著者
AMMARIA AOUAR METRI ADEL SIDI-YAKHLEF CHRISTIAN BIÉMONT MOHAMED SAÏDI OKACHA CHAÏF SID AHMED OURAGHI
出版者
日本人類学会
雑誌
Anthropological Science (ISSN:09187960)
巻号頁・発行日
vol.120, no.3, pp.209-216, 2012 (Released:2012-12-21)
参考文献数
61

We characterized 2005 individuals from nine populations in the region of Tlemcen in Western Algeria for the ABO, rhesus, MNSs, and Duffy blood groups, in association with genetic traits. The results were compared to those for other populations in Algeria, North Africa, and Southern Europe, in order to situate and clarify the genetic status of this region. Principal-component analyses and phylogenetic trees of the matrices of the genetic distances, on the regional and Mediterranean scales, reveal strong homogeneity at the regional level and convergence between North African populations. This indicates high genetic affinities among these populations. This study highlights the differences between the two sides of the Mediterranean, probably due to the independent peopling history of these populations after they had settled. The resulting genetic structure of these populations is best explained by a combination of gene flow, ecology, and history.
著者
Haruka Fujikawa Taise Kawakami Ryunosuke Nakashima Aoi Nasu Shunsuke Kamei Hirofumi Nohara Yuka Eto Keiko Ueno-Shuto Toru Takeo Naomi Nakagata Mary Ann Suico Hirofumi Kai Tsuyoshi Shuto
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
pp.b19-01091, (Released:2020-01-31)
参考文献数
36
被引用文献数
9

Epithelial sodium channel (ENaC) is an amiloride-sensitive sodium ion channel that is expressed in epithelial tissues. ENaC overexpression and/or hyperactivation in airway epithelial cells cause sodium over-absorption and dysregulated ciliary movement for mucus clearance; however, the agents that suppress constitutive airway ENaC activation are yet to be clinically available. Here, we focused on macrolides, which are widely used antibiotics that have many potential immunomodulatory effects. We examined whether macrolides could modulate constitutive ENaC activity and downstream events that typify cystic fibrosis (CF) and chronic obstructive pulmonary diseases (COPD) in in vitro and in vivo models of ENaC overexpression. Treatment of ENaC-overexpressing human bronchial epithelial cells (β/γENaC-16HBE14o- cells) with three macrolides (erythromycin, clarithromycin, azithromycin) confirmed dose-dependent suppression of ENaC function. For in vivo studies, mice harboring airway specific βENaC overexpression (C57BL/6J-βENaC-Tg mice) were treated orally with azithromycin, a well-established antimicrobial agent that has been widely prescribed. Azithromycin treatment modulated pulmonary mechanics, emphysematous phenotype and pulmonary dysfunction. Notably, a lower dose (3 mg kg-1) of azithromycin significantly increased forced expiratory volume in 0.1 second (FEV0.1), an inverse indicator of bronchoconstriction. Although not statistically significant, improvement of pulmonary obstructive parameters such as emphysema and lung dysfunction (FEV0.1%) was observed. Our results demonstrate that macrolides directly attenuate constitutive ENaC function in vitro and may be promising for the treatment of obstructive lung diseases with defective mucociliary clearance, possibly by targeting ENaC hyperactivation.
著者
Hans-Rudolf Weiss Deborah Turnbull Sarah Seibel Alexander Kleban
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.31, no.12, pp.983-991, 2019 (Released:2019-12-03)
参考文献数
50
被引用文献数
14

