著者

Mamiko Kai Kazutaka Hayashi Ippei Kaida Hatsumi Aki Magobei Yamamoto

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.25, no.12, pp.1608-1613, 2002 (Released:2002-12-01)

参考文献数

33

被引用文献数

10 13

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The aims of this study were to examine the enhancing effects of aloe-emodin anthrone (AEA) on the colonic membrane permeability of water-soluble and poorly permeable compounds and to clarify the mechanism of the permeation-enhancing activity of AEA. The permeation-enhancing activity of AEA was estimated from changes in the permeability coefficient of 5(6)-carboxyfluorescein (CF) in rat colonic mucosa using a Ussing-type chamber. Various inhibitors were used to investigate the mechanism of action of AEA. The structural change in the membrane and the cytotoxicity of AEA in the intestinal mucosa were evaluated by measuring the electrical resistance of the membrane (Rm) and lactate dehydrogenase (LDH) activity, respectively. AEA significantly increased the permeation of CF in a dose-dependent manner. The enhanced permeability was significantly suppressed by a histamine H1 receptor antagonist, pyrilamine, and a mast cell stabilizer, ketotifen, but not by a histamine H2 receptor antagonist, cimetidine. The enhancing effect was also inhibited by an inhibitor of protein kinase C (PKC). Potential difference and short-circuit current values decreased, while Rm values remained constant throughout the experiment. The addition of AEA to the mucosal solution decreased Rm to 30%, but then remained constant. LDH activity with AEA was not significantly different from that of the control. In conclusion, AEA is a candidate for effective absorption enhancers without damage of the membrane and cytotoxicity. We propose that AEA stimulates mast cells within the colonic mucosa to release histamine, which probably bind to the H1 receptor. The intracellular PKC route activated by H1 receptor activation enhances the permeability of water-soluble and poorly permeable drugs via opening of tight junctions in rat colonic membrane.

著者

山本 順子 ヤマモト ジュンコ J. YAMAMOTO

雑誌

紀要. 言語・文学編

巻号頁・発行日

vol.43, pp.211-227, 2011

著者

Puneeta Pandey Vijai Dharmamony Yamamoto Jun Sakurai Yasunori

出版者

Inter-Research

雑誌

Marine ecology progress series (ISSN:01718630)

巻号頁・発行日

vol.551, pp.277-281, 2016-06-10

被引用文献数

5

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Batch spawning, intermittent spawning and multiple spawning represent common reproductive strategies among cephalopods. These flexible spawning strategies are also common in fishes, and are thought to be a female trait that is programmed depending on environmental parameters. The ommastrephid squid Todarodes pacificus, being a terminal spawner, is considered to have a single spawning event, extruding one large egg mass and dying soon thereafter. Females that are interrupted by males exhibiting mating behavior, while extruding the egg mass, spawn multiple egg masses over the course of 2-3 d instead of dying soon after spawning the first egg mass. We demonstrate that male mating behavior causes 'forced' intermittent spawning by females (i.e. more than one spawning event). We hypothesize that in T. pacificus, some males use this strategy to mate with females unable to repel advances while spawning, thus providing the male with the opportunity to contribute sperm and enhance gene flow.

著者

Sho Yamamoto Tetsuri Kikuchi Yutaka Yamagiwa Takashi Handa

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

vol.86, no.3, pp.379-388, 2017 (Released:2017-07-22)

