著者

国武 栄三郎 石西 伸 児玉 泰

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.30, no.3, pp.417-429, 1975-08-28 (Released:2009-04-21)

参考文献数

24

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Studies of mental fatigue caused by exposure to the aircraft noise was carried out experimentally on 9 female students engaged in some intellectual performance. The tape-recorded noise of the flying Jet engine was controlled from 85dB(A) to 95dB(A) in the peak level. The subjects were exposed continuously to the noise during 50 minutes and 100 minutes, respectively, in an insulated room protected from general outer noise.Through the noise exposure period, the subjects performed intellectual tasks, that is, the Kraepelin- Uchida's test and card-sorting test. At the same time, pulse rates and pulse waves of their fingertips were measured. Before and after each exposure, the mental fatigue was measured by the critical fusion frequency (C.F.F.), the color naming test (C.N.) and the discriminative reaction of the multiple performance test (M.P.). And the information of subjective sensations of human fatigue were collected by the questionnaire, Cornal Medical Index (C.M.I.) were used for psychophysiological complaints. The control data of each subject were obtained by the same experiment except noise.The following conculusions were derived from observations. The grade of mental fatigue increased in the case of the noise exposure rather than in the case of the noiseless situation. In C.F.F., fatigue increased 13% under noise exposure of 50 minutes, 37% under that of 100 minutes. In C.N. and M.P. as wel as C.F.F. the same gradiance between the noise exposure and fatigue were found. Furthermore, fatigue revealed itself more clearly in C.N. than in C.F.F., namely, the rate of prolongation of the time required for color identifying exceeded the critical level of mental fatigue, while the rate of mental fatigue in C.F.F. was within the normal or allowable range.The results of the questionnaire of subjective sensations of fatigue and of the C.M.I. in the case of the noise exposure showed no remarkable differences compared with those of the noiseless situation. But, it was found that some complaints of sensations of fatigue increased slightly during noise exposure compared with those in the noiseless situation. These complaints were the symptoms probably caused by the sympagotonic hypertension. Moreover, from the observation of the pulse rates and pulse waves, it was recognized that a biological lags of the relaxation of the sympathetic nerves system might occur when they were released from the intellectual tasks.From the observation mentioned above, it is considered that there is a posibility of the inhibition of the learning effectiveness in school children when they are exposed to the aircraft noise such as the subjects were exposed to in this experiment. The exposed aircraft noise level used in this study, calculated from the peak levels and flying numbers, corresponds to 80 W.E.C.P.N.L.. It can be said that mental fatigue is induced markedly by the noise of 80 W.E.C.P.N.L.. It is suggested that the noise level of 80 W.E.C.P.N.L. is not harmless to human being in the case of intellectual performance, especially during school hours.

著者

石原 房雄

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.20, no.4, pp.283-290, 1965-10-10 (Released:2009-02-17)

参考文献数

9

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In the first report I have compared the elements in soil and drink water of 14 so called long life and 7 short life villages.This time I have analysed those of 10 long life and 12 short life villages (Table 1, 2). By their milligram equivalent ratio, I could described most clearly the difference between both villages, that is the ratio of Mg/Ca, Ca/K, Ca/Ca+Mg+K+Na, Ca-Na (Fig. 1, 3). Over again by the distributions curve of those equivalent ratio, it shows more evidently the difference both villages, such as the ratio of Mg/Ca on the lengthwise the ratio of Ca-Na on the breadthwise (Fig. 4, 5, 6).Farther I have analysed the trace elements in soil, such as Co, Cr, Cu, Ni, Cd, and that of short life villages content always 2-3 times more than that of long life villages (Table 3).

著者

佐藤 英樹 鈴木 克彦 中路 重之 菅原 和夫 戸塚 学 佐藤 光毅

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.53, no.2, pp.431-440, 1998-07-15 (Released:2009-02-17)

