1 0 0 0 OA 二人行脚 : 信仰仏利
1 0 0 0 OA わが国における動物実験倫理指針の運用と課題
- 著者
- 鍵山 直子
- 出版者
- 日本動物心理学会
- 雑誌
- 動物心理学研究 (ISSN:09168419)
- 巻号頁・発行日
- vol.59, no.1, pp.131-134, 2009 (Released:2009-07-28)
- 参考文献数
- 5
Based on the Law for the Humane Treatment and Management of Animals, the Ministry of the Environment specifies “Standards Relating to the Care and Management of Laboratory Animals and Relief of Pain”. Regarding the use of laboratory animals, Japan has avoided stringent laws and regulations and adopted a system of rationalization based on voluntary management in each institution. These measures are intended to reinforce the independence of institutions to promote creative and flexible research. By legalization of the 3R-principle, ministries promoting science and technology have established basic policies for rationalization of animal experimentation in research institutions under their jurisdiction. The Science Council of Japan formulated the “Guidelines for Proper Conduct of Animal Experiments”. These guidelines were elaborated by collaboration of representatives from all scientific fields related to animal experiments including biological, pharmaceutical, agricultural, veterinary and medical sciences. To verify the voluntary management of laboratory animal care and use, 1) a collaborating committee of laboratory animal facilities of national, public and private universities, 2) Japan Health Sciences Foundation and 3) Japanese Society for Laboratory Animal Resources are investigating or testing third party evaluation systems, respectively. Accreditation by AAALAC International has been completed for seven facilities in Japan.
1 0 0 0 OA 立方晶氷lc
- 著者
- 本堂 武夫
- 出版者
- 北海道大学低温科学研究所
- 雑誌
- 低温科学 (Low temperature science) (ISSN:18807593)
- 巻号頁・発行日
- vol.64, pp.70-70, 2006-03-22
1 0 0 0 OA 代表性を有する書き言葉コーパスを活用した日本語教育研究
- 著者
- 砂川 有里子
- 巻号頁・発行日
- 2012
科学研究費補助金研究成果報告書:特定領域研究2006-2010
1 0 0 0 OA 現代アメリカの学校認証評価における学校改善支援機能に関する学術調査研究
- 著者
- 濱田 博文
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA 骨髄球系細胞活性化制御分子CD300を標的とした敗血症治療法の開発
- 著者
- 田原 聡子
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA スキル獲得と車両運動データベースによる農作業用ヒューマン・インターフェースの開発
- 著者
- 瀧川 具弘
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA RNA局在と局所的翻訳制御を介した細胞極性の形成と細胞の運命決定機構
- 著者
- 入江 賢児
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA 参加型森林管理の普及条件と資源動態:森林インフラストラクチャーを手がかりに
- 著者
- 増田 美砂
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA アフリカ農村部の産前検診と健康~無作為実験によるプログラム評価
- 著者
- 高崎 善人
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA 遺伝的多様性に基づく慢性気道疾患の制御―難治性病態の解明と薬理遺伝学―
- 著者
- 檜澤 伸之
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA 多糖類・脂質マイクロ分散系の作出と大腸送達システムの構築
- 著者
- 中嶋 光敏
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA 国境を超越して生存する少数民族に関わる絶滅危惧植物遺伝資源と伝統知識の保全
- 著者
- 渡邉 和男
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
1 0 0 0 OA 複合微生物系における細菌間シグナルによる呼吸代謝調節の解析と応用
- 著者
- 野村 暢彦
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
- 著者
- Ishitsuka Yosuke Kawachi Yasuhiro Taguchi Shijima Maruyama Hiroshi Fujisawa Yasuhiro Furuta Junichi Nakamura Yasuhiro Otsuka Fujio
- 出版者
- Nature Publishing Group
- 雑誌
- Journal of investigative dermatology (ISSN:0022202X)
- 巻号頁・発行日
- vol.132, no.7, pp.1775-1784, 2012-07
- 被引用文献数
- 14 4
The epidermis is a self-renewing tissue, the homeostasis of which is dependent upon the tight balance between proliferation and differentiation based on appropriate regulation of the cell cycle. The cell cycle regulation is dependent on the interactions among a number of cell cycle regulatory molecules, including the pituitary tumor-transforming gene 1 (PTTG1), also known as securin, a regulator of sister chromatid separation and transition from metaphase to anaphase. This study was conducted to clarify the less-known functions of PTTG1 in the epidermis by the use of keratinocytes cultured under two-dimensional (2D) or three-dimensional (3D) conditions. Forced overexpression of PTTG1 caused upregulation of cyclin B1, cyclin-dependent kinase 1 (CDK1), and c-Myc, resulting in enhanced proliferation and suppression of early differentiation without apparent alterations in terminal differentiation, and the exogenous PTTG1 was downregulated in association with cell cycle exit. In contrast, depletion of PTTG1 caused their downregulation and constrained proliferation with retention of differentiation capacity. These findings suggested that PTTG1 could alter the proliferation status by modulating the expression levels of the other cell cycle regulatory proteins, and excess PTTG1 primarily affects early differentiation of keratinocytes under the stability regulation associated with cell cycle exit.
