著者

Hideto SOBUKAWA Mitsuhiro WATANABE Rui KANO Takaaki ITO Masanobu ONOZAKI Atsuhiko HASEGAWA Hiroshi KAMATA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.11, pp.1527-1529, 2011 (Released:2011-12-01)

参考文献数

9

被引用文献数

4 9

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Bovine mastitis due to Prototheca zopfii leads to reduced milk production and is difficult to cure. Therefore, prevention is the best approach and this is best achieved through the use of effective disinfectants. The aim of this study was to evaluate the in vitro algaecide efficacy of conventional disinfectants against strains of P. zopfii genotype 1 and 2. The minimal algaecide concentration (MAC) of alkyldiaminoethylglycine hydrochloride, chlorhexidine, dioxide chlorine, povidone iodine and sodium hypochlorous acid against 10 isolates and the type strain (SAG2063T) of P. zopfii genotype 1 as well as 10 isolates and the type strain (SAG2021T) of P. zopfii genotype 2 were examined using the micro dilution method. This in vitro study indicated that alkyldiaminoethylglycine hydrochloride, chlorhexidine, povidone iodine and sodium hypochlorous acid, but not dioxide chlorine, are effective against both genotypes of P. zopfii.

著者

Miki Nonaka Nagomi Kurebayashi Takashi Murayama Masami Sugihara Kiyoshi Terawaki Seiji Shiraishi Kanako Miyano Hiroshi Hosoda Shosei Kishida Kenji Kangawa Takashi Sakurai Yasuhito Uezono

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.64, no.Suppl., pp.S35-S39, 2017 (Released:2017-06-24)

参考文献数

14

被引用文献数

2 9

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Cancer was considered an incurable disease for many years; however, with the development of anticancer drugs and state-of-the art technologies, it has become curable. Cardiovascular diseases in patients with cancer or induced by cancer chemotherapy have recently become a great concern. Certain anticancer drugs and molecular targeted therapies cause cardiotoxicity, which limit the widespread implementation of cancer treatment and decrease the quality of life in cancer patients significantly. The anthracycline doxorubicin (DOX) causes cardiotoxicity. The cellular mechanism underlying DOX-induced cardiotoxicity include free-radical damage to cardiac myocytes, leading to mitochondrial injury and subsequent death of myocytes. Recently, circulating orexigenic hormones, ghrelin and des-acyl ghrelin, have been reported to inhibit DOX-induced cardiotoxicity. However, little is known about the molecular mechanisms underlying their preventive effects. In the present study, we show the possible mechanisms underlying the effects of ghrelin and des-acyl ghrelin against DOX-induced cardiotoxicity through in vitro and in vivo researches.

著者

Kozo Okamoto Hiromi Owada Tadashi Fujita Masahiro Kazumori Michiko Otsuka Hiromu Seko Yoshifumi Ota Naotaka Uekiyo Hiroshi Ishimoto Masahiro Hayashi Haruma Ishida Akiyoshi Ando Masaya Takahashi Kotaro Bessho Hironobu Yokota

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2020-028, (Released:2020-07-10)

被引用文献数

14

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To discuss the feasibility of the Himawari follow-on program, impacts of a hyperspectral sounder on a geostationary satellite (GeoHSS) is assessed using an observing system simulation experiment. Hypothetical GeoHSS observations are simulated by using an accurate reanalysis dataset for a heavy rainfall event in western Japan in 2018. The global data assimilation experiment demonstrates that the assimilation of clear-sky radiances of the GeoHSS improves the forecasts of the representative meteorological field and slightly reduces the typhoon position error. The regional data assimilation experiment shows that assimilating temperature and relative humidity profiles derived from the GeoHSS improves the heavy rainfall in the Chugoku region of western Japan as a result of enhanced southwesterly moisture flow off the northwestern coast of the Kyushu Island. These results suggest that the GeoHSS provides valuable information on frequently available vertically resolved temperature and humidity and thus improves the forecasts of severe events.