参考文献数

43

被引用文献数

6 5

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Lilium auratum var. auratum Lindl. is distributed in the eastern part of Honshu, the main island of Japan. L. auratum var. platyphyllum Baker is endemic to the Izu archipelago, which consists of nine large islands located in south of Honshu’s Izu peninsula. Both varieties have been used as important parents of Oriental hybrid lily cultivars. They have large white flowers with yellow central stripes and colored spots on their tepals. L. auratum var. platyphyllum has larger flowers and wider leaves than L. auratum var. auratum. L. auratum var. platyphyllum has yellow spots, whereas L. auratum var. auratum has red or brown ones. Natural hybridization between these two taxa has been suggested on the basis of spot colors of populations in the Izu archipelago and the Izu peninsula. However, their genetic diversity and hybridity in nature have not been reported. We performed morphological analysis using 72 individuals of L. auratum var. auratum from seven populations and 72 individuals of L. auratum var. platyphyllum from six populations. We also performed simple sequence repeat (SSR) analysis using 102 individuals of L. auratum var. auratum from seven populations and 134 individuals of L. auratum var. platyphyllum from six populations. Both analyses revealed that L. auratum var. auratum and L. auratum var. platyphyllum are genetically different and that L. auratum var. platyphyllum has genetic diversity among populations in the archipelago.

著者

Sho Yamamoto Yutaka Yamagiwa Zentaro Inaba Takashi Handa

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

vol.87, no.1, pp.115-123, 2018 (Released:2018-02-06)

参考文献数

33

被引用文献数

2 2

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Lilium japonicum Thunb. which has pink or white-colored funnel-like flowers, is distributed in Kyushu, Shikoku, and the western part of Honshu, the main island of Japan. L. auratum Lindl. which has large white flowers with yellow central stripes and red spots, is distributed in the eastern part of Honshu. Natural hybridization of these two species has only been found on the Izu Peninsula of Honshu. However, details of the variation and hybridity of the interspecific hybrid population of these species on this peninsula remain unknown. In the present study, we conducted a morphological examination using 43, 21, and 90 individuals of L. japonicum, L. auratum, and the putative hybrid, respectively, from six, four, and ten populations of the Izu Peninsula, respectively. In addition, we performed simple sequence repeat (SSR) analysis using 47, 41, and 106 individuals of L. japonicum, L. auratum, and the putative hybrid, respectively, from six, four, and ten populations, respectively. Putative hybrid populations that resembled L. japonicum in morphology and SSR profile were found in the southern to eastern part of the peninsula, whereas those that resembled L. auratum and those exhibiting an intermediate morphology and SSR profile were found in the southern part of the peninsula. Large morphological variations exist in putative hybrid in the southern population, and interspecific hybridization has occurred in the southern and eastern populations. These results suggest that the center of natural hybridization is located in the southern part of the Izu Peninsula.

著者

山元 一晃 浅川 翔子 加藤 林太郎 Kazuaki YAMAMOTO Shoko ASAKAWA Rintaro KATO

出版者

金城学院大学

雑誌

金城学院大学論集. 人文科学編 = Treatises and Studies by the Facalty of Kinjo Gakuin University. Studies in Humanities (ISSN:18800351)

巻号頁・発行日

vol.19, no.1, pp.138-147, 2022-09-30

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筆者らが作成した看護留学生向けのライティング教材について,実際に使用した学生にインタビューを実施し,その難易度,使いやすさ,有用性などについて検証を行った。その結果,一定程度留学生が役に立ったと感じていることが分かった。「患者情報の記録」「先生とのメール」は有用性が高かったと感じている一方で,「私の理想の看護師」「施設情報」については,既習だったこと,特に難しくなかったことから,役立ったとは感じていなかったようである。また,「看護展開」などは,実際の実習などで課されたものよりも易しく,難易度を上げてもよいのではないかという指摘があった。さらに,領域別に書くことや,実際の患者は合併症を抱えていることなどの相違点があったようである。テキストで扱われていなかった内容として,変更が生じた場合の修正の仕方,指導者への説明やカンファレンスなど口頭でのやりとり,専門用語などについても含めて欲しいとの要望があった。自習で使えるかについては,意見が分かれ,解説があるため自習も可能という指摘があった一方で,最初は自力ではできなかったなどの指摘もあった。

