著者

Takuro NAGAHARA Koichi OHNO Itsuma NAGAO Taisuke NAKAGAWA Yuko GOTO-KOSHINO Masaya TSUBOI James K. CHAMBERS Kazuyuki UCHIDA Hirotaka TOMIYASU Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0257, (Released:2022-03-14)

被引用文献数

1

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Intestinal lymphangiectasia (IL) is often observed in dogs with chronic small intestinal diseases. Hypoplasia of the lymphatic vessel due to decreased lymphangiogenesis, which has been suggested in human idiopathic IL, may contribute to the pathogenesis of canine IL. This study aimed to evaluate the diameter and number of lymphatic vessels in full-thickness small intestinal specimens of dogs with IL. Immunohistochemical labeling of lymphatic endothelial cell markers was performed on retrospectively retrieved full-thickness small intestinal specimens. Sixteen dogs with histologically confirmed IL were included, of which 10 had lymphoplasmacytic enteritis (LPE), and six had granulomatous lymphangitis (GL). Nine dogs that died from non-gastrointestinal disorders and with little or no abnormalities in the small intestine were used as controls. Lymphatic vessel diameters in dogs with IL were significantly increased in all layers of the small intestine, including the villus lacteal, lamina propria, submucosa, muscularis, and mesentery, compared with controls (all P<0.01). There was no significant difference in the lymphatic vessel diameters between dogs with LPE and GL (all P>0.05). There was no significant difference in the number of lymphatic vessels between dogs with IL and the controls in all layers of the small intestine (all P>0.05). This study demonstrated that IL was observed in all layers of the small intestine, including the submucosa, muscularis, and mesentery, independent of the underlying disease. Factors other than reduced lymphatic vessels would contribute to the pathogenesis of IL in dogs.

著者

Tsukuda M. Abe S. Hasegawa K. Ninomiya T. Omura I.

出版者

Elsevier

雑誌

Microelectronics Reliability (ISSN:00262714)

巻号頁・発行日

vol.88-90, pp.482-485, 2018-09-30

被引用文献数

3

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In this paper, we propose the criteria of bias voltage from parasitic capacitance and demonstrate the criteria in an experiment with the present IGBT. The bias voltage criteria are theoretically predicted for the new generation IGBT based on the scaling principle. For safe switching, the required gate voltage bias is predicted to be −1.2V or less for the present IGBTs and −6V or less is required to completely cancel the gate noise voltage. From the IGBT design, the bias voltage of scaling IGBT requires −2V to completely cancel the gate noise voltage.

著者

ABRAHAM K.

出版者

岩崎学術出版社

雑誌

アブラハム論文集 : 抑うつ 強迫 去勢の精神分析

巻号頁・発行日

1993

被引用文献数

1

著者

K. Negishi

出版者

美学会

雑誌

美学 (ISSN:05200962)

巻号頁・発行日

vol.24, no.2, pp.72-73, 1973-09-30 (Released:2017-05-22)

著者

DIETMAYER K. C.

雑誌

IV2001

巻号頁・発行日

pp.25-30, 2001

被引用文献数

1

著者

原 和彦 金 信弘 大川 英希 佐藤 構二 受川 史彦 ATLAS Collaboration Hara K. Kim S.H. Okawa H. Sato K. Ukegawa F.

出版者

Elsevier B.V.

雑誌

Physics letters. B (ISSN:03702693)

巻号頁・発行日

no.759, pp.601-621, 2016-08

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Measurements of the W±→ℓ±ν and Z→ℓ+ℓ− production cross sections (where ℓ±=e±,μ±) in proton–proton collisions at √s=13 TeV are presented using data recorded by the ATLAS experiment at the Large Hadron Collider, corresponding to a total integrated luminosity of 81 pb−1. The total inclusive W±-boson production cross sections times the single-lepton-flavour branching ratios are σtotW+=11.83 ±0.02(stat)±0.32(sys)±0.25 (lumi) nb and σtotW−=8.79 ±0.02(stat)±0.24(sys)±0.18 (lumi) nb for W+ and W−, respectively. The total inclusive Z -boson production cross section times leptonic branching ratio, within the invariant mass window 66<mℓℓ<116 GeV, is σtotZ=1.981 ±0.007(stat)±0.038(sys)±0.042 (lumi) nb. The W+, W−, and Z -boson production cross sections and cross-section ratios within a fiducial region defined by the detector acceptance are also measured. The cross-section ratios benefit from significant cancellation of experimental uncertainties, resulting in σfidW+/σfidW−=1.295 ±0.003(stat)±0.010 (sys) and σfidW±/σfidZ=10.31 ±0.04(stat)±0.20 (sys). Theoretical predictions, based on calculations accurate to next-to-next-to-leading order for quantum chromodynamics and to next-to-leading order for electroweak processes and which employ different parton distribution function sets, are compared to these measurements.