著者

Rommaneeya LEELA-ARPORN Hiroshi OHTA Genya SHIMBO Kiwamu HANAZONO Tatsuyuki OSUGA Keitaro MORISHITA Noboru SASAKI Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.12, pp.1697-1704, 2019 (Released:2019-12-18)

参考文献数

18

被引用文献数

14

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Thus far, there are few computed tomography (CT) characteristics that can distinguish benign and malignant etiologies. The criteria are complex, subjective, and difficult to use in clinical applications due to the high level of experience needed. This study aimed to identify practical CT variables and their clinical relevance for broadly classifying histopathological diagnoses as benign or malignant. In this prospective study, all dogs with liver nodules or masses that underwent CT examination and subsequent histopathological diagnosis were included. Signalments, CT findings and histopathological diagnoses were recorded. Seventy liver nodules or masses in 57 dogs were diagnosed, comprising 18 benign and 52 malignant lesions. Twenty-three qualitative and quantitative CT variables were evaluated using univariate and stepwise multivariate analyses, respectively. Two variables, namely, the postcontrast enhancement pattern of the lesion in the delayed phase (heterogeneous; odds ratio (OR): 14.7, 95% confidence interval (CI): 0.82–262.03, P=0.0429) and the maximal transverse diameter of the lesion (>4.5 cm; OR: 33.3, 95% CI: 2.29–484.18, P=0.0006), were significantly related to the differentiation of benign from malignant liver lesions, with an area under the curve of 0.8910, representing an accuracy of 88.6%. These findings indicate that features from triple-phase CT can provide information for distinguishing pathological varieties of focal liver lesions and for clinical decision making. Evaluations of the maximal transverse diameter and postcontrast enhancement pattern of the lesion included simple CT features for predicting liver malignancy with high accuracy in clinical settings.

著者

Mari Ogura Yuji Morita Wakako Takabe Masayuki Yagi Fuka Okuda Misato Kon Kenichi Asada Tetsuro Urata Hiroshi Yatou Hiroomi Maeda Yoshikazu Yonei

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.7, no.1, pp.29-41, 2020 (Released:2020-05-08)

参考文献数

31

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Objective: We investigated the effects of the intake of ostrich meat (OM), which is characterized by high protein and low fat, on the body, focusing on protein and amino acid metabolism and growth hormone (GH) secretion. Methods: Plasma amino acid levels, growth hormone (GH) secretion after exercise and autonomic nervous function (device used: VM500 [Fatigue Science Laboratory Inc.]) were measured in 12 healthy subjects (33.3 ± 6.9 years old, BMI 21.6 ± 1.6) after ingestion of the test food (OM) or control food for one week each. Results: A significant increase in the blood levels of branched-chain amino acids (BCAAs), lysine and histidine, and an increase in those for 1-methylhistidine and 3-methylhistidine, which are the indicators of muscle protein breakdown, were observed after the intake of OM, suggesting that protein metabolism in the muscles was activated. Subclass analysis excluding cases with high GH before exercise load showed a significant increase in GH secretion after a walking exercise (30 min) only after the intake of OM. The autonomic nervous function test did not reveal any significant findings. There were no OM-related adverse events during the study. Conclusion: OM is a low-fat meat containing physiologically significant amino acids in large quantities, and it was suggested that OM could be safe and suitable for a protein and amino acid supplement.

著者

宮原 裕 Hiroshi Miyahara

出版者

安田女子大学

雑誌

安田女子大学紀要 = Journal of Yasuda Women's University (ISSN:02896494)

巻号頁・発行日

no.47, pp.289-300, 2019-02-28

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がん治療における薬物療法では従来の殺細胞性の抗がん剤には限界があり、分子標的治療薬が登場した。近年、免疫チェックポイント阻害薬が悪性黒色腫をはじめとして多くのがん腫で再発、進行がんを対象に第Ⅲ相試験が行われ一定の効果が得られることから免疫療法として使用されるようになった。しかし、従来の抗がん剤ではみられなかった内分泌障害や消化管障害などの免疫関連有害事象が起こることが明らかとなった。それらに対しては、発症に早期に気づき対処することが求められる。悪性黒色腫に対しニボルマブやイピリムマブを投与し有害事象を来した自験例を示し考察を加えた。起こりうる免疫関連有害事象は多くの臓器に多岐にわたるので、治療科の医師のみでなく、腫瘍内科医、内分泌・代謝内科、消化器内科等の医師および、施設内の看護師、薬剤師を含めた診療連携体制が極めて重要であることを強調した。

