著者

玉嶋 勝範 加藤 徳弘 吉松 英明 小野 元治 岡本 潤 宮崎 英一郎 岡崎 真一郎

出版者

九州病害虫研究会

雑誌

九州病害虫研究会報 (ISSN:03856410)

巻号頁・発行日

vol.55, pp.156-161, 2009 (Released:2010-03-02)

参考文献数

11

被引用文献数

1

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イチョウの害虫であるイチョウヒゲビロウドカミキリについて,イチョウの被害地域調査,成虫の発生調査法,果樹類で登録のある Beauveria brongniartii 剤の本虫に対する効果的な使用方法を検討した。大分県の本種によるイチョウの被害地域調査で,1991年報告の28市町村から新たに21市町村(旧市町村)を確認した。成虫は日中枯れた枝葉で静止していることが判明したことから,簡易な成虫の発生調査法として枯れ枝葉トラップを考案した。B. brongniartii 剤上に本種の成虫を 1回歩行させた後,20℃で飼育した結果,接種8~14日後に高率に感染・死亡することが判明した。ギンナン園において B. brongniartii 剤をイチョウのすべての主幹部(地上0.5~1.5m)に設置することによって,殺虫効果が認められた。

著者

太田 文彦

出版者

日本失語症学会 (現 一般社団法人 日本高次脳機能障害学会)

雑誌

失語症研究 (ISSN:02859513)

巻号頁・発行日

vol.7, no.2, pp.154-159, 1987 (Released:2006-11-10)

参考文献数

16

著者

Graziana Lupattelli Stefano De Vuono Marcello Boni Rony Helou Massimo Raffaele Mannarino Anna Rita Roscini Abdalkader Alaeddin Matteo Pirro Gaetano Vaudo

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.18663, (Released:2013-08-01)

参考文献数

33

被引用文献数

6 13

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Aim: Several factors contribute to the development of atherogenesis in patients with obesity. The aim of our study was to evaluate the different roles of insulin resistance, strictly correlated to visceral adiposity, and the body mass index (BMI), an estimate of overall adiposity, on early vascular impairment in patients with morbid obesity.Methods: We enrolled 65 morbidly obese subjects (BMI 44.6±7 kg/m2) who were free of previous cardiovascular events and 28 nonobese subjects (control group) in a cross-sectional study. The presence of glycemia and insulinemia, the levels of lipids and liver parameter and the ultrasonographic assessment of the flow-mediated dilatation (FMD), carotid intima-media thickness (IMT) and visceral fat area (VFA) were evaluated in all subjects.Results: In the obese patients with a median HOMA value of ≥3.5, the FMD was significantly lower (p<.05) and the left carotid maximum-IMT was significantly higher (p<.05) than those observed in the group with lower HOMA values. No vascular differences were found between the two groups that were subdivided according to the BMI median value. Both the left max-IMT and FMD exhibited a significant correlation with HOMA-IR (“ρ”.292, p=0.02 , “ρ”−.292, p=0.02 respectively) but not with BMI. According to a multivariate analysis, the VFA was an independent predictor of a reduced FMD (β −.541, p.002; p of the model .002), while age (β .611 p<.0001) and HOMA-IR (β .399 p<.001) were independent predictors of the left max-IMT (p of the model .002).Conclusions: The HOMA-IR, which is strictly related to visceral fat and is an index of metabolic impairment, and not BMI, which reflects of global adiposity, can be used to identify early vascular impairment in patients with morbid obesity.

著者

Nathalie TOUBLANC Brigitte D LACROIX Junichi YAMAMOTO

出版者

日本薬物動態学会 会長/日本薬物動態学会 DMPK編集委員長

雑誌

Drug Metabolism and Pharmacokinetics (ISSN:13474367)

巻号頁・発行日

pp.DMPK-13-RG-045, (Released:2013-07-23)

参考文献数

32

被引用文献数

20

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Levetiracetam [E Keppra®] is a second generation antiepileptic drug for different types of epilepsy in adults and children ≥1 month. The objective is to develop a population pharmacokinetic model to describe the pharmacokinetics of levetiracetam in Japanese children and adults as well as North American children, the purpose being to explore potential dosing recommendations in Japanese children. Levetiracetam plasma concentration-time data were obtained from Japanese adult and paediatric clinical studies. The data were analysed through non-linear mixed effects modelling. The model was used to perform simulations and compare the exposure in Japanese children and adults. It was subsequently extended to North American children through an external validation. A one-compartment model with first-order absorption and first-order elimination adequately described the data. The exposure parameters determined based on the simulations in children were well within the adult range. The external validation against historical data from North American children was successful. The integrated population pharmacokinetic model provided a good description of the data, confirming the similarity of levetiracetam pharmacokinetics in these various populations. In Japanese children, a target dose of 10 to 30 mg/kg twice daily ensures the same exposure as the recommended dose in Japanese adults of 500 to 1500 mg twice daily.

