著者

Shigeru Sugiyama Kenji Wakisaka Kenta Imanishi Masashi Kurashina Naohiro Shimoda Masahiro Katoh Jhy-Chern Liu

出版者

The Society of Chemical Engineers, Japan

雑誌

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)

巻号頁・発行日

vol.52, no.9, pp.778-782, 2019-09-20 (Released:2019-09-20)

参考文献数

17

被引用文献数

10

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To obtain calcium phosphates—a phosphate rock equivalent—from the incineration ash of chicken manure, which is obtained from power generation systems that use the manure as fuel, the incineration ash was treated with an aqueous solution of nitric acid to elute phosphorus. By using 0.3 M HNO3, most of the phosphorus could be eluted from 1.0 g of ash within 0.1 h. Unlike in the case of composted chicken manure which was previously examined in our laboratory, the concentration of HNO3 was increased for elution from the incineration ash. The use of incineration ash of chicken manure enabled the removal of inorganic species at a lower boiling or sublimation temperature, and organic species by calcination in the power generation system. The phosphorus contents of the incineration ash and nitric acid extract were higher than that of composted chicken manure. XRD analysis showed that the treatment of the obtained nitric acid extract with aqueous NH3 yielded a precipitate of poorly-crystallized calcium hydroxyapatite (Ca10(PO4)6(OH)2), which is one of the main components of phosphate rock. To confirm the formation and purity of calcium phosphate species, precipitation calcination was conducted at 1,078 K for 5 h. XRD analysis revealed that the calcined solid was tricalcium phosphate, and no contamination was evident. These results reveal that a phosphate rock equivalent could be easily obtained from the incineration ash of chicken manure, which implies that approximately 14% of the phosphate rock that is currently being imported into Japan could be replaced by this product.

著者

Fraysse-Kim Soonhee

出版者

名古屋商科大学

雑誌

NUCB journal of language culture and communication (ISSN:13443984)

巻号頁・発行日

vol.11, no.2, pp.65-84, 2010

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The term 'ideology' was originally coined by Antoine Destutt De Tracy to describe a 'science of ideas'(l'etude des idees). However, no sooner had the term appeared, than the word began to be treated as a synonym for an abstract idea or concept far removed from reality. Since the advent of Marxism, there have been constant disputes and various views on ideology, due to two potentially conflictive theories on ideology expressed by Marx himself, and the clarification of the point at stake, or reconsideration of the theory, has been neglected by traditional Marxists. Indeed ideology was considered mainly as a form of 'bourgeois' propaganda' or 'false consciousness'.Louis Althusser, a French structuralist, defied those traditional interpretations of the idea of Marx and undertook his own reading of Marx's works. In his theory, he elaborated Marxism as an interpretative discipline ( une discipline interpretative (Garo 2008 : 45) liberating it from simple communist or socialist theory. It is in his efforts to redefine Marxism that he conceived an original theory of ideology in which he clarified the materialistic nature of ideology and its function constituting individuals as ideological subjects. This article is a reading of Althusser's theory of ideology. The reading was done on Althusser's two texts, namely pour Marx and Ideologie et appareils ideologiques d'Etat. The investigation focuses on his key idea on ideology expressed in the notions of Problematique,Subjection, and Ideological State Apparatuses, seeking to understand the way ideology functions in society through an Althussian perspective.

著者

LEE Meng-Tze LIN Pay-Liam CHANG Wei-Yu SEELA Balaji Kumar JANAPATI Jayalakshmi

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-048, (Released:2019-05-10)

被引用文献数

15

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In the present work, long-term (10 years) raindrop size distribution (RSD) measurements from Joss-Waldvogel Disdrometer (JWD) installed at National Central University (NCU, 24&deg58′6″N 121&deg11′27″E), Taiwan and vertical profile of radar reflectivity were used to analyze the variations in gamma parameters of six seasons (winter, spring, mei-yu, summer, typhoon, and autumn) and types of precipitation. The normalized gamma distribution of RSD revealed that the highest mean Dm (Mass-weighted average diameter) values occurred in summer, whereas the highest mean log10Nw (normalized intercept parameter) values were found in winter. Furthermore, most of the rainfall rate falling at less than 20 mm h-1 occurs in Northern Taiwan. In this study, we used radar reflectivity to differentiate between convective and stratiform systems. It was revealed that the mean Dm values are higher in convective systems, whereas the mean log10Nw values are higher in stratiform systems. The structure of RSD in stratiform systems remains constant in all seasons; however, convection is similar to maritime type. The microphysical characteristics that are responsible for different RSD features in different seasons and types of precipitation are illustrated with the help of contoured frequency by altitude diagrams of radar reflectivity.