著者

Akihito Miyoshi Nobuhiro Nishii Yoji Okamoto Shinpei Fujita Kenji Kawamoto Keisuke Okawa Shigeki Hiramatsu Kazufumi Nakamura Hiroshi Morita Hiroshi Ito

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.3, pp.456-462, 2020-02-25 (Released:2020-02-25)

参考文献数

21

被引用文献数

1 5

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Background:In heart failure (HF) patients implanted with high-energy devices, worsening of HF can be diagnosed from intrathoracic impedance (ITI) before symptoms appear. Early therapeutic intervention can prevent HF worsening, but the optimal intervention remains unknown. This study aimed to examine which lifestyle modifications or medications can improve HF indicators in asymptomatic HF patients diagnosed from ITI.Methods and Results:This multicenter, prospective, randomized study included patients with high-energy devices, left ventricular ejection fraction <40%, or with a history of HF hospitalization. After the OptiVol alert was evoked by decreased ITI, patients underwent examinations. If they were diagnosed with HF, they were randomly assigned to 3 groups: lifestyle modification, diuretic, or nitrate. After 1 week, they underwent the same examinations. The primary endpoint was change in ITI and serum B-type natriuretic peptide (BNP). Totally, 57 patients were randomized. In all 3 groups, ITI was significantly increased post-intervention compared with pre-intervention. In the diuretic and nitrate groups, logBNP post-intervention was significantly lower than pre-intervention, but not in the lifestyle modification group.Conclusions:Compared with lifestyle modifications, diuretic and nitrate therapy for 1 week may be more effective management of HF detected by decreased ITI. However, lifestyle modification may have the additional benefits of reducing the workload or cost.

著者

佐々木 博 Sasaki Hiroshi

出版者

筑波大学地球科学系

雑誌

筑波大学人文地理学研究 = Tsukuba studies in human geography (ISSN:03860183)

巻号頁・発行日

vol.18, pp.163-190, 1994-03-25

著者

Hiromi Shinano Sakiko Miyazaki Kayo Miura Hiroshi Ohtsu Naohiro Yonemoto Kiyoshi Matsuoka Hakuou Konishi Hiroyuki Daida Mitsue Saito Kazuhiro Sase

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-19-0119, (Released:2020-03-24)

参考文献数

48

被引用文献数

2

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Background:The prognosis of cancer survivors has dramatically improved, but effective strategies for cancer treatment-related cardiovascular disorders (CTRCD) remain to be elucidated in the emerging field of cardio-oncology. In this study, we investigated risk factors for CTRCD in breast cancer patients treated with trastuzumab.Methods and Results:We performed a retrospective analysis of 141 consecutive women who received adjuvant trastuzumab, and underwent baseline (BL) and follow-up (FU) echocardiography at Juntendo University between April 2010 and December 2016. The major concomitant treatment was anthracyclines in 94% and radiotherapy in 53%. During the median treatment period of 11 months, there were 22 (15.6%) cardiology consultations, 3 (2.1%) treatment interruptions with irreversible CTRCD, and no deaths. Left ventricular ejection fraction (LVEF) was decreased from a median 67.5% (BL) to 63.4% (FU; P<0.0001), with reduced LVEF noted in 26.2% at FU<90%BL, in 13.5% at FU<BL–10%, and in 5.7% at LVEFFU<53%. A significantly greater percentage of patients with CTRCD (FU<BL–10% and LVEFFU<53%) had cardiovascular risk factors (CVRF; 42.9% vs. 8.2%, P=0.02). On multivariable analysis, CVRF were also significantly associated with CTRCD (OR, 11.96; 95% CI: 1.30–110.34).Conclusions:Adjuvant trastuzumab for early-stage breast cancer was associated with reduced LVEF; and CVRF were an independent predictor for CTRCD. The concomitant effect of anthracyclines should not be underestimated, even at lower doses.

