著者

柳沢 文徳 竹内 端彌 川島 裕博 波多野 忠義 山口 千尋 関口 俊次郎 石川 一

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.12, no.1, pp.41-45, 1957-04-01 (Released:2009-02-17)

参考文献数

6

著者

森岡 郁晴 和泉 有里奈 井上 雅 岡田 佳奈子 坂口 佳穂 宮井 那津季

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.69, no.2, pp.146-152, 2014

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Objectives: The purpose of this study was to clarify the effect of stone spa bathing (Ganban-yoku) and hot-spring bathing on brachial-ankle pulse wave velocity (baPWV) in healthy, late middle-aged females. Methods: The subjects were 13 females (mean age, 47.3 years). The skin and tympanic temperatures, blood pressure, and baPWV were measured before and after stone spa bathing and hot-spring bathing. For the stone spa bathing, the subjects lay down three times for approximately 10 min each time over warm stone beds. Results: Although body weight showed no change after the hot-spring bathing, it significantly increased after the stone spa bathing. The increase was significantly related to the amount of water intake. The skin and tympanic temperatures increased to a smaller degree after the stone spa bathing than after the hot-spring bathing. The diastolic blood pressure decreased to a smaller degree after the stone spa bathing. BaPWV showed no significant change after bathing both in the stone spa and in the hot-spring. The results of multiple regression analysis showed that the factors significantly related to the change in baPWV after the stone spa bathing were the changes in skin and tympanic temperatures and habit of smoking, and that after the hot-spring bathing was the change in skin temperature. Conclusions: The results suggest that, compared with the hot-spring bathing, stone spa bathing causes less strain on the body. The stone spa bathing and hot-spring bathing showed no marked effect on baPWV. However, there is a possibility that the stone spa bathing may be used as a load for investigating arterial stiffness.

著者

河野 敦子 石川 秀樹 中村 富予 河野 公一

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.65, no.3, pp.422-446, 2010 (Released:2010-05-27)

参考文献数

118

被引用文献数

6 7

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Enviromental factors have been consistently associated with colon cancer risk. In particular, consumption of Western-style diet including red meat is the most widely accepted etiologic risk factor. It has been reported that dietary factors change the proportion of intestinal flora, and it also affects the composition of fecal bile acids and the intestinal activity of some mutagens. In addition, it was suggested that modulating the composition of intestinal flora may reduce the occurrence of colorectal cancer. In this review, we present the clinical studies on the association between intestinal flora and the risk of colorectal cancer that have been carried out to date. The clinical studies of intestinal bacteria related to colorectal cancer risk have not shown consistent results so far, compared with the accomplishments of some basic studies. On the other hand, it was suggested in some clinical studies that lactic acid bacteria reduce the occurrence of colorectal cancer.

著者

林田 真梨子 鎌田 由佳 大田 智子 児島 沙由梨 増見 恭子 村田 成範 木下 健司

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.70, no.2, pp.134-138, 2015 (Released:2015-05-21)

参考文献数

15

被引用文献数

2 7

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Objectives: The purpose of this study was to identify associations between ALDH2 and ADH1B genotypes and ethanol-induced cutaneous erythema and assess the accuracy of an ethanol patch test in young Japanese women. Methods: The subjects were 942 female Japanese university students. They were given an ethanol patch test and examined for ethanol-induced cutaneous erythema both immediately after removing the patch and 10 minutes after removing the patch. A saliva sample was used to determine the ALDH2 and ADH1B genotype of each subject by realtime PCR. Results: The sensitivity and specificity of erythema immediately after removing the patch as the marker for the presence of inactive ALDH2 were 69.6% and 87.7%, respectively, and the sensitivity and specificity of erythema 10 minutes after removing the patch were 85.2% and 85.1%, respectively. The sensitivity of erythema after 10 minutes was markedly lower in the ADH1B*1/*1 carriers than in the ADH1B*2 carriers (8.3% vs. 89.7%, p<0.0001), and the specificity was significantly higher in the ADH1B*1/*1 carriers than in the ADH1B*2 carriers (96.9% vs. 84.3%, p<0.05). Conclusions: Overall, both sensitivity and specificity were satisfactorily high, but having the ADH1B*1/*1 genotype prevented a positive reaction for inactive ALDH2 and caused false-negative results. The data also suggested that having the ADH1B*2/*2 genotype caused a positive reaction in subjects with the ALDH2*1/*1 genotype. Despite these exceptions, the ethanol patch test has enough accuracy and can be used easily to subjects who don’t drink alcohol. This is a valuable tool for improving the health literacy of younger generation subjects.