著者

Suranjith Bandara KORALEGEDARA Chuan-Yao LIN Yang-Fan SHENG

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.97, no.4, pp.821-839, 2019 (Released:2019-08-02)

参考文献数

52

被引用文献数

3

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In this present study, we analyzed the synoptic and mesoscale dynamics and underlying mechanism of an extreme rainfall and flood event that occurred in Sri Lanka between 14-17 May 2016, using the Weather Research and Forecasting Model simulations with a horizontal grid size of 3 km and observational data. This extreme rainfall event was associated with a low-pressure system (LPS) that originated over the Bay of Bengal in the Indian Ocean and passed over Sri Lanka. The observed maximum accumulation of rainfall during the event exceeded 300 mm at several weather stations on 15-16 May and it resulted in severe flooding and landslides, particularly in the western part of the island. The model closely simulated the timing of the initiation of the LPS and its development along the east coast of Sri Lanka. The model could capture the overall rainfall tendency and pattern of this event. Synoptic and mesoscale analyses indicated that this extreme rainfall event occurred as the cumulative effect of a sustained low-level convergence zone, generated by an enhanced westerly monsoon flow and the circulation of the LPS, alongside a continuous supply of high-magnitude moisture, strong vertical motion, and orographic effects of the Central Mountains of Sri Lanka. Model sensitivity experiments indicated that the rainfall over the western slope area of the mountains was enhanced by mountain lifting, whereas western coastal rainfall was reduced because the mountains blocked the northeasterly flow of the LPS.

著者

杉山 将 Muller Klaus-Robert

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告 (ISSN:09135685)

巻号頁・発行日

vol.104, no.760, pp.129-134, 2005-03-30

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教師付き学習では, 訓練入力とテスト入力が同じ確率分布に従うと仮定することが多い.しかし, 内挿, 外挿, 能動学習などでは, この仮定が満たされない.このような状況下では, 交差確認法などの標準的な汎化誤差推定法はバイアスを持ってしまい, 適切にモデル選択を行うことができない.そこで本論文では, 訓練入力とテスト入力の分布が異なる場合にうまく対応できる汎化誤差推定法を提案する.提案する汎化誤差推定量は, 学習したい真の関数がモデルに含まれる場合には不偏性を持ち, 一般には漸近的不偏性を持つ.外挿問題の計算機実験により, 提案する汎化誤差推定量を用いたモデル選択は, 交差確認法によるモデル選択よりも優れていることを示す.

著者

Soon-Seek YOON Jae-Won BYUN Min-Jeong KIM You-Chan BAE Yeun-Kyung SHIN Sorah YOON Garam LEE Jae-Young SONG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.2, pp.275-277, 2011 (Released:2011-03-03)

参考文献数

10

被引用文献数

1 7

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Clinical grape poisoning in two dogs (a 1.6-year-old male Shih Tzu and a 5-year-old female Yorkshire Terrier) was described in the present study. Clinical signs included decreased urine output in the Shih Tzu and ataxia in the Yorkshire Terrier after grape ingestion. The Shih Tzu died 5 days post-grape ingestion, while the Yorkshire Terrier died 3 days post-grape ingestion. Erythematous serosae and mucosae, multifocal red small intestinal foci, and blood and grape seeds were identified in the intestinal lumen. Brownish-yellow crystals were bilaterally identified in the renal pelvis. The primary histological findings were acute tubular necrosis of the proximal convoluted tubules, severe necrosis, and mineralization in the renal cortical tubules. Blood urea nitrogen, creatinine, and alanine aminotransferase were increased in the dogs. Many Korean veterinary clinicians have suspected clinical grape poisoning. However, to our knowledge, grape poisoning has not been identified by pathologic and clinicopathologic basis until this writing in Korea. Education and knowledge about the risks of grape poisoning is necessary for the prevention of accidental exposures.