著者

Hiroshi OHTA Jumpei YAMAZAKI Jaroslav JELINEK Teita ISHIZAKI Yumiko KAGAWA Nozomu YOKOYAMA Noriyuki NAGATA Noboru SASAKI Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0547, (Released:2020-03-25)

被引用文献数

4

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DNA methylation is the covalent modification of methyl groups to DNA mostly at CpG dinucleotides and one of the most studied epigenetic mechanisms that leads to gene expression variability without affecting the DNA sequence. Genome-wide analysis of DNA methylation identified the signatures that could define subtypes of human lymphoma patients. The objective of this study was to conduct the genome-wide analysis of DNA methylation in dogs with gastrointestinal lymphoma (GIL). Genomic DNA was extracted from endoscopic biopsies from 10 dogs with GIL. We performed Digital Restriction Enzyme Assay of DNA Methylation (DREAM) for genome-wide DNA methylation analysis that could provide highly quantitative information on DNA methylation levels of CpG sites across the dog genome. We successfully obtained data of quantitative DNA methylation level for 148,601–162,364 CpG sites per GIL sample. Next, we analyzed 83,132 CpG sites to dissect the differences in DNA methylation between GIL and normal peripheral blood mononuclear cells (PBMCs). We found 383–3,054 CpG sites that were hypermethylated in GIL cases compared to PBMCs. Interestingly, 773 CpG sites including promoter regions of 61 genes were identified to be commonly hypermethylated in more than half of the cases, suggesting conserved DNA methylation patterns that are abnormal in GIL. This study revealed that there was a large number of hypermethylated sites that are common in most of canine GIL. These abnormal DNA methylation could be involved in tumorigenesis of the canine GIL.

著者

Karla Cristine C. DOYSABAS Mami OBA Tomoki ISHIBASHI Hideki SHIBATA Hitoshi TAKEMAE Hiroshi SHIMODA Tetsuya MIZUTANI Atsuo IIDA Eiichi HONDO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0021, (Released:2020-02-12)

被引用文献数

2

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Adenosine 5’-triphosphate (ATP), the major energy currency of the cell, is involved in many cellular processes, including the viral life cycle, and can be used as an indicator of early signs of cytopathic effect (CPE). In this study, we demonstrated that CPE can be analyzed using an FRET-based ATP probe named ATP indicator based on Epsilon subunit for Analytical Measurements (ATeam). The results revealed that as early as 3 hr, the virus infected cells showed a significantly different Venus/cyan fluorescent protein (CFP) ratio compared to the mock-infected cells. The ATeam technology is therefore useful to determine the early signs of ATP-based CPE as early as 3 hr without morphology-based CPE by light microscopy, and enables high throughput determination of the presence of microorganisms in neglected samples stored in laboratories.

著者

林 千夏 池田 宏 HAYASHI Chinatsu IKEDA Hiroshi

出版者

筑波大学陸域環境研究センター

雑誌

筑波大学陸域環境研究センター報告 = Bulletin of the Terrestrial Environment Research Center,the University of Tsukuba (ISSN:13463381)

