著者
吉廣 尚大 冨田 隆志 橋本 佳浩
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.42, no.6, pp.445-452, 2016-06-10 (Released:2017-06-10)
参考文献数
13
被引用文献数
5 2

This study investigated whether the review of systems (ROS), an evaluation method that covers all organ systems, improves the quality of pharmaceutical care provided in intensive care units (ICUs). We retrospectively examined patients from the respiratory and emergency intensive care departments admitted to the ICU of our hospital in 2012 (before the introduction of ROS; non-ROS group, n = 93) and in 2014 (after the introduction of ROS; ROS group, n = 65). The number of pharmaceutical interventions and adverse drug events prevented by pharmacists per 1000 patient days were higher in the ROS group (265.7 and 57.8 for the ROS group and 190.8 and 39.9 for the non-ROS group). Pharmacists' proposals were accepted at a significantly higher rate in the ROS group than in the non-ROS group (89.5% vs 72.3%, P < 0.01), and the accepted proposals in the ROS group were implemented for a wider range of organ systems. These results indicate that the ROS was helpful in terms of identifying the patients' clinical manifestations and evaluating the adequacy and safety of medication administered in the ICU, which resulted in improved and precise proposals by pharmacists. Moreover, the ROS approach introduced in this study was considered to be suitable for pharmaceutical activities in the ICU and to contribute to improving the quality of pharmaceutical care.
著者
冨田 隆太 阿部 今日子
出版者
一般社団法人 日本建築学会
雑誌
日本建築学会技術報告集 (ISSN:13419463)
巻号頁・発行日
vol.27, no.67, pp.1303-1308, 2021-10-20 (Released:2021-10-20)
参考文献数
14
被引用文献数
1

To prevent COVID-19, the apartment housing was filled with more people for a longer time while at home in Japan. These conditions are thought to have produced something close to the maximum noise load of the apartment housing. In order to better understand the reaction of the residents to this situation, we decided to conduct a questionnaire and collect data. As a result, compared to before stay home, the number of sounds that were heard and worrisome during stay home increased to 1.3 times. In addition, about 10% of the residents were involved in noise problems during stay home.
著者
橋本 知幸 數間 亨 武藤 敦彦 皆川 恵子 永廣 香菜 當山 啓介 足立 雅也 池田 文明 駒形 修 冨田 隆史 森川 茂 澤邉 京子
出版者
The Japan Society of Medical Entomology and Zoology
雑誌
衛生動物 (ISSN:04247086)
巻号頁・発行日
vol.66, no.1, pp.7-12, 2015-03-25 (Released:2015-09-25)
参考文献数
23
被引用文献数
1 1

A field evaluation of the acaricidal effect on ticks was conducted in Chiba Prefecture in 2014. Eleven formulations of organophosphates and pyrethroids, including emulsifiable concentrate (EC), flowable (FL), dust and CO2 gas formulation, were evaluated simultaneously. These formulations were respectively applied to zones 2 m wide by 17–60 m long with dosages between 0.05–0.25 g AI/m2, which are the recommended dosages for cockroach control in buildings. The numbers of ticks collected by the dragging method with flannels were compared between pre- and post-treatment. The genus Haemaphysalis and Amblyomma were captured during the test period. All the formulations drastically suppressed the tick density on day 1. High reduction rates of more than 90% were observed until day 4 in all formulations, and persistence for at least for 31 days was recognized in fenitrothion EC, FL and fenthion dust. Phenothrin CO2 gas formulation that flows in the air with little residue in the soil or on foliage also yielded a long suppression effect at a dosage of 0.05 g AI/m2. Tick infestation from outside the test plot seemed to be feeble after the treatment. These results suggested that all the formulations achieved superior suppression effect on the ticks.
著者
冨田 隆志 佐伯 康之 鴫田 江理嘉 河田 麻美 木村 康浩 木平 健治
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.129, no.4, pp.451-457, 2009 (Released:2009-04-01)
参考文献数
16
被引用文献数
1 1 1

We conducted a survey on the immunization requirements of the students in the fourth year of the 4-year-course departments of pharmacy in Japan by using a self-administered questionnaire, which was mailed to the directors of the institutes. Of the 61 departments invited, 54 responded. Program of seroprevalence examination or vaccination was not in place against measles, rubella, mumps and varicella, and hepatitis B in 31.5% (17/54), 53.7% (29/54), 57.4% (31/54), and 68.5% (37/54), respectively. Surveillance of the history of infection and vaccination was carried out in 21 departments, but only 5 departments insisted on documented evidence of immunity. Students who were proven to be susceptible to these diseases were required to receive immunization in most departments that performed seroprevalence examination. Seroprevalence examination was carried out in colleges in 83.3% (25/30), and the expenses were born by department in 70.0% (21/30). On the other hand, vaccination was carried out in colleges in 30.0% (9/30), and the expenses were born by department in 6.7% (2/30). Of the 54 departments, 29, 11, and 3 departments executed these programs in the 3rd year, 4th year, and at the time of admission, respectively. Influenza vaccination during the year of clinical clerkship and tuberculosis skin test was required in 20.4% (11/54) and 37.0% (20/54), respectively; these were carried out in the colleges in 8 and 19 departments and the expenses were born by department in 1 and 18 departments, respectively. Countermeasures against these infectious diseases were found to be insufficient in most departments of pharmacy.
著者
松島 葵 冨田 隆志 鴫田 江理嘉 吉川 博 柳田 徳栄 髙松 花絵 松尾 裕彰
出版者
一般社団法人 日本医薬品情報学会
雑誌
医薬品情報学 (ISSN:13451464)
巻号頁・発行日
vol.24, no.4, pp.206-210, 2023-02-28 (Released:2023-04-07)
参考文献数
9