著者

Md. Shafiullah Parvej Md Ashraful Alam Mio Shono Mst. Nusrat Zahan Mst. Misrat Masuma Parvez Wahedul Karim Ansari Md. Sayduzzaman Jowel Mohammad Sharif Uddin Eriko Kage-Nakadai Md. Tanvir Rahman Yoshikazu Nishikawa

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2019.016, (Released:2019-08-30)

参考文献数

35

被引用文献数

4

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Using multiplex real-time PCR, 960 fecal samples collected from poultry, cattle, and diarrheic patients in Bangladesh were screened for diarrheagenic Escherichia coli (DEC). Invasion-related gene virB had the highest prevalence in human patients (41%) and was shown to be positively correlated first with afaB for diffuse adhesion and second with aggR for aggregative adhesion. These three genes were specific to patients. In contrast, Shiga toxin genes stx1 (57%) and stx2 (40%) were prevalent in cattle samples. eae for attaching and effacing lesion, and elt and est of enterotoxins were detected from all three sample sources. Heat map and hierarchical clustering assigned the samples into five different clusters with patient samples positive for virB and afaB placing together in one cluster. Although detection of virulence genes cannot be a direct indication of the distribution of DEC organisms, their detection suggests that Shigella spp. or enteroinvasive E. coli are the most prevalent among diarrheagenic bacteria in Bangladesh and that diffusely adherent E. coli are concomitant bacterium. eae-possessing organisms in patients may come from cattle and poultry sources. The small number of stx-positive patients could be explained by the small number of animal samples that were positive for both eae and stx.

著者

Daisuke Nakamura Keisuke Yasumura Hitoshi Nakamura Yutaka Matsuhiro Koji Yasumoto Akihiro Tanaka Yasuharu Matsunaga-Lee Masamichi Yano Masaki Yamato Yasuyuki Egami Ryu Shutta Yasushi Sakata Jun Tanouchi Masami Nishino

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.2, pp.313-319, 2019-01-25 (Released:2019-01-25)

参考文献数

24

被引用文献数

2 19

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Background: There are few reports about the differences between drug-eluting stents (DES) and bare metal stents (BMS) in neoatherosclerosis associated with in-stent restenosis (ISR), so we compared the frequency and characteristics of neoatherosclerosis with ISR evaluated by optical coherence tomography (OCT) in the present study. Methods and Results: Between March 2009 and November 2016, 98 consecutive patients with ISR who underwent diagnostic OCT were enrolled: 34 patients had a BMS, 34 had a 1st-generation DES, and 30 had a 2nd-generation DES. Neoatherosclerosis was defined as a lipid neointima (including a thin-cap fibroatheroma [TCFA] neointima, defined as a fibroatheroma with a fibrous cap <65 µm) or calcified neointima. As a result, lipid neointima, TCFA neointima and calcified neointima were detected in 39.8%, 14.3%, and 5.1%, respectively, of all patients. The frequency of neoatherosclerosis was significantly greater with DES than BMS (48.4% vs. 23.5%, P=0.018). The minimum fibrous cap thickness was significantly thicker with DES than BMS (110.3±41.1 µm vs. 62.5±17.1 µm, P<0.001). In addition, longitudinal extension of neoatherosclerosis in the stented segment was less with DES than BMS (20.2±15.1% vs. 71.8±27.1%, respectively, P=0.001). Conclusions: OCT imaging demonstrated that neoatherosclerosis with ISR was more frequent with DES than BMS and its pattern exhibited a more focal and thick fibrous cap as compared with BMS.

著者

Genta Nakano María Teresa Ramírez-Herrera Néstor Corona

出版者

Japan Society for Natural Disaster Science

雑誌

Journal of Natural Disaster Science (ISSN:03884090)

巻号頁・発行日

vol.39, no.2, pp.19-33, 2019 (Released:2019-05-13)

参考文献数

37

被引用文献数

2

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Disaster risk reduction education is provided through external support at schools. Most educational programs evaluate the level of knowledge transfer. However, the particular context of school is not considered, even though it prescribes the understanding of students. In this study, tsunami education was provided by a non-Mexican NGO at two schools in Acapulco, Mexico, and questionnaire surveys were conducted. The surveys identified that students were more interested in obtaining knowledge than learning action for their self-protection. This tendency in motivation was generated by the school context: the school teaches decontextualized knowledge despite the need to contextualize disaster education in daily life. This disparity caused a gap in the communication between the NGO members and the students. Therefore, it is important that disaster education programs remove students from the school context and place them in the context of daily life. More localized content could help remove students from the context of school. This study argues that the effectiveness of disaster education is influenced by the context in which students learn, and the findings suggest that educational practices should be designed on the basis of the context of the learners.

