著者

Maki Itoh Mary A. Hums Akiko Arai Etsuko Ogasawara

出版者

Japan Society of Physical Education, Health and Sport Sciences

雑誌

International Journal of Sport and Health Science (ISSN:13481509)

巻号頁・発行日

pp.201630, (Released:2018-03-02)

参考文献数

22

被引用文献数

1

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The purpose of this qualitative study was to (a) determine structural barriers that must be overcome to cultivate female leaders and coaches and (b) study the development of a support system for female leaders and coaches. This study relied on in-depth interviews as the primary means of collecting data. Formal semi-structured interviews were conducted with seven former or currently active female Paralympians, including some who were current coaches. After analyzing the participants' responses, five distinct themes emerged: (a) social identity, (b) challenges of “double minority status” as women and persons with a disability, (c) underrepresentation of women as Paralympic coaches, (d) athletes wanting to be coaches indicating they needed formal training, and (e) current coaches feeling overwhelmed by task requirements not related directly to working with athletes. The first of these relate to realizing identity and the other four to overcoming barriers. The results offer insight into the career challenges and career perceptions of coaches and also former or currently active female Paralympians. The results provide researchers with insight into the status of careers of women in a segment of the sport industry, the Paralympic Movement, which has not yet been thoroughly explored.

著者

Hidetoshi Yoshitani Akihiro Isotani Jae-Kwan Song Shinichi Shirai Hiromi Umeda Jeong Yoon Jang Takeshi Onoue Misako Toki Byung-Joo Sun Dae-Hee Kim Nobuyuki Kagiyama Akihiro Hayashida Jong-Min Song Masataka Eto Yosuke Nishimura Kenji Ando Michiya Hanyu Kiyoshi Yoshida Robert A. Levine Yutaka Otsuji

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0390, (Released:2018-08-22)

参考文献数

24

被引用文献数

3

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Background: Basal interventricular septum (IVS) hypertrophy (BSH) with reduced basal IVS contraction and IVS-aorta angle is frequently associated with aortic stenosis (AS). BSH shape suggests compression by the longitudinally elongated ascending aorta, causing basal IVS thickening and contractile dysfunction, further suggesting the possibility of aortic wall shortening to improve the BSH. Surgical aortic valve replacement (SAVR), as opposed to transcatheter AVR (TAVR), includes aortic wall shortening by incision and stitching on the wall and may potentially improve BSH. We hypothesized that BSH configuration and its contraction improves after SAVR in patients with AS. Methods and Results: In 32 patients with SAVR and 36 with TAVR for AS, regional wall thickness and systolic contraction (longitudinal strain) of 18 left ventricular (LV) segments, and IVS-aorta angle were measured on echocardiography. After SAVR, basal IVS/average LV wall thickness ratio, basal IVS strain, and IVS-aorta angle significantly improved (1.11±0.24 to 1.06±0.17; −6.2±5.7 to −9.1±5.2%; 115±22 to 123±14°, P<0.001, respectively). Contractile improvement in basal IVS was correlated with pre-SAVR BSH (basal IVS/average LV wall thickness ratio or IVS-aorta angle: r=0.47 and 0.49, P<0.01, respectively). In contrast, BSH indices did not improve after TAVR. Conclusions: In patients with AS, SAVR as opposed to TAVR improves associated BSH and its functional impairment.

著者

Dominik A. MEGGER Leona L. POTT Kristin ROSOWSKI Birgit ZÜLCH Stephanie TAUTGES Thilo BRACHT Barbara SITEK

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.33, no.12, pp.1387-1394, 2017-12-10 (Released:2017-12-10)

参考文献数

28

被引用文献数

3

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Tandem mass tags (TMT) are usually introduced at the levels of isolated proteins or peptides. Here, for the first time, we report the labeling of whole cells and a critical evaluation of its performance in comparison to conventional labeling approaches. The obtained results indicated that TMT protein labeling using intact cells is generally possible, if it is coupled to a subsequent enrichment using anti-TMT antibody. The quantitative results were similar to those obtained after labeling of isolated proteins and both were found to be slightly complementary to peptide labeling. Furthermore, when using NHS-based TMT, no specificity towards cell surface proteins was observed in the case of cell labeling. In summary, the conducted study revealed first evidence for the general possibility of TMT cell labeling and highlighted limitations of NHS-based labeling reagents. Future studies should therefore focus on the synthesis and investigation of membrane impermeable TMTs to increase specificity towards cell surface proteins.

