著者

Satoshi TAKEMOTO Akane YAMAMOTO Shozo TOMONAGA Masayuki FUNABA Tohru MATSUI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.59, no.6, pp.560-563, 2013 (Released:2014-01-30)

参考文献数

19

被引用文献数

7 18

---

Mast cells, multifunctional effector cells of the immune system, are implicated in the pathogenesis of hepatic steatosis and fibrosis. Magnesium (Mg) deficiency was reported to increase triglyceride concentration in the liver, and to exacerbate the collagen deposition induced by carbon tetrachloride in the liver. Although Mg deficiency increases mast cells in the small intestine, the kidney and bone marrow, the effect of Mg deficiency on mast cells has not been clarified in the liver. We examined the emergence of mast cells in the liver of Sprague-Dawley rats given an Mg-deficient diet. Rats were fed a control diet or an Mg-deficient diet for 4 wk. Mg deficiency increased the levels of mRNA known to be expressed by mast cells in the liver; the mRNA of α- and β-chain high-affinity immunoglobulin E receptor (FcεR1α, FcεR1β), and the mRNA of mast cell protease 1 (Mcpt1), and mast cell protease 2 (Mcpt2). Histological observation showed that some mast cells were locally distributed around portal triads in the Mg-deficient group but mast cells were scarcely found in the control group. These results clearly indicate that Mg deficiency induces the emergence of mast cells around portal triads of the liver in Sprague-Dawley rats.

著者

Kazuhiko Tanabe Akiko Yamamoto Noriyuki Suzuki Naohiko Osada Yasuhiro Yokoyama Hisanori Samejima Atsushi Seki Misa Oya Taizo Murabayashi Masaru Nakayama Masanobu Yamamoto Kazuto Omiya Haruki Itoh Masahiro Murayama

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.62, no.5, pp.341-346, 1998 (Released:2001-11-25)

参考文献数

20

被引用文献数

8 10

---

We have previously reported that chronic sleep deprivation causes a deficiency of intracellular magnesium (Mg) and decreased exercise tolerance. The aim of this study was to clarify whether oral administration of Mg could be effective in restoring the exercise tolerance that is decreased by chronic sleep deprivation. A bicycle ergometer cardiopulmonary exercise test was performed by 16 healthy volunteers (mean age 21.9 years). They were divided into 2 groups: 8 received doses of 100 mg of Mg orally per day for 1 month (Mg group) and the remaining 8 received no Mg and served as the control group. The study conditions were designed as follows: (1) the usual state (good sleep); and (2) the sleep-deprived state (sleeping time up to 60% Iess than the usual state for 1 month). The ratio of intracellular Mg content of the sleep-deprived state to the usual sleep state was significantly higher in the Mg group (p <0.05) than the untreated control group. There was no difference between the sleep-deprived state and the usual state with regard to anaerobic threshold and peak oxygen uptake in the Mg group, whereas both of these decreased in the sleep-deprived state in the control group. These results indicate that decreased exercise tolerance observed in the sleep-deprived state could be improved by oral Mg administration. (Jpn Circ J 1998; 62: 341-346)

著者

Yamamoto Tomoyuki Sato Yuzuru Kataoka Naoto Takagi Hiroaki

出版者

Department of Mathematics, Hokkaido University

雑誌

Hokkaido University technical report series in mathematics (ISSN:13484338)

巻号頁・発行日

vol.118, pp.1, 2007-01-01

著者

Kazuki TAKAHASHI Yasuyuki KANEKO Akiko SHIBANAI Shushi YAMAMOTO Ayana KATAGIRI Tatsuyuki OSUGA Yoshiyuki INOUE Kohei KURODA Mika TANABE Tamaki OKABAYASHI Kiyokazu NAGANOBU Isao MINOBE Akatsuki SAITO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0010, (Released:2022-03-24)

被引用文献数

17

---

The hepatitis B virus (Hepadnaviridae) induces chronic hepatitis and hepatic cancer in humans. A novel domestic cat hepadnavirus (DCH) was recently identified in several countries, however, the DCH infection status of cats in Japan is unknown. Therefore, we investigated the DCH infection rate of 139 cat samples collected in Japan. We identified one positive blood sample (0.78%) from a 17-year-old female cat with chronically elevated alanine aminotransferase. Phylogenetic analysis demonstrated that the DCH strain identified in this study is genetically different from strains in other countries. Further investigations are required to elucidate the evolution of DCH and the impact of DCH infection on hepatic diseases in domestic cats.