著者

Jin-Young CHOI Jung-Hyun KIM Hyun-Jung HAN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0225, (Released:2019-08-12)

被引用文献数

2

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A 10-year-old male castrated Maltese was referred with clinical signs of hematuria, stranguria, and pollakiuria. The dog was diagnosed with sterile hemorrhagic cystitis with urethroliths and cystoliths. To remove the uroliths, the dog underwent retrograde urohydropropulsion followed by a cystotomy. The following day, persistent bleeding in the urinary bladder was identified with large hematoma, hematuria and anemia. In order to reduce bleeding, the dog received 10 mg/kg of tranexamic acid (TXA) intravenously. Immediately after TXA administration, the dog developed anaphylactic shock manifested by hypotension, hypothermia, tachycardia and a dull mentation. Thus, an emergency treatment including bolus injection of crystalloid, administration of dexamethasone and diphenhydramine, and oxygen supplementation was given, after which the dog quickly recovered within a few minutes.

著者

Kiyotaka Nakamagoe Ayako Shioya Tetsuto Yamaguchi Hiroyuki Takahashi Reiko Koide Tatsuya Monzen Jun-ichi Satoh Akira Tamaoka

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.50, no.22, pp.2839-2844, 2011 (Released:2011-11-15)

参考文献数

19

被引用文献数

6 10

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A 38-year-old Japanese man with Nasu-Hakola disease (NHD) had repeated pathological fractures and frontal lobe symptoms which developed when he was 18 and 26 years old, respectively. Neuropsychological testing showed memory impairment, and in particular, visuo-spatial memory at the age of 35. Furthermore, single-photon emission computed tomography revealed precuneus hypoperfusion. The patient later suffered prolonged convulsive seizures, which left him in a persistent vegetative state. Genetic testing confirmed a heterozygous mutation in the DAP12 gene (a single-base deletion of 141 G in exon 3) specific to NHD. Precuneus dysfunction might contribute to characteristic memory impairment of NHD.

著者

Sung-Yong Choi Jung-Hyun Choi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.3, pp.837-843, 2016 (Released:2016-03-31)

参考文献数

44

被引用文献数

3 11

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[Purpose] The purpose of this study was to examine the effects of cervical traction treatment, cranial rhythmic impulse treatment, a manual therapy, and McKenzie exercise, a dynamic strengthening exercise, on patients who have the neck muscle stiffness of the infrequent episodic tension-type (IETTH) headache and frequent episodic tension-type headache(FETTH), as well as to provide the basic materials for clinical interventions. [Subjects] Twenty-seven subjects (males: 15, females: 12) who were diagnosed with IETTH and FETTH after treatment by a neurologist were divided into three groups: (a cervical traction group (CTG, n=9), a cranial rhythmic contractiongroup (CRIG, n=9), and a McKenzie exercise group (MEG, n=9). An intervention was conducted for each group and the differences in their degrees of neck pain and changes in muscle tone were observed. [Results] In the within-group comparison of each group, headache significantly decreased in CTG. According to the results of the analysis of the muscle tone of the upper trapezius, there was a statistically significant difference in MEG on the right side and in CRIG on the left side. According to the results of the analysis of the muscle tone of the sternocleidomastoid muscle, there was a statistically significant difference in MEG on the right side and in CRIG on the left side. [Conclusion] In the comparison of the splenius capitis muscle between the groups, there was a statistically significant difference on the right side. Hence, compared to the other methods, cervical traction is concluded to be more effective at reducing headaches in IETTH and FETTH patients.

著者

Anawat SUPPASRI Panon LATCHAROTE Tanuspong POKAVANICH Khaled AL-SALEM Abdullah Al-Enezi Shinji TODA Fumihiko IMAMURA

出版者

公益社団法人 土木学会

雑誌

土木学会論文集B2(海岸工学) (ISSN:18842399)

巻号頁・発行日

vol.72, no.2, pp.I_1675-I_1680, 2016 (Released:2016-11-15)

