著者
阿部 隆三 及川 真一 佐野 隆一 藤井 豊 義江 和子 後藤 由夫
出版者
Japan Atherosclerosis Society
雑誌
動脈硬化 (ISSN:03862682)
巻号頁・発行日
vol.12, no.4, pp.951-956, 1984

In the present study, effect of probucol (500mg×2, daily) on serum lipids and lipoproteins in S. F. family who showed typical familial hyper-cholesterolemia (FH) were investigated. The results were as follows:<br>1) The values of serum cholesterol (TC) before and after treatment of probucol were 348±14mg/dl and 220±12mg/dl, respectively. These data shows significant reduction of serum cholesterol after treatment of probucol. The percent of reduction of serum cholesterol was 36.4%. This value was significantly higher than the value (17%) in the other FH.<br>2) Though levels of LDL- and HDL-C were decreased after treatment of probucol, LDL-C level was markedly decrease in S. F family as compared with other FH. Reduction of HDL-C after treatment of probucol was not significant difference between in S. F family and other FH.<br>3) Total biliary lipids after treatment of probucol increased from 68.8μmol/ml to 141.9μmol/ml in a patient of S. F family. Level of bile acid increased after treatment of probucol, especially, in this case. On the other hand, the change of biliary lipids after treatment of probucol was not seen in other FH.<br>From these data, though mechanism of marked reduction of LDL-C in S. F family after treatment of probucol was still unclear, metabolism of cholesterol to synthesis of bile acid might have especially involved to marked reduction of serum LDL-C in S. F family.
著者
佐野 隆一 藤井 豊 義江 和子 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫
出版者
一般社団法人 日本動脈硬化学会
雑誌
動脈硬化 (ISSN:03862682)
巻号頁・発行日
vol.13, no.2, pp.349-353, 1985

Three dysbetalipoproteinemic subjects with the E 2/2 homozygous phenotype were analysed serum lipoproteins and serum apolipoprotein E and B levels. Two subjects were normocholesterolemic and one was hypercholesterolemic (type III hyperlipoproteinemia). A patient with type III phenotype had cholesterol-rich VLDL, although the other two normocholesterolemic subjects didn't have it. Both normo- and hypercholesterolemic subjects had elevated levels of serum apo E and a reduction in serum apo B. Therefore, serum apo E/apo B ratio of a patient with type III phenotype was extremely high as compared with other lipoprotein disorders. These ratio of normocholesterolemic dysbetalipoproteinemia was also high as compared with those except for type V hyperlipoproteinemia. It is suggested that dysbetalipoproteinemia might be easily caught in general population by screening examination of serum apo E/apo B ratio.
著者
佐野 隆一 阿部 隆三 平川 秀紀 金沢 義彦 小泉 勝 豊田 隆謙 後藤 由夫 及川 真一
出版者
Japan Atherosclerosis Society
雑誌
動脈硬化 (ISSN:03862682)
巻号頁・発行日
vol.11, no.3, pp.671-676, 1983