[Purpose] Specific exercises and brace treatment are the two evidence-based modes of treatment for patients with scoliosis. The purpose of this paper is to present the first end-results from a prospective cohort that commenced treatment in 2011 with a CAD based Chêneau derivate and is then compared to the published results achieved with the Boston Brace. [Participants and Methods] Inclusion criteria for the study, refers to the SRS inclusion criteria on bracing, except the range of Cobb angles which was extended to curvatures of up to 45°. Twenty-eight patients were weaned from their CAD Chêneau style brace. The results of this cohort have been compared with the BRAIST study by Weinstein et al. with the help of the Z-test. [Results] A success rate of 92.9% has been achieved. This was compared to the success rate of 72% in the BRAIST study. The differences were highly significant in the Z-test. [Conclusion] The results achieved with the GBW are significantly and better than the results achieved with the Boston brace. Therefore, the standards for bracing should be reviewed with the results that symmetric compression with Boston bracing is not as successful, when compared to asymmetric high correction bracing results, which allow a standardized classification-based corrective approach.
著者
Kazuyoshi Suenari Takayuki Nakano Shunsuke Tomomori Nobuo Shiode Satoshi Higa Shih-Ann Chen
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.2, no.2, pp.75-82, 2020-02-10 (Released:2020-02-10)
参考文献数
68
被引用文献数
2

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and induces cardiac dysfunction and stroke. The development of AF requires a trigger and also an electroanatomic substrate capable of both initiating and perpetuating AF. In the past decade, ectopic beats originating from the pulmonary veins (PV) have been identified as a source of paroxysmal AF. Thus, strategies that target the PV, including the PV antrum, are the cornerstone of most AF ablation procedures. Recently, alternative technologies to radiofrequency catheter ablation for paroxysmal AF such as balloon ablation modalities have been developed. The purpose of this review is to discuss cryoballoon ablation for paroxysmal AF.
著者
落合-大平 知美 倉島 治 長谷川 寿一 平井 百樹 松沢 哲郎 吉川 泰弘
出版者
日本霊長類学会
雑誌
霊長類研究 Supplement 第22回日本霊長類学会大会
巻号頁・発行日
pp.85, 2006 (Released:2007-02-14)

大型類人猿情報ネットワーク(GAIN)および旧ナショナルバイオリソースプロジェクト・チンパンジーフィージビリティスタディでは、国内で飼育されている大型類人猿の基本情報を収集および公開するとともに、廃棄される遺体の有効利用など、非侵襲的な方法での研究利用の推進をおこない、飼育動物の生活の質(QOL)の向上などにつながる研究の促進と、その研究成果のフィードバックに取り組んできた。本発表では、大型類人猿を飼育する36施設を実際に訪問しておこなわれたヒアリングと、社団法人日本動物園水族館協会(2004年6月2日現在、国内の91の動物園と69の水族館が加盟)によりまとめられた血統登録書や過去の文献などから、大型類人猿の日本での飼育の歴史についてまとめたので報告する。 日本の大型類人猿の飼育の歴史は、江戸時代である1792年にオランウータン(Pongo pygmaeusもしくはPongo abelii)が長崎の出島に輸入されたのが最初である。1898年には上野動物園でオランウータンが、1927年には天王寺動物園でチンパンジー(Pan troglodytes)が展示されている。ゴリラ(Gorilla gorilla)がやってきたのは、戦後の1954年であり、移動動物園で展示された。1950年以降は日本各地に動物園が設立され、1980年に日本がCITESを批准するまで、ボノボ(Pan paniscus)を含むたくさんの大型類人猿が輸入されている。近年は、チンパンジーが56施設352個体(2005年12月31日現在)、ゴリラが11施設29個体(2005年9月30日現在)、オランウータンが24施設53個体(2004年12月31日現在)飼育されているが、亜種問題や血縁関係の偏りなどが明らかになっており、遺伝的多様性を確保したままの個体数の維持が課題となっている。
著者
Yudi ZHANG Debiao HE Xinyi HUANG Ding WANG Kim-Kwang Raymond CHOO Jing WANG
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE Transactions on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E103.D, no.2, pp.188-195, 2020-02-01 (Released:2020-02-01)
参考文献数
31
被引用文献数
16