著者

西城 潔 長岡 大輔 福田 正己 ARKHANGEROV A. KUNITSKY V.

出版者

Japan Association for Quaternary Research

雑誌

第四紀研究 (ISSN:04182642)

巻号頁・発行日

vol.34, no.4, pp.315-317, 1995-10-31

参考文献数

4

被引用文献数

1

著者

Hida H. Ito T. Katsurada H. Kitagawa K. Taguchi Y. Murase A. Yamagami A. Arai K. Hiraoka T. Itakura K. Kasio T. Kawamura H. Kimura I. Mochizuki S. Murata M. Okazaki T.

出版者

Department of Mathematics, Hokkaido University

雑誌

Hokkaido University technical report series in mathematics (ISSN:13484338)

巻号頁・発行日

vol.137, pp.1, 2008-09

著者

Niclas G. Karlsson Chunsheng Jin Miguel A. Rojas-Macias Barbara Adamczyk

出版者

FCCA(Forum: Carbohydrates Coming of Age)

雑誌

Trends in Glycoscience and Glycotechnology (ISSN:09157352)

巻号頁・発行日

vol.29, no.166, pp.E35-E46, 2017-03-25 (Released:2017-03-25)

参考文献数

77

被引用文献数

12

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The adaption of methods from last century’s glycoanalysis into packages for performing the 21st century’s O-linked glycomics has been slow. However, the involvement of O-linked glycans in many of the physical barriers in the body (cell membranes, epithelial and mucosal layers and cartilage surface) points towards a role in many of this century’s health sector challenges. These include but are not limited to inflammation, infections, and degradation of tissue due to aging. This review focus on the development of O-linked glycomics, including current state-of-the-art release methods, analytical characterisation using mass spectrometry and liquid chromatography. The future outcome emerging technologies for O-linked glycomics including novel chemistry, analytical methods for quantification and characterisation and glycobioinformatics is presented.

著者

Mohamad Samir A. EID Hitoshi AIDA

出版者

一般社団法人 電子情報通信学会

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E100.D, no.8, pp.1738-1750, 2017-08-01 (Released:2017-08-01)

参考文献数

37

被引用文献数

3

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Distributed Denial of Service (DDoS) attacks based on HTTP and HTTPS (i.e., HTTP(S)-DDoS) are increasingly popular among attackers. Overlay-based mitigation solutions attract small and medium-sized enterprises mainly for their low cost and high scalability. However, conventional overlay-based solutions assume content inspection to remotely mitigate HTTP(S)-DDoS attacks, prompting trust concerns. This paper reports on a new overlay-based method which practically adds a third level of client identification (to conventional per-IP and per-connection). This enhanced identification enables remote mitigation of more complex HTTP(S)-DDoS categories without content inspection. A novel behavior-based reputation and penalty system is designed, then a simplified proof of concept prototype is implemented and deployed on DeterLab. Among several conducted experiments, two are presented in this paper representing a single-vector and a multi-vector complex HTTP(S)-DDoS attack scenarios (utilizing LOIC, Slowloris, and a custom-built attack tool for HTTPS-DDoS). Results show nearly 99.2% reduction in attack traffic and 100% chance of legitimate service. Yet, attack reduction decreases, and cost in service time (of a specified file) rises, temporarily during an approximately 2 minutes mitigation time. Collateral damage to non-attacking clients sharing an attack IP is measured in terms of a temporary extra service time. Only the added identification level was utilized for mitigation, while future work includes incorporating all three levels to mitigate switching and multi-request per connection attack categories.

著者

Haruki Momma Susumu S. Sawada Robert A. Sloan Yuko Gando Ryoko Kawakami Shin Terada Motohiko Miyachi Chihiro Kinugawa Takashi Okamoto Koji Tsukamoto Cong Huang Ryoichi Nagatomi Steven N. Blair

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20160199, (Released:2017-11-25)

参考文献数

29

被引用文献数

6

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Background: The “Physical Activity Reference for Health Promotion 2013” provides “fit” reference values for cardiorespiratory fitness (CRF) for good health. The importance of achieving a fit CRF level for several years on the subsequent prevention of type 2 diabetes mellitus (T2DM) remains to be clarified.

