著者

Hirobumi Kawamura Tomohiko Nishigami Ayako Yamamoto Morihiro Tsujishita Kenichi Ito Nobuhisa Ohya Mineko Takagi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.11, pp.1996-1999, 2017 (Released:2017-11-22)

参考文献数

18

被引用文献数

3

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[Purpose] The purpose of this study was to develop a proposal for an effective interventional option for therapeutic stimulation sites by comparing the pain-relieving effect of transcutaneous electrical nerve stimulation (TENS) applied to the same dermatome level of the contralateral sites of the dorsal wrist joint with the pain or the neck, or both sites simultaneously. [Subjects and Methods] A control was first established by triggering pain in the left dorsal wrist joints of adult females by using heat stimulation. Three interventions were then performed, comprising the TENS to the contralateral wrist joint (CW) and to the neck (N) at the same dermatome level as the site of pain, and the TENS to both CW and N simultaneously (CWN). Levels of pain and cerebral blood flow were also measured. [Results] The pain levels of three interventions were found to be significantly decreased compared with the control; however, no significant differences in the levels of pain were seen between any combinations of three interventions. Furthermore, no significant differences were seen between any interventions in terms of cerebral blood flow. [Conclusion] The results suggest that in order for TENS to be effective, it is necessary to make effective use of the dermatome.

著者

Yuki Asai Takumi Tashiro Yoshihiro Kondo Makoto Hayashi Hiroki Arihara Saki Omote Ena Tanio Saena Yamashita Takashi Higuchi Ei Hashimoto Momoko Yamada Hinako Tsuji Yuji Hayakawa Ryohei Suzuki Hiroya Muro Yoshiaki Yamamoto

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.4, pp.614-620, 2023-04-01 (Released:2023-04-01)

参考文献数

33

被引用文献数

1

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Digoxin toxicity (plasma digoxin concentration ≥0.9 ng/mL) is associated with worsening heart failure (HF). Decision tree (DT) analysis, a machine learning method, has a flowchart-like model where users can easily predict the risk of adverse drug reactions. The present study aimed to construct a flowchart using DT analysis that can be used by medical staff to predict digoxin toxicity. We conducted a multicenter retrospective study involving 333 adult patients with HF who received oral digoxin treatment. In this study, we employed a chi-squared automatic interaction detection algorithm to construct DT models. The dependent variable was set as the plasma digoxin concentration (≥ 0.9 ng/mL) in the trough during the steady state, and factors with p < 0.2 in the univariate analysis were set as the explanatory variables. Multivariate logistic regression analysis was conducted to validate the DT model. The accuracy and misclassification rates of the model were evaluated. In the DT analysis, patients with creatinine clearance <32 mL/min, daily digoxin dose ≥1.6 µg/kg, and left ventricular ejection fraction ≥50% showed a high incidence of digoxin toxicity (91.8%; 45/49). Multivariate logistic regression analysis revealed that creatinine clearance <32 mL/min and daily digoxin dose ≥1.6 µg/kg were independent risk factors. The accuracy and misclassification rates of the DT model were 88.2 and 46.2 ± 2.7%, respectively. Although the flowchart created in this study needs further validation, it is straightforward and potentially useful for medical staff in determining the initial dose of digoxin in patients with HF.

著者

Keisuke Kida Takeshi Kitai Norio Suzuki Kohei Ashikaga Seisyou Kou Nobuyuki Kagiyama Tetsuo Yamaguchi Takahiro Okumura Atsushi Mizuno Shogo Oishi Yasutaka Inuzuka Eiichi Akiyama Satoshi Suzuki Masayoshi Yamamoto Yuya Matsue

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0269, (Released:2021-07-09)

参考文献数

24

被引用文献数

3

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Background:Atrial fibrillation (AF) is a common arrhythmia in patients with acute heart failure (AHF). Heart rate (HR) also changes significantly over time. However, the association between changes in HR in AF patients and prognosis is uncertain.Methods and Results:We investigated the association between HR reduction in AF achieved within 48 h of admission and 60-day mortality in patients with AHF from the REALITY-AHF study. The percentage HR (%HR) reduction was calculated as (baseline HR–HR at 48 h) / baseline HR × 100. The primary endpoint was 60-day all-cause mortality. In 468 patients with confirmed AF at both admission and 48 h after admission, the median HR at these time points was 105±31 and 84±18 beats/min, respectively. The median %HR reduction was 15.4% (interquartile range 2.2–31.4%). During the 60 days of admission, 39 deaths (8.3%) were recorded, and the %HR reduction within 48 h was significantly associated with 60-day mortality in the unadjusted model (hazard ratio [HR] 0.85; 95% confidence interval [CI] 0.77–0.95; P=0.005) and after adjusting for other covariates (HR 0.81; 95% CI 0.68–0.96; P=0.016).Furthermore, the %HR reduction was associated with a significant reduction in 60-day mortality in patients with higher baseline HR.Conclusions:%HR reduction is associated with a better short-term prognosis in patients with AHF presenting with AF, particularly in those with a rapid ventricular response.