著者

佐田 文宏

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.1, pp.41-46, 2016 (Released:2016-01-30)

参考文献数

38

被引用文献数

5 21

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Japan has the highest proportion of low-birth-weight infants among OECD countries for over 20 years. In 2011, the proportion of low-birth-weight infants in Japan was 9.6%, whereas the mean proportion in OECD countries was only 6.8%. In particular, young Japanese women’s strong desire to be thin has been pointed out as the underlying cause. Indeed, the frequencies of unhealthy thinness among third-year female junior and senior high school Japanese students have been increasing since the start of “Healthy Parents and Children 21”, and both groups have reached about 20%. The hypothesis of the fetal origins of adult disease (Barker’s theory) was proposed by Professor David J. Barker of Southampton University, who had conducted descriptive epidemiological studies in England and Wales and birth cohort studies in Hertfordshire, for example. In early 21st century, it became the wider theory known as the “Developmental Origins of Health and Disease (DOHaD)”, which was composed of developmental plasticity and the mismatch concept. Birth cohort studies are believed to be suitable for epidemiological studies to demonstrate the DOHaD theory. These studies and their collaborations are very popular in European countries, whereas such collaborations lagged behind in Japan. Recently, a new paradigm, “preemptive medicine”, has been proposed in Japan. The importance of interdisciplinary studies focusing on fetal and childhood periods was also recommended as a political strategy. We just expect the realization of nationwide large-scale interdisciplinary research projects based on DOHaD and preemptive medicine and the establishment of a central research institute of these studies.

著者

稲葉 洋平 宇津木 里香 大久保 忠利 内山 茂久 太田 敏博 欅田 尚樹

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:18826482)

巻号頁・発行日

vol.71, no.1, pp.76-83, 2016 (Released:2016-01-30)

著者

那須 昭夫

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.8, no.4, pp.168-172, 1954

被引用文献数

8

著者

松山 茂

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.7, no.3, pp.187-191, 1953

著者

米山 京子 石榑 清司 池田 順子 永田 久紀

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.39, no.2, pp.587-594, 1984

被引用文献数

1

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尿中Hydroxyproline(H.P)およびクレアチニン排泄量の日々の変動ならびに,蛋白質摂取量との関係を健康な大人5人(女2人と男3人)を対象として,連続する17∼42日間について,昼間と夜間の排泄量を分けて検討した。次の結果が得られた。<br>1.尿中H.PおよびH.P/クレアチニンの日間変動は5人ともかなり大きかった(変異係数はH.P:12.6∼19.8%,H.P/クレアチニン:13.2∼19.5%)。クレアチニンの日間変動はH.Pよりはるかに小さかった(変異係数3.6∼8.5%)。これらの物質の時系列データの自己相関分析では,一定の変動パターンは見られなかった。<br>2.5人中4人で,昼間と(又は)夜間の尿中H.Pは当日又は1∼2日前の蛋白質摂取量と有意の正の相関が見られた。この結果は,尿中H.P排泄量は食事中の蛋白質摂取量によって影響されうることを示唆している。<br>3.尿中H.Pの昼間と夜間の排泄量の相違は5人ともわずかであった。

著者

槇村 浩一 佐藤 一朗 杉田 隆 山崎 丘

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.66, no.1, pp.77-82, 2011 (Released:2011-02-25)