著者

OKANISHI MASANORI SENTOKU ASUKA FUJIMOTO SHINTA JIMI NAOTO NAKAYAMA RYO YAMANA YUSUKE YAMAUCHI HIROKI TANAKA HAYATE KATO TETSUYA KASHIO SHO UYENO DAISUKE YAMAMOTO KOHKI MIYAZAKI KATSUMI ASAKURA AKIRA

出版者

Seto Marine Biological Laboratory, Kyoto University

雑誌

Publications of the Seto Marine Biological Laboratory (ISSN:00372870)

巻号頁・発行日

vol.44, pp.7-52, 2016-12

---

We herein present the results of a survey which assessed the benthic fauna from subtidal to continental shelf depth in the Shirahama area from 2012 to 2016. Our research resulted in the identification of 132 species from 75 families in seven phyla, Cnidaria, Annelida, Tardigrada, Arthropoda, Mollusca, Echinodermata and Chordata. This includes 24 newly recorded species to Shirahama. Two species were also new records for Japanese waters. Furthermore, six undescribed species and five potentially undescribed species were recorded. We provide a selection of relevant photos for future taxonomic studies and monitoring of environmental changes.

著者

Hiroyuki Tsutsui Mitsuaki Isobe Hiroshi Ito Hiroshi Ito Ken Okumura Minoru Ono Masafumi Kitakaze Koichiro Kinugawa Yasuki Kihara Yoichi Goto Issei Komuro Yoshikatsu Saiki Yoshihiko Saito Yasushi Sakata Naoki Sato Yoshiki Sawa Akira Shiose Wataru Shimizu Hiroaki Shimokawa Yoshihiko Seino Koichi Node Taiki Higo Atsushi Hirayama Miyuki Makaya Tohru Masuyama Toyoaki Murohara Shin-ichi Momomura Masafumi Yano Kenji Yamazaki Kazuhiro Yamamoto Tsutomu Yoshikawa Michihiro Yoshimura Masatoshi Akiyama Toshihisa Anzai Shiro Ishihara Takayuki Inomata Teruhiko Imamura Yu-ki Iwasaki Tomohito Ohtani Katsuya Onishi Takatoshi Kasai Mahoto Kato Makoto Kawai Yoshiharu Kinugasa Shintaro Kinugawa Toru Kuratani Shigeki Kobayashi Yasuhiko Sakata Atsushi Tanaka Koichi Toda Takashi Noda Kotaro Nochioka Masaru Hatano Takayuki Hidaka Takeo Fujino Shigeru Makita Osamu Yamaguchi Uichi Ikeda Takeshi Kimura Shun Kohsaka Masami Kosuge Masakazu Yamagishi Akira Yamashina on behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.10, pp.2084-2184, 2019-09-25 (Released:2019-09-25)

参考文献数

608

被引用文献数

435

著者

髙岡 昂太 坂本 次郎 北條 大樹 橋本 笑穂 山本 恒雄 北村 光司 櫻井 瑛一 西田 佳史 本村 陽一 K. Takaoka J. Sakamoto D. Hojo E. Hashimoto Yamamoto K. Kitamura E. Sakurai Y. Nishida Y. Motomura

雑誌

SIG-SAI = SIG-SAI

巻号頁・発行日

vol.33, no.5, pp.1-7, 2018-11-22

---

As the number of reported child abuse cases is increasing, the workload of child welfare social workers is highly escalated. This study aims to find the characteristics of recurrent cases in order to support the social workers. We collected data around the child abuse and neglect from a prefecture database and analyzed it with Probabilistic Latent Semantic Analysis and Bayesian Network modeling. As the result, pLSA showed the four different clusters and Bayesian Network revealed a graphical model about the features of recurrence cases. The Interpretable modeling can be effectively deployed in those child welfare agencies to save children who are suffering from child abuse cases.

著者

Tohru Masuyama Takeshi Tsujino Hideki Origasa Kazuhiro Yamamoto Takashi Akasaka Yutaka Hirano Nobuyuki Ohte Takashi Daimon Satoshi Nakatani Hiroshi Ito

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.4, pp.833-842, 2012 (Released:2012-03-23)