著者

Chihiro Nishiura Yosuke Inoue Ikuko Kashino Akiko Nanri Motoki Endo Masafumi Eguchi Takeshi Kochi Noritada Kato Makiko Shimizu Teppei Imai Akiko Nishihara Makoto Yamamoto Hiroko Okazaki Kentaro Tomita Toshiaki Miyamoto Shuichiro Yamamoto Tohru Nakagawa Toru Honda Takayuki Ogasawara Naoko Sasaki Ai Hori Isamu Kabe Tetsuya Mizoue Seitaro Dohi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.9, pp.431-437, 2022-09-05 (Released:2022-09-05)

参考文献数

23

被引用文献数

1 1

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Background: While it is essential to understand how long is sufficient for return-to-work when designing paid sick-leave systems, little attempt has been done to collect cause-specific information on when and how many of sickness absentees returned to work, became unemployed, or passed away.Methods: We studied the first sick-leave episode of ≥30 consecutive days in those ≤55 years of age during 2012–2013 among employees of 11 Japanese private companies (n = 1,209), which were followed until 2017. Overall and disease-specific cumulative incidences of return-to-work, resignations, and deaths were estimated using competing risk analysis.Results: During the 3.5-year period (follow-up rate: 99.9%), 1,014 returned to work, 167 became unemployed, and 27 died. Overall, return-to-work occurred within 1 year in 74.9% of all absentees and in 89.3% of those who successfully returned to work. Resignation occurred within 1 year in 8.7% of all absentees and in 62.9% of all subjects who resigned. According to ICD-10 chapters, the cumulative incidence of return-to-work ranged from 82.1% for mental disorders (F00–F99) to 95.3% for circulatory diseases (I00–I99). The cumulative incidence of return-to-work due to mental disorders ranged from 66.7% in schizophrenia (F20) to 95.8% in bipolar affective disorders (F31). Death was rarely observed except for cases of neoplasms (C00–D48), of which the cumulative incidence of death reached 14.2% by 1.5 years.Conclusion: Return-to-work and resignations occurred commonly within 1 year of sick leave among long-term sickness absentees in the Japanese private companies. Our findings may assist occupational physicians and employers in developing effective social protection schemes.

著者

Yosuke Inoue Shuichiro Yamamoto Andrew Stickley Keisuke Kuwahara Toshiaki Miyamoto Tohru Nakagawa Toru Honda Teppei Imai Akiko Nishihara Isamu Kabe Tetsuya Mizoue Seitaro Dohi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.6, pp.283-289, 2022-06-05 (Released:2022-06-05)

参考文献数

45

被引用文献数

3 5

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Background: Although previous research has focused on the association between long working hours and several mental health outcomes, little is known about the association in relation to mental health-related sickness absence, which is a measure of productive loss. We aimed to investigate the association between overtime work and the incidence of long-term sickness absence (LTSA) due to mental disorders.Methods: Data came from the Japan Epidemiology Collaboration on Occupational Health Study (J-ECOH). A total of 47,422 subjects were followed-up in the period between April 2012 and March 2017. Information on LTSA was obtained via a study-specific registry. Baseline information was obtained at an annual health checkup in 2011; overtime working hours were categorized into <45; 45–79; 80–99; and ≥100 hours/month.Results: During a total follow-up period of 211,443 person-years, 536 people took LTSA due to mental disorders. A Cox proportional hazards model showed that compared to those with less than 45 hours/month of overtime work, those with 45–79 hours/month were at a lower risk of LTSA due to mental health problems (hazard ratio [HR] 0.63; 95% confidence interval [CI], 0.56–0.71) while those with overtime work of ≥100 hours/month had a 2.11 (95% CI, 1.12–3.98) times higher risk of LTSA due to mental health problems.Conclusion: Engaging in excessive overtime work was linked with a higher risk of LTSA due to mental health problems while the lower risk observed among individuals working 45–79 hours/month of overtime work might have been due to a healthy worker effect.