巻号頁・発行日

no.1, pp.43-50, 2001-02

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The Shimanto River, in the southwest of Shikoku Island, forms incised meanders. It has been suggested that gorges are formed as meanders incise bedrock during tectonic uplift, or a lowering of the baselevel of erosion. However, it is known that the formation of incised meanders is dependent on many other factors.The Shimanto River is composed of a main stream and two major tributaries. Incised meanders occur especially in the middle section of the main stream. It is clear that scarcely any lateral erosion occurs here, as the meanders have very small terraces.The study site is located in the Shimanto Belt, which is composed of interbedded sandstone and mudstone. The sandstone is resistant to erosion, but the mudstone is easily eroded and transported by the river in suspension. There is little sediment load in the river because the area has not experienced recent uplift. Also, since the sediment load is mainly mud, there is very little bedload in the river, which results in a rough, bedrock channel floor. It is proposed that the lack of bedload supplied to the channel and the rough channel floor influence the lateral erosion of the channel and lead to the formation of incised meanders.To test this hypothesis, a flume experiment was conducted using a channel with fixed meanders and varying degrees of roughness of the channel bed. It was found that the greater the roughness of the channel bed, the weaker the concentration of streampower at meanders. It is therefore concluded that little lateral erosion is produced at channel bends over a rough bed. It seems likely that incised meanders are formed in the middle section of the Shimanto River because there is little bedload in the channel, resulting in a very rough, bedrock channel floor and a reduction in the efficient streampower for cutting banks erosion at the bends. This in turn reduces lateral erosion.

著者

Yasuaki Takeji Tomohiko Taniguchi Takeshi Morimoto Naritatsu Saito Kenji Ando Shinichi Shirai Genichi Sakaguchi Yoshio Arai Yasushi Fuku Yuichi Kawase Tatsuhiko Komiya Natsuhiko Ehara Takeshi Kitai Tadaaki Koyama Shin Watanabe Hirotoshi Watanabe Hiroki Shiomi Eri Minamino-Muta Shintaro Matsuda Hidenori Yaku Yusuke Yoshikawa Kazuhiro Yamazaki Masahide Kawatou Kazuhisa Sakamoto Toshihiro Tamura Makoto Miyake Hisashi Sakaguchi Koichiro Murata Masanao Nakai Norio Kanamori Chisato Izumi Hirokazu Mitsuoka Masashi Kato Yutaka Hirano Tsukasa Inada Kazuya Nagao Hiroshi Mabuchi Yasuyo Takeuchi Keiichiro Yamane Takashi Tamura Mamoru Toyofuku Mitsuru Ishii Moriaki Inoko Tomoyuki Ikeda Katsuhisa Ishii Kozo Hotta Toshikazu Jinnai Nobuya Higashitani Yoshihiro Kato Yasutaka Inuzuka Yuko Morikami Kenji Minatoya Takeshi Kimura on befalf of the CURRENT AS Registry Investigators and K-TAVI Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0951, (Released:2020-02-01)

参考文献数

35

被引用文献数

12

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Background:There are no data comparing transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) outcomes in real clinical practice in Japan.Methods and Results:We combined 2 independent registries, the K-TAVI Registry (a 6-center prospective registry of consecutive patients who underwent TAVI) and the CURRENT AS Registry (a large, 27-center registry of 3,815 consecutive patients with severe aortic stenosis [AS]). In the K-TAVI Registry, 338 patients underwent TAVI with SAPIEN XT balloon-expandable valves from October 2013 to January 2016, whereas in the CURRENT AS Registry 237 patients with severe AS underwent SAVR from January 2003 to December 2011. Propensity score matching was conducted, with final cohort comprising 306 patients. The cumulative 2-year incidence of all-cause death and heart failure (HF) hospitalization did not differ significantly between the TAVI and SAVR groups (13.7% vs. 12.4% [P=0.81] and 7.9% vs 3.9% [P=0.13], respectively). After adjusting for residual confounders, there were no significant differences between the TAVI and SAVR groups in the risk for all-cause death (hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.35–1.58; P=0.43) or HF hospitalization (HR 1.27; 95% CI 0.40–4.59; P=0.69).Conclusions:These findings from 2 independent Japanese registries suggest that the 2-year risk of all-cause mortality and HF does not differ significantly between TAVI and SAVR groups in real-world practice in Japan.