In the present study, the effect of probucol (500mg×2, daily) on serum lipids and lipoproteirs level were studied in 9 patients with familial hypercholesterolemia (FH) during 3-4 months. The diagnosis of FH was established according to the criteria both of Fredrickson et al and of Makuchi et al. Thickness of Achilles tendon was over 9mm in all patients and the xanthomas were observed in 4 of 9 patients.<br>Before and 3-4 months after treatment of probucol the measurement of serum triglyceride (TG), total cholesterol (TC) and apolipoprotein (Apo) A-I and A-II were made. At the same time, serum VLDL, LDL, HDL<sub>2</sub> and HDL<sub>3</sub> were separated by successive ultracentrifugation. Thereafter, TG, TC and protein of each lipoprotein fraction were measured.<br>TG and TC were determined by enzymatic method, Apo A-I and A-II were done by single immunodiffusion assay, and protein was done by dye-binding method.<br>All data were expressed as mean ±S.E. and statistically analized by Student's t-test.<br>The results were as follows:<br>1) VLDL-TG levels were slightly increased, although no significance was found between VLDL-TG level before and after treatment.<br>2) The levels of serum TC were 388±37mg/dl and 308±28mg/dl (-21%, p<0.05) before and after probucol administration, respectively. LDL-cholesterol (LDL-C) levels decreased from 325±37mg/dl before treatment to 262±32mg/dl (-19%, p<0.05) after treatment. HDL-C values significantly decreased from 42±5mg/dl to 26±4mg/dl (-38%, p<0.01), and especially HDL<sub>2</sub>-C showed significant fall (-48%, p<0.01).<br>3) Serum Lecithin: Cholesterol Acyltransferase (LCAT) activities were not changed.<br>4) The concentrations of Apo LDL decreased from 139±18mg/dl to 106±17mg/dl (-29%), but it was not significant statistically. Apo A-I levels decreased significantly from 92±10mg/dl to 66±10mg/dl (-28%, p<0.01). On the other hand, Apo A-II levels were unchanged.<br>These observations suggested that probucol would be a useful drug to improve serum and LDL cholesterol levels in FH. However, we should take care to use this drug because of its effect on HDL metabolism.
著者
藤井 豊 鈴木 教敬 堀 三郎 佐野 隆一 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫
出版者
一般社団法人 日本動脈硬化学会
雑誌
動脈硬化
巻号頁・発行日
vol.13, no.6, pp.1385-1387, 1986

Diabetes mellitus is frequently complicated with atherosclerosis. PWV (pulse wave velocity) is an indicator for the sclerotic change of thoratic and abdominal aorta. We studied the relation between PWV and lipid metabolism in diabetics.<br>The subjects who took part in this study were 54 diabetics who were aged from 50 to 59 years old and had a duration of illness over 5 years. Fasting blood sugar level and the concentration of glycosylated hemoglobin (HbA<sub>1</sub>) were measured. Serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), apo B and apo A-I were measured by enzymatic methods and SRID, respectively. PWV was measured by the methods of Hasegawa, et al.<br>We concluded that (1) PWV increased in poorly controlled diabetics (FBS 180mg/dl) more than in well controlled diabetics (FBS 119mg/dl), and (2) PWV had significant positive-relation to serum TC, TG, apo B, apo A-I and apo B/A-I ratio, and had significant negative-relation to HDL-C.<br>According to these data we should improve not only glucose metabolism but also derangement of lipid metabolism.
著者
及川 眞一 阿部 隆三 後藤 由夫
出版者
一般社団法人 日本動脈硬化学会
雑誌
動脈硬化 (ISSN:03862682)
巻号頁・発行日
vol.9, no.6, pp.1035-1039, 1982
被引用文献数
2

It is thought that multi-factors may relate to the occurence and exaggeration of arterial sclerosis in diabetes mellitus. We pointed out the calcification of peripheral arteries in the legs on X-ray photographs as a sign of arteriosclerosis, and studied its prevalence in diabetics and nondiabetics. Furthermore, in order to clarify what correlates with the arteriosclerosis, we analysed the laboratory data and studied the differences between the diabetics with or without the peripheral arterial calcification.<br>We concluded that the incidence of the peripheral arterial calcification in diabetics (32%) was twofold higher than that in non-diabetics (16%).<br>It was clarified that the incidence of the calcification increased significantly in diabetics who had insulin treatment as compared with those who had oral agents or only diet therapy. Similarly, it was significantly higher in diabetics who were complicated with proliferative retinopathy than those who had simple or no retinopathy. And also, diabetics with longer duration of illness had significantly high incidence of the calcification as compared with those with shorter duration.<br>It was relatively higher frequency in diabetics who had hypertention and were controled poorly than those who had normotention and were controled well, respectively, but there was no significance between them.<br>There were no relationships between the peripheral arterial calcification and obesity, serum concentration of lipids, ischemic changes on ECG and aortic arch-calcification in diabetics.<br>These results suggested that the peripheral arterial calcification might relate to the metabolic derangement in diabetes mellitus.
著者
山田 憲一 阿部 隆三 鈴木 進 及川 真一 後藤 由夫
出版者
Japan Atherosclerosis Society
雑誌
動脈硬化 (ISSN:03862682)
巻号頁・発行日
vol.10, no.3, pp.489-495, 1982

