuyuki Gomi Toyokazu Ishikawa Yoshinobu Okuno Yasuko Mori Hideo Asada Koichi Yamanishi Hiroyasu Iso

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.22, no.2, pp.167-174, 2012-03-05 (Released:2012-03-05)

参考文献数

33

被引用文献数

2 20

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Background: The incidence and risk factors for herpes zoster have been studied in cross-sectional and cohort studies, although most such studies have been conducted in Western countries. Evidence from Asian populations is limited, and no cohort study has been conducted in Asia. We are conducting a 3-year prospective cohort study in Shozu County in Kagawa Prefecture, Japan to determine the incidence and predictive and immunologic factors for herpes zoster among Japanese.Methods: The participants are followed for 3 years, and a telephone survey is conducted every 4 weeks. The participants were assigned to 1 of 3 studies. Participants in study A gave information on past history of herpes zoster and completed health questionnaires. Study B participants additionally underwent varicella-zoster virus (VZV) skin testing, and study C participants additionally underwent blood testing. If the participants develop herpes zoster, we evaluate clinical symptoms, measure cell-mediated immunity and humoral immunity using venous blood sampling, photograph skin areas with rash, conduct virus identification testing by polymerase chain reaction (PCR) and virus isolation from crust sampling, and evaluate postherpetic pain.Results: We recruited 12 522 participants aged 50 years or older in Shozu County from December 2009 through November 2010. The participation rate was 65.7% of the target population.Conclusions: The present study is likely to provide valuable data on the incidence and predictive and immunologic factors for herpes zoster in a defined community-based population of Japanese.

著者

田中 秀明 加藤 公児 山下 栄樹

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.51, no.3, pp.189-194, 2009-06-30 (Released:2010-12-01)

参考文献数

18

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Vaults are among the largest cytoplasmic ribonucleoprotein particles and are found in numerous eukaryotic species. Although roles in multidrug resistance and innate immunity have been suggested, the cellular function remains unclear. We have determined the X-ray structure of rat liver vault at 3.5 Å resolution. A vault particle shell was composed of 78 MVP (Major vault protein) chains with 39-fold dihedral symmetry. The shoulder domain of MVP is structurally similar to SPFH (stomatin/prohibitin/flotillin/HflK/C) domain involved in lipid raft association.

著者

Manabu KOIKE Yasutomo YUTOKU Aki KOIKE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0333, (Released:2012-11-14)

被引用文献数

4 11

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The DNA repair protein Ku70 is a key player in chemoresistance to anticancer agents (e.g., etoposide) or radioresistance. The responses of different organs to radiation vary widely and likely depend on the cell population in the organs. Previously, we established and characterized Ku70-deficient murine lung epithelial (Ku70 −/− MLE) cells and found that these cells are more sensitive than Ku70 +/− MLE cells (control cells) to X-irradiation, as determined by clonogenic survival assay; however, the mechanism underlying this sensitivity remains unclear. In this study, we examined the mechanism by which X-irradiation triggers the death of Ku70 −/− MLE cells. Our results showed that Ku70 −/− MLE cells were more sensitive to radiation-induced apoptosis than control cells, although X-irradiation activated caspase-3 and caspase-7, and cleaved PARP in both cell lines. We also examined the expression level of phosphorylated H2AX (γH2AX), which is a marker of DSB, and observed the phosphorylation of H2AX and the elimination of γH2AX in both cell lines after X-irradiation. The elimination in Ku70 −/− MLE cells was slower than that in control cells, suggesting that DSB repair activity in the Ku70 −/− MLE cells is lower than that in control cells. These findings suggest that Ku70 might play a key role in the inhibition of apoptosis through the DSB repair pathway in lung epithelial cells. Our findings also suggest that these cell lines might be useful for the study of Ku70 functions and the Ku70-dependent DSB repair pathway in lung epithelial cells.

著者

Jin HUR Byung Woo JEON Yeong Ju KIM In Gyeong OH John Hwa LEE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0378, (Released:2012-11-14)

被引用文献数

1 6

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Escherichia coli strains were isolated from the feces of 130 diarrheic calves at different farms locations in Korea. The presence of the virulence genes, such as fanC, f41, f17a, eaeA, clpG, afa-8D, sta, stx1 and stx2, in each E. coli isolate was examined. Among the 314 isolates, 157 carried one or more of the virulence genes tested in this study. The most prevalent virulence gene was clpG (45.9%), although f17A (36.9%) and afa-8D (21.7%) were also frequently observed. The sta, stx1 and eaeA genes were detected in between approximately 13 and 17% of the isolates, and the fanC and fim41a genes were detected to a lesser extent. Collectively, our data indicated that diarrhea in calves in these locations can be ascribed to various virulence factors, and the pathogenesis may be more related to virulence genes such as, clpG, f17A, and afa-8D.