Unlike black-box cryptography, an adversary in a white-box security model has full access to the implementation of the cryptographic algorithm. Thus, white-box implementation of cryptographic algorithms is more practical. Nevertheless, in recent years, there is no white-box implementation for public key cryptography. In this paper, we propose the first white-box implementation of the identity-based signature scheme in the IEEE P1363 standard. Our main idea is to hide the private key to multiple lookup tables, so that the private key cannot be leaked during the algorithm executed in the untrusted environment. We prove its security in both black-box and white-box models. We also evaluate the performance of our white-box implementations, in order to demonstrate utility for real-world applications.
著者
Shiho Toyama Ayuko Takatani Tomohiro Koga Mizuna Eguchi Momoko Okamoto Sosuke Tsuji Yushiro Endo Toshimasa Shimizu Remi Sumiyoshi Takashi Igawa Shin-ya Kawashiri Naoki Iwamoto Kunihiro Ichinose Mami Tamai Hideki Nakamura Tomoki Origuchi Masako Furuyama Maiko Tabuchi Shinichiro Kobayashi Kengo Kanetaka Mikiko Hashisako Kuniko Abe Daisuke Niino Shinya Sato Yasushi Miyazaki Atsushi Kawakami
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.2782-19, (Released:2019-07-22)
参考文献数
20
被引用文献数
1

A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment.
著者
Yasuaki Takeji Tomohiko Taniguchi Takeshi Morimoto Naritatsu Saito Kenji Ando Shinichi Shirai Genichi Sakaguchi Yoshio Arai Yasushi Fuku Yuichi Kawase Tatsuhiko Komiya Natsuhiko Ehara Takeshi Kitai Tadaaki Koyama Shin Watanabe Hirotoshi Watanabe Hiroki Shiomi Eri Minamino-Muta Shintaro Matsuda Hidenori Yaku Yusuke Yoshikawa Kazuhiro Yamazaki Masahide Kawatou Kazuhisa Sakamoto Toshihiro Tamura Makoto Miyake Hisashi Sakaguchi Koichiro Murata Masanao Nakai Norio Kanamori Chisato Izumi Hirokazu Mitsuoka Masashi Kato Yutaka Hirano Tsukasa Inada Kazuya Nagao Hiroshi Mabuchi Yasuyo Takeuchi Keiichiro Yamane Takashi Tamura Mamoru Toyofuku Mitsuru Ishii Moriaki Inoko Tomoyuki Ikeda Katsuhisa Ishii Kozo Hotta Toshikazu Jinnai Nobuya Higashitani Yoshihiro Kato Yasutaka Inuzuka Yuko Morikami Kenji Minatoya Takeshi Kimura on befalf of the CURRENT AS Registry Investigators and K-TAVI Registry Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-19-0951, (Released:2020-02-01)
参考文献数
35
被引用文献数
12

Background:There are no data comparing transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) outcomes in real clinical practice in Japan.Methods and Results:We combined 2 independent registries, the K-TAVI Registry (a 6-center prospective registry of consecutive patients who underwent TAVI) and the CURRENT AS Registry (a large, 27-center registry of 3,815 consecutive patients with severe aortic stenosis [AS]). In the K-TAVI Registry, 338 patients underwent TAVI with SAPIEN XT balloon-expandable valves from October 2013 to January 2016, whereas in the CURRENT AS Registry 237 patients with severe AS underwent SAVR from January 2003 to December 2011. Propensity score matching was conducted, with final cohort comprising 306 patients. The cumulative 2-year incidence of all-cause death and heart failure (HF) hospitalization did not differ significantly between the TAVI and SAVR groups (13.7% vs. 12.4% [P=0.81] and 7.9% vs 3.9% [P=0.13], respectively). After adjusting for residual confounders, there were no significant differences between the TAVI and SAVR groups in the risk for all-cause death (hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.35–1.58; P=0.43) or HF hospitalization (HR 1.27; 95% CI 0.40–4.59; P=0.69).Conclusions:These findings from 2 independent Japanese registries suggest that the 2-year risk of all-cause mortality and HF does not differ significantly between TAVI and SAVR groups in real-world practice in Japan.
著者
Simon Vial-Pradel Yoshinori Hasegawa Ayami Nakagawa Shido Miyaki Yasunori Machida Shoko Kojima Chiyoko Machida Hiro Takahashi
出版者
Japanese Society for Plant Cell and Molecular Biology
雑誌
Plant Biotechnology (ISSN:13424580)
巻号頁・発行日
vol.36, no.4, pp.213-222, 2019-12-25 (Released:2019-12-27)
参考文献数
34
被引用文献数
2