参考文献数

30

被引用文献数

46 49

---

Background: Diuretics are the most prescribed drug in heart failure (HF) patients. However, clinical evidence about their long-term effects is lacking. The purpose of this study was to compare the therapeutic effects of furosemide and azosemide, a short- and long-acting loop diuretic, respectively, in patients with chronic heart failure (CHF). Methods and Results: In this multicenter, prospective, randomized, open, blinded endpoint trial, we compared the effects of azosemide and furosemide in patients with CHF and New York Heart Association class II or III symptoms. 320 patients (160 patients in each group, mean age 71 years) were followed up for a minimum of 2 years. The primary endpoint was a composite of cardiovascular death or unplanned admission to hospital for congestive HF. During a median follow-up of 35.2 months, the primary endpoint occurred in 23 patients in the azosemide group and in 34 patients in the furosemide group (hazard ratio [HR], 0.55, 95% confidence interval [CI] 0.32-0.95: P=0.03). Among the secondary endpoints, unplanned admission to hospital for congestive HF or a need for modification of the treatment for HF were also reduced in the azosemide group compared with the furosemide group (HR, 0.60, 95%CI 0.36-0.99: P=0.048). Conclusions: Azosemide, compared with furosemide, reduced the risk of cardiovascular death or unplanned admission to hospital for congestive HF. (Circ J 2012; 76: 833-842)

著者

山本 裕子 Yuko S. Yamamoto

巻号頁・発行日

2011

著者

Kazue Ishitsuka Mayumi Tsuji Megumi Yamamoto Rie Tanaka Reiko Suga Mami Kuwamura Toshihide Sakuragi Masayuki Shimono Koichi Kusuhara the Japan Environment and Children’s Study Group

出版者

The Japanese Society for Hygiene

雑誌

Environmental Health and Preventive Medicine (ISSN:1342078X)

巻号頁・発行日

vol.28, pp.47, 2023 (Released:2023-08-30)

参考文献数

50

---

Background: Fish are a rich source of essential nutrients that protect against preterm birth. However, as fish can absorb environmental pollutants, their consumption can also increase the risk of preterm birth. This study aimed to assess whether maternal fish consumption during pregnancy is associated with preterm birth in a nationwide large Japanese cohort that consumed relatively high amounts and many types of fish.Methods: This study included 81,428 mother-child pairs enrolled in a nationwide prospective Japanese birth cohort study. Fish consumption was assessed using a validated food frequency questionnaire. Multivariate logistic regression was used to investigate the association of total consumption of fish, fatty fish and lean fish, fish paste, and seafood and clams with preterm birth, adjusted for potential confounders.Results: There was no association between overall fish consumption and preterm births. However, the highest quintile of fish paste consumption was significantly associated with an increased risk of preterm birth (odds ratio [OR]: 1.11; 95% confidence interval [CI: 1.04, 1.17]). The consumption of baked fish paste at least three times per week was significantly associated with preterm birth (OR: 1.20; 95% CI: 1.03, 1.40). Consumption of other types of fish, except fish paste, was not significantly associated with preterm birth risk.Conclusions: Fish paste consumption may increase the risk of preterm birth. Further studies are required to confirm this association.

著者

Atsushi SATO Takaaki FUJITA Yuichi YAMAMOTO

出版者

Japanese Society of Physical Therapy

雑誌

Physical Therapy Research (ISSN:21898448)

巻号頁・発行日

pp.E9914, (Released:2017-07-28)

参考文献数

26

被引用文献数

6 7

---

Purpose: This study aimed to calculate cut-off values of activities of daily living independence level for stroke patient home discharge based on the number of family caregivers. Method: The subjects comprised 1442 stroke patients (26 hospitals) who were registered of the Japanese Rehabilitation Database. Receiver operating characteristic curves were used to elucidate the BI and FIM® instrument scores necessary for home discharge. Analysis was performed for each subject according to the number of family caregivers, i.e., no caregiver, one person, two persons or more, and overall. Result: The BI cut-off points that discriminated between home discharge and other were 65/60 points overall, 75/70 points in patients with no caregiver, 65/60 points in patients with one caregiver, and 60/55 points in patients with two or more caregivers. The FIM® instrument cut-off points were 90/89 points overall, 101/100 points in patients with no caregiver, 87/86 points in patients with one caregiver, and 87/86 points in patients with two or more caregivers. Conclusion: Our results indicated that home discharge for patients with many caregivers was possible even with low ADL independence levels, and that there was a large difference in cut-off values depending on the presence or absence of one caregiver.