著者

MERY A

雑誌

Mol Biol Cell

巻号頁・発行日

vol.16, pp.2414-2423, 2005

被引用文献数

3 86

著者

Ryo Ishibashi Taiji Ueno Satoru Saito Tatsuya Mima Matthew A Lambon Ralph Gorana Pobric

出版者

日本認知心理学会

雑誌

日本認知心理学会発表論文集 日本認知心理学会第15回大会

巻号頁・発行日

pp.146, 2017 (Released:2017-10-16)

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事物の意味を認知することは人間の持つ高次認知機能のうちでも特に中心的な機能の一つである。本研究では経頭蓋直流電流刺激(tDCS)を用いて、近年意味認知の中枢と考えられている大脳皮質左前側頭葉(ATL)の活動を促進したときに日本語単語意味認知能力の向上が見られるかどうかを検討した。結果としてtDCSによる類義語の判断成績向上が認められ、この効果は事前調査で難易度が高いとされた試行群において得に顕著であった。本知見はATL領域と意味認知との関係についてその因果的関係をさらに強力に立証すると同時に、意味認知障害の臨床においてtDCSが意味認知能力の維持・向上の補助手段として用いられる可能性について示唆するものである。

著者

山本 亞実 大城 未緒 南 由歩 竹谷 怜子 小野 久江 A. Yamamoto M. Oshiro Y. Minami R. Taketani H. Ono

雑誌

関西学院大学心理科学研究 (ISSN:21876355)

巻号頁・発行日

vol.42, pp.1-5, 2016-03-25

著者

PENDLEBURY David A.

出版者

一般社団法人 情報科学技術協会

雑誌

情報の科学と技術 (ISSN:09133801)

巻号頁・発行日

vol.67, no.10, pp.546-549, 2017-10-01 (Released:2017-10-01)

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ユージン・ガーフィールドは20世紀後半の情報革命の牽引者であった。彼は,著者が自分の論文の中の引用文献で作ったリンクを活用して,引用索引を科学文献検索の世界に導入した。引用索引は,研究者に新たに正確な情報検索の手段を提供するだけでなく,科学文献から科学の構造と動向研究を可能にし,科学をマッピングする方法に拡大するとともに,国,研究機関,雑誌,著者の研究のパフォーマンス分析にも導入されている。彼は,情報科学者としてだけでなく,科学と芸術分野やホームレス支援の社会福祉団体へも多大な貢献をおこなった。デービッド・ペンドルベリー(安藤聡子 訳)

著者

IWABUCHI Hironobu PUTRI Nurfiena Sagita SAITO Masanori TOKORO Yuka SEKIGUCHI Miho YANG Ping BAUM Bryan A.

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2018-001, (Released:2017-09-15)

被引用文献数

46

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An algorithm for retrieving the macroscopic, physical and optical properties of clouds from thermal infrared measurements is applied to the Himawari-8 multiband observations. A sensitivity study demonstrates that the addition of the single CO2 band of Himawari-8 is effective for the estimation of cloud top height. For validation, retrieved cloud properties are compared systematically with collocated active remote sensing counterparts with small time lags. While retrievals agree reasonably for single-layer clouds, multilayer cloud systems with optically thin upper clouds overlying lower clouds are the major source of error in the present algorithm. Validation of cloud products is critical for identifying the characteristics, advantages and limitation of each product and should be continued in the future. As an application example, data are analyzed for eight days in the vicinity of the New Guinea to study the diurnal cycle of the cloud system. The present cloud property analysis investigates cloud evolution through separation of different cloud types and reveals typical features of diurnal cycles related to the topography. Over land, middle clouds increase from 0900 to 1200 local solar time (LST), deep convective clouds develop rapidly during 1200–1700 LST with a subsequent increase in cirrus and cirrostratus cloud amounts. Over the ocean near coastlines, a broad peak of convective cloud fraction is seen in the early morning. The present study demonstrates the utility of frequent observations by Himawari-8 for life cycle study of cloud systems, owing to the ability to capture their continuous temporal variations.