参考文献数

10

被引用文献数

3

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The Arabian Gulf (also known as Persian Gulf) region is one of the most important oil producers to fuel the world and most of the population is located along the coasts. The present study aimed, for the first time, to carry out some preliminary assessment of the tsunami hazards in the Arabian Gulf region using numerical model. This study tsunamis generated by submarine earthquakes with the earthquake magnitude (Mw) of 8.3-9.0 along the Makran Subduction Zone (MSZ) and surface landslides with the volume of 0.5-1.0 km3 along Iranian coast inside the Arabian Gulf. TUNAMI model was applied in this study to predict the tsunami propagation. The model adopts the staggered leap-frog scheme to solve shallow water equations describing nonlinear long-wave theory. GEBCO 30 arc-second grid data was used as bathymetry and topography data for tsunami numerical simulation. This size of the computational grid was ascertained by many previous studies for its suitability in evaluating tsunami hazards in this region. For surface landslides, tsunami generation was simulated using a two-layer numerical model developed by solving nonlinear long-wave equations within two interfacing layers with appropriate kinematic and dynamic boundary conditions at seabed, interface, and water surface. In case of the earthquakes along MSZ, Mw 8.3 has low impact to locations inside the Arabian Gulf. Mw 8.6 has considerable impact mainly at the Gulf entrance meanwhile Mw 9.0 has high impact at the Gulf entrance and negligible impact for the whole Gulf region. In case of the surface landslides inside the Arabian Gulf, the impact is rather local but major near the sources. Detailed estimation of landslide volume, tsunami simulation using very fine topography and bathymetry data and coupling tide and tsunami wave modeling will be considered for the future works.

著者

Keiko Fujii-Abe Masahiro Umino Hiroshi Kawahara Chika Terada Kazuhito Satomura Haruhisa Fukayama

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.61, no.2, pp.364-369, 2019 (Released:2019-06-18)

参考文献数

31

被引用文献数

6

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Although in clinical dentistry the major method used for pain relief is oral administration of analgesics, alternative methods are available, such as transcutaneous electrical nerve stimulation (TENS), acupuncture, vibration and conditioned pain modulation (CPM), formerly termed diffuse noxious inhibitory control. The aim of the present study was to investigate the combined effects of non-noxious (TENS) and noxious (CPM) stimuli on postoperative pain after extraction of an impacted wisdom tooth. The study involved 44 patients who were scheduled to undergo impacted wisdom tooth extraction. The patients were randomly allocated into four groups: noxious stimuli, non-noxious stimuli, combined noxious and non-noxious stimuli, and a sham group. On the day after tooth extraction, stimulation procedures for pain relief were performed and changes in the level of perceived pain were scored using a visual analog scale (VAS). The combination of non-noxious and noxious stimuli decreased the VAS scores by 63.7%, indicating a more potent analgesic effect than that in the non-noxious, noxious, and sham groups. This method of analgesia using a combination of non-noxious and noxious stimuli can be applied to patients who are unable to tolerate analgesics, such as those with allergy, hypersensitivity or digestive disorders, and those who are pregnant.

著者

渡邊 淳也 Watanabe Jun-ya

出版者

筑波大学文藝・言語学系

雑誌

文藝言語研究 言語篇 (ISSN:03877515)

巻号頁・発行日

no.50, pp.41-84, 2006

著者

田村 学 板倉 徹 MANGIN J-F. REGIS J. 生田 聡子 吉光 喜太郎 鈴木 孝司 村垣 善浩 伊関 洋

雑誌

Journal of Japan Society of Computer Aided Surgery : J.JSCAS (ISSN:13449486)

巻号頁・発行日

vol.12, no.3, pp.304-305, 2010-11-02

参考文献数

2

被引用文献数

1

著者

Ritsuo NISHIDA Chul-Sa KIM Hiroshi FUKAMI Ryozo IRIE

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.55, no.7, pp.1787-1792, 1991 (Released:2006-04-05)

参考文献数

14

被引用文献数

19

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Two new pyrrolizidine alkaloids, ideamines A and B, together with other analogs (lycopsamine and parsonsine) were isolated in the N-oxide forms from adult bodies of the Apocynaceae-feeding danaine butterfly, Idea leuconoe. Ideamine A was characterized as a homolog of lycopsamine, in which the viridifloric acid moiety was replaced by a 2-ethyl-2, 3-dihydroxybutanoic moiety. Likewise, ideamine B was identified as a nor-derivative of parsonsine, in which the trachelanthic acid moiety was replaced by a 2-ethyl-2, 3-dihydroxybutanoic moiety diastereomeric to the necic acid from ideamine A.