著者

Hiroyuki Tsutsui Tomomi Ide Hiroshi Ito Yasuki Kihara Koichiro Kinugawa Shintaro Kinugawa Miyuki Makaya Toyoaki Murohara Koichi Node Yoshihiko Saito Yasushi Sakata Wataru Shimizu Kazuhiro Yamamoto Yasuko Bando Yu-ki Iwasaki Yoshiharu Kinugasa Isamu Mizote Hitoshi Nakagawa Shogo Oishi Akiko Okada Atsushi Tanaka Takashi Akasaka Minoru Ono Takeshi Kimura Shun Kosaka Masami Kosuge Shin-ichi Momomura on behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0431, (Released:2021-09-29)

参考文献数

252

被引用文献数

84

著者

Tetsuo YAMAMOTO Manabu KINOSHITA Nariyoshi SHINOMIYA Sadayuki HIROI Hidekazu SUGASAWA Yoshitaro MATSUSHITA Takashi MAJIMA Daizoh SAITOH Shuhji SEKI

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.51, no.2, pp.145-156, 2010 (Released:2010-03-25)

参考文献数

38

被引用文献数

38 28

---

While bone marrow or stem cell transplantation can rescue bone marrow aplasia in patients accidentally exposed to a lethal radiation dose, radiation-induced irreversible gastrointestinal damage (GI syndrome) is fatal. We investigated the effects of ascorbic acid on radiation-induced GI syndrome in mice. Ascorbic acid (150 mg/kg/day) was orally administered to mice for 3 days, and then the mice underwent whole body irradiation (WBI). Bone marrow transplantation (BMT) 24 h after irradiation rescued mice receiving a WBI dose of less than 12 Gy. No mice receiving 14 Gy-WBI survived, because of radiation-induced GI syndrome, even if they received BMT. However, pretreatment with ascorbic acid significantly suppressed radiation-induced DNA damage in the crypt cells and prevented denudation of intestinal mucosa; therefore, ascorbic acid in combination with BMT rescued mice after 14 Gy-WBI. DNA microarray analysis demonstrated that irradiation up-regulated expressions of apoptosis-related genes in the small intestine, including those related to the caspase-9-mediated intrinsic pathway as well as the caspase-8-mediated extrinsic pathway, and down-regulated expressions of these genes in ascorbic acid-pretreated mice. Thus, pretreatment with ascorbic acid may effectively prevent radiation-induced GI syndrome.

著者

Jun Tamiya Wakako Sakaguchi Kimiko Nakagawa Toshiharu Yamamoto Juri Saruta Nobuhisa Kubota Akira Kawata Iwao Hasegawa Nobushiro Hamada Keiichi Tsukinoki

出版者

JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

雑誌

ACTA HISTOCHEMICA ET CYTOCHEMICA (ISSN:00445991)

巻号頁・発行日

pp.22-00089, (Released:2023-04-08)

被引用文献数

1

---

SARS-CoV-2 infects a variety of tissues, including the oral cavity. However, there are few reports examining the association of SARS-CoV-2 with tongue mucosal tissues with sticky tongue debris. This study investigated the presence of SARS-CoV-2 and its associated molecules by dissecting tongue tissue from autopsy specimens of 23 patients who died of COVID-19-related illness (pneumonia). Immunohistochemical staining, electron microscopy, and PCR analysis were performed on the tongue tissue specimens. The mucosal epithelium of the tongue formed a very thick keratinized with well-developed filiform papillae in all cases. ACE2 and TMPRSS2 were consistently co-expressed in all samples in the epithelium. The S-protein was strongly expressed in basal cells and the epithelial surface. S-protein-positive viral particles were detected in the tongue’s stratified squamous epithelium via an immunoelectron microscope. Based on PCR amplification of the N1 and N2 regions, the SARS-CoV-2 gene was detected on the tongue epithelium, tongue submucosa, and in tongue debris. This suggests that tongue debris, including the squamous epithelial tissue, could be a source of SARS-CoV-2 in saliva. Furthermore, removing tongue debris may decrease the amount of SARS-CoV-2 in the oral cavity.

著者

Shamima Akter Tohru Nakagawa Toru Honda Shuichiro Yamamoto Keisuke Kuwahara Hiroko Okazaki Huanhuan Hu Teppei Imai Akiko Nishihara Toshiaki Miyamoto Naoko Sasaki Takayuki Ogasawara Akihiko Uehara Makoto Yamamoto Taizo Murakami Makiko Shimizu Masafumi Eguchi Takeshi Kochi Ai Hori Satsue Nagahama Kentaro Tomita Maki Konishi Ikuko Kashino Akiko Nanri Isamu Kabe Tetsuya Mizoue Naoki Kunugita Seitaro Dohi for the Japan Epidemiology Collaboration on Occupational Health Study Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.82, no.12, pp.3005-3012, 2018-11-24 (Released:2018-11-24)