DNA methylation in higher organisms has become an expanding field of study as it often involves the regulation of gene expression. Although Whole Genome Bisulfite Sequencing (WG-BS) based on next-generation sequencing (NGS) is the most versatile method, this is a costly technique that lacks in-depth analytic power. There are no conventional methods based on NGS that enable researchers to easily compare the level of DNA methylation from the practical number of samples handled in the laboratory. Although the targeted BS method based on Sanger sequencing is generally used in this case, it lacks in-depth analytic power. Therefore, we propose a new method that combines the high throughput analytic power of NGS and bioinformatics with the specificity and focus offered by PCR-amplification-based bisulfite sequencing methods. We use in silico size sieving of DNA-fragments and primer matchings instead of whole-fragment alignment in our bioinformatics analyses, and named our method SIMON (Simple Inference for Methylome based On NGS). The results of our targeted BS method based on NGS (SIMON method) show that small variations in DNA methylation patterns can be precisely and efficiently measured at a single nucleotide resolution. SIMON method combines pre-existing techniques to provide a cost-effective technique for in-depth studies that focus on pre-identified loci. It offers significant improvements with regard to workflow and the quality of the acquired DNA methylation information. Because of the high accuracy of the analysis, small variations of DNA methylation levels can be precisely determined even with large numbers of samples and loci.
著者
Ryoko YAMADA Sayaka KUZE-ARATA Yasushi KIYOKAWA Yukari TAKEUCHI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.19-0519, (Released:2020-01-23)
被引用文献数
12

Undesirable behaviors exhibited by cats are regarded as feline behavioral problems. Like canine behavioral problems, feline behavioral problems are commonly reported by owners. Thus, in order to advise cat owners appropriately, veterinarians, particularly general veterinary practitioners, are encouraged to have sufficient knowledge of these problems. However, in ordinary Japanese homes, only a small number of feline behavioral problems have been investigated in terms of prevalence and relevant factors. Comprehensive survey data may improve understanding of feline behavioral problems. In the present study, we distributed an online survey including general information and questions about 17 feline behaviors which can be problematic for owners, to investigate: (1) the prevalence of feline behavioral problems, (2) the most common behavioral problems, and (3) relevant factors for each behavior. We collected 1,376 valid responses. Among all cats, 75.7% exhibited at least one behavioral problem. “Pica” and “Showing fear while on the examination table” were the most frequently reported behavioral problems. To identify factors related to the expression of each behavior, we conducted multiple logistic regression analyses, with the presence of behaviors as objective variables and cats’ general information as explanatory variables. Age, sex, breed, number of cats in the household, and type of residence were each associated with more than one behavior. The present study revealed the prevalence of 17 feline behavioral problems in Japanese homes and relevant factors of each behavior. These findings will help veterinarians understand and address feline behavioral problems.
著者
漆原 和子 喜納 宏之 新垣 和夫 佐々木 正和 ミオトケ フランツ-ディーター
出版者
駒澤大学
雑誌
駒澤地理 (ISSN:0454241X)
巻号頁・発行日
vol.33, pp.33-47, 1997-03