著者

藤津 裕亮 山本 真行 Fujitsu Hiroaki Yamamoto Masa-yuki

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

平成28年度宇宙科学に関する室内実験シンポジウム 講演集 = Proceedings of 2017 Symposium on Laboratory Experiment for Space Science

巻号頁・発行日

2017-02

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平成28年度宇宙科学に関する室内実験シンポジウム (2017年2月27日-28日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県

著者

Junji Yamamoto Hidemi Ishibashi Yuuki Hagiwara Lena Yokokura Kiyoaki Niida

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.56, no.1, pp.31-39, 2022 (Released:2022-02-28)

参考文献数

36

被引用文献数

1

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In the Horoman peridotite complex, the peridotite containing olivine-filled channels is known to exist. To examine the distribution pattern of the channel olivine, we performed non-destructive microanalyses of Raman spectra at 51 points of the olivine with 5 mm intervals along the channel. Compared with the Raman spectra of a reference euhedral olivine, for which the crystallographic orientation is known, there is no abrupt change in the crystallographic orientation in the 250 mm line analysis region of the channel. Moreover, Mg/Fe ratios of the channel olivine show gradual change over the entire measured area. If the channel olivine is an aggregate of olivine grains crystallized from magma infiltrating into the channel, then there should be olivine grains with both uneven crystallographic orientation and a homogeneous Mg/Fe ratio. Therefore, the olivine in the channel is regarded as a single crystal with slight growth zoning. The peridotite with the channel had been a part of mantle that was uplifted by the collision of plates. Therefore, the channel is a trace of magma migrating in the mantle. Magma migration in mantle drives the material–thermal circulation system connecting the Earth’s interior and surface. Furthermore, the size of the mineral in mantle reflects its stress field. Therefore, the magma channel involving such a large olivine is a unique specimen that reveals the particular characteristics of magmatism occurring in the Earth’s interior.