参考文献数

28

被引用文献数

20

---

Background: The effect of smoking on mortality in working-age adults remains unclear. Accordingly, we compared the effects of cigarette smoking and smoking cessation on total and cause-specific mortality in a Japanese working population. Methods and Results: This study included 79,114 Japanese workers aged 20–85 years who participated in the Japan Epidemiology Collaboration on Occupational Health Study. Deaths and causes of death were identified from death certificates, sick leave documents, family confirmation, and other sources. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated via Cox proportional hazards regression. During a maximum 6-year follow-up, there were 252 deaths in total. Multivariable-adjusted HRs (95% CIs) for total mortality, cardiovascular disease (CVD) mortality, and tobacco-related cancer mortality were 1.49 (1.10–2.01), 1.79 (0.99–3.24), and 1.80 (1.02–3.19), respectively, in current vs. never smokers. Among current smokers, the risks of total, tobacco-related cancer, and CVD mortality increased with increasing cigarette consumption (Ptrend<0.05 for all). Compared with never smokers, former smokers who quit <5 and ≥5 years before baseline had HRs (95% CIs) for total mortality of 1.80 (1.00–3.25) and 1.02 (0.57–1.82), respectively. Conclusions: In this cohort of workers, cigarette smoking was associated with increased risk of death from all and specific causes (including CVD and tobacco-related cancer), although these risks diminished 5 years after smoking cessation.

著者

Shunroku YAMAMOTO Masahiko TOMORI

出版者

Japan Society of Civil Engineers

雑誌

Journal of JSCE (ISSN:21875103)

巻号頁・発行日

vol.1, no.1, pp.322-328, 2013 (Released:2013-11-20)

参考文献数

13

被引用文献数

19 24

---

During the 2011 off the Pacific coast of Tohoku Earthquake, the earthquake early warning system operated by East Japan Railway Company controlled the Shinkansen trains through information from its seismic stations before large shakings hit the line. By analyzing the event history of the system recorded in its monitoring PCs, it was confirmed that the system first detected the seismic motion at 14:46:38.9 (JST) based on the data of the Kinkazan seismic station located closest to the epicenter, and issued the first control signal to trains between Shiroishi-Zaoh station and Kitakami station of the Tohoku Shinkansen line at 14:47:02.9 through the excess of acceleration threshold of the Kinkazan seismic station. The signal was issued 12-22 seconds earlier than the time SI value exceeding 18 cm/s along the line, which is the required value to stop trains based on company rules. After issuing the first control signal, other seismic stations began issuing signals through the excess of acceleration threshold almost sequentially according to certain delays caused by wave propagation from the hypocenter. Eventually, 27 trains (19 of them were running) along the line were safely controlled. In this paper, after summarizing the configuration of the earthquake early warning system of East Japan Railway Company and the warning logics adopted for the system, the system performance during the 2011 off the Pacific coast of Tohoku Earthquake is evaluated and discussed in detail.

著者

菅野 博之 大塚 英志 泉 政文 山本 忠宏 本多 マークアントニー 大内 克哉 Hiroyuki KANNO Eiji OHTSUKA Masafumi IZUMI Tadahiro YAMAMOTO Mark Anthony HONDA Katsuya OUCHI

出版者

神戸芸術工科大学

雑誌

芸術工学2012

巻号頁・発行日

2012-11-30

---

WEB上にまんが表現が移行するということは、「単行本」や「雑誌」がWEBの環境下で新たな適応を求められることを意味する。現在のまんが表現は「コマ」を映画の1カットに見立て「モンタージュ」的に接続する一方、2頁単位の「見開き」に「構成」として配置するものであるが、そのような方法はWEB上では一度解体する。本研究では「横スクロール」形式によってiPadなどのタブレット上に帯状に描かれたまんがを表示する技法において、紙のまんがに替わる新しい文法形式を検証するため、中世の絵巻物「信貴山縁起」の手法の解析を行った。その結果、画面を上下二分割する中心軸上で読者の視線を上下させる技法を確認し、それがiPad対応の横スクロールまんがにも用いることができることを確認した。その他「異時間図法」など、絵巻の技法は応用可能であることが確認できた。「絵巻」と「横スクロール形式のWEBコミック」の方法上の互換性は高く、そこに「紙のまんが」や「アニメーションの技法」をどのようにあらためて導入するかが次の重要な課題である。Transitioning the presentation of MANGA on the web means that a new adaptation under the web environment is desired for the presentational syntax of MANGA, which has been defined through print media such as 'books' and 'magazines'. The current presentation of MANGA is something that is a continuation of 'frames' selected as 1 scene of a video and joined in a 'montage'-like manner, arranged as a 'composition' in two-page unit 'spreads', however this type of method is momentarily demolished on the web. In this study, we performed an analysis of the techniques of the medieval picture scroll "The Legend of Mount Shigi(Shigisan-engi)", in order to verify the new syntactical form taking the place of 'paper MANGA', through the technique of displaying comics drawn as a strip for tablets such as the iPad via a 'horizontal scroll' format. Those results confirmed a technique of causing the reader's line of sight to go up and down via a core dividing the image into two upper and lower parts, and confirmed that it can also be utilized for horizontal scroll MANGA for the iPad. We were able to confirm that others picture scroll techniques such as 'drawing of different times.