著者

Y. Otsuka T. Ogawa A. Saito T. Tsugawa S. Fukao S. Miyazaki

出版者

The Seismological Society of Japan, Society of Geomagnetism and Earth, Planetary and Space Sciences, The Volcanological Society of Japan , The Geodetic Society of Japan , The Japanese Society for Planetary Sciences

雑誌

Earth, Planets and Space (ISSN:13438832)

巻号頁・発行日

vol.54, no.1, pp.63-70, 2002 (Released:2010-03-09)

参考文献数

24

被引用文献数

239

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The dual frequency radio signals of the Global Positioning System (GPS) allow measurements of the total number of electrons, called total electron content (TEC), along a ray path from GPS satellite to receiver. We have developed a new technique to construct two-dimensional maps of absolute TEC over Japan by using GPS data from more than 1000 GPS receivers. A least squares fitting procedure is used to remove instrumental biases inherent in the GPS satellite and receiver. Two-dimensional maps of absolute vertical TEC are derived with time resolution of 30 seconds and spatial resolution of 0.15° × 0.15° in latitude and longitude. Our method is validated in two ways. First, TECs along ray paths from the GPS satellites are simulated using a model for electron contents based on the IRI-95 model. It is found that TEC from our method is underestimated by less than 3 TECU. Then, estimated vertical GPS TEC is compared with ionospheric TEC that is calculated from simultaneous electron density profile obtained with the MU radar. Diurnal and day-to-day variation of the GPS TEC follows the TEC behavior derived from MU radar observation but the GPS TEC is 2 TECU larger than the MU radar TEC on average. This difference can be attributed to the plasmaspheric electron content along the GPS ray path. This method is also applied to GPS data during a magnetic storm of September 25, 1998. An intense TEC enhancement, probably caused by a northward expansion of the equatorial anomaly, was observed in the southern part of Japan in the evening during the main phase of the storm.

著者

Aoki S. Fukugita M. Hashimoto S. Ishikawa K.-I. Ishizuka N. Iwasaki Y. Kanaya K. Kaneda T. Kaya S. Kuramashi Y. Okawa M. Onogi T. Tominaga S. Tsutsui N. Ukawa A. Yamada N. Yoshié T.

出版者

American Physical Society

雑誌

Physical review D (ISSN:05562821)

巻号頁・発行日

vol.62, no.9, pp.094501, 2000-10

被引用文献数

14 18

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We present a study for the pion decay constant fπ in the quenched approximation to lattice QCD with the Kogut-Susskind (KS) quark action, with the emphasis given to the renormalization problems. Numerical simulations are carried out at the couplings β=6.0 and 6.2 on 323×64 and 483×64 lattices, respectively. The pion decay constant is evaluated for all KS flavors via gauge invariant and noninvariant axial vector currents with the renormalization constants calculated by both the nonperturbative method and perturbation theory. We obtain fπ=89(6) MeV in the continuum limit as the best value using the partially conserved axial vector current, which requires no renormalization. From a study for the other KS flavors we find that the results obtained with the nonperturbative renormalization constants are well convergent among the KS flavors in the continuum limit, confirming restoration of SU(4)A, flavor symmetry, while perturbative renormalization still leaves an apparent flavor breaking effect even in the continuum limit.

著者

LARME A. C.

雑誌

Biabetes Care

巻号頁・発行日

vol.21, pp.1391-1396, 1998

被引用文献数

2 187

著者

Emile Mehanna Hiram G. Bezerra David Prabhu Eric Brandt Daniel Chamié Hirosada Yamamoto Guilherme F. Attizzani Satoko Tahara Nienke Van Ditzhuijzen Yusuke Fujino Tomoaki Kanaya Gregory Stefano Wei Wang Madhusudhana Gargesha David Wilson Marco A. Costa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.9, pp.2334-2340, 2013 (Released:2013-08-23)