Diabetic autopsy cases were collected from the Annual Report of Pathological Autopsy Cases published by Japanese of Pathology for the year 1976-1978. 2089 primary diabetic cases were collected and the cause of death and pathoanatomical findings in various organs were analysed in these primary diabetic cases, and following results were obtained.<br>1) The main causes of death were cardiovascular diseases (43.1%), malignant neoplasma (22.6%), infections (16.2%), diabetic coma (1.9%) and hypoglycemia (0.3%).<br>2) In cardiovascular diseases, the leading cause was diabetic nephropathy (15.6%), followed by cerebral (14.6%) and coronary (10.5%) artery disease.<br>3) The frequency of arteriosclerotic cardiovascular diseases and malignant neoplasmas as cause of death increased with age. Diabetic nephropathy appeared as a cause of death in 3rd decade and the leading cause of death was diabetic nephropathy in 3rd decade (52%) and 4th decade (32%), and over 5th decade decreased with age. Cerebral vascular and coronary artery diseases increased with age and cerebral vascular disease was the leading cause of death over 6th decade.<br>4) In pathoanatomical findings, the frequencies of glomerulosclerosis, myocardial infarction, cerebral infarction and homorrhage were 40.9%. 17.2%, 15.6% and 7.0%, respectively. Myocrdial infarction and cerebral infarction were found in 4th decade and increased with age, while cerebral hemorrhage decreased over 6th decade with age. Diabetic glomerulosclerosis was found in the cases of 2nd decade and high frequencies of glomerulosclerosis were found in all decade and it was higher than those of other vascular lesions.<br>These results showed the characteristics in the causes of death of diabetics in Japan are a lower incidence of coronary artery disease and a high incidence of diabetic nephropathy.
著者
佐野 隆一 阿部 隆三 及川 真一 藤井 豊 後藤 由夫 高瀬 貞夫
出版者
Japan Atherosclerosis Society
雑誌
動脈硬化 (ISSN:03862682)
巻号頁・発行日
vol.15, no.4, pp.1005-1008, 1987

The lipid levels of serum and lipoproteins were examined in eleven patients with myotonic dystrophy (MD) and ten normal subjects. Hyperlipoproteinemia was seen in six patients, including type IIb of three patients, type IIa of two and type V of one. Total cholesterol (C) and triglyceride (TG) levels of serum and lipoproteins in MD were not significant. TG/C ratio of lipoproteins in MD were not so high compared with normals.<br>The mean age of the patients with hyperlipoproteinemia was significantly higher than that of normolipoproteinemia. The correlation coefficients between age and lipid levels of serum and lipoproteins were examined. The age was positively correlated to serum C and VLDL-TG levels. Further, in the MD patients except for case 1 with type V hyperlipoproteinemia, the age was positively correlated to LDL-TG and LDL-C levels, and negatively correlated to HDL-TG levels.<br>In conclusion, the LDL levels increased and the HDL levels decreased with age in MD. These results suggest that the abnormalities of serum lipid metabolism is one of the characteristic changes in MD.
著者
阿部 隆三 丸浜 喜亮 奥口 文宣 及川 真一 柿崎 正栄 鈴木 勃志 後藤 由夫
出版者
一般社団法人 日本内科学会
雑誌
日本内科学会雑誌 (ISSN:00215384)
巻号頁・発行日
vol.69, no.11, pp.1452-1457, 1980