参考文献数

35

被引用文献数

12 14

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We investigated the effects of acute endurance exercise and habitual physical activity for health maintenance on human neutrophil function in 12 untrained men. The acute exercise condition was a continuous exercise for 90 minutes at the intensity of 50% and 55% of maximal oxygen uptake (VO2max) on an ergometer. The training program was 3km jogging three times per week for 8 weeks. The capacity of neutrophils to produce reactive oxygen species (ROS) was detected with lucigenin-dependent chemiluminescence (LgCL) and luminol-dependent chemiluminescence (LmCL) on stimulation with opsonized zymosan (OZ) and phorbol myristate acetate (PMA).As for the acute exercise effects, both LgCL and LmCL responses of neutrophils stimulated using PMA consistently increased after exercise at 50% VO2max, whereas those stimulated with OZ remained unchanged. At 55% VO2max, LgCL responses to both stimulants increase maximally 1h after exercise, and then decreased 3h after exercise, whereas LmCL responses to both stimulants increased continuously after exercise at 55% VO2max. These phenomena observed at 55% VO2max compared to 50% VO2max suggests the improved capacity of producing ROS neutrophils after exercise. The number of neutrophils also increased maximally 1h after exercise, due to the mobilization of band neutrophils (shift to the left), suggesting that functional changes was associated with cell mobilization. The increase in the capacity of neutrophils to produce ROS and marked neutrophilia following the acute endurance exercise suggests that a large quantity of ROS may be produced in vivo.As for the training effects, the LgCL and LmCL responses were maintained in the exercise group as compared to the decreased ones in the control group. The difference between the exercise group and the control group was observed only in LgCL response to OZ. Humoral immune factors (IgG, IgA, IgM, C3, C4) and serum opsonic activity were also unaltered. These phenomena suggest that homeostasis might be kept constant in terms of immunity through regular physical activity.

著者

東 賢一

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.73, no.2, pp.143-146, 2018 (Released:2018-05-31)

参考文献数

17

被引用文献数

1

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After the 1990s, many effective measures were taken to improve indoor air pollution in Japan. However, as a result of major changes in building materials, consumer products, and lifestyle, and new scientific findings on health effects associated with indoor environmental pollution, new issues have been indicated, such as chemical pollutants in indoor dusts or indoor pollutants caused by new chemicals that were substituted from chemicals that Indoor Air Quality Guideline was set. On the other hand, scientific evidence for the links between housing environment and health has accumulated substantially in recent decades. Therefore, the World Health Organization (WHO) is developing Housing and Health Guidelines to provide policymakers with recommendations on healthy housing conditions such as thermal comfort, indoor air pollution, crowding, and home injuries. In this paper, the basic principles of healthy housing, the current status of Japanese dwellings, and the recent approaches of WHO are summarized.

著者

野村 卓生

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.2, pp.107-110, 2016 (Released:2016-05-27)

参考文献数

22

被引用文献数

1

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The limitations of what physical therapists can differ from country to country. In Japan, physical therapists are national licensed health care professionals who can help patients improve or restore their mobility. Most Japanese physical therapists provide care for people in health care facilities, medical-welfare transitional facilities, and welfare facilities for the elderly. Currently, physical therapists are unable to sufficiently contribute to primary preventive health care in Japan. However, there are many health problems that physical therapists could help alleviate. For example, low back pain (LBP) more likely than any other condition prevents people from working; thus, making the establishment of effective measures to prevent and reduce LBP vital. An estimated 20,500,000 Japanese individuals have diabetes mellitus (DM) or are at a high risk of developing the disease. DM commonly accompanies stroke and/or heart disease, and is characterized by complications that result from chronic hyperglycemia. Evidence-based physical therapy is effective for the prevention and treatment of LBP and DM. The Japanese Physical Therapy Association established the Japanese Society of Physical Therapy (JSPT) in June 2013. The JSPT has 12 departmental societies and 10 sections. We believe that the JSPT will advance the study of the potential role of physical therapists in primary preventive health care. In the future, it is expected that Japanese physical therapists will contribute to primary preventive health care.

著者

竹内 昌平 黒田 嘉紀

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.65, no.1, pp.48-52, 2010 (Released:2010-02-05)

参考文献数

20

被引用文献数

6 8

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Objectives: On April 24th, 2009, a new swine-origin influenza A (H1N1) was first reported in Mexico. Japan confirmed cases of the flu on May 9th, and the pandemic in Japan has become full-scale. The Ministry of Health, Labor and Welfare of Japan announced that the first peak of this pandemic was predicted to occur in October, 2009. Therefore, it is most important to predict the progress of this pandemic to be able to use medical resources effectively in Japan. Methods: We used a modified susceptible-exposed-infected-recovered (SEIR) model to calculate the number of infected people and hospital bed shortage during this pandemic. In this model, available medical resources were investigated on the basis of four vaccination scenarios. Results: Our model showed that it would take a further six months for the pandemic to peak than was predicted by the Ministry of Health, Labor and Welfare of Japan. Without vaccination, at the peak of the pandemic 23,689 out of 400,000 people would be infected and the hospital bed shortage would reach 7,349 in total. Conclusions: We suggest that mathematical models are strong tools to predict the spread of infectious diseases. According to our model, it is possible to prevent hospital bed shortage by vaccination.