日本における石灰岩片の溶食率の地域差,経年変化を知るために北海道から南大東島まで7地点において,その測定を行った。この報告は,南大東島における溶食率の経年変化と,土壌中のCO_2濃度の経年変化について考察を試みたものである。1年ごとの溶食率は降水量の大な1993年に最大であった。一方,1994年は夏高温で水不足量(WD)が大であったが,水過剰量(WS)も大で溶食率は小さくなった。しかし1995年は,年降水量が少なく,かつ水不足量が大であり,空中,A_3層位,B_2層位ともに溶食率は最小であった。WDが少ない1993年には土壌中のCO_2濃度は高く,B_2層位の石灰岩片の溶食率も大であった。1994年には土壌中のCO_2濃度は低く,B_2層位の溶食率も低い。WDが大きく土壌が乾燥した1995年にはA_3,B_2層位ともに溶食率も最小であった。CO_2濃度の変化は1993年の一雨ごとの観測結果から,一定量を越える雨の後3〜4日で極大を示し,乾燥した時期が長びくと,CO_2濃度は低下することがわかった。土壌中の湿度は,有機物の分解を促進し,バクテリアの活動,根の活動を活発化させることに大きく寄与していると思われる。一方,畑の耕運による作土の孔隙率が大きいときには,生産されたCO_2は空中に放出されていて,Ap層位ではCO_2濃度は低い。
著者
法学セミナ-編集部
出版者
日本評論社
雑誌
法学セミナ- (ISSN:04393295)
巻号頁・発行日
no.279, pp.p138-142, 1978-06
著者
Shingo Nakayama Michihiro Satoh Hirohito Metoki Takahisa Murakami Kei Asayama Azusa Hara Takuo Hirose Ryusuke Inoue Megumi Tsubota-Utsugi Masahiro Kikuya Takefumi Mori Atsushi Hozawa Koichi Node Yutaka Imai Takayoshi Ohkubo
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.2, no.1, pp.24-32, 2020-01-10 (Released:2020-01-10)
参考文献数
41
被引用文献数
6

Background:N-terminal pro-B-type natriuretic peptide (NT-proBNP) is known to increase in heart failure patients. Given that no reports have described the association between NT-proBNP and chronic kidney disease (CKD) incidence in Asian populations, we investigated this association in the Japanese population.Methods and Results:We followed up 867 participants without CKD from the general population of Ohasama, Japan. We defined CKD as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2and/or proteinuria. In accordance with previous studies, the participants were classified into 4 groups according to NT-proBNP level (<30.0, 30.0–54.9, 55.0–124.9, and ≥125.0 pg/mL). The Cox model was applied to assess adjusted hazard ratios (HR) for CKD incidence after full adjustment including baseline eGFR. Participant mean age was 59.1 years, and 587 (67.7%) were women. During the mean follow-up period of 9.7 years, 177 participants developed CKD. When the group with NT-proBNP <30.0 pg/mL was used as the reference, adjusted HR for CKD incidence in the 30.0–54.9, 55.0–124.9, and ≥125.0 pg/mL groups were 1.34 (95% CI: 0.90–2.01), 1.25 (95% CI: 0.81–1.92), and 1.83 (95% CI: 1.05–3.18), respectively.Conclusions:NT-proBNP can be significantly predictive for CKD incidence in Asian populations.
著者
Hyun-Kyu Cha Hyuk-Shin Cho Jong-Duk Choi
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.26, no.7, pp.981-983, 2014 (Released:2014-07-30)
参考文献数
19
被引用文献数
6 11

[Purpose] The purpose of the study was to determine the effects of a sciatic nerve mobilization technique on improvement of lower limb function in patient with poststroke hemiparesis. [Subjects] Twenty- two stroke patients participated in this study. [Methods] They were randomly selected based on selection criteria and divided into two groups. In the subject group (n=10), sciatic nerve mobilization with conventional physical therapy was applied to patients. In the control group (n=10), only conventional physical therapy was applied to stroke patients. [Results] There were significant differences between the two groups in pressure, sway, total pressure, angle of the knee joint, and functional reaching test results in the intervention at two weeks and at four weeks. [Conclusion] The present study showed that sciatic nerve mobilization with conventional physical therapy was more effective for lower limb function than conventional physical therapy alone in patient with poststroke hemiparesis.
著者
Chan-Myeong Kim Yong- Soo Kong Yoon-Tae Hwang Ji-won Park
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.30, no.7, pp.943-947, 2018 (Released:2018-07-03)
参考文献数
38
被引用文献数
6