30才,男性で5~6才頃から黄色腫を有し,著明な高コレステロール血症を呈した症例の家族検診,および培養線維芽細胞の検討成績から家族性高コレステロール血症ホモ接合体と診断した症例を報告する.家族検診の脂質検査では, 11例中9例に高コレステロール血症がみられ,そのうち, 8例にIIa型高脂血症がみられた.また,本症例の弟に著明な黄色腫が認められた.一方,心電図所見では, 1例に虚血性変化がみられた.培養線維芽細胞の検討では,本症のアセテートからステロールへの合成能が,正常人培養線維芽細胞に比べ約18倍高い.また,本症例細胞のHMG-CoA reductase活性は,正常人細胞と比べ約15倍高い.さらに,正常人細胞では,培養液をリポ蛋白deficient mediumにすると,細胞内HMG CoA-reductaseの酵素誘導がおこり増加するが,本症例では全く誘導がみられない.以上の結果から, LDLレセプターを直接測定していないが, Goldsteinらの提唱しているLDLレセプターの完全欠損症,すなわち,家族性高コレステロール血症ホモ接合体の症例であることを証明しえた.本症例の治療成績では,クロフィブレートやコレスチポールに全く抵抗を示し,他の強力な治療法を行なう必要があると考えられる.
著者
伊藤 貞嘉 阿部 圭志 尾股 健 保嶋 実 吉永 馨
出版者
社団法人 日本腎臓学会
雑誌
日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日
vol.30, no.1, pp.85-90, 1988

To examine the role of prostaglandins (PGs) in the macula densa mechanism of renin release, rabbit afferent arteriole (Af) alone and afferent arteriole with macula densa attached (Af+MD) were microdissected and incubated consecutively. Hourly renin release rate from a single Af (or Af+MD) was calculated and expressed as ngAI&middot;h<SUP>-1</SUP>&middot;Af<SUP>-1</SUP> (or Af+MD<SUP>-1</SUP>)/h (where AI is angiotensin I). Basal renin release rate from Af was 0.84&plusmn;0.14ngAI&middot;h<SUP>-1</SUP>&middot;Af<SUP>-1</SUP>/h (X&plusmn;SEM, n=23) and remained stable throughout the incubations. Basal renin release rate from Af+MD was 0.33&plusmn;0.04ngAI&middot;h<SUP>-1</SUP>Af+MD<SUP>-1</SUP>/h (n=17), which was significantly lower (p<0.01) than that from Af. When furosemide (1.5 mM) was added to Af, no significant change in renin release rate was observed. However, when furosemide was added to Af+MD, renin release rate increased from 0.40&plusmn;0.05 to 1.59&plusmn;0.15ngAI&middot;h<SUP>-1</SUP>&middot;Af+MD<SUP>-1</SUP>/h (n=10, p<0.01). After the pretreatment with indomethacin, a cyclooxygenase inhibitor, furosemide still increased renin release rate from 0.17&plusmn;0.02 to 0.56&plusmn;0.09 ng AI&middot;h<SUP>-1</SUP>&middot;Af+MD<SUP>-1</SUP>/h (n=5, p<0.05) ; however, indomethacin pretreatment reduced both basal and furosemide-stimulated renin release rate (p<0.05). In the presence of PGI<SUB>2</SUB> (10 &mu;M), renin release rate from Af increased from 0.45&plusmn;0.14 to 1.49&plusmn;0.53 ng AI&middot;h<SUP>-1</SUP>&middot;AN/h (n=9, p<0.05), and further increased to 4.50&plusmn;1.24 ng AI&middot;h<SUP>-1</SUP>&middot;Af<SUP>-1</SUP>/h (p<0.02) after removal from PGI<SUB>2</SUB>. When PGE<SUB>2</SUB> (10 &mu;M) was added to Af+MD, renin release rate increased from 0.54&plusmn;0.09 to 1.26&plusmn;0.24ng AI&middot;h<SUP>-1</SUP>Af+MD<SUP>-1</SUP>/h (n=8, p< 0.05). However PGE<SUB>2</SUB> had no effect on renin release rate from Af alone. We concluded that (1) the prostaglandin system may be a modulating factor of response in the macula densa mechanism of renin release, (2) PGI<SUB>2</SUB> has direct action on renin release from affer-ent arteriole, and (3) PGE<SUB>2</SUB> may participate in the control of renin release through the action on the macula densa.
著者
主代 昇 阿部 圭志 伊藤 貞嘉 三沢 誠一 吉永 馨
出版者
社団法人 日本腎臓学会
雑誌
日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日
vol.34, no.10, pp.1107-1111, 1992