著者

Ramprasad Muthukrishnan Ayesha Abdul Rashid Fatma Al-Alkharji

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.31, no.7, pp.493-497, 2019 (Released:2019-07-02)

参考文献数

24

被引用文献数

9

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[Purpose] This study examined the effectiveness of extracorporeal shock wave therapy versus ultrasound therapy, combined with the mobilization and therapeutic exercise in both groups, in participants with diabetic frozen shoulder. [Participants and Methods] Twenty participants with diabetic frozen shoulder were divided into an experimental group who received extracorporeal shock wave therapy, mobilization and exercises (n=10, Mean: 43.70) and the control group who received ultrasound, mobilization and exercises (n=10 Mean: 45.50). The clinical outcomes, i.e., a) pain b) active range of motions of the shoulder, c) disability scores by Disabilities of the Arm, Shoulder and Hand scale and d) global rating of change was measured weekly for four weeks. [Results] Significant improvements in pain, all active range of motions and disability scores were observed at the end of the 4th week in both groups. Additionally, the experimental group benefitted significant pain reduction (median difference: 7 in experimental versus 6 in control group), reduced number of therapy sessions and thus the costs of treatment compared to the control group. [Conclusion] Extracorporeal shock wave therapy significantly reduced pain in people with diabetic frozen shoulder with a reduction of treatment cost compared to the control group.

著者

Masamitsu FUTAI Ge-Hong SUN-WADA Yoh WADA Naomi MATSUMOTO Mayumi NAKANISHI-MATSUI

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.95, no.6, pp.261-277, 2019-06-11 (Released:2019-06-11)

参考文献数

87

被引用文献数

74

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Vacuolar-type ATPase (V-ATPase), initially identified in yeast and plant vacuoles, pumps protons into the lumen of organelles coupled with ATP hydrolysis. The mammalian counterpart is found ubiquitously in endomembrane organelles and the plasma membrane of specialized cells such as osteoclasts. V-ATPase is also present in unique organelles such as insulin secretory granules, neural synaptic vesicles, and acrosomes of spermatozoa. Consistent with its diverse physiological roles and unique localization, the seven subunits of V-ATPase have 2–4 isoforms that are organelle- or cell-specific. Subunits of the enzyme function in trafficking organelles and vesicles by interacting with small molecule GTPases. During osteoclast differentiation, one of the four isoforms of subunit a, a3, is indispensable for secretory lysosome trafficking to the plasma membrane. Diseases such as osteopetrosis, renal acidosis, and hearing loss are related to V-ATPase isoforms. In addition to its role as an enzyme, V-ATPase has versatile physiological roles in eukaryotic cells.

著者

Christian-Hendrik Heeger Amr Abdin Shibu Mathew Bruno Reissmann Kivanc Yalin Spyridon Liosis Thomas Fink Riccardo Proietti Charlotte Eitel Julia Vogler Christine Lemeš Tilman Maurer Andreas Rillig Roza Meyer-Saraei Tobias Graf Peter Wohlmuth Britta Goldmann Feifan Ouyang Karl-Heinz Kuck Andreas Metzner Roland Richard Tilz

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0151, (Released:2019-06-28)

参考文献数

22

被引用文献数

20

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Background:Second-generation cryoballoon (CB2)-based pulmonary vein isolation (PVI) has demonstrated encouraging results in the treatment of atrial fibrillation (AF). This study sought to assess data on the safety, efficacy and clinical success of CB2-based PVI in patients with heart failure (HF) and reduced ejection fraction (HFrEF).Methods and Results:CB2-based PVI was performed in 551 consecutive patients in 3 highly experienced EP centers. Patients with HF and LVEF ≤40% were included (HFrEF group, n=50/551, 9.1%). Data were compared with propensity score-matched patients without HF and preserved left ventricular EF (LVEF) (n=50, control group). The median LVEF was HFrEF: 37% (35, 40) and control: 55% (55, 55), P<0.0001. Major periprocedural complications were registered in 4/50 (8%, HFrEF group) and 3/50 (6%, control group), P=0.695. The 12-month freedom from AF recurrence was 73.1% (95% confidence interval (CI): 61–88, HFrEF group) and 72.6% (95% CI: 61–87, control group), P=0.25. NYHA class decreased from 2.4±0.8 (baseline) to 1.7±0.8 at 12-month follow-up (P<0.0001). LVEF improved from a median of 37% (35, 40) prior to ablation to a median of 55% (40, 55), P<0.0001.Conclusions:CB2-based PVI in patients with HFrEF appeared to be safe, was associated with comparable periprocedural complications and showed promising clinical success rates equal to those for patients with preserved LVEF. NYHA class and LVEF significantly improved at 12-month follow-up.