著者

若田 哲史 高木 幸夫 小泉 昭夫

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.75, pp.19015, 2020 (Released:2020-03-05)

参考文献数

35

被引用文献数

3

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Objectives: We investigated the quality of life (QOL) of patients using the Free/Low-Cost Medical Care Program, which is a system that enables people in financial difficulities to receive treatment free of charge or at a low cost. We also investigated the background charateristics and lifestyle of the patients.Methods: The subjects were 226 outpatients who used the Free/Low-Cost Medical Care Program (use group) and 226 outpatients who did not use the program (non-use group). The method was an anonymous cross-sectional servey by mail. The survey items included basic attributes, health-related QOL (HRQOL), feeling of being poor, lifestyle diseases, lifestyle, and connection with the community.Results: The number of respondants with valid responses was 97 in the use group and 85 in the non-use group. Among the basic attributes, there were a significant differense between the use group and the non-use group in the family structure, type of work, household income, and educational background. The HRQOL scores of the physical and social summary components were significantly lower in the use group than in the non-use group. The HRQOL scores of mental summary component were higher than the national standard HRQOL score in both the use and non-use groups.Conclusions: In this study, it was considered that old age affected the HRQOL scores of the physical and social components. It was considered from the HRQOL scores of the mental aspect that the use of the Free/Low-Cost Medical Care Program might have contributed to mental stability a certain to extent.

著者

龍田 希 仲井 邦彦 鈴木 恵太 黒川 修行 細川 徹 佐藤 洋

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.68, no.3, pp.189-196, 2013 (Released:2013-09-28)

参考文献数

30

被引用文献数

1 1

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Objectives: The Boston Naming Test (BNT) has been used to assess the language development of children in many epidemiology studies, and its usefulness is confirmed. The BNT consists of 60 black and white line drawings of objects and animals. There are no normative data available for this test for Japanese children. The purpose of this study was to collect normative information in Japan and to examine the correlation between the score of the BNT and Intelligence Quotient (IQ) of the Wechsler Intelligence Scale for Children third edition (WISC-III). Methods: The BNT was translated into Japanese and administered in children registered to the birth cohort of the Tohoku Study of Child Development at the age of 84 months. The participants for analysis in this study were 449 children (237 boys, 212 girls). Results: There were four items with percentage scores below 1%; Igloo, Knocker, Muzzle, and Yoke. Many Japanese children could answer ‘abacus’ and ‘compass’, which are difficult for US children. Although the score of the BNT correlated with IQ of the WISC-III (p<0.001), as compared with the previous studies, the correlation coefficient was low. Conclusions: The BNT is quick and easy to use and valuable for researchers in evaluating language ability in children. Since the BNT was developed in the United States, the cultural values of that country are reflected in the BNT score. This implies that the BNT should be modified to fit Japanese population.

著者

李 卿 川田 智之

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.69, no.2, pp.117-121, 2014 (Released:2014-05-24)

参考文献数

26

被引用文献数

2 13

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Since 2004, we have conducted a series of studies of the effect of forest therapy on human health and established forest therapy as a new preventive strategy. We have found that forest therapy has many beneficial effects on human health. However, there is almost no study dealing with the possibility of clinical applications of forest therapy. In this review, we discuss the possibility of clinical applications of forest therapy from the following viewpoints: 1. Forest therapy can decrease blood pressure, heart rate, sympathetic nerve activity, and levels of stress hormones, such as urinary adrenaline and noradrenaline, and can increase parasympathetic nerve activity, suggesting its preventive effect on hypertension. 2. Forest therapy can also decreace the scores for anxiety, depression, anger, fatigue, and confusion and increase the score for vigor in the Profile of Mood States (POMS) test, suggesting its preventive effect on mental depression. 3. Forest therapy can increase the activity and number of human natural killer (NK) cells and the intracellular levels of anticancer proteins, suggesting its preventive effect on cancers. 4. These findings suggest that forest therapy may have preventive effects on lifestyle-related diseases. However, the above preventive effects of forest therapy should be confirmed in clinical research.