著者

Hiroshi WADA

出版者

The Society for Near Eastern Studies in Japan

雑誌

Orient (ISSN:04733851)

巻号頁・発行日

vol.36, pp.123-128, 2001 (Released:2008-03-24)

参考文献数

36

著者

Toshimi Michigami Yasuhisa Ohata Makoto Fujiwara Hiroshi Mochizuki Masanori Adachi Taichi Kitaoka Takuo Kubota Hideaki Sawai Noriyuki Namba Kosei Hasegawa Ikuma Fujiwara Keiichi Ozono

出版者

The Japanese Society for Pediatric Endocrinology

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.29, no.1, pp.9-24, 2020 (Released:2020-01-09)

参考文献数

48

被引用文献数

28

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Hypophosphatasia (HPP) is a rare bone disease caused by inactivating mutations in the ALPL gene, which encodes tissue-nonspecific alkaline phosphatase (TNSALP). Patients with HPP have varied clinical manifestations and are classified based on the age of onset and severity. Recently, enzyme replacement therapy using bone-targeted recombinant alkaline phosphatase (ALP) has been developed, leading to improvement in the prognosis of patients with life-threatening HPP. Considering these recent advances, clinical practice guidelines have been generated to provide physicians with guides for standard medical care for HPP and to support their clinical decisions. A task force was convened for this purpose, and twenty-one clinical questions (CQs) were formulated, addressing the issues of clinical manifestations and diagnosis (7 CQs) and those of management and treatment (14 CQs). A systematic literature search was conducted using PubMed/MEDLINE, and evidence-based recommendations were developed. The guidelines have been modified according to the evaluations and suggestions from the Clinical Guideline Committee of The Japanese Society for Pediatric Endocrinology (JSPE) and public comments obtained from the members of the JSPE and a Japanese HPP patient group, and then approved by the Board of Councils of the JSPE. We anticipate that the guidelines will be revised regularly and updated.

著者

Hiroshi NITTONO Kazumi WATARI

出版者

Psychologia Society

雑誌

PSYCHOLOGIA (ISSN:00332852)

巻号頁・発行日

vol.60, no.1, pp.3-15, 2017 (Released:2018-05-03)

参考文献数

48

被引用文献数

2 4

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The distribution of free samples is known to be an effective tool for sales promotion. By means of event-related brain potentials (ERPs), the present study examined whether tasting a food sample has a stronger effect on brand perception than merely reading a leaflet about the product. Thirty-two university students were asked to read a leaflet about a certain confection brand (target product, either baked cake or chocolate) with or without tasting a sample (n = 16 each). They then performed a category classification task in which 12 colored pictures of different confection brand packages (six baked cakes and six chocolates) were presented one by one in a random order. The participants’ task was to press a button whenever the pictures of the designated confection category (i.e., the category other than the category of the target product) appeared on the screen. ERP responses to the target brand and the other five brands in the same category were compared. The results showed that the specific effect of sampling appeared only from about 500 ms. The target brand elicited a larger late positive potential (LPP) than the other brands only for the participants who sampled it. The findings suggest that, compared with merely reading the information about a product, tasting a sample makes the brand more motivationally salient than the other brands in the same food category.

著者

石破 洋 Hiroshi ISHIBA

雑誌

島根女子短期大学紀要 (ISSN:02889226)

巻号頁・発行日

vol.29, pp.A1-A8, 1991-03-30

著者

Naoki MORITA Kazuo YONEKURA Ichiro YASUZUMI Mitsuyoshi TSUNORI Gaku HASHIMOTO Hiroshi OKUDA

出版者

The Japan Society of Mechanical Engineers

雑誌

Mechanical Engineering Letters (ISSN:21895236)

巻号頁・発行日

vol.2, pp.16-00082, 2016 (Released:2016-03-03)

参考文献数

9

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Structural elements which have 6 degrees of freedom (DOFs) at each node, such as shell and beam elements, are widely used in structural analysis. A matrix originating from finite element method (FEM) is stored in some sparse matrix storage format with a suitable block size for the number of DOFs at each node. When both 6 DOF structural elements and general 3 DOF solid elements are employed, the sparse matrix storage format becomes complicated due to combination of different block sizes. High computational efficiency of finite element analysis has become more important in large-scale structural problems. The complicated storage format leads to deterioration of computing performance in solving linear equations by an iterative procedure, conjugate gradient (CG) iterations for example. A computational technique is required that allows us to use existing parallel linear solvers without deteriorating the performance for solving linear equation systems originating from combination of solid and structural elements. This research aims to develop 3×3 DOF blocking structural elements to enhance the computational intensity of iterative linear solver, such as the CG method. As numerical results, the proposed 3×3 DOF blocking elements have shown better performance for each CG iteration than the conventional structural elements. The computational efficiencies are 95.0% with single thread execution and 76.6% with 8-thread execution of a theoretical peak performance based on the STREAM benchmark.