著者

Junichi Sugawara Mami Ishikuro Taku Obara Tomomi Onuma Keiko Murakami Masahiro Kikuya Fumihiko Ueno Aoi Noda Satoshi Mizuno Tomoko Kobayashi Yohei Hamanaka Kichiya Suzuki Eiichi Kodama Naho Tsuchiya Akira Uruno Yoichi Suzuki Osamu Tanabe Hideyasu Kiyomoto Akito Tsuboi Atsushi Shimizu Seizo Koshiba Naoko Minegishi Soichi Ogishima Gen Tamiya Hirohito Metoki Atsushi Hozawa Nobuo Fuse Kengo Kinoshita Shigeo Kure Nobuo Yaegashi Shinichi Kuriyama Masayuki Yamamoto

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.2, pp.69-79, 2022-02-05 (Released:2022-02-05)

参考文献数

33

被引用文献数

3 11

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Background: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants.Methods: Expectant mothers living in Miyagi Prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group.Results: A total of 23,406 pregnancies involving 23,730 fetuses resulted in 23,143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes, and hypertensive disorders of pregnancy.Conclusions: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

著者

Ai Kagase Masanori Yamamoto Mikan Kojima Takahiro Tokuda

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.12, pp.609-610, 2022-12-09 (Released:2022-12-09)

著者

Masanori Yamamoto Ai Kagase Ryotaku Kawabata Takahiro Tokuda

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.12, pp.611-612, 2022-12-09 (Released:2022-12-09)

著者

Noriaki Nagai Tetsushi Yamamoto Wataru Tanabe Yoshimasa Ito Satoshi Kurabuchi Kuniko Mitamura Atsushi Taga

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.64, no.3, pp.331-335, 2015 (Released:2015-03-01)

参考文献数

16

被引用文献数

8 12

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We investigate whether maple syrup is a suitable sweetener in the management of type 2 diabetes using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The enhancement in plasma glucose (PG) and glucose absorption in the small intestine were lower after the oral administration of maple syrup than after sucrose administration in OLETF rats, and no significant differences were observed in insulin levels. These data suggested that maple syrup might inhibit the absorption of glucose from the small intestine and preventing the enhancement of PG in OLETF rats. Therefore, maple syrup might help in the prevention of type 2 diabetes.

著者

Kotaro Sato Koki Fujii Noriyuki Yamamoto Norihisa Ichimura Satoshi Yamaguchi Hirohisa Yamada Hideharu Hibi Shinya Toyokuni

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.71, no.2, pp.129-135, 2022 (Released:2022-09-01)

参考文献数

22

被引用文献数

2

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COVID-19 is pandemic since 2020 and further information is necessary on the risk factors associated with the infection of SARS-CoV-2. As an entry mechanism, SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as receptor and transmembrane serine protease 2 (TMPRSS2) to activate fusion with host plasma membrane. Because dysgeusia is an early symptom of COVID-19, we here studied the expression of ACE2 and TMPRSS2 in the tongue and the associated tissues of mice and humans with immunohistochemistry and immunoblot analysis. ACE2 expression was low in the human tongue but was observed in the squamous epithelium, perineurium, arterial wall, salivary glands as well as taste buds. In contrast, mice showed high expression. In sharp contrast, TMPRSS2 expression was high in all the cells mentioned above in humans but relatively low in mice except for salivary glands. We then performed semi-quantitation of immunohistochemistry data of human ACE2 and TMPRSS2 and analyzed for age, sex, alcohol intake, and smoking habit with logistic regression analysis. We found that alcohol intake and female gender were the significant risk factors for increasing TMPRSS2 expression. In conclusion, TMPRSS2 is an important factor to be considered regarding SARS-CoV-2 entry and amplification in the oral cavity, which is promoted through drinking habit.