著者

児玉 浩子

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.73, no.1, pp.75-82, 2018 (Released:2018-01-31)

参考文献数

44

被引用文献数

1

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The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Deficiencies of selenium and iodine are observed in patients who receive special formulas of milk and enteral formula with low selenium and iodine concentrations, respectively. In contrast, neonatal transient hypothyroidism due to excess intake of iodine in pregnant women has also reported in Japan. It is expected that collaborative studies by researchers and clinicians will contribute to clarify the detail mechanism, diagnosis and treatment of these abnormalities.

著者

太田 庸起子 中野 篤浩 松本 理

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.47, no.4, pp.811-817, 1992-10-15 (Released:2009-02-17)

参考文献数

19

被引用文献数

4 6

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The hair from 9 children living in a Keshan disease prevalent district and from 10 children living in a Keshan disease non-prevalent district in China was analyzed. At the same time, the hair from 35 children of the same age residing in Tsukuba district in Japan was analyzed for comparison of the concentration of essential trace elements with that of children living in the Keshan disease prevalent district. Se concentration was determined by a fluorophotometric method and 16 other elements were analyzed by ICP emission spectrometry. Hg was analyzed by the heating evaporation method and by neutron activation analysis. The Se concentration in the hair of children living in the prevalent district was very low, being one-tenth that of the Japanese. The Ni concentration was particularly low in the prevalent district, and it determined to study more about the effects of Ni deficiency on health. In the prevalent district, Mg and Ca levels were low and those of Pb, Fe, Al, Ti were relatively high. Mn concentrations of both districts in China were very high when compared to the Japanese. The results of this study showed that the low Se concentration in Keshan disease is in agreement with previously reported data. Ecological factors, including nutrition were considered to be important in the etiology of this disease.

著者

山本 和子 緒方 昭 中森 靖郎 浅野 長一郎 畠中 駿逸

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.28, no.4, pp.416-424, 1973-10-30 (Released:2009-02-17)

参考文献数

12

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The purpose of this paper is to make clear a comprehensive relationship between two groups of measurements of blood pressure and physical constitution. The first group of measurements include pulse rate, systolic blood pressure and diastolic blood pressure, and the second group of measurements include height, weight, chest circumference, circumference of the upper arm and sitting height.These figures are taken from the Nutrition Survey of Japanese, including 6617 males and 8909 females, investigated in May, 1961.Appling the canonical correlation analysis, we found the following results.1) Only two canonical correlations were statistically significant.2) The value of the first canonical correlation was 0.262 for males and 0.381 for females. The corresponding canonical variables were considered as a blood pressure factor and a physical type factor, respectively.3) It seemed that, as the physical type factor changed with age, the blood pressure factor also changed proportionately.4) The value of the second canonical correlation was rather small but significant, 0.094 for males and 0.108 for females. The corresponding canonical variables seemed to be a pulse-pressure factor and a second physical type factor related to weight (positive) and chest circumference (negative).5) In addition, it was also found that the pulse rate has little to do with the physical type.

著者

中村 裕之

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.43, no.4, pp.872-886, 1988-10-15 (Released:2009-02-17)

参考文献数

54

被引用文献数

1

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In order to clarify the involvement of the central nervous system (CNS) in the responses of organisms to exposure to whole body vibration, dopamine (DA) metabolism and levels of DA-related neuropeptides: substance P-like immunoreactivity (SP-LI), somatostatin-like immunoreactivity (SRIF-LI) and neurotensin-like immunoreactivity (NT-LI) in various discrete regions of the rat brain were examined in the following three groups; a group exposed to whole body vibration (4G, 20Hz, 1.5 hours), a group exposed to noise (68-72 dB (A), 1.5 hours) associated with the driving of a vibration generator, and a control group. Simultaneously, changes of both rectal temperatures and plasma corticosterone levels and the development of gastric ulcers were examined as indices of the autonomic-endocrine function.1. Rectal temperatures and plasma corticosterone levels were increased by the exposure to whole body vibration, as compared with those of the group exposed to noise. Furthermore, gastric ulcers developed in all of the rats exposed to whole body vibration.2. The whole body vibration increased the DA turnover rate in the frontal cortex and the nucleus accumbens, compared with those in the noise group. SP-LI in the nucleus accumbens was also increased significantly.3. The striatal SRIF-LI was increased in the rats subjected to whole body vibration.4. SP-LI and SRIF-LI in the amygdala were increased in the whole body vibration group as compared with in the noise group. A significant increase of NT-LI was also observed in the hypothalamus.5. SP-LI was reduced and NT-LI was increased in the frontal cortex of the rats exposed to whole body vibration.6. The noise exposure caused no changes in rectal temperature, plasma corticosterone levels or gastric mucosa. However, the DA turnover in the amygdala increased significantly compared with that of the control group, suggesting that the DA neurons projecting to the amygdala were involved in emotional changes induced by the exposure to noise stress.7. The combined effects of noise and whole body vibration could not be observed in this study.In conclusion, the findings obtained in the present study indicate that DA systems in the CNS, especially the mesocortical DA system, may be involved in various responses of the organism, including emotional changes in a functional relationship with SP, SRIF and NT neuron systems in various brain regions when subjected to whole body vibration.