著者

Aad G. Abbott B. Abdallah J. Abdinov O. Abeloos B. Aben R. Abolins M. AbouZeid O. S. Abramowicz H. Abreu H. Abreu R. Abulaiti Y. Acharya B. S. Adamczyk L. Adams D. L. Adelman J. Adomeit S. Adye T. Affolder A. A. Agatonovic-Jovin T. Agricola J. Aguilar-Saavedra J. A. Ahlen S. P. Ahmadov F. Aielli G. Akerstedt H. Åkesson T. P A Akimov A. V. Alberghi G. L. Albert J. Albrand S. Alconada Verzini M. J. Aleksa M. Aleksandrov I. N. Alexa C. Alexander G. Alexopoulos T. Alhroob M. Alimonti G. Alison J. Alkire S. P. Allbrooke B. M M Allen B. W. Allport P. P. Aloisio A. Alonso A. Alonso F. Alpigiani C. Alvarez Gonzalez B. Álvarez Piqueras D. Alviggi M. G. Amadio B. T. Amako K. Amaral Coutinho Y. Amelung C. Amidei D. Amor Dos Santos S. P. Amorim A. Amoroso S. Amram N. Amundsen G. Anastopoulos C. Ancu L. S. Andari N. Andeen T. Anders C. F. Anders G. Anders J. K. Anderson K. J. Andreazza A. Andrei V. Angelidakis S. Angelozzi I. Anger P. Angerami A. Anghinolfi F. Anisenkov A. V. Anjos N. Annovi A. Antonelli M. Antonov A. Antos J. Anulli F. Aoki M. Aperio Bella L. Arabidze G. Arai Y. Araque J. P. Arce A. T H Arduh F. A. Arguin J. F. Argyropoulos S. Arik M. Armbruster A. J. Armitage L. J. Arnaez O. Arnold H. Arratia M. Arslan O. Artamonov A. Artoni G. Artz S. Asai S. Asbah N. Ashkenazi A. Åsman B. Asquith L. Assamagan K. Astalos R. Atkinson M. Atlay N. B. Augsten K. Avolio G. Axen B. Ayoub M. K. Azuelos G. Baak M. A. Baas A. E. Baca M. J. Bachacou H. Bachas K. Backes M. Backhaus M. Bagiacchi P. Bagnaia P. Bai Y. Baines J. T. Baker O. K. Baldin E. M. Balek P. Balestri T. Balli F. Balunas W. K. Banas E. Banerjee Sw Bannoura A. A E Barak L. Barberio E. L. Barberis D. Barbero M. Barillari T. Barisonzi M. Barklow T. Barlow N. Barnes S. L. Barnett B. M. Barnett R. M. Barnovska Z. Baroncelli A. Barone G. Barr A. J. Barranco Navarro L. Barreiro F. Barreiro Guimarães da Costa J. Bartoldus R. Barton A. E. Bartos P. Basalaev A. Bassalat A. Basye A. Bates R. L. Batista S. J. Batley J. R. Battaglia M. Bauce M. Bauer F. Bawa H. S. Beacham J. B. Beattie M. D. Beau T. Beauchemin P. H. Beccherle R. Bechtle P. Beck H. P. Becker K. Becker M. Beckingham M. Becot C. Beddall A. J. Beddall A. Bednyakov V. A. Bedognetti M. Bee C. P. Beemster L. J. Beermann T. A. Begel M. Behr J. K. Belanger-Champagne C. Bell A. S. Bell W. H. Bella G. Bellagamba L. Bellerive A. Bellomo M. Belotskiy K. Beltramello O. Belyaev N. L. Benary O. Benchekroun D. Bender M. Bendtz K. Benekos N. Benhammou Y. Benhar Noccioli E. Benitez J. Benitez Garcia J. A. Benjamin D. P. Bensinger J. R. Bentvelsen S. Beresford L. Beretta M. Berge D. Bergeaas Kuutmann E. Berger N. Berghaus F. Beringer J. Berlendis S. Bernard C. Bernard N. R. Bernius C. Bernlochner F. U. Berry T. Berta P. Bertella C. Bertoli G. Bertolucci F. Bertram I. A. Bertsche C. Bertsche D. Besjes G. J. Bessidskaia Bylund O. Bessner M. Besson N. Betancourt C. Bethke S. Bevan A. J. Bhimji W. Bianchi R. M. Bianchini L. Bianco M. Biebel O. Biedermann D. 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Chwastowski J. J. Chytka L. Ciapetti G. Ciftci A. K. Cinca D. Cindro V. Cioara I. A. Ciocio A. Cirotto F. Citron Z. H. Ciubancan M. Clark A. Clark B. L. Clark P. J. Clarke R. N. Clement C. Coadou Y. Cobal M. Coccaro A. Cochran J. Coffey L. Colasurdo L. Cole B. Cole S. Colijn A. P. Collot J. Colombo T. Compostella G. Conde Muiño P. Coniavitis E. Connell S. H. Connelly I. A. Consorti V. Constantinescu S. Conta C. Conti G. Conventi F. Cooke M. Cooper B. D. Cooper-Sarkar A. M. Cornelissen T. Corradi M. Corriveau F. Corso-Radu A. Cortes-Gonzalez A. Cortiana G. Costa G. Costa M. J. Costanzo D. Cottin G. Cowan G. Cox B. E. Cranmer K. Crawley S. J. Cree G. Crépé-Renaudin S. Crescioli F. Cribbs W. A. Crispin Ortuzar M. Cristinziani M. Croft V. Crosetti G. Cuhadar Donszelmann T. Cummings J. Curatolo M. Cúth J. Cuthbert C. Czirr H. Czodrowski P. D'Auria S. D'Onofrio M. Da Cunha Sargedas De Sousa M. J. Da Via C. Dabrowski W. Dai T. Dale O. Dallaire F. Dallapiccola C. Dam M. Dandoy J. R. Dang N. P. Daniells A. C. Dann N. S. Danninger M. Dano Hoffmann M. Dao V. Darbo G. Darmora S. Dassoulas J. Dattagupta A. Davey W. David C. Davidek T. Davies M. Davison P. Davygora Y. Dawe E. Dawson I. Daya-Ishmukhametova R. K. De K. de Asmundis R. De Benedetti A. De Castro S. De Cecco S. De Groot N. de Jong P. De la Torre H. De Lorenzi F. De Pedis D. De Salvo A. De Sanctis U. De Santo A. De Vivie De Regie J. B. Dearnaley W. J. Debbe R. Debenedetti C. Dedovich D. V. Deigaard I. Del Peso J. Del Prete T. Delgove D. Deliot F. Delitzsch C. M. Deliyergiyev M. Dell'Acqua A. Dell'Asta L. Dell'Orso M. Della Pietra M. della Volpe D. Delmastro M. Delsart P. A. Deluca