著者

丸井 輝美 力武 諒子 柴田 昌和 江連 博光 伊藤 純治 鈴木 雅隆 後藤 昇

出版者

昭和大学学士会

雑誌

昭和医学会雑誌 (ISSN:00374342)

巻号頁・発行日

vol.65, no.3, pp.259-263, 2005-06-28 (Released:2010-09-09)

参考文献数

11

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2003年度昭和大学医学部解剖学実習で, 58歳男性 (癌性悪液質・下咽頭癌により死亡) のご遺体で大動脈弓から左椎骨動脈が直接分岐する例に遭遇したので報告する.本例はAdachi-Williams-中川分類のC型に相当し, Adachiの報告では日本人の出現頻度は約5%で, 当大学の本年度解剖実習では30体中1例 (出現頻度: 3%) であった.本例は, 大動脈弓の第一枝として腕頭動脈が起始, 第二枝として左総頚動脈が分岐し, 第三枝として左椎骨動脈が大動脈弓から分岐していた.また, 左椎骨動脈は第4頚椎の横突孔に入り上行していた.一般的に左鎖骨下動脈は大動脈弓からの第三枝として起始しているが, 本例では第四枝として起始していた.

著者

原 涼子 奥出 祥代 林 孝彰 北川 貴明 神前 賢一 久保 朗子 郡司 久人 常岡 寛

出版者

公益社団法人 日本視能訓練士協会

雑誌

日本視能訓練士協会誌 (ISSN:03875172)

巻号頁・発行日

vol.40, pp.107-111, 2011 (Released:2012-02-22)

参考文献数

11

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目的:心因性視覚障害は、視力障害や視野障害の他に色覚異常を訴えることが多い。今回、心因性視覚障害と診断され、片眼の色感覚が消失した1例を経験したので報告する。症例:16歳、女児。右眼で見た時の色感覚の消失を自覚し、近医を受診。2009年6月に東京慈恵会医科大学附属病院眼科へ紹介受診となった。症例は高校生であり、部活動に加え生徒会や学校行事など、学校生活の中で様々な役割を担っており忙しい毎日を過ごしていた。矯正視力は右眼(1.5)、左眼(1.5)であり、右眼のGoldmann視野は、V/4イソプターのらせん状視野、I/4からI/1イソプターの求心性視野狭窄を呈した。色覚検査として、仮性同色表、New Color Test、色相配列検査を片眼ずつ行い、いずれの検査も右眼のみ強度の色覚異常が検出された。特にNew Color Testでは有彩色と無彩色を分けることが難しく、主訴と一致する結果であった。全視野刺激網膜電図における杆体反応・錐体反応の潜時・振幅は正常範囲内であった。頭部MRIに異常所見はなかった。心因性視覚障害と診断し、経過観察していたところ、2010年2月に、色覚が改善したと本人から報告があり、2010年5月に再度色覚検査、視野検査を行ったところ、結果は全て正常であった。経過中、左眼の視機能異常は検出されなかった。結論:心因性視覚障害と診断されたのが、文化祭の実行委員になった直後であったことから、ストレス等による環境的・心理的要因がその背景にあると考えられた。

著者

本川 弘一 三田 俊定

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.40, no.3-4, pp.298-320, 1941-07-31 (Released:2008-11-28)

参考文献数

25

被引用文献数

1 1 6

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Bei der Elektrenkephalographie des Menschen lässt sich eine von den eigentlichen Hirnströmen sicher unterscheidbare langsame Schwankung auf Augenbelichtung hin nachweisen. Da sie detn bei Tieren gefundenen “On”-Effekt der optischen Hirnrinde etwas ähnlich ist, wurde sie ohne weiteres der Grosshirnrinde zugeschrieben. Angesichts ihres mit dem cerebralen “On”-Effekt bei Tieren nicht ganz übereinstimmenden Verhaltens wurde ihre vermeintliche Herkunft in Zweifel gezogen und folgende Untersuchung angestellt, um das Wesen dieser Potentialschwankung aufzuklären: 1. Sie ist von Lid- und Augenbewegungen unabhängig, was mit der elektrischen Registriermethode der Lid- und Augenbewegungen einwandfrei nachgewiesen wurde. 2. Ein rotes Licht ist weniger wirksam als ein weisses oder ein blaues, um diese Schwankung hervorzurufen. 3. Durch Untersuchungen über die Potentialverteilung auf dem Kopf wurde festgestellt, dass diese Schwankung von den Augen oder wenigstens von ihrer Nähe herruhrt. 4. Der naturgetreue Verlauf dieser Schwankung wurde mittels eines Gleichstromverstärkers und eines Oszillographen registriert, um festzustellen, dass sie in jeder Hinsicht mit dem Elektroretinogramm des Menschen iibereinstimmt. 5. Auf rhythmische optische Reize lassen sich in Bestätigung des Adrian schen Befunds periodische Schwankungen des Potentials nachweisen. Das Bild and andere Eigenschaften dieser Flickerantwort sind auf der vorderen and der hinteren Hälfte des Kopfes sehr verschieden, indem Netzhautprozess beim ersteren Fall eine überwiegende Rolle spielt. Es sei nachdrücklich betont, lass sich der Belichtungsstrom der Netzhaut bei der Elektrenkephalographie unter Umständen geltend macht, um eine Konfusion mit Hirnströmen hervorzurufen, besonders wenn eine Elektrode in der Nähe der Augen liegt.