Objective: In the instructions for package inserts (PI) of prescription drugs revised in June 2017, the section “persons with reproductive potential” was established under “precautions concerning patients with specific backgrounds.” The description rules associated with contraceptive duration were modified in these. In this study, we investigated descriptions of contraceptive duration in PI that were prepared based on the revised instructions, interview forms (IF), and other proper use materials (PM).Methods: We collected PI, IF, and PM of prescription drugs containing a new active ingredient approved from April 2017 to March 2022 for which the PI were prepared based on the revised instructions and investigated descriptions of PI, contraceptive duration, and its evidence in each information material.Results: Of the 181 drugs studied, 43.1 and 12.7% required females and males to use contraception during the period of drug consumption, respectively. Among these, the ratio of drugs that had descriptions of contraceptive duration were 15.4 and 0% for females and males at PI, respectively; 51.3 and 39.1% for female sand males at IF, respectively. Anticancer drugstended to describe contraceptive duration in the PM rather than PI or IF. For some drugs, there was no description of contraceptive duration in any of the materials. Contraceptive durations ranged from the period of administration of that drug to over a year for females and approximately one week to six months for males. The reasons for these contraceptive durations were diverse.Conclusion: Contraceptive information in the PI based on revised instructions were not sufficient for use by healthcare workers, even when the IF and PM were confirmed. These results suggest that there is a need for standardizing the descriptions, types of materials to be described, and choice of evidence for contraceptive duration.
著者
冨田 隆太 阿部 今日子
出版者
日本建築学会
雑誌
日本建築学会環境系論文集 (ISSN:13480685)
巻号頁・発行日
vol.86, no.790, pp.873-882, 2021-12-01 (Released:2021-12-01)
参考文献数
23
被引用文献数
1

The "floor" that is in constant contact with people is important for users to spend comfortably and safely in the architectural space. Improving floor performance (safety and comfort) is considered to be an important issue for all generations, including children, adults and the elderly. The purpose of this study is to be safe and comfortable for children and the elderly, and to solve the problem of floor impact sound. It is "Development of tatami with consideration for sound insulation performance and safety and formulation of design guidelines". In this paper, we first focused on tatami as a basic study. We examined heavy-weight floor impact sound, the hardness at the time of a fall collision, and the hardness at the time of walking. In addition to commercially available straw tatami and building material tatami, five types of tatami mats focusing on vibration isolation were prototyped and experimentally examined. For reference, we also examined light-weight floor impact sound. As a result of this paper, the following findings were obtained. 1) Straw tatami and building material tatami had no effect on the heavy-weight floor impact sound level reduction in the 63 Hz band, and were about 0 to -1 dB. In tatami mats that was prototyped in this paper, considering the vibration isolation, we were able to achieve a performance improvement of 3 dB by reducing the heavy-weight floor impact sound level in the 63 Hz band. 2) Regarding the hardness at the time of a fall collision, straw tatami and building material tatami were 50 to 53 G. The prototype tatami mats had a large impact mitigation effect of 20 to 31 G. 3) Of the prototype tatami mats that were able to realize (1) and (2), T4 and T5 were also good for walking. 4) Regarding the four types of performance related to floor hardness, the relationship of quantitative evaluation of each performance was clarified. It turns out that none of the performances correspond linearly. It was suggested that it is necessary to examine each layer in the floor cross section and the combination of each layer for each performance. As described above, in this paper, it was found that the prototype tatami mat does not impair the walking feeling, and the effect can be obtained by the amount of reduction in heavy-weight floor impact sound level and the hardness at the time of a fall collision. In addition, the effectiveness of introducing such a vibration-proof structure into tatami mats was suggested.
著者
冨田 隆志
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.137, no.12, pp.1497-1504, 2017 (Released:2017-12-01)
参考文献数
31