参考文献数

20

被引用文献数

1 6

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It is important to promote microbiological research essential for long-term manned space activities under microgravity and in a completely closed environment in space craft in relation to long-duration space expeditions on the International Space Station (ISS) or to the moon and Mars in the future. Environmental monitoring data from the space shuttle, the Mir, and the ISS have already shown that microorganisms isolated from air and on inner surfaces of space craft were generally carried by crew members. The Japanese Experiment Module (JEM) “KIBO” was attached to the ISS and started its operation from 2008. It is an invaluable opportunity to begin the survey of the transition of microbiota, particularly fungal biota, in JEM from “brand-new” to “well-used” condition at various periods. Therefore, we are preparing the on-board analyzing systems for microbiota in air and on inner surfaces of ISS/JEM and normal microbiota of the astronauts themselves. In this paper, we introduce the current status and future plans on fungal research on ISS/JEM to protect flight crew members and flight hardware from potentially hazardous microorganisms from the environmental and biomedical aspects of Japan Aerospace Exploration Agency (JAXA).

著者

檜垣 靖樹 庄野 菜穂子 西住 昌裕

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.52, no.2, pp.504-510, 1997-07-15 (Released:2009-04-21)

参考文献数

27

被引用文献数

1 1

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The effects of aerobic capacity and body fat accumulation on the insulin response after an oral glucose load were investigated in 21 college students. The subjects were divided into three groups based on their insulin response after an oral glucose load: the first group showed a hyper and prolonged insulin response; HI (n=6), the second group showed a lower insulin response; LI (n=6), and the third group consisted of other subjects; MI (n=9). The maximal oxygen consumption in the HI group (29.6±3.3ml/kg/min) was significantly lower than that in the LI group (42.5±3.1ml/kg/min, P<0.05). Although no significant difference was observed in the body mass index between the HI (24.6±1.9) and LI groups (22.2±0.4, p>0.05), the body fat and the waist-to-hip ratio were significantly higher in the HI group (25.3±3.1%, 0.87±0.03) than in the LI group (12.9±0.7%, 0.76±0.01, P<0.05). All subjects in the LI group performed regular exercise, while none of the subjects in the HI group performed any regular exercise. These results suggest that an inactive life style, decreased aerobic capacity and increased body fat accumulation all appear to result in an increased insulin response after a glucose load.

著者

浅田 史成 高野 賢一郎

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.2, pp.111-118, 2016 (Released:2016-05-27)

参考文献数

50

被引用文献数

2

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Musculoskeletal disorders in workers decrease the productivity of companies and result in socioeconomic losses. Low back pain accounted for approximately 60% of occupational diseases in the past and this is still true at present, making it a major occupational health problem in Japan. Herein, the findings about low back pain are explained as follows: the correlation between imaging examination findings and low back pain is low; psychosocial factors are involved in the onset of low back pain and how it becomes chronic; and improvement of activity is more useful than rest. Furthermore, the advantages of employing physical therapists for improving occupational health are as follows: they can 1) evaluate and intervene ergonomically; 2) provide instructions using a behavioral modification technique based on psychosocial factors; and 3) provide instructions regarding exercise programs considering obstacles to the development of a good exercise habit (painful diseases including osteoarthritis and other diseases such as hypertension and diabetes). In addition, falling, whose incidence has recently been increasing and is an important issue in occupational health, is examined from the aspect of musculoskeletal disorders. The following activities of physical therapists are introduced: the items to be checked during a tour of inspection of a workplace and detailed descriptions of work management and working environment management measures. Physical therapists are rarely involved in studies of low back pain and falling, but their knowledge and skills have been demonstrated to contribute to improving occupational health.

著者

西尾 雅七

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.1, no.1, pp.2a-3, 1946 (Released:2010-08-10)

参考文献数

1

著者

大神 信孝 押野 玲奈 二宮 裕将 李 香 加藤 昌志

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.72, no.1, pp.38-42, 2017 (Released:2017-02-02)

参考文献数

25

被引用文献数

1

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The inner ears contain the organ of Corti, vestibule and semicircular canal. The organ of Corti is crucial for hearing, while the vestibule and semicircular canal play important roles in maintaining balance. Exposure to noise at excessive levels is known to cause damages of the inner ears, resulting in noise-induced hearing loss. On the other hand, noise levels (dB) are used for the evaluation of health risks by exposure to noise, although noise consists of sound with broad frequencies (Hz). Thus, information about the frequency-dependent effect of noise on health is largely unknown. In this review, we first introduce noise-induced hearing loss caused by exposure to audible noise. We then describe the imbalance in mice exposed to low-frequency noise (100 Hz).