C. DeMarco D. A. Demers S. Demichev M. Demilly A. Denisov S. P. Denysiuk D. Derendarz D. Derkaoui J. E. Derue F. Dervan P. Desch K. Deterre C. Dette K. Deviveiros P. O. Dewhurst A. Dhaliwal S. Di Ciaccio A. Di Ciaccio L. Di Clemente W. K. Di Domenico A. Di Donato C. Di Girolamo A. Di Girolamo B. Di Mattia A. Di Micco B. Di Nardo R. Di Simone A. Di Sipio R. Di Valentino D. Diaconu C. Diamond M. Dias F. A. Diaz M. A. Diehl E. B. Dietrich J. Diglio S. Dimitrievska A. Dingfelder J. Dita P. Dita S. Dittus F. Djama F. Djobava T. Djuvsland J. I. do Vale M. A B Dobos D. Dobre M. Doglioni C. Dohmae T. Dolejsi J. Dolezal Z. Dolgoshein B. A. Donadelli M. Donati S. Dondero P. Donini J. Dopke J. Doria A. Dova M. T. Doyle A. T. Drechsler E. Dris M. Du Y. Duarte-Campderros J. Duchovni E. Duckeck G. Ducu O. A. Duda D. Dudarev A. Duflot L. Duguid L. Dührssen M. Dunford M. Duran Yildiz H. Düren M. Durglishvili A. Duschinger D. Dutta B. Dyndal M. Eckardt C. Ecker K. M. Edgar R. C. Edson W. Edwards N. C. Eifert T. Eigen G. Einsweiler K. Ekelof T. El Kacimi M. Ellajosyula V. Ellert M. Elles S. Ellinghaus F. Elliot A. A. Ellis N. Elmsheuser J. Elsing M. Emeliyanov D. Enari Y. Endner O. C. Endo M. Ennis J. S. Erdmann J. Ereditato A. Ernis G. Ernst J. Ernst M. Errede S. Ertel E. Escalier M. Esch H. Escobar C. Esposito B. Etienvre A. I. Etzion E. Evans H. Ezhilov A. Fabbri F. Fabbri L. Facini G. Fakhrutdinov R. M. Falciano S. Falla R. J. Faltova J. Fang Y. Fanti M. Farbin A. Farilla A. Farina C. Farooque T. Farrell S. Farrington S. M. Farthouat P. Fassi F. Fassnacht P. Fassouliotis D. Faucci Giannelli M. Favareto A. Fayard L. Fedin O. L. Fedorko W. Feigl S. Feligioni L. Feng C. Feng E. J. Feng H. Fenyuk A. B. Feremenga L. Fernandez Martinez P. Fernandez Perez S. Ferrando J. Ferrari A. Ferrari P. Ferrari R. Ferreira de Lima D. E. Ferrer A. Ferrere D. Ferretti C. Ferretto Parodi A. Fiedler F. Filipcic A. Filipuzzi M. Filthaut F. Fincke-Keeler M. Finelli K. D. Fiolhais M. C N Fiorini L. Firan A. Fischer A. Fischer C. Fischer J. Fisher W. C. Flaschel N. Fleck I. Fleischmann P. Fletcher G. T. Fletcher G. Fletcher R. R M Flick T. Floderus A. Flores Castillo L. R. Flowerdew M. J. Forcolin G. T. Formica A. Forti A. Foster A. G. Fournier D. Fox H. Fracchia S. Francavilla P. Franchini M. Francis D. Franconi L. Franklin M. Frate M. Fraternali M. Freeborn D. Fressard-Batraneanu S. M. Friedrich F. Froidevaux D. Frost J. A. Fukunaga C. Fullana Torregrosa E. Fusayasu T. Fuster J. Gabaldon C. Gabizon O. Gabrielli A. Gabrielli A. Gach G. P. Gadatsch S. Gadomski S. Gagliardi G. Gagnon L. G. Gagnon P. Galea C. Galhardo B. Gallas E. J. Gallop B. J. Gallus P. Galster G. Gan K. K. Gao J. Gao Y. Gao Y. S. Garay Walls F. M. García C. García Navarro J. E. Garcia-Sciveres M. Gardner R. W. Garelli N. Garonne V. Gascon Bravo A. Gatti C. Gaudiello A. Gaudio G. Gaur B. Gauthier L. Gavrilenko I. L. Gay C. Gaycken G. Gazis E. N. Gecse Z. Gee C. N P Geich-Gimbel Ch Geisler M. P. Gemme C. Genest M. H. Geng C. Gentile S. George S. Gerbaudo D. Gershon A. Ghasemi S. Ghazlane H. Giacobbe B. Giagu S. Giannetti P. Gibbard B. Gibson S. M. Gignac M. Gilchriese M. Gillam T. P S Gillberg D. Gilles G. Gingrich D. M. Giokaris N. Giordani M. P. Giorgi F. M. Giorgi F. M. Giraud P. F. Giromini P. Giugni D. Giuliani C. Giulini M. Gjelsten B. 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Wilkens H. G. Williams H. H. Williams S. Willis C. Willocq S. Wilson J. A. Wingerter-Seez I. Winklmeier F. Winston O. J. Winter B. T. Wittgen M. Wittkowski J. Wollstadt S. J. Wolter M. W. Wolters H. Wosiek B. K. Wotschack J. Woudstra M. J. Wozniak K. W. Wu M. Wu M. Wu S. L. Wu X. Wu Y. Wyatt T. R. Wynne B. M. Xella S. Xu D. Xu L. Yabsley B. Yacoob S. Yakabe R. Yamaguchi D. Yamaguchi Y. Yamamoto A. Yamamoto S. Yamanaka T. Yamauchi K. Yamazaki Y. Yan Z. Yang H. Yang H. Yang Y. Yang Z. Yao W. M. Yap Y. C. Yasu Y. Yatsenko E. Yau Wong K. H. Ye J. Ye S. Yeletskikh I. Yen A. L. Yildirim E. Yorita K. Yoshida R. Yoshihara K. Young C. Young C. J S Youssef S. Yu D. R. Yu J. Yu J. M. Yu J. Yuan L. Yuen S. P Y Yusuff I. Zabinski B. Zaidan R. Zaitsev A. M. Zakharchuk N. Zalieckas J. Zaman A. Zambito S. Zanello L. Zanzi D. Zeitnitz C. Zeman M. Zemla A. Zeng J. C. Zeng Q. Zengel K. Zenin O. Ženiš T. Zerwas D. Zhang D. Zhang F. Zhang G. Zhang H. Zhang J. Zhang L. Zhang R. Zhang R. Zhang X. Zhang Z. Zhao X. Zhao Y. Zhao Z. Zhemchugov A. Zhong J. Zhou B. Zhou C. Zhou L. Zhou L. Zhou M. Zhou N. Zhu C. G. Zhu H. Zhu J. Zhu Y. Zhuang X. Zhukov K. Zibell A. Zieminska D. Zimine N. I. Zimmermann C. Zimmermann S. Zinonos Z. Zinser M. Ziolkowski M. Živkovic L. Zobernig G. Zoccoli A. zur Nedden M. Zurzolo G. Zwalinski L.