Several issues concerning medicines remain unclear, including the availability of known, but not easily recognizable information. This review evaluates the mechanisms of side effects and the various risk indications included in package inserts. The results can be summarized as follows. 1) Short-term exposure to gatifloxacin significantly induced insulin secretion and increased the cytosolic Ca2+ concentration of islet cells by augmenting extracellular Ca2+ influx and its release from the endoplasmic reticulum. Alternatively, there was a decline in the cellular insulin level and reactivity to sulfonylurea after prolonged exposure. The insulin depletion was greater than that produced by other fluoroquinolones. 2) The elution of di(2-ethylhexyl)phthalate (DEHP) from the infusion set could be associated with the solubilizers in the injection medicines. The package inserts of several products containing polysorbate or ethanol had no warning about DEHP. Although there was a slight correlation between polysorbate content and descriptions on package inserts, the use of DEHP-containing devices was prohibited for some products, even with limited amounts of polysorbate. Therefore, the package insert statements should be reviewed to reflect appropriately the extent of DEHP elution. 3) Risk management plan consists of strategies to minimize the potential risks of medicines. One approach could be to introduce reminders on package inserts; however, of 268 potential risks associated with 81 products, 56 were not mentioned in package inserts. Because most postmarketing pharmacovigilance plans depend on spontaneous reporting by healthcare personnel, the descriptions on package inserts should be reexamined.
著者
冨田 隆史 葛西 真治
出版者
国立感染症研究所
雑誌
基盤研究(C)
巻号頁・発行日
2002

一般に昆虫の雌成虫体内では,卵巣発育のためにエクジステロイドが分泌される。エクジステロイド合成系と性ホルモン合成系に関与するチトクロムP450の特定を目的として,マイクロアレイ法により86個のキイロショウジョウバエ全P450遺伝子の発現量を雌雄間で比較した。発現量に性差があった15種類のP450遺伝子につき,定量PCR法による検証を行った。エクダイソン合成系への関与が既知のCyp302a1とCyp315a1や機能不明なCYP6A19の遺伝子が雌成虫体内で約20倍多く発現していることを明らかにした。逆に,Cyp312a1は,雄成虫で数十倍多く発現していることが明らかになった。Cyp312a1遺伝子の多くは腹部で発現し,蛹期より徐々に増大し成虫5日目でピークに達していることから,この酵素は雄生殖器管内で働いている可能性が高い。フェノバルビタール(PB)はほ乳類,昆虫類,菌類などさまざまな生物種でP450の一般的な誘導剤として知られている。P450遺伝子の転写機構を解明する目的で,PBの誘導を受けるP450遺伝子をマイクロアレイ法により特定した。PB処理により10数種のP450が成虫体内で誘導されることを明らかにした。これらの中には殺虫剤抵抗性バエでDDT解毒作用を示すことが知られているCYP6G1の遺伝子も含まれていた。
著者
冨田 隆 田矢 功司 島村 栄員 岡田 喜克 岩崎 誠 五嶋 博道 吉田 洋一
出版者
一般社団法人日本消化器外科学会
雑誌
日本消化器外科学会雑誌 (ISSN:03869768)
巻号頁・発行日
vol.17, no.8, pp.1574-1578, 1984-08-01
被引用文献数
20

大腸癌治癒切除例のうち手術時隣接臓器への浸潤が認められ他臓器合併切除を施行したものは 17.2% (10/58) で, 長期生存は3年10ヶ月, 2年6ヶ月の2症例であるが, 局所再発や播種性腹膜炎による死亡は2例のみで, 合併切除の有効性を示すものと思われた. 肉眼的他臓器浸潤例のうち組織学的に癌浸潤は 57.1% にみられ, 他の42.9%は結合織や膿瘍形成による炎症性癒着であった. 特に膿瘍形成例でその内腔に癌細胞が浮遊し, 相手臓器まで膿瘍腔が連続進展していることから癌浸潤が考えられた. したがって炎症性癒着といえども癌直接浸潤を考慮すべきである.
著者
井上 勝夫 福島 寛和 冨田 隆太 橋本 修 吉村 純一
出版者
日本大学
雑誌
基盤研究(B)
巻号頁・発行日
2002

本研究は,集合住宅を対象として,以下に示す4項目について検討を行ったものである。(1)住宅購入予定者が住宅に要求する性能の調査(2)住宅広告に記載されている住宅性能項目と内容に関する調査(3)住宅販売に携わる営業担当者の住宅性能に関する知識及び説明方法に関する調査(4)消費者が理解し易い音環境性能(遮音性能)の表現方法に関する検討その結果,(1)については,1都3県の23物件,315人を対象とし、直接面接方式による調査を行なったところ,1位:音環境性能,2位:光環境性能,3位:耐震性能の結果を得,音環境性能に関する要求が最も高いことが判った。(2)については,732枚の集合住宅に関する広告を調査した結果,住宅性能に関する記載は全ての広告においてあるが,その記述方法・内容は定性的または建築仕様による表現が多く,性能を定量的かつ具体的に消費者が捕らえることができない状況にあることが判った。(3)については,マンション販売に携わる営業担当者の住宅性能に関する知識はかなり低く,消費者が彼らの説明によって性能を理解するのは難しい状況にあることが判った。よって,今後,営業担当者に対して住宅性能に関する徹底した教育を行う必要性を示した。(4)については,集合住宅の居住者に対し,遮音性能に関するアンケート調査結果(311票)から,遮音性能を消費者が理解しやすい生活実感として表現する方法・内容を検討し,その具体的内容を提案した。