著者

大神 信孝 飯田 真智子 小又 尉広 中野 千尋 呉 雯婷 李 香 加藤 昌志

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.70, no.2, pp.100-104, 2015 (Released:2015-05-21)

参考文献数

24

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Noise stress generated in industry is one of the environmental factors that physically affects the functions of the inner ear. Exposure to noise can cause hearing loss, resulting in serious problems in occupational and daily life. At present, however, there are very limited ways to prevent hearing impairments. The inner ear consists of the organ of Corti, vestibule and semicircular canal. Functional or morphological damage of these tissues in the inner ear caused by genetic factors, aging or environmental factors can result in hearing or balance impairments. In this review, we first introduce a deafness-related molecule found by our clinical research. Our experimental research using genetically engineered mice further demonstrated that impaired activity of the target molecule caused congenital and age-related hearing loss with neurodegeneration of spiral ganglion neurons in the inner ears. We also describe impaired balance in mice caused by exposure to low-frequency noise under experimental conditions with indoor environmental monitoring. We believe that our approaches to pursue both experimental research and fieldwork research complementarily are crucial for the development of a method for prevention of impairments of the inner ear.

著者

内野 碩

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.30, no.3, pp.397-403, 1975

被引用文献数

3

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In the previous papers, the author has clarified that excessive intake of S-methylcysteine sulfoxide (methiin) extracted from cabbage caused splenic hypertrophy and anemia. The present study was undertaken in order to clarify these effects of methiin on rats fed a low protein, high protein or commercial diet.<BR>(I) Male Wistar rats were separated into six groups and the following six different diet were given. Group A: a low protein (6% casein) diet, group B: low protein supplemented with 4% methiin, group C: normal protein (12% casein), group D: normal protein supplemented with 4% methiin, group E: high protein (18% casein), group F: high protein supplemented with 4% methiin. After 35 days, the rats werr sacrificed and various analyses were carried out. Red blood cell counts, hemoglobin and hematocrit in blood decreased and splenic weight and iron levels in spleen and liver increased in the methiin-supplemented groups B, D and F.<BR>(II) Male Wistar rats were separated into five groups and the following five different diets were given for 50 days. Group A: a synthetic diet (15% casein), group B: synthetic diet supplemented with 2% methiin, group C: commercial diet (Oriental Co., MF), group D: commercial deit supplemented with 1% methiin, group E: commercial diet supplemented with 2% methiin. The data revealed that symptoms of anemia and splenic hypertrophy were seen also in rats fed a methiin supplemented commercial diet as well as rats fed a methiin supplemented synthetic diet.

著者

佐野 晴洋 山下 節義 川西 正祐 井口 弘 吉永 侃夫 小城 勝相 塚本 幾代 藤田 博美 岡本 浩子 加藤 伸勝 宮本 宣博 浮田 義一郎 山根 秀夫 森 律 池田 栄三 乾 修然 藤岡 惇 阿部 醇吉

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.37, no.2, pp.566-579, 1982-06-30 (Released:2009-02-17)

参考文献数

32

被引用文献数

1 3

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An epidemiological survey and clinical investigations were carried out on 162 retired workers from manganese mines and ore grinders, who were the residents of the Tamba district of Kyoto Prefecture. Most of the workers had been employed in small industrial factories with less than five employees under very poor working conditions. Fifty-five percent of them had worked in the mines and factories for longer than 11 years. Forty-six percent had been retired for 11-20 years, whereas 27% for longer than 21 years. A group of 124 people living in the same region but who had not been exposed to manganese served as the control group.The incidence of subjective symptoms associated with chronic manganese poisoning such as emotional instability, psychomotor irritability and neurologic abnormalities was apparently high in the experimental group and it increased with the period of exposure to manganese dust. Twenty-eight percent of the workers reported the subjective symptoms while they were employed, but 45% of them reported as late as six years after they retired.Of the retired workers, five (3.1%) had parkinsonism, three (1.9%) showed symptoms of hemiparkinsonism, and fifteen (9.3%) showed neurological symptoms including maskedlike, gait unbalance, slurred speech and imparied fine movements. Forty-five percent of these patients recognized these abnormalities for more than five years after they had left the contaminated workings. It is noteworthy that 39% of the retired workers were diagnosed as having pneumoconiosis.Some of the problems encountered in diagnosing manganese poisoning after exposure has been terminated is also discussed here.