著者

KASABIAN A. K.

雑誌

Plast. Reconstr. Surg.

巻号頁・発行日

vol.96, pp.1145-1153, 1995

被引用文献数

1 26

著者

KASABIAN A. K.

雑誌

J Trauma

巻号頁・発行日

vol.31, pp.495-500, 1991

被引用文献数

2 27

著者

Jha Sanjay K.

出版者

電気・情報関係学会九州支部連合大会委員会

雑誌

電気関係学会九州支部連合大会講演論文集 平成29年度電気・情報関係学会九州支部連合大会(第70回連合大会)講演論文集

巻号頁・発行日

pp.199-200, 2017-09-19 (Released:2019-06-29)

著者

大塚 攻 堀口 健雄 Lopes R.M. Choi K.H. 岩崎 敬二

出版者

日本プランクトン学会

巻号頁・発行日

vol.51, no.2, pp.101-118, 2004 (Released:2011-07-08)

著者

Dieter K. Huzel and David H. Huang

出版者

American Institute of Aeronautics and Astronautics

巻号頁・発行日

1992

著者

K.ホフマン著 山崎正勝 小長谷大介 栗原岳史訳

出版者

シュプリンガー・ジャパン

巻号頁・発行日

2006

著者

チャウドゥリ K. N. 川勝 平太

出版者

社会経済史学会

雑誌

社会経済史学 (ISSN:00380113)

巻号頁・発行日

vol.51, no.1, pp.1-16, 1985

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This paper argues that the transition from pre-modern trade to post-Industrial Revolution trade in Asia and indeed in the world generally incorporated a fundamental change in its causation. Pre-modern trade was essentially derived from socially-determined demand arising out of cultural habits and interpretations, but of course, the force of demand operated through market forces and relative prices. Nineteenth-century international trade, on the other hand, was founded on the supply and the production side of the world economy. The fundamental changes in the system of economic production based on the application of machinery and the capitalist organisation made movements of industrial raw materials, food stuffs, and even manufactured goods appear as induced effects of the needs of producers to keep production going. In the pre-modern period, the thinking of merchants and others involved in the business of distant trade, was overwhelmingly influenced by demand factors. This is far removed from the present-day situation in which international trade is primarily a function of the relative distribution of technological endowments. In the earlier period, the technology of production had stabilised itself over many centuries and was treated as if it was a constant. The force of change and the opportunity for accumulating wealth came mainly from shifts in demand and an improvement in the institutional arrangements of economic exchange which lowered costs. There is little disagreement among historians that Asia's inter-regional trade underwent a profound change between 1800 and 1900. The transformation touched both the direction and the composision of goods exchanged. The payments mechanism itself gave rise to induced changes and brought into being the famous trian gular commercial relations between India, China, and Britain, which developed into a true multilateral systems of trade and payments mechanism during the second half of the nineteenth century. Imperialism as an economic force fused together with its political manifestations to form the most powerful historical phenomenon of the time.

著者

Naofumi YOSHIDA Satoshi WATANABE Hiroyuki YAMASAKI Hajime SAKUMA Aya K. TAKEDA Tomoya YAMASHITA Ken-ichi HIRATA

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

pp.2021-056, (Released:2021-12-07)

被引用文献数

13

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Imbalance of the gut microbiota plays an important role in the pathogenesis of various diseases. Although many clinical studies have analyzed the gut microbiota, the definition of normal gut microbiota remains unclear. In this study, we aim to establish the average gut microbiota in the healthy Japanese population. Using 16S ribosomal RNA gene sequencing, we analyzed gut microbial data from fecal samples obtained from 6,101 healthy Japanese individuals. Based on their ages, the individuals were divided into three groups: young, middle-age, and old. Individuals were further categorized according to body mass index (BMI) into lean, normal, and obese groups. The α and β diversities in the old group were significantly higher than those in the young and middle-age groups. The Firmicutes/Bacteroidetes ratio of subjects in the obese category was significantly lower compared with those of subjects in the lean and normal categories in the young and middle-age groups. Genus Bacteroides was the dominant gut microbiota across all the BMI categories in all the age groups. Among the top ten genera, the abundances of Bacteroides, Bifidobacterium, Anaerostipes, Blautia, Dorea, Fusicatenibacter, Lachnoclostridium, and Parabacteroides were significantly lower in the old group than in the young and middle-age groups. The correlation network at the genus level revealed different microbe-microbe interactions associated with age and BMI. We determined the average Japanese gut microbiota, and this information could be used as a reference. The gut microbiota greatly differs based on the life stage and metabolic status of the host, and this gives rise to a variety of host–gut microbe interactions that can lead to an increased susceptibility to disease.