著者

岡本 和士 柳生 聖子 大野 和子 岡本 伸夫 高橋 玲 大塚 亨 前田 清 斎藤 征夫 加藤 孝之

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.43, no.5, pp.1028-1035, 1988-12-15 (Released:2009-02-17)

参考文献数

39

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We examined the relationship of body fat distribution to lipid metabolism in 50 obese women who participated in a weight reduction program.Body fat distribution was assessed by measurement of the waist-to-hip size ratio (WHR), minimal waist size and maximal hip size measured in a standing position.Obese women were separated into two subgroups by WHR; predominantly upper- or lower-body-segment obesity (UBSO or LBSO).After adjusting for ideal body weight, we found significantly high correlations with WHR (r=0.82, p<0.01), serum total cholesterol, serum triglyceride, VLDL and ApoB, which were significantly higher in UBSO; while HDL-ch and ApoA-1 were significantly lower in UBSO than LBSO.However, in UBSO, serum triglyceride and A. I. were significantly decreased; and HDL-ch was significantly increased after weight reduction.In conclusion, we suggested that the site of fat predominance offers a better diagnostic or prognostic marker for lipid metabolism abnormality than the degree of obesity alone.

著者

砂川 武 三尾 隆弥 住野 公昭

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.56, no.2, pp.500-513, 2001-07-15 (Released:2009-02-17)

参考文献数

50

被引用文献数

1

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The oxidative decomposition of skin lipids by UV exposure and its cell toxicity were studied in vivo and in vitro, using guinea pigs, to investigate the role of oxidative damage in cell membranes and mitochondria in nuclear genome DNA damage resulting in skin cell death by ultraviolet (UV) exposure.Two new methods were developed for this research: selective methylation by trimethylsilyldiazomethane (TMSCHN2) of free fatty acids in crude skin lipids for gas chromatography-mass spectrometry (GC-MS) analysis, and the improvement of the thiobarbituric acid (TBA) reaction for lipid peroxide analysis, which was obtained by adding 0.01% BHT and 1mM EDTA, an antioxidant additive, into the reaction system described by Ohkawa.The following findings were noted:1. Using an optical microscope, the infiltration of inflammatory cells such as neutrophils, lymphocytes and monocytes was noted after skin tissue was exposed to UV.2. The increase of lipid peroxide in exposed areas was small. In the epidermis the increase was about 2 times higher than the non-exposed areas.3. The fragments of lipid were generated in accordance with the increase of free fatty acids (C16:0, C18:1, :2, C18:0) in the surface of the exposed skin by GC-MS precise assay, and the level of 7-dehydrocholesterol was decreased.4. The skin homogenate received peroxidation by ultraviolet more easily than living skin, and its peroxidation was inhibited with fat-soluble antioxidative agents such as flavonoids, BHT, BHA, and vitamin E and the metal chelating agent such as Fenton reaction inhibitor as expected; however, it was promoted by water soluble antioxidative agents such as glutathione and vitamin C, which are useful to the human body.5. Steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin and aspirin, had no inhibitory effect on lipid peroxidation by ultraviolet as properties of chemicals.