Tissue renin content within the kidney decreases from outer to inner cortex. However, it is not known whether this gradient is due to a decrease in the number of afferent arterioles from the outer to inner cortex or the decrease in renin content per afferent arteriole. Furthermore, it is still controversial whether sodium depletion increases or decreases this gradient. According to Taugner et al., sodium depletion induces the extension of renin positive part of afferent arterioles from vascular pole toward interlobular artery. Since the length of extension may differ among superficial, midcortical, and juxtamedullary afferent arterioles, the observed gradient may vary depending on whether the entire afferent arteriole or only the vascular pole is examined. In the present study, we microdissected the entire afferent arterioles from superficial, middle, and juxtamedullary cortex of rabbit kidney, and examined tissue renin content. We studied: 1. whether tissue renin content per afferent arteriole decreases from the outer to inner cortex. 2. whether sodium depletion affects the gradient of tissue renin content within the cortex. In result, we reached the conclusions, as follows: 1. Tissue renin content per afferent arteriole decreases steeply from superficial to midcortical to juxtamedullary afferent arterioles. 2. The absolute difference in renin content among the three types of afferent arterioles becomes greater during sodium depletion. The internephron heterogeneity of tissue renin content may contribute to functional heterogeneity.
著者
阿部 和敬 中野 圭介
雑誌
情報処理学会論文誌プログラミング(PRO) (ISSN:18827802)
巻号頁・発行日
vol.12, no.2, pp.14, 2019-05-21

マクロ木変換器(MTT)とは,入出力を木構造とする累積引数付き再帰関数のモデルである.複数のMTTの合成として表現される関数を,1つのMTTで表現することをMTTの融合という.一般にはMTTを融合できるとは限らないが,特定の条件下では融合手法が知られている.VoigtländerとKühnemannは,入力木のコピー回数に関する条件を満たす2つのMTTの融合手法を示した.ただし,1つのMTTで表現できるにもかかわらず,彼らの手法を繰り返すことでは融合できない3つ以上の合成も存在する.Manethは,任意の個数のMTTの合成が最終的な出力木のサイズに関する制約を満たすとき,合成に相当する1つのMTTが構成できることを証明した.しかし,彼の研究は融合可能性の証明が目的のため構成は煩雑である.そこで本発表では,高階木変換器(HTT)を用いてVoigtländerとKühnemannの手法を一般化し,Manethの証明に実用に向いた別証明を与える.HTTとは,MTTの一般化として提案された高階関数のモデルである.本融合は,まずMTTの合成を1つのHTTとして表現し,HTTに現れる高階関数のオーダを下げていくことで,MTTへの融合を実現する.理論上融合が不可能な場合でも,本融合は合成に相当する1つのHTTを得ることができる.
著者
阿部 和敬 中野 圭介
雑誌
情報処理学会論文誌プログラミング(PRO) (ISSN:18827802)
巻号頁・発行日
vol.12, no.2, pp.14, 2019-05-21

マクロ木変換器(MTT)とは,入出力を木構造とする累積引数付き再帰関数のモデルである.複数のMTTの合成として表現される関数を,1つのMTTで表現することをMTTの融合という.一般にはMTTを融合できるとは限らないが,特定の条件下では融合手法が知られている.VoigtländerとKühnemannは,入力木のコピー回数に関する条件を満たす2つのMTTの融合手法を示した.ただし,1つのMTTで表現できるにもかかわらず,彼らの手法を繰り返すことでは融合できない3つ以上の合成も存在する.Manethは,任意の個数のMTTの合成が最終的な出力木のサイズに関する制約を満たすとき,合成に相当する1つのMTTが構成できることを証明した.しかし,彼の研究は融合可能性の証明が目的のため構成は煩雑である.そこで本発表では,高階木変換器(HTT)を用いてVoigtländerとKühnemannの手法を一般化し,Manethの証明に実用に向いた別証明を与える.HTTとは,MTTの一般化として提案された高階関数のモデルである.本融合は,まずMTTの合成を1つのHTTとして表現し,HTTに現れる高階関数のオーダを下げていくことで,MTTへの融合を実現する.理論上融合が不可能な場合でも,本融合は合成に相当する1つのHTTを得ることができる.Macro tree transducers (MTTs) are models for recursive functions (with accumulating parameters) on tree-structured data. Constructing a single MTT equivalent to a composition of given MTTs is called 'fusion' of the MTTs. Although it is not always possible to fuse given MTTs in general, fusion methods under certain conditions are known. Voigtländer and Kühnemann showed a fusion method of two MTTs restricted about the number of copying an input tree. However, a repetition of their method cannot necessarily fuse more than two MTTs even in the case where there exists a single MTT equivalent to the composition of them. Maneth proved that we can construct an MTT equivalent to a composition of given multiple MTTs restricted about the size of final output trees. However, since he is interested only in the fusibility, the construction is complicated. This presentation gives another proof adapted to practical uses for Maneth's proof as a generalization of Voigtländer and Kühnemann's method with high-level tree transducers (HTTs). Htt was proposed as a generalization of MTT, which is a model of higher-order functions. Our fusion method comprises two steps: first, a single HTT is obtained as a composition of given multiple MTTs; then, the orders of functions are lowered as much as possible. In this approach, we can obtain a 'fused' HTT even where there is no single MTT equivalent to the composition of MTTs.
著者
阿部,余四男
出版者
東京動物學會
雑誌
動物学雑誌
巻号頁・発行日
vol.48(8-10), 1936-10-15