参考文献数

23

被引用文献数

15 67

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Background: Coronary artery calcification (CAC) presents unique challenges for percutaneous coronary intervention. Calcium appears as a signal-poor region with well-defined borders by frequency-domain optical coherence tomography (FD-OCT). The objective of this study was to demonstrate the accuracy of intravascular FD-OCT to determine the distribution of CAC. Methods and Results: Cadaveric coronary arteries were imaged using FD-OCT at 100-μm frame interval. Arteries were subsequently frozen, sectioned and imaged at 20-μm intervals using the Case Cryo-Imaging automated systemTM. Full volumetric co-registration between FD-OCT and cryo-imaging was performed. Calcium area, calcium-lumen distance (depth) and calcium angle were traced on every cross-section; volumetric quantification was performed offline. In total, 30 left anterior descending arteries were imaged: 13 vessels had a total of 55 plaques with calcification by cryo-imaging; FD-OCT identified 47 (85%) of these plaques. A total of 1,285 cryo-images were analyzed and compared with corresponding co-registered 257 FD-OCT images. Calcium distribution, represented by the mean depth and the mean calcium angle, was similar, with excellent correlation between FD-OCT and cryo-imaging respectively (mean depth: 0.25±0.09 vs. 0.26±0.12mm, P=0.742; R=0.90), (mean angle: 35.33±21.86° vs. 39.68±26.61°, P=0.207; R=0.90). Calcium volume was underestimated in large calcifications (3.11±2.14 vs. 4.58±3.39mm3, P=0.001) in OCT vs. cryo respectively. Conclusions: Intravascular FD-OCT can accurately characterize CAC distribution. OCT can quantify absolute calcium volume, but may underestimate calcium burden in large plaques with poorly defined abluminal borders.  (Circ J 2013; 77: 2334–2340)

著者

SENGOR A. M. C.

出版者

Cambridge University Press

雑誌

The Tectonic evolution of Asia

巻号頁・発行日

pp.486-640, 1996

被引用文献数

1

著者

Sohn H.-J. Kim J.-H. Choi K.-S. Nah J.-J. Joo Y.-S. Jean Y.-H. Ahn S.-W. Kim O.-K. Kim D.-Y. Balachandran A.

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.64, no.9, pp.855-858, s・vii, 2002-09-25

被引用文献数

1 101

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7歳雄のヘラジカ(Cervus elaphus nelsoni)が体重減少,削痩,過度な流涎,歯軋り,発熱,食欲不振および呼吸困難の症状を3週間呈した後に,安楽殺され,剖検された.このヘラジカは1997年3月9日にカナダから韓国に輸入された.肉眼病変は瀰漫性の線維素性肺炎であった.組織学的には軽度な神経細胞の空胞変性と限局した脳幹部神経核の神経網の海面状変性と広範な星状膠細胞の増生が見られた.プロテアーゼ抵抗性プリオン蛋白質(PrP^<res>)に対する免疫組織化学では全ての脳組織切片で陽性であったが,延髄の閂の切片で最も顕著であった.PrP^<res>は脳および脊髄のウエスタンブロット法でも検出された.本ヘラジカと接触のあった残りのヘラジカおよびシカは淘汰され,慢性消耗性疾患は陰性であった.著者らの知る限りでは,本症例は米国およびカナダ以外の国での最初の症例であった.

著者

Kathleen M. Broughton Mark A. Sussman

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.81, no.2, pp.142-148, 2017-01-25 (Released:2017-01-25)

参考文献数

92

被引用文献数

14

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Cardiovascular disease remains the leading cause of death worldwide and developing novel therapies to treat and cure the disease remains a high priority in the healthcare research community. Adult stem cells were successful in entering numerous clinical trials over the past 15 years in attempts to regenerate the heart. First-generation adult stem cell therapies for myocardial regeneration were highly promising in small animal models but realized benefits in humans were far more modest. Consequently, second-generation therapeutic approaches in early implementation phases have focused on enhancing cellular properties with higher survival and regenerative potential. Genetic programming dictates cellular fate, so understanding genetic composition and responses at the gene level to influence the outcome of the cell is essential for successful outcomes in regenerative medicine. Genetic editing is at the forefront of scientific innovation and as basic scientific research continues to expand upon understanding eukaryotic regenerative themes, a clearer vision of the possible future therapeutic approaches can be realized. Ultimately, enhancing biology and manipulating evolutional selection of cellular properties will be critical to achieving clinically relevant and biologically meaningful cardiac regeneration.