著者

Tomoko Kobayashi Mika Kobayashi Naoko Minegishi Masahiro Kikuya Taku Obara Mami Ishikuro Chizuru Yamanaka Tomomi Onuma Keiko Murakami Fumihiko Ueno Aoi Noda Akira Uruno Junichi Sugawara Kichiya Suzuki Eiichi N. Kodama Yohei Hamanaka Naho Tsuchiya Mana Kogure Naoki Nakaya Makiko Taira Mika Sakurai-Yageta Toru Tamahara Junko Kawashima Maki Goto Akihito Otsuki Ritsuko Shimizu Soichi Ogishima Hiroaki Hashizume Fuji Nagami Tomohiro Nakamura Atsushi Hozawa Tadao Kobayashi Nobuo Fuse Shinichi Kuriyama Shigeo Kure Masayuki Yamamoto

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

pp.2022.J103, (Released:2022-12-01)

被引用文献数

1

著者

石田 弘穂 山本 健太 吉元 あや美 武曽 歩 太田 英明 Ishida Mitsuho Yamamoto Kenta Yoshimoto Ayami Musou Ayumi Ohta Hideaki

出版者

中村学園大学・中村学園大学短期大学部

雑誌

中村学園大学・中村学園大学短期大学部研究紀要 = Bulletin of Nakamura Gakuen University and Nakamura Gakuen University Junior College (ISSN:13477331)

巻号頁・発行日

no.54, pp.155-159, 2022-03-01

著者

Naoko Nagano Manabu Suzuki Shota Yamamoto Konomi Kobayashi Motoyasu Iikura Shinyu Izumi Masayuki Hojo Haruhito Sugiyama

出版者

National Center for Global Health and Medicine

雑誌

Global Health & Medicine (ISSN:24349186)

巻号頁・発行日

pp.2022.01057, (Released:2022-11-20)

参考文献数

30

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Bronchial artery embolization (BAE) is the first choice treatment for hemoptysis. With advances in endovascular treatment, various embolic materials have become available. However, the optimal embolic material for the treatment of cryptogenic hemoptysis has not been determined. This study aimed to investigate the short- and long-term efficacy of BAE using a gelatin sponge in the treatment of patients with cryptogenic hemoptysis. The clinical characteristics, angiographic findings, and short- and long-term outcomes of BAE were retrospectively analyzed in 22 consecutive patients who underwent BAE for control of cryptogenic hemoptysis between January 2010 and September 2018. Selective angiography and super-selective BAE were successfully performed for all patients. A gelatin sponge was used in all patients. Further, polyvinyl alcohol was mixed with the gelatin sponge in 11 patients (50%). Angiography showed that the bronchial artery was responsible for hemoptysis in all patients, along with the intercostal artery in one patient (4.5%) and the inferior phrenic artery in one patient (4.5%). Immediate hemostasis was achieved in all patients. The recurrence-free rate was 100% for 1 month, 94.1% for 3 months, 94.1% for 12 months, and 87.4% for 24 months. Of two patients with recurrent hemoptysis, one underwent bronchoscopic hemoptysis and the other received intravenous hemostatic agents. No patient underwent BAE for recurrence. No severe complications occurred. In conclusion, BAE using a gelatin sponge has short- and long-term hemostatic efficacy for treating cryptogenic hemoptysis without any severe complications. A gelatin sponge is a suitable embolic material for patients with cryptogenic hemoptysis.

著者

Kazuaki Aoki Shungo Yamamoto Kentaro Tochitani

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.13, pp.2083-2084, 2022-07-01 (Released:2022-07-01)

参考文献数

2

被引用文献数

7

著者

山本 美紀 Miki YAMAMOTO

出版者

創価大学日本語日本文学会

雑誌

日本語日本文学 = Studies in Japanese Language and Japanese Literature (ISSN:09171762)