Mr.POCOCK attempted (P.Z.S. London, 1935, Part III) to include the Corean wolf together with all the other forms of wolves in Chinese Tartary, Thian Shan, Kashmir, Tibet, Mongolia and China proper in Canis lupus laniger HODGSON. And as the basis of including the Corean wolf in laniger, he says that the skull size and pelage colour of it in my despription may fall into the individual variations among laniger. I clearly stated that Canis lupus coreanus ABE has as large a skull as laniger, and that in the pelage colour there in not a little variation, so that I do not take such points as diagnosis; but that it is recognized by its slenderer snout in comparison with laniger or any other middle sized or large sized wolves. So Mr.POCOCK's protest is wide of the mark. I measured my materials anew and two more skulls in Mr.SAITO's collection (both formerly kept in Uyeno Zoological Garden alive) after POCOCK's method, and I find more clearly that all our materials agree in the slenderer snout in comparison with all the laniger specimens which he showed: Width outside pm^2 being 35, 39, 40, 42 in the former and 47, 481/2, 551/2, in the latter, palate between pm^2 being 29, 29, 28, 301/2 in the former and 33, 351/2, 37 in the latter, palate between pm^1 being 261/3, 28, 28, 29 in the former and 34, 32, 31 in the latter, etc., as the table shows. Thus the gap between C.l.laniger and C.l.coreanus far exceeds the gap between his so called C.l.rex and N.E.Siberian wolf. Sometimes north-eastern larger wolves may intrude into Corea over the frozen River Yalou, but such larger stragglers can neither be laniger nor nullify the existence of the peninsular form C.l.coreanus.
著者
山田 貴久 福並 正剛 大森 正晴 熊谷 和明 辻村 英一郎 阿部 泰士 西川 永洋 伯耆 徳武
出版者
公益財団法人 日本心臓財団
雑誌
心臓 (ISSN:05864488)
巻号頁・発行日
vol.26, no.Supplement6, pp.104-107, 1994-12-25 (Released:2013-05-24)
参考文献数
7

洞不全症候群(SSS)における心房筋の電気生理学的異常を体表面加算平均心電図(SAE)により検出しうるか否かを検討した.対象はSSS群37例と正常洞結節機能を有し発作性心房細動(Paf)の既往のないControl群67例である.SAEのフィルターは40~300Hzとし,P波同期法にて200心拍加算平均し記録した.その空間マグニチュード波形においてフィルター化P波の初期部10,20,30msec間の平均電位(EP10,EP20,EP30),その終末部10,20,30msec間の平均電位(LP10,LP20,LP30)を計測した.EP10,EP20,EP30はともにSSS群でControl群に比し有意に低値を示した.LP10,LP20,LP30はPafを伴うSSS群では有意に低値を示したが,Pafを伴わないSSS群とControl群間には有意差を認めなかった.SSSにおけるSAEの特徴は心房波初期部分の電位が低値を示すことであり,この心房波初期電位によりSSSを検出しうることが示唆された.