著者

Kazuhisa Kodama Tomohiro Sakamoto Toru Kubota Hideyuki Takimura Hiroshi Hongo Hiromichi Chikashima Yoshiyuki Shibasaki Toru Yada Koichi Node Takeo Nakayama Koichi Nakao

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.12, pp.582-592, 2019-12-10 (Released:2019-12-10)

参考文献数

18

被引用文献数

2

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Background:Clinical studies on heart failure (HF) using diagnosis procedure combination (DPC) databases have attracted attention recently, but data obtained from such databases may lack important information essential for determining the severity of HF.Methods and Results:Using a HF database that collates DPC data and electronic medical records from 3 hospitals in Japan, we investigated factors contributing to prolonged hospitalization and in-hospital death, based on clinical characteristics and data obtained early during hospitalization in 2,750 Japanese patients with HF hospitalized between 2011 and 2015. Mean age was 77.0±13.0 years; 55.3% (n=1,520) were men, and 39.1% (n=759) had left ventricular ejection fraction <40%. In-hospital mortality was 6.0% (n=164) and mean length of stay for patients who were discharged alive was 18.2±13.7 days (median, 15 days). Factors contributing to in-hospital death were advanced age, higher New York Heart Association (NYHA) class, low albumin and sodium, and high creatinine and C-reactive protein (CRP). Factors contributing to prolonged hospitalization were higher NYHA class, low Barthel index, low albumin, and high B-type natriuretic peptide, lactate dehydrogenase, and CRP.Conclusions:We have constructed a database of HF hospitalized patients in acute care hospitals in Japan. This approach may be helpful to address clinical parameters of HF patients in any acute care hospital in Japan.

著者

Yohei Tomaru Hiroshi Kamada Yuta Tsukagoshi Shogo Nakagawa Mio Onishi Kenta Tanaka Ryoko Takeuchi Yuki Mataki Shumpei Miyakawa Masashi Yamazaki

出版者

THE JAPANESE ASSOCIATION OF RURAL MEDICINE

雑誌

Journal of Rural Medicine (ISSN:1880487X)

巻号頁・発行日

vol.14, no.2, pp.176-180, 2019 (Released:2019-11-20)

参考文献数

10

被引用文献数

2

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Objectives: The purpose of this study was to evaluate the relationship between exercise time and musculoskeletal problems and to determine the appropriate amount of exercise for children in both lower- and higher-grade levels of elementary and junior high schools.Materials and Methods: Mark-sheet-type questionnaires were distributed to and collected from all elementary and junior high schools in two cities. We collected 22,494 questionnaires in total. The relationship between exercise time and musculoskeletal problems was analyzed. The χ2 test and multivariate logistic regression analysis were used for statistical analyses.Results: The mean exercise time in school, in addition to physical education time, was 3.1 hours per week. In 56% of the children, the exercise time was less than 2 hours per week, and in 13% of the children, the exercise time was more than 10 hours per week. Although the rate of sports injury increased with an increase in exercise time, the duration of one-leg stand (a test of balance and muscle strength) also increased with an increase in exercise time. The cut-off values for sports injuries in boys/girls were 2.9/2.9 hours, 4.0/2.9 hours, and 7.5/4.2 hours in lower grade elementary school, higher grade elementary school, and junior high school, respectively.Conclusions: Although an appropriate amount of exercise improves one’s physical health and ability, excessive exercise leads to musculoskeletal problems. Approximately 7 hours/week of exercise is recommended for junior high school students. In elementary school, the exercise time should be carefully decided as the musculoskeletal system of the students is still immature.