1 0 0 0 OA 構造部材・耐火被覆材・区画部材の相互作用が鋼構造物の高温時構造安定性に及ぼす影響
- 著者
- 鈴木 弘之
- 巻号頁・発行日
- 2011
科学研究費補助金研究成果報告書:基盤研究(A)2008-2010
- 著者
- Hayashi Hitoshi Wang Aohan Kawabata Kohsuke Goto Hiromasa
- 出版者
- Elsevier
- 雑誌
- Materials chemistry and physics (ISSN:02540584)
- 巻号頁・発行日
- vol.137, no.3, pp.816-824, 2013-01
- 被引用文献数
- 11
A series of chiral three-ring type compounds with rigid shape was employed as chiral inducers for induction of chiral cholesteric liquid crystal (cholesteric LC) from achiral nematic LC. Helical twisting power of the chiral compounds was estimated with the Cano wedge method. Cholesteric LC electrolyte solution was prepared by adding the chiral compounds. Subsequently, polymerization in the cholesteric LC was carried out to produce chiroptically active polymer films. This method is different from conventional methods for synthesizing chiral polymers because neither chiral monomers nor asymmetric catalysts are employed. Surface structure and optical properties of the polymer thus prepared were examined.
1 0 0 0 OA 脳腫瘍に対する血管新生抑制療法の展開:新規治療法と抵抗性の克服
- 著者
- 高野 晋吾
- 巻号頁・発行日
- 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011
- 著者
- Ogasawara Yui Murai Yuta Sakihama Yasuko Hashidoko Yasuyuki Hashimoto Makoto
- 出版者
- Japan Institute of Heterocyclic Chemistry
- 雑誌
- Heterocycles (ISSN:03855414)
- 巻号頁・発行日
- vol.86, no.1, pp.735-743, 2012-12-31
- 被引用文献数
- 1
The click reaction is one of the latest techniques for the chemical modification of bioactive compounds. Chemical modifications of α-amino acid side chains are gaining significance as useful and important tools for biochemical research. Biotinylation at side chain of propargylglycine using click reaction was examined. The detail quantitative analysis of Cu(I) concentration are performed to proceed the click reaction effectively.
1 0 0 0 大学生の海岸に対する心象風景の形象について
- 著者
- 松島 肇 及川 昌樹 上田 裕文
- 出版者
- Japanese Institute of Landscape Architecture
- 雑誌
- ランドスケープ研究 (ISSN:13408984)
- 巻号頁・発行日
- vol.75, no.5, pp.537-540, 2012
- 被引用文献数
- 1 2
The coastal line of our country is long, approximately 35,000km, and various forms such as a muddy beach, a sandybeach, a rocky beach and a cliff. The coastal area was very important area for our life, industry, transportation, etc. from ancienttime. It is important to understand "the mindscape" which a modern Japanese holds for coastal landscape because of the decrease of the natural coast and the terrible recreational use of the coastal area. In this study, it was intended to identify the structure ofcoastal "mindscape" and factors that would influence their mindscape. The questionnaire survey was conducted to graduate andundergraduate students from August to October 2010. The questionnaire was consisted with two main part, survey about figureof the coastal mindscape and individual background of respondents. As a result, the "sandy beach" and sea were the majorcomponent of mindscape. Because most respondents enjoyed sea bathing as recreational use, it was guessed that the viewpointfrom the beach were dominated and inland area, like coastal dune, was not described. About the mindscape of half respondents were influenced by real scenery they had seen, but the remaining respondents were influenced by some kind of media such asphotographs or TV programs.