出版者

Elsevier

雑誌

Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics (ISSN:03702693)

巻号頁・発行日

vol.756, pp.52-71, 2016-05-10

被引用文献数

12

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In the pp→tt process the angular distributions of top and anti-top quarks are expected to present a subtle difference, which could be enhanced by processes not included in the Standard Model. This Letter presents a measurement of the charge asymmetry in events where the top-quark pair is produced with a large invariant mass. The analysis is performed on 20.3 fb-1 of pp collision data at √s=8TeV collected by the ATLAS experiment at the LHC, using reconstruction techniques specifically designed for the decay topology of highly boosted top quarks. The charge asymmetry in a fiducial region with large invariant mass of the top-quark pair (mtt>0.75 TeV) and an absolute rapidity difference of the top and anti-top quark candidates within -2<|yt|-|yt|<2 is measured to be 4.2±3.2%, in agreement with the Standard Model prediction at next-to-leading order. A differential measurement in three tt- mass bins is also presented.

著者

Naoki KANEKO Rie YAMAMOTO Taka-Aki SATO Koichi TANAKA

出版者

日本学士院

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.90, no.3, pp.104-117, 2014-03-11 (Released:2014-03-11)

参考文献数

41

被引用文献数

10 51 1

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Proteolytic processing of the amyloid precursor protein (APP) by β-secretase and γ-secretase leads to the generation and deposition of amyloid β (Aβ) in Alzheimer’s disease (AD). N-terminally or C-terminally truncated Aβ variants have been found in human cerebrospinal fluid and cultured cell media using immunoprecipitation and mass spectrometry. Unfortunately, the profile of plasma Aβ variants has not been revealed due to the difficulty of isolating Aβ from plasma. We present here for the first time studies of Aβ and related peptides in human plasma. Twenty-two Aβ-related peptides including novel peptides truncated before the β-secretase site were detected in human plasma and 20 of the peptides were identified by tandem mass spectrometry. Using an internal standard, we developed a quantitative assay for the Aβ-related peptides and demonstrated plasma dilution linearity and the precision required for their quantitation. The present method should enhance the understanding of APP processing and clearance in AD progression.

著者

Koji Ito Kenji Miyata Masahiro Mohri Hideki Origuchi Hideo Yamamoto

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.1, pp.23-29, 2017-01-01 (Released:2017-01-01)

参考文献数

15

被引用文献数

16

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Objective It is recommended that middle-aged and elderly individuals reduce their salt intake because of the high prevalence of hypertension. The consumption of miso soup is associated with salt intake, and the reduced consumption of miso soup has been recommended. Recent studies have demonstrated that the consumption of miso soup can attenuate an autonomic imbalance in animal models. However, it is unclear whether these results are applicable to humans. This study examined the cross-sectional association between the frequency of miso soup consumption and the blood pressure and heart rate of human subjects. Methods A total of 527 subjects of 50 to 81 years of age who participated in our hospital health examination were enrolled in the present study and divided into four groups based on the frequency of their miso soup consumption ([bowl(s) of miso soup/week] Group 1, <1; Group2, <4; Group3, <7; Group4, ≥7). The blood pressure levels and heart rates of the subjects in each group were compared. Furthermore, a multivariable analysis was performed to determine whether miso soup consumption was an independent factor affecting the incidence of hypertension or the heart rate. Results The frequency of miso soup consumption was not associated with blood pressure. The heart rate was, however, lower in the participants who reported a high frequency of miso soup consumption. A multivariable analysis revealed that the participants who reported a high frequency of miso soup consumption were more likely to have a lower heart rate, but that the consumption of miso soup was not associated with the incidence of hypertension. Conclusion These results indicate that miso soup consumption might decrease the heart rate, but not have a significant effect on the blood pressure of in middle-aged and elderly Japanese individuals.

著者

Kai Yoshimura Masaaki Yamamoto Tomoya Inoue Hidenori Fukuoka Keiji Iida Wataru Ogawa

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ22-0108, (Released:2022-07-14)

被引用文献数

9

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Coronavirus disease 2019 (COVID-19) is associated with endocrine disorders, but their long-term clinical course remains unclear. We here report the 15-month clinical course for an individual with multiple endocrine disorders of the pituitary gland and testis likely triggered by COVID-19. A 65-year-old man with no history of endocrinopathy was admitted for acute COVID-19 pneumonia. Although his respiratory condition improved after administration of antiviral drugs, his blood pressure dropped suddenly to a preshock level and was refractory to vasopressors. The circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations were low, and secondary adrenal insufficiency was suspected. Administration of hydrocortisone rapidly ameliorated the hypotension, and the patient was discharged taking 15 mg of hydrocortisone daily. An insulin tolerance test performed 3 months later revealed impaired ACTH, cortisol, and growth hormone (GH) responses, indicative of combined hypopituitarism. The patient also manifested symptoms of hypogonadism, and a hormonal workup suggested primary hypogonadism. At 12 months after discharge, GH and ACTH responses had recovered completely and partially, respectively. After another 3 months, basal ACTH and cortisol levels had been restored to the normal range and the patient discontinued hydrocortisone replacement without exacerbation of symptoms, although his hypogonadism persisted. The patient thus developed transient GH and ACTH deficiency that lasted for more than a year as well as persistent primary hypogonadism during intensive care for COVID-19. Certain prolonged symptoms of COVID-19 might be accounted for by such hormonal disturbance.