著者

上田 宏

出版者

日本比較内分泌学会

雑誌

比較内分泌学 (ISSN:18826636)

巻号頁・発行日

vol.37, no.140, pp.5-13, 2011 (Released:2011-05-11)

参考文献数

26

著者

Takashi Ikawa Hiroaki Tokiwa Shuji Akai

出版者

社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.70, no.11, pp.1123-1133, 2012-11-01 (Released:2012-12-05)

参考文献数

86

被引用文献数

7 17

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The silyl- and boryl-directed regiocontrol of benzyne reactions and their theoretical analyses using density functional theory (DFT) are described herein. The Diels-Alder reactions of both 3-silyl- and 3-borylbenzynes with substituted furans and the [3+2] cycloadditions of 3-silylbenzynes with 1,3-dipoles predominantly produced distal cycloadducts, whereas the [3+2] cycloadditions of the borylbenzynes exclusively produced proximal cycloadducts. Moreover, primary amines selectively underwent nucleophilic addition reactions at the more hindered ortho-position of the silyl group of the benzynes. The origin of these anomalous regiochemistries was theoretically evaluated using the natural bond orbital and reaction pathway analyses including the transition states of these reactions. On the basis of DFT calculations, it is proposed that the reactions of the borylbenzynes were controlled by the electrostatic effect of the boryl group, whereas those of the silylbenzynes were primarily governed by the steric effect of the silyl group.

著者

Kentaro Okuma Koki Hirano Chisato Shioga Noriyoshi Nagahora Kosei Shioji

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.86, no.5, pp.615-619, 2013-05-15 (Released:2013-05-15)

参考文献数

30

被引用文献数

19

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By combination of 1,3-dipolar cycloaddition and N–O single bond insertion, tandem synthesis of dibenzo[1,4]oxazepino[4,5-a]quinolines was accomplished. Reaction of quinoline N-oxides with arynes afforded 2-(2-hydroxyphenyl)quinolines and 7-membered pentacyclic oxazepino[4,5-a]quinolines.

著者

冨田 泰志 小林 朗 鶴貝 満男

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.133, no.8, pp.1607-1615, 2013-08-01 (Released:2013-08-01)

参考文献数

25

被引用文献数

3

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To lower the burden on the global environment, renewable energy resources are increasingly being integrated to power systems, in particular, a great deal of photovoltaics (PVs) in Japan are expected to be installed on the roof-top of residential houses. However, this will make the supply-demand balance control and the voltage control of a power system difficult. A measure to reduce this impact is consuming excess power in local area where PVs are located.We have developed a control algorithm for adjusting the operating pattern of multiple heat pump water heaters as a group to maximize the consumption of excess power of PVs in local area. The problem was formulated as a combinatorial optimization problem, and the tabu search method was applied as a meta-heuristics solution. The result of a case study for group control of six consumers that used the same low-voltage transformer showed an operating pattern that has the following features. First, the consumption of excess PV power was maximized. Second, the consumption of commercial electric power was minimized. We also compared the result by controlling a group of six consumers with the result by controlling of six consumers that had been controlled individually, and showed that the consumption of PV excess power was increased by 46% at the same level of commercial electric power consumption.

著者

小玉 祐太 吉田 俊哉 宮下 收

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌D(産業応用部門誌) (ISSN:09136339)

巻号頁・発行日

vol.133, no.8, pp.845-851, 2013-08-01 (Released:2013-08-01)

参考文献数

20

被引用文献数

2 2

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This paper deals with the speed-up effect of maximum power point tracking (MPPT) control for vehicle applications. A photovoltaic panel is set on a car running on a city road and its static characteristics are recorded by the proposed high-speed measurement system. The effectiveness of MPPT controllers with various sampling frequencies is evaluated with the recorded data by simulation. In the car application, a higher sampling frequency achieves higher MPPT efficiency.

著者

Wichai CHERDSHEWASART Yosaporn KITSAMAI Suchinda MALAIVIJITNOND

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.0701160049-0701160049, (Released:2007-01-17)

被引用文献数

26 34

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The aim of this study was to evaluate the estrogenic activity of tuberous samples of phytoestrogen-rich Pueraria mirifica collected from 25 of 76 provinces in Thailand by vaginal cornification assay. Tuberous powders were prepared and administered to ovariectomized rats for 14 consecutive days at dosages of 10, 100, and 1,000 mg/kg BW respectively, and were compared with a daily treatment with 200 μg/100 g BW 17β-estradiol (E2). Rats treated with 10 mg/kg BW Pueraria mirifica showed no vaginal cornification. Treatment with 100 mg/kg BW Pueraria mirifica from 13 out of 25 plant samples resulted in development of vaginal cornification. The cell count percentages of the vaginal smeared cells for the treatment with the 2 plant samples that exhibited the fastest vaginal cornification revealed large variation in their estrogenic activities. Treatment with 1,000 mg/kg BW Pueraria mirifica from all plant samples produced vaginal cornification with the mean value for the period (day) of first appearance of cornified cells being 4.08 days compared to 2 days with 200 μg/100g BW E2. The overall appearance period (day) of cornified cells during the treatment and post-treatment period with 1,000 mg/kg BW per day Pueraria mirifica was shorter than treatment with 200 μg/100 g BW E2. The results demonstrate that the plant population shows differential estrogenic activity as evaluated by vaginal cornification assay.