著者

斎藤 征夫 柳生 聖子 服部 泰子 大野 和子 岡本 伸夫 高橋 玲 大塚 匠子 大塚 亨 前田 清 岡本 和士 加藤 孝之

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.44, no.5, pp.953-961, 1989-12-15 (Released:2009-02-17)

参考文献数

26

被引用文献数

4 8

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We investigated the condition of the liver in a total of 5486 subjects (3889 males and 1597 females) who received adult-disease screening examinations.The following results were obtained.1. Fatty liver was found in 13.9% of the males and 3.8% of the females with a male/female ratio of about 3.7 to 1. In males, the prevalence of fatty liver was lower in those in their 20's than in any other age ranks, while there was little difference in the age range from the 30's to the 50's. In females, the prevalence sharply increased in those in their 50's.2. The percentage of fatty liver increased with the obesity index in both males and females.3. With respect to alcohol drinking, the prevalence of fatty liver was not affected by the presence or absence of alcohol drinking, the daily drinking quantity and total drinking quantity.4. Of those screened for adult disease, 14.7% of the males and 2.7% of the females had abnormal liver function, with a male/female ratio of about 5.4 to 1. In both males and females, the prevalence of fatty liver was higher in those who had abnormal rather than normal liver function.

著者

藤巻 可弓 荒川 千夏子 吉永 淳 渡辺 知保 芹澤 滋子 今井 秀樹 白石 寛明 水本 賀文

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.59, no.4, pp.403-408, 2004-11-15 (Released:2009-02-17)

参考文献数

14

被引用文献数

14 21

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Objective: The daily bisphenol A (BPA) intake level of Japanese pregnant women was surveyed based on the measurement of the urinary excretion level of a BPA metabolite.Methods: Spot urine samples were collected from 56 pregnant women who visited the gynecology division of a hospital for a routine health check between June and October 2003. The urinary concentrations of the BPA metabolite and creatinine were measured by GC/MS/MS and spectrophotometry, respectively. Daily BPA intake was assumed to be equal to daily excretion.Results: The daily intake of BPA among Japanese pregnant women was estimated to be in the range of <0.3 to 7.9μg/day (median<2.0μg/day), being consistent with the levels in previous studies for non-pregnant Japanese women. This level was far below the current Acceptable Daily Intake (0.01mg/kg/day) which was set by the European Commission. The maximum estimated intake per body weight (0.16μg/kg/day) reached 1/10 of the Lowest Adverse Effect Level of BPA for pregnant mice for a reproductive effect on the offspring (2μg/kg/day).Conclusion: It is desirable to lessen BPA intake from a precautionary viewpoint, particularly in pregnant women.

著者

坂口 力

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.19, no.6, pp.369-373, 1965-02-10 (Released:2009-02-17)

参考文献数

40

被引用文献数

1

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The studies were carried out to investigate the changes in the ammonia content of brain, liver, and blood under different physical environments. The environmental conditions studied were noise, cold, and immobilization.The adult male rats were exposed to 100∼105 phone noise characterized by wide octave band spectrum for 3 hours, or to cold (-10±1°C) for 3 hours, or were immobilized for 2 hours. There-after, the animals were killed by two different methods; the one was decapitated at room temperature and the other was dropped into the mixture of solid carbon dioxide and acetone. The brain and liver were rapidly removed, and homogenized in ice-cold 10% trichloroacetic acid with glass homogenizers. The blood samples were obtained by heart puncture. The determination of ammonia was made by Conway's method using Seligson-Hirahata's apparatus.As the results, under the noise condition, the ammonia content was elevated significantly in the brain, liver, and blood, but not under the other conditions.It may be concluded that the noise acts not as metabolic stimuli but as neurotropic stimuli with a peculiar nature.