[Purpose] The purposes of this study were to strengthen gluteus maximus and trunk muscles depending upon the hip joint direction by bridging exercise on an unstable and stable surface, and to suggest an intervention method for efficient and selective exercise. [Participants and Methods] The test measured the muscle activities with the external rotation and internal rotation of 25 degrees and hip joint neutral position of 0 degree on a stable and unstable surface each exercise 3 times for 9 seconds. [Results] External oblique abdominis showed a higher muscle activity on the unstable surface and internal rotation. Erector spinae showed no significant difference on the surfaces and demonstrated the highest muscle activity at the internal rotation. Gluteus maximus showed a higher muscle activity on the stable surface and external rotation and the interaction effect between the surface and the angle indicated a statistical significance as well. [Conclusion] Muscle activities appear different depending upon the change of surface and joint angle, and it can be said that the correct mobilization of muscle fiber relying on the muscle arrangement direction and muscle contraction direction is the most important factor for gluteus maximus.
著者
Daisuke NISHIO-HAMANE Masayuki OHNISHI Tetsuo MINAKAWA Jun-ichi YAMAURA Shohei SAITO Ryo KADOTA
出版者
一般社団法人日本鉱物科学会
雑誌
Journal of Mineralogical and Petrological Sciences (ISSN:13456296)
巻号頁・発行日
vol.107, no.1, pp.1-7, 2012 (Released:2012-02-29)
参考文献数
17
被引用文献数
3 7

The first Cr-dominant amphibole, ehimeite, ideally NaCa2Mg4CrSi6Al2O22(OH)2, has been found in a chromitite deposit in the Akaishi Mine, Higashi-Akaishi Mountain, Ehime Prefecture, Japan. Ehimeite occurs as prismatic crystals of up to 1.5 cm in length and 0.5 cm in width and is found in association with chromite, kämmererite (Cr-rich clinochlore), Cr-poor clinochlore, phlogopite, and uvarovite. It is transparent, emerald green to pale green in color with pale green streaks, and has a vitreous luster. Optically, it is biaxial positive with α = 1.644(2), β = 1.647(2), γ = 1.659(2), and 2Vcalc. = 53°. It has a Mohs’ hardness of 6 and densities of 3.08(3) g/cm3 (measured using heavy liquids) and 3.121 g/cm3 (calculated from powder diffraction data and the empirical formula). The empirical formula is (Na0.88K0.07)Σ0.95(Ca1.89Na0.02Mg0.09)Σ2.00(Mg4.03Cr0.62Al0.19Fe3+0.07Fe2+0.07Ti0.03)Σ5.00(Si6.14Al1.86)Σ8.00O22(OH)2 on the basis of O = 22 and OH = 2, and ehimeite mainly forms a solid solution, NaCa2Mg4(Cr, Al)Si6Al2O22(OH)2, with pargasite. It has a monoclinic unit cell with a = 9.9176(14) Å, b = 18.0009(12) Å, c = 5.2850(7) Å, β = 105.400(7)°, V = 909.6 (17) Å3, and Z = 2, and it belongs to the space group C2/m, as refined from powder XRD data. The eight strongest lines in the powder XRD pattern [d (Å), I/I0, hkl] are (3.370, 58, 150), (2.932, 43, 221), (2.697, 81, 151), (2.585, 50, 061), (2.546, 100, 202), (2.346, 42, 351), (2.156, 35, 261), and (1.514, 55, 263). The crystal structure has been refined to R1 = 0.0488 using single-crystal XRD data. It has been concluded that ehimeite in the Akaishi Mine was formed by the reaction of chromitite and the metamorphic fluid in the retrograde stage of serpentinization during the Sanbagawa metamorphism.