著者

Michio Yamamoto Dai Keino Shinichiro Sumii Tomoko Yokosuka Hiroaki Goto Ayano Inui Tsuyoshi Sogo Makio Kawakami Mio Tanaka Masakatsu Yanagimachi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.62, no.12, pp.1813-1816, 2023-06-15 (Released:2023-06-15)

参考文献数

17

被引用文献数

4

---

We herein report a case of hepatitis-associated aplastic anemia (HAAA) that occurred after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. In this patient, progressive pancytopenia observed two months after acute hepatitis following the second dose of the SARS-CoV-2 vaccine indicated the development of HAAA. Although some reports have suggested that SARS-CoV-2 vaccination may be involved in the development of autoimmune diseases, no cases of HAAA developing after SARS-CoV-2 vaccination have been reported. SARS-CoV-2 vaccination in children has only started relatively recently, so the range of side effects in children has not yet been thoroughly described. Therefore, we need to strengthen surveillance for symptoms of children who are vaccinated.

著者

Yasuhiro Ito Akira Miyauchi Makoto Fujishima Masashi Yamamoto Takahiro Sasaki

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ23-0395, (Released:2023-10-04)

被引用文献数

1

---

Active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC enlargement in young patients may be affected by high serum levels of thyroid-stimulating hormone. This review notes that one patient showed lung metastasis after conversion surgery (CS) following AS, but there are no reports of patients dying of thyroid carcinoma during or after AS. Some PTMCs enlarge or show newly appeared metastatic nodes requiring CS, and findings on the postoperative prognosis and incidence of significant surgical complications (e.g., permanent vocal cord paralysis, hypoparathyroidism) do not differ significantly between patients who underwent CS after AS and those who underwent immediate surgery (IS). IS has been associated with significantly higher incidences of these complications compared to AS as the initial management. Several studies have examined the quality of life (QoL) of patients who underwent AS versus IS, and reported discrepant findings regarding various psychological conditions (including anxiety). Medical costs for AS and IS vary regionally, and in Japan, the 10-year total cost of IS was 4.1 times greater than that of AS in 2017. Taken together, the existing findings demonstrate that AS can be appropriate for the initial management of patients with PTMC.

著者

Masashi Kanai Takuya Toda Kojiro Yamamoto Marina Akimoto Yuta Hagiwara

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.7, pp.322-329, 2022-07-08 (Released:2022-07-08)

参考文献数

41

被引用文献数

1

---

Background: The overlap of multiple lifestyle-related diseases increases the risk of vascular diseases. This study investigated the effects of a mobile health (mHealth)-based disease management program on blood pressure and the safety of this program in people with multiple lifestyle-related diseases at risk of developing vascular disease.Methods and Results: This retrospective observational study was conducted using secondary data collected by PREVENT Inc. People with a full history of hypertension, diabetes, and dyslipidemia and who participated in a 6-month mHealth-based disease management program were included in the study. The primary outcome was blood pressure. Adverse events during the program were investigated to evaluate safety. In total, 125 participants (mean [±SD] age 55.3±6.2 years) were examined. Systolic and diastolic blood pressure were significantly lower after the intervention than at baseline (systolic blood pressure, 128.0±12.3 vs. 131.9±12.7 mmHg [P<0.001]; diastolic blood pressure, 81.2±9.3 vs. 83.6±8.9 mmHg; P=0.003). No serious adverse events occurred during the program.Conclusions: The present results indicate that the mHealth-based disease management program may reduce blood pressure in people with multiple lifestyle-related diseases at risk of developing vascular disease and that the program is safe. These findings will help shape future health instructions using mHealth-based interventions.