著者

三浦 竜司 山下 聡 南 尚嗣 八久保 晶弘 坂上 寛敏 松本 良 庄子 仁 高橋 信夫 Young K Jin Anatoly Obzhirov Oleg Khlystov MIURA Ryuji YAMASHITA Satoshi MINAMI Hirotsugu HATIKUBO Akihiro SAKAGAMI Hirotoshi MATSUMOTO Ryo SHOJI Hitoshi TAKAHASHI Nobuo

出版者

公益社団法人 地盤工学会 北海道支部

雑誌

地盤工学会北海道支部技術報告集

巻号頁・発行日

no.53, pp.49-58, 2013-01

著者

Kazuhiro KOJIMA James K. CHAMBERS Ayano ISHII Kazuhito SEGAWA Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0579, (Released:2021-12-27)

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An 8-year 8-month-old castrated male Munchkin presented with vomiting, anorexia and hypoactivity. Computed tomography revealed excessive gas accumulation within the intestinal lumen and gas bubbles in the liver, spleen, and portal venous system, indicating hepatic portal venous gas. The cat died without any significant improvement, and mild splenomegaly was found at necropsy. Histologically, multiple gas vacuoles were diffusely observed in the liver and spleen. In the stomach, multiple gas vacuoles and scattered focal ulcers were detected within the mucosa. Multifocal hemorrhage was noted in the small and large intestines, whereas gas vacuoles were not present. Based on these findings, a gastric ulcer under high gas pressure may have provided an entry point for gas into the portal venous system.

著者

WACK K. E.

雑誌

Hepatology

巻号頁・発行日

vol.33, pp.363-378, 2001

被引用文献数

5 126

著者

出射 浩 柚木 美羽 小島 信一郎 黒田 賢剛 渡辺 理 花田 和明 辻村 亨 久保 伸 Taylor G. Bertell N. Ono M. 恩地 拓己 高瀬 雄一 福山 淳 村上 定義 假家 強 長谷川 真 中村 一男 江尻 晶 松本 直希 Mishra K. 福山 雅治

出版者

一般社団法人 日本物理学会

雑誌

日本物理学会講演概要集

巻号頁・発行日

vol.73, pp.805, 2018

著者

リーゼンフーバー K.

出版者

上智大学

雑誌

ソフィア : 西洋文化ならびに東西文化交流の研究 (ISSN:04896432)

巻号頁・発行日

vol.25, no.4, pp.184-185, 1976-12-30

著者

中川 靖章 錦見 俊雄 桑原 宏一郎 岡 昌吾 木下 秀之 中尾 一泰 趙 晃済 稲住 英明 加藤 貴雄 中尾 一和 木村 剛 Nishida Motohiro Kato Takao Fukushima Hiroyuki Yamashita Jun K. Wijnen Wino J. Creemers Esther E. Kangawa Kenji Minamino Naoto Nakao Kazuwa Kimura Takeshi

出版者

Wiley Blackwell

雑誌

Journal of the American Heart Association (ISSN:20479980)

巻号頁・発行日

vol.6, no.2, 2017-02

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Background-Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. The precise mechanisms governing the increase in proBNP remain unclear, however. Methods and Results-We used our recently developed, highly sensitive human proBNP assay system to investigate the mechanisms underlying the increase in plasma proBNP levels. We divided 53 consecutive patients hospitalized with heart failure into 2 groups based on their aortic plasma levels of immunoreactive BNP. Patients with higher levels exhibited more severe heart failure, a higher proportion of proBNP among the immunoreactive BNP forms secreted from failing hearts, and a weaker effect of BNP as estimated from the ratio of plasma cyclic guanosine monophosphate levels to log-transformed plasma BNP levels. Glycosylation at threonines 48 and 71 of human proBNP contributed to the increased secretion of proBNP by attenuating its processing, and GalNAc-transferase (GALNT) 1 and 2 mediated the glycosylation-regulated increase in cardiac human proBNP secretion. Cardiac GALNT1 and 2 expression was suppressed by microRNA (miR)-30, which is abundantly expressed in the myocardium of healthy hearts, but is suppressed in failing hearts. Conclusions-We have elucidated a novel miR-30-GALNT1/2 axis whose dysregulation increases the proportion of inactive proBNP secreted by the heart and impairs the compensatory actions of BNP during the progression of heart failure.