著者

Takahiro Nakashima Katsutaka Hashiba Migaku Kikuchi Junichi Yamaguchi Sunao Kojima Hiroyuki Hanada Toshiaki Mano Takeshi Yamamoto Akihito Tanaka Kunihiro Matsuo Naoki Nakayama Osamu Nomura Tetsuya Matoba Yoshio Tahara Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.5, pp.187-193, 2022-05-10 (Released:2022-05-10)

参考文献数

30

被引用文献数

4

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Background: To achieve early reperfusion therapy for ST-elevation myocardial infarction (STEMI), proper and prompt patient transportation and activation of the catheterization laboratory are required. We investigated the efficacy of prehospital 12-lead electrocardiogram (ECG) acquisition and destination hospital notification in patients with STEMI.Methods and Results: This is a systematic review of observational studies. We searched the PubMed database from inception to March 2020. Two reviewers independently performed literature selection. The critical outcome was short-term mortality. The important outcome was door-to-balloon (D2B) time. We used the GRADE approach to assess the certainty of the evidence. For the critical outcome, 14 studies with 29,365 patients were included in the meta-analysis. Short-term mortality was significantly lower in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (odds ratio 0.72; 95% confidence interval [CI] 0.61–0.85; P<0.0001). For the important outcome, 10 studies with 2,947 patients were included in the meta-analysis. D2B time was significantly shorter in the group with prehospital 12-lead ECG acquisition and destination hospital notification than in the control group (mean difference −26.24; 95% CI −33.46, −19.02; P<0.0001).Conclusions: Prehospital 12-lead ECG acquisition and destination hospital notification is associated with lower short-term mortality and shorter D2B time than no ECG acquisition or no notification among patients with suspected STEMI outside of a hospital.

著者

本多 マークアントニー 泉 政文 山本 忠宏 大塚 英志 橋本 英治 Mark Anthony HONDA Masafumi IZUMI Tadahiro YAMAMOTO Eiji OHTSUKA Eiji HASHIMOTO

出版者

神戸芸術工科大学

雑誌

芸術工学2013

巻号頁・発行日

2013-11-25

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WEB表現へのまんがの適応について、その方向性として、①縦及び横の「スクロール形式 」、②「見開き」に基づくまんがの文法を解体し、一頁単位の表示に基づく文法にシフトした形式 、③静止画のスライドショー形式、の3つが仮説としてたてられ、今回の共同研究では、①のうち「縦スクロール形式」と③の「スライドショー形式」について、そこで採用されるべき文法を仮定し、それに基づき実験作品を制作した。縦スクロール形式においては日本まんが表現の「映画的手法」をいかに導入するかに研究の主眼を置いた。その結果、アイレベルを基準とし、それに続くコマでのアングルの極端な切り換え、コマの縦幅の極端な変化における「尺」(時間)の表現などの、紙媒体で成立した手法の中心的な部分が、WEBへの置き換えが可能であることが確認された。その結果、「横スクロール形式」よりも「縦スクロール形式」の方が映画的手法の移植に向いているという仮説が新たに得られた。また「横スクロール」においては、画面の天地ほぼ中央に視線誘導の基準となる中心線を置くことで視覚の流動性を確保したが、「縦スクロール」では画面を二分割して構図を構成することで画面の左右中央に基準線が存在するのに近い印象を与えることができた。

著者

Takaaki Tomofuji Daisuke Ekuni Koichiro Irie Tetsuji Azuma Naofumi Tamaki Takayuki Maruyama Tatsuo Yamamoto Tatsuo Watanabe Manabu Morita

出版者

バイオメディカルリサーチプレス

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.32, no.5, pp.343-349, 2011 (Released:2011-10-28)

参考文献数

31

被引用文献数

4 44

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Gingival response to periodontal inflammation generates excessive lipid peroxide and such a condition may augment systemic health through increased circulating lipid peroxide. The purpose of the present study was to investigate whether the generation of lipid peroxide in periodontal inflammation could induce tissue injury in the liver, heart, kidney and brain using a rat model. Twelve Wistar rats (8 week-old male) were divided into 2 groups: the periodontal inflammation group, receiving topical application of lipopolysaccharide and proteases to the gingival sulcus for 4 weeks, and the control group using instead pyrogen-free water. After blood samples were collected, specimens from the brain, heart, liver and kidney were resected to determine the concentration of 8-hydroxydeoxyguanosine (an indicator of oxidative DNA damage). Gingival and serum levels for hexanoyl-lysine were measured to evaluate lipid peroxide. Administration of lipopolysaccharide and proteases induced periodontal inflammation, with increasing gingival and serum levels of hexanoyl- lysine. The level of 8-hydroxydeoxyguanosine increased 2.27, 2.01, 1.49 and 1.40 times in mitochondrial DNA from the liver, heart, kidney and brain of rats with periodontal inflammation, respectively. The results reveal that excessive production of lipid peroxide following periodontal inflammation is involved in oxidative DNA damage of the brain, heart, liver and kidney.

