- 著者
-
石井 義昭
細田 純子
若山 文恵
安藤 正子
- 出版者
- 一般社団法人 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.5, no.3, pp.176-185, 1979 (Released:2011-08-11)
- 参考文献数
- 4
Compatibility of enteric-coated Futraful E Granules (FTEG) with 60 commercial preparations was investigated. In combination with FTEG, changes in appearance (wetness, coagulation, coloration and liquefaction) under the worst condition (30°, RH 92%) were observed in only 3 of the 60 preparations: neophylline, theocolin and sodium bicarbonate. In thin-layer chromatography, decomposed compounds producedin combination of FTFG with the 3 preparations were identified as5-fluorouracil. In the dissolution test, FTEG was not dissolved in1st fluid (J. P. IX) in the same combination. Therefore, the combination of FTEG with 2 of the 3 preparations should be avoided, but the combination with the remaining 57 preparations is possible if attention is paid topackaging, duration of administration and other conditions.