- 著者
 
          - 
             
             Gertraud Maskarinec
             
             Phyllis Raquinio
             
             Bruce S. Kristal
             
             Adrian A. Franke
             
             Steven D. Buchthal
             
             Thomas M. Ernst
             
             Kristine R. Monroe
             
             John A. Shepherd
             
             Yurii B. Shvetsov
             
             Loïc Le Marchand
             
             Unhee Lim
             
          
 
          
          
          - 出版者
 
          - Japan Epidemiological Association
 
          
          
          - 雑誌
 
          - Journal of Epidemiology (ISSN:09175040)
 
          
          
          - 巻号頁・発行日
 
          - pp.JE20200538,  (Released:2021-02-27)
 
          
          
          - 参考文献数
 
          - 39
 
          
          
          - 被引用文献数
 
          - 
             
             
             7
             
             
          
        
 
        
        
        Aims. As the proportion of visceral (VAT) to subcutaneous adipose tissue (SAT) may contribute to type 2 diabetes (T2D) development, we examined this relation in a cross-sectional design within the Multiethnic Cohort that includes Japanese Americans known to have high VAT. The aim was to understand how ectopic fat accumulation differs by glycemic status across ethnic groups with disparate rates of obesity, T2D, and propensity to accumulate VAT.Methods. In 2013-16, 1,746 participants aged 69.2 (2.7) years from five ethnic groups completed questionnaires, blood collections, and whole-body DXA and abdominal MRI scans. Participants with self-reported T2D and/or medication were classified as T2D, those with fasting glucose >125 and 100-125 mg/dL as undiagnosed cases (UT2D) and prediabetes (PT2D), respectively. Using linear regression, we estimated adjusted means of adiposity measures by T2D status.Results. Overall, 315 (18%) participants were classified as T2D, 158 (9%) as UT2D, 518 (30%) as PT2D, and 755 (43%) as normoglycemic (NG) with significant ethnic differences (p<0.0001). In fully adjusted models, VAT, VAT/SAT, and percent liver fat increased significantly from NG, PT2D, UT2D, to T2D (p<0.001). Across ethnic groups, the VAT/SAT ratio was lowest for NG participants and highest for T2D cases. Positive trends were observed in all groups except African Americans, with highest VAT/SAT in Japanese Americans.Conclusions. These findings indicate that VAT plays an important role in T2D etiology, in particular among Japanese Americans with high levels of ectopic adipose tissue, which drives the development of T2D to a greater degree than in other ethnic groups.