著者

Tomoko Machino-Ohtsuka Kentaro Minami Hiro Yamasaki Tomofumi Nakatsukasa Naoto Kawamatsu Kimi Sato Masayoshi Yamamoto Kazushi Maruo Tomoko Ishizu Yasushi Kawakami Masaki Ieda

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0271, (Released:2023-06-30)

参考文献数

26

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Background: In patients with atrial fibrillation (AF) and severe blood stasis in the left atrial appendage (LAA), dense spontaneous echo contrast (SEC) disturbs the distinct visualization of the LAA interior, thus making thrombus diagnosis inconclusive. We aimed to prospectively assess the efficacy and safety of a protocol for a low-dose isoproterenol (ISP) infusion to reduce SEC to exclude an LAA thrombus.Methods and Results: We enrolled 17 patients with AF and dense SEC (Grade 4 or sludge). ISP was infused with gradually increasing doses of 0.01, 0.02, and 0.03 μg/kg/min at 3-min intervals. After increasing the dose to 0.03 μg/kg/min for 3 min, or when the LAA interior was visible, the infusion was terminated. We reassessed the SEC grade, presence of an LAA thrombus, LAA function, and left ventricular ejection fraction (LVEF) within 1 min of ISP termination. Compared with baseline, ISP significantly increased LAA flow velocity, the LAA emptying fraction, LAA wall velocities, and LVEF (all P<0.01). ISP administration significantly reduced the SEC grade (median) from 4 to 1 (P<0.001). The SEC grade decreased to ≤2 in 15 (88%) patients, and the LAA thrombus was excluded. There were no adverse events.Conclusions: Low-dose ISP infusion may be effective and safe to reduce SEC and exclude an LAA thrombus by improving LAA function and LVEF.

著者

Yutaka TAKETANI Masashi MASUDA Hisami YAMANAKA-OKUMURA Sawako TATSUMI Hiroko SEGAWA Ken-ichi MIYAMOTO Eiji TAKEDA Hironori YAMAMOTO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.61, no.Supplement, pp.S173-S175, 2015 (Released:2015-11-24)

参考文献数

11

被引用文献数

5 10

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Chronic kidney disease (CKD) is an increasing problem worldwide. The number of end-stage renal disease patients requiring treatment by dialysis is estimated to be increasing by 10,000 patients per year in Japan. Furthermore, an estimated 13 million people are living with CKD in Japan. Various complications are associated with CKD, including cardiovascular disease (CVD). More than one-third of CKD patients die from CVD. Thus, prevention of CVD is a primary concern for the treatment of CKD patients. CKD-mineral and bone disorder (CKD-MBD) is a serious complication that typically leads to CVD. Hyperphosphatemia is thought to be a central-risk factor for CKD-MBD. Therefore, managing hyperphosphatemia is crucial to prevent CKD-MBD and CVD. It is difficult to achieve the target serum phosphate level through dietary modifications alone in patients with hyperphosphatemia, because most foods contain phosphate. Thus, phosphate binders such as calcium carbonate are commonly prescribed to CKD patients with hyperphosphatemia, but these have undesirable side effects. Inhibition of intestinal phosphate transport activity has also been investigated as an alternative approach for controlling serum phosphate levels in CKD patients. Nicotinamide, which is the amide of niacin, can inhibit intestinal phosphate transport. Niacin and related compounds have also been developed as drugs for hyperlipidemia conditions, especially hypertriglyceridemia with low high-density lipoprotein. This type of dyslipidemia is frequently observed in CKD patients and is a modifiable risk factor for CVD. Thus, niacin and related compounds may have utility for the treatment of both hyperphosphatemia and dyslipidemia in CKD patients to prevent CVD.

著者

山本 宏樹 Hiroki Yamamoto

出版者

東京理科大学

雑誌

理大科学フォーラム (ISSN:13461206)

巻号頁・発行日

vol.33, no.5, pp.34-39, 2016-05

著者

Daisuke Sueta Kenji Sakamoto Hiroki Usuku Koichiro Fujisue Kenshi Yamanaga Yuichiro Arima Seiji Takashio Satoru Suzuki Eiichiro Yamamoto Koichi Kaikita Kenichi Tsujita

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.11, pp.531-533, 2019-11-08 (Released:2019-11-08)

参考文献数

5

被引用文献数

6 9

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Background:Although “disaster-related death” as a category awarded disaster-related compensation includes death not caused by the tragedy itself, the actual definition remains unclear.Methods and Results:In the Kumamoto earthquake 2016, compared with the Great East Japan Earthquake 2011, excessive mental and physical stress and suicide were observed significantly more as causes of disaster-related death.Conclusions:It is essential to give maximum consideration to refugees to support them while in shelters.