著者

Hataitip TRISOMBOON Suchinda MALAIVIJITNOND Wichai CHERDSHEWASART Gen WATANABE Kazuyoshi TAYA

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

vol.52, no.4, pp.537-542, 2006 (Released:2006-08-25)

参考文献数

30

被引用文献数

17 19

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To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment period, and 60-day post-treatment period. The results show that the sexual skin exhibited reddish coloration within 24 h after PM-treatment and remained this way for the first half of the PM-feeding period. The changes in sexual skin coloration were not dose-dependent. The present results indicate that PM had estrogenic action by increasing reddish sexual skin coloration in aged menopausal monkeys.

著者

Hataitip TRISOMBOON Suchinda MALAIVIJITNOND Juri SUZUKI Yuzuru HAMADA Gen WATANABE Kazuyoshi TAYA

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

vol.50, no.6, pp.639-645, 2004 (Released:2005-01-07)

参考文献数

35

被引用文献数

18 19

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To determine the effect of Pueraria mirifica (PM) on serum parathyroid hormone (PTH) and calcium levels on aged menopausal monkeys (Macaca fascicularis), subjects were treated with 10, 100, or 1,000 mg/day of PM. Blood samples were collected every 5 days for 30, 90, and 60 days during pre-treatment, treatment, and post-treatment periods, respectively. Sera were assayed for PTH, estradiol, and calcium levels. PM-1,000 had the strongest effect on the decrease in PTH (0.001<P≤0.05) and calcium levels (0.001<P≤0.03) during the treatment period. PTH levels remained low for the first 15 days of the post-treatment period (0.01≤P ≤0.05). PM-10 induced a significant decrease in PTH level on day 80 (P=0.02) during the treatment period and a significant decrease in calcium level on day 75 (P<0.01). There were no changes in serum PTH and calcium levels throughout the study period in the PM-100 group. Estradiol levels decreased significantly during the treatment period in all treatment groups. The results suggest that long-term treatment with 1,000 mg/day of PM decreases serum PTH and calcium levels in aged menopausal monkeys, indicating that PM ameliorates bone loss caused by estrogen deficiency.

著者

前田 高弘

出版者

日本科学哲学会

雑誌

科学哲学 (ISSN:02893428)

巻号頁・発行日

vol.34, no.1, pp.89-93, 2001-05-30 (Released:2009-05-29)

著者

五島 朋子

出版者

日本堆積学会

雑誌

堆積学研究 (ISSN:1342310X)

巻号頁・発行日

vol.71, no.3, pp.223-227, 2012-12-28 (Released:2013-02-25)

参考文献数

9

著者

藤野 滋弘 小松原 純子 後藤 和久

出版者

日本堆積学会

雑誌

堆積学研究 (ISSN:1342310X)

巻号頁・発行日

vol.71, no.3, pp.217-218, 2012-12-28 (Released:2013-02-25)

著者

安田 佳那子

出版者

日本堆積学会

雑誌

堆積学研究 (ISSN:1342310X)

巻号頁・発行日

vol.71, no.3, pp.219-222, 2012-12-28 (Released:2013-02-25)

参考文献数

5

著者

小松原 純子 後藤 和久

出版者

日本堆積学会

雑誌

堆積学研究 (ISSN:1342310X)

巻号頁・発行日

vol.71, no.2, pp.167-169, 2012-10-06 (Released:2012-11-08)

著者

高野 修 後藤 和久 小松原 純子

出版者

日本堆積学会

雑誌

堆積学研究 (ISSN:1342310X)

巻号頁・発行日

vol.71, no.2, pp.157-160, 2012-10-06 (Released:2012-11-08)

著者

野添 敏郎 丹松 克男

出版者

一般社団法人 映像情報メディア学会

雑誌

テレビジョン学会誌 (ISSN:03866831)

巻号頁・発行日

vol.38, no.7, pp.629-633, 1984-07-20 (Released:2011-08-17)

参考文献数

48

著者

Fumiko Sekiguchi Atsufumi Kawabata

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

pp.13R05CP, (Released:2013-08-01)

参考文献数

42

被引用文献数

19 64

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Low-voltage-activated T-type Ca2+ channels (T-channels), especially Cav3.2 among the three isoforms (Cav3.1, Cav3.2, and Cav3.3), are now considered to play pivotal roles in processing of pain signals. Cav3.2 T-channels are functionally modulated by extracellular substances such as hydrogen sulfide and ascorbic acid, by intracellular signaling molecules including protein kinases, and by glycosylation. Cav3.2 T-channels are abundantly expressed in both peripheral and central endings of the primary afferent neurons, regulating neuronal excitability and release of excitatory neurotransmitters such as substance P and glutamate, respectively. Functional upregulation of Cav3.2 T-channels is involved in the pathophysiology of inflammatory, neuropathic, and visceral pain. Thus, Cav3.2 T-channels are considered to serve as novel targets for development of drugs for treatment of intractable pain resistant to currently available analgesics.