著者

三根 晴雄

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.14, no.8, pp.964-971, 1959-12-01 (Released:2009-02-17)

参考文献数

7

著者

福岡 秀興

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.69, no.2, pp.82-85, 2014 (Released:2014-05-24)

参考文献数

10

被引用文献数

3 2

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Presently, the incidences of noncommunicable diseases (NCD) have been increasing in both low- and middle-income countries worldwidely. Effective long-term and multigeneration interventions to decrease the risk of NCD should be developed and introduced. The environment in utero alters phenotypes mainly through epigenetic mechanisms. The epigenetic changes induced in an unfavorable developmental environment have lifelong effects on cardiovascular and metabolic functions, susceptibility to cardiovascular disease, obesity, and other NCD. Although compared with animals, epigenetic analysis of human specimens is restricted except for peripheral blood, placental, or umbilical specimens, recently, important human studies have been reported concerning the epigenetic analysis of Line 1 gene from the umbilical blood, umbilical RXRα, or the peripheral nuclear cell IGF-2. The birth weight is an indirect marker of in-the-womb nutritional status. The incidence of low-birth-weight infants, weighing less than 2,500 g, has been increasing in Japan. Presently, it is higher than that in the latter half of the 20 s of the Showa era, and is the highest among the OECD countries. This trend suggests that in Japan the intrauterine nutritional status has been deteriorating. We have to change this trend and put much attention on the prepregnancy and pregnancy nutrition for the present and future generations.

著者

吉村 博之

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.37, no.6, pp.848-865, 1983-02-28 (Released:2009-02-17)

参考文献数

83

被引用文献数

1 1

---

The increase in the standard population death rate from pulmonary cancer warrants attention. Three factors can be attributed to this increase: air pollution, cigarette smoking, and occupational exposure to carcinogens. The present paper reports on the results of a study of the relationship between air pollution and pulmonary cancer. Rats, mice, and hamsters were subjected to up to 12 months exposure to diluted gasoline engine exhaust containing 300±50ppm CO, 0.21ppm NO, 0.08ppm NO2, 28ppmC hydrocarbon in the form of methane and 32ppb O3. Further experimentation consisted of combined treatments with carcinogens-rats with diisopropanolnitrosamine, mice with ethylcalbamate, and hamsters with diethylnitrosamine to determine whether the incidence of tumors would increase. No animals exposed exclusively to exhaust gas diveloped pulmonary tumors, indicating that exhaust caused no lung tumorigenesis. However, the frequency of pulmomary tumors increased in animals subjected to combinations of exhaust and carcinogens. The incidence of malignant pulmonary tumors in the rats group exposed for 12 months to carcinogens only was 8.7%, while that in the group exposed to the combination was 30.3%, with the rates for mice 72.7% as against 91.7%, and for hamsters, 3.8% as against 10%. The results indicate that gasoline engine exhaust increases the development of lung tumors, and that exhaust plus other carcinogens significantly increases the risks.

著者

小山 洋 佐藤 雅彦 遠山 千春

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.57, no.4, pp.624-635, 2003-01-15 (Released:2009-02-17)

参考文献数

90

被引用文献数

2 1

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As the last manuscript in our series of review articles on cadmium (Cd) and health effects, we reviewed research articles on epidemiologic and experimental studies on exposure levels of Cd in occupational and environmental settings in various countries, disposition and body burden of Cd, critical concentrations of Cd in the kidney of humans and animals with a focus on biomarkers for renal dysfunction, and life expectancy in Cd-polluted areas and reference areas. After this manuscript was compiled, cadmium levels in rice crops received significant attention, since the risk assessment of cadmium is now under review and discussion by the Joint Expert Committee of Food Additives and Contaminants organized by the Food Agricultural Organization and World Health Organization in 2003. We hope that the information compiled in this review may provide directions for future studies on the health risk assessment of Cd.

著者

平澤 恭子

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.73, no.1, pp.46-50, 2018 (Released:2018-01-31)

参考文献数

11

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Over the past few decades, advances in neonatal medicine have increased survival rates among very-low-birth-weight (VLBW) babies. Despite improvements in short-term outcomes, there is increasing concern about the probability of mild cognitive dysfunction in this population. Our analysis of VLBW babies born in our hospital revealed that the incidence of mild developmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactive disorder (ADHD) at the age of 3 years is 7.2%, which is markedly higher than the 2.8% incidence of ASD in the general population. Because problems related to ASD or ADHD tend to become more prominent as children grow up, the ages at diagnosis of developmental disorders are generally 6 years or above. Thus, in our follow up study of VLBW babies at age 6, the incidence of these developmental disorders had risen to 30%. These patients are apparently obstinate and difficult to train, causing parental problems with child care. It is important to support these children and help them establish good relationships with their parents. Given these problems, it is necessary to follow up VLBW children in the longterm, at least until they are elementary school students.