著者

Toru YOSHIURA Satoru TAKEUCHI Terushige TOYOOKA Arata TOMIYAMA Kojiro WADA Yasuaki NAKAO Takuji YAMAMOTO Kentaro MORI

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2023-0157, (Released:2023-11-08)

参考文献数

28

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In Japan, brain docking has enhanced the detection of unruptured intracranial aneurysms in healthy adults. At our institution, surgical clipping is the first-line treatment for unruptured intracranial aneurysms (UIA). In this study, the differences in neurological and radiological outcomes, as well as cognitive and psychological results, between standard clipping and keyhole clipping for these aneurysms detected via brain docking were evaluated. The study included 131 aneurysms detected via "brain dock." Of these, 65 were treated with keyhole clipping surgery (keyhole clipping group), and 66 were treated with standard clipping surgery (standard clipping group). Evaluations at 3 months included the National Institutes of Health Stroke Scale, modified Rankin Scale, Mini-Mental State Examination, Hasegawa's Dementia Scale-revised, Beck Depression Inventory, Hamilton Rating Scale for Depression, and radiological abnormalities. The mean operative time and postoperative hospitalization period were significantly shorter in the keyhole clipping group than in the standard clipping group (p < 0.001). Between the groups, no significant differences in postoperative neurological complications or radiological abnormalities were found. The keyhole clipping group demonstrated slightly but significantly better Beck Depression Inventory and Hamilton Rating Scale for Depression scores than the standard clipping group (Beck Depression Inventory, p = 0.046; Hamilton Rating Scale for Depression, p < 0.01). Both the Beck Depression Inventory and Hamilton Rating Scale for Depression scores at 3 months were significantly enhanced (p < 0.001) in the keyhole clipping group. These findings propose that keyhole clipping could be considered a new therapeutic option for small UIA detected via brain docking.

著者

Yusuke Takashima Mai Suyama Kohei Yamamoto Tomohiko Ri Kazuhiko Narisawa Yousuke Degawa

出版者

The Mycological Society of Japan

雑誌

Mycoscience (ISSN:13403540)

巻号頁・発行日

pp.MYC574, (Released:2022-06-17)

被引用文献数

1

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Myconymphaea yatsukahoi is a fungus that has only been isolated once from a forest in the Sugadaira Research Station, Nagano, Japan. Over 20 y have passed since its first discovery but since then it has not been rediscovered. Here, we re-isolated M. yatsukahoi from the type locality and another location, Tambara Moor, Gunma, Japan. Sporophores of this species were detected by direct field observation in Sugadaira and by induction from soil from Tambara. We attempted to narrow down isolation sources of this species by investigating the excrements of Lithobiomorpha and Scolopendromorpha centipedes, which are frequently found in the two locations where the species is distributed. In both locations, we found M. yatsukahoi in the excrements of Lithobiomorpha but not Scolopendromorpha. Myconymphaea yatsukahoi appears to be a coprophilous fungus and the excrements of the predators living in soil may be promising isolation sources for understanding the hidden diversity of kickxellalean fungi.

著者

Norihiko MUROGA Yoko HAYAMA Takehisa YAMAMOTO Akihiro KUROGI Tomoyuki TSUDA Toshiyuki TSUTSUI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.399-404, 2012 (Released:2012-04-29)

参考文献数

17

被引用文献数

88 110 23

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Foot-and-mouth disease (FMD) occurred recently for the first time in a decade in Japan. The index case was detected on a beef-breeding farm in Miyazaki Prefecture, Southern Japan, on April 20, 2010. After confirmation of this first case, control measures such as stamping out, movement restriction and disinfection were implemented. However, these strategies proved insufficient to prevent the spread of FMD and emergency vaccination was adopted. Up until the last outbreak on July 4, 2010, a total of 292 outbreaks had been confirmed, with about 290,000 animals having been culled. The epidemic occurred in an area with a high density of cattle and pigs, making disease control difficult. Invasion of the disease into a high-density area aided its rapid spread and led to difficulties in locating suitable burial sites. Epidemiological investigations indicated that the disease was introduced into Japan approximately one month before detection. This delay in initial detection is considered to have allowed an increased number of outbreaks in the early stage of the epidemic. Nevertheless, the epidemic was contained within a localized area in Miyazaki Prefecture and was eradicated within three months because of intensive control efforts including emergency vaccination. Although this epidemic devastated the livestock industry in Japan, many lessons can be learnt for the future prevention and control of infectious diseases in animals.

著者

Minoru Ono Osamu Yamaguchi Tomohito Ohtani Koichiro Kinugawa Yoshikatsu Saiki Yoshiki Sawa Akira Shiose Hiroyuki Tsutsui Norihide Fukushima Goro Matsumiya Masanobu Yanase Kenji Yamazaki Kazuhiro Yamamoto Masatoshi Akiyama Teruhiko Imamura Kiyotaka Iwasaki Miyoko Endo Yoshihiko Ohnishi Takahiro Okumura Koichi Kashiwa Osamu Kinoshita Kaori Kubota Osamu Seguchi Koichi Toda Hiroshi Nishioka Tomohiro Nishinaka Takashi Nishimura Toru Hashimoto Masaru Hatano Haruhiko Higashi Taiki Higo Takeo Fujino Yumiko Hori Toru Miyoshi Motoharu Yamanaka Takayuki Ohno Takeshi Kimura Shunei Kyo Yasushi Sakata Takeshi Nakatani on behalf of the JCS/JSCVS/JATS/JSVS Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0880, (Released:2022-04-05)

参考文献数

288

被引用文献数

10