巻号頁・発行日

no.28, pp.1-12, 2018-03-18

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藤原定家は、歌の創作においては本歌取りを得意とし、多くの歌を残している。彼は本歌取りの重要を「本歌取りだと分かるように創作することである」とした。つまり、本歌は想起されるべきものであり、本歌取りの歌はその本歌の読みを内包して創作されているということになる。本歌取りと同じ創作手法を用いられているのが、「物語二百番歌合」である。物語歌を番えて成っているこの作品もまた、もとになった物語を想起することが想定されているかのような方法が採られており、それが歌を読む際のガイドとして機能しているかのようである。一方、本歌取りの歌も「物語二百番歌合」もその作品だけで読むことが可能であり、もとになった歌や読みを想起することが必須ということではない。想起しても想起しなくても、本歌取りの歌には本歌やその読みが、「物語二百番歌合」の歌にはその歌の収められていた物語内容が内包されている。本歌取りの歌を読むということ、「物語二百番歌合」を読むということはつまり、すでにそのもととなった歌と物語を読んでいるということなのだ。

著者

Kenta YAMAMOTO Ayumi YAHADA Kumi SASAKI Koji SAKAMOTO Kazunori OGAWA Hideaki OHTA

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.19, no.1, pp.39-49, 2013 (Released:2013-03-09)

参考文献数

23

被引用文献数

3 10

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The composition of volatile components in 18 Citrus Archicitrus species, 17 Citrus Metacitrus species and two Fortunella species, according to the classification system established by Tanaka, was investigated using headspace gas chromatography-mass spectrometry. The composition of 48 volatile compounds in the juice of these species was determined, and principal component analysis was performed. Scores for the 1st and 2nd principal components are plotted as a scatter diagram. In Citrus Archicitrus, samples of Citrophorum, Cephacitrus and Aurantium formed individual groups, but others did not. In Citrus Metacitrus, samples of Acrumen were divided into two different groups. The composition of volatile components in citrus juice was consistent with each grouping of Tanaka’s system, in particular, in the case of dividing the Citrus genus into the two subgenera Archicitrus and Metacitrus.

著者

石川 和江 磯 麻衣子 松井 優果 塩谷 亜希子 山本 國夫 Kazue ISHIKAWA Maiko ISO Yuka MATSUI Akiko SHIOTANI Kunio YAMAMOTO

出版者

大手前大学健康栄養学部

雑誌

食糧・栄養と健康 = Otemae Journal for Food, Nutrition & Health (ISSN:24363251)

巻号頁・発行日

vol.2, pp.27-34, 2022-03-31

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<目的>現在、メントールを含有した飲料であるミントティーが多く市販されている。食品添加物でもあるメントールを含むミントティーの継続的な摂取が生理反応や感覚に及ぼす影響を調べた研究は少ない。また、女子学生は学生生活の中で冷えや暑さを感じることが多い。そこで本研究では女子学生を対象に、メントールを含むハーブ(ミント)の継続摂取による効果や安全性を明らかにすることを目的とした。<方法>この研究は、専門学校および大学の女子学生を対象とした。対象者は、メントール含有ペパーミント飲料(以下、ミントティー)を1日3回1週間連続摂取した。我々は、ミントティー摂取前と1週間継続摂取後、および2週間後に身体計測(身長、体重、BMI、基礎代謝、体温、血圧、脈拍)温冷感覚アンケート、クレペリン検査を実施し、ミントティーの温冷感覚への影響および安全性について検討した。さらに、クレペリン検査後に、主観的感覚アンケートを行った。統計解析は、15名の時間経過による変化および、ミントティー摂取前の温冷感覚アンケートの結果をもとに、感覚冷感群(以下、冷感群)、感覚暑感群(以下、暑感群)の2群に分類して分析した。<結果および考察>データ解析対象者は15名であった。15名全体では、生理応答、クレペリン検査に時間経過による有意な変化は見られなかったが、主観的アンケートでは、「疲れ感」に有意な変化がみられ、飲用前(以下、0週)に比べて飲用1週間後(以下、1週)に有意に低下した(p=0.020)。冷感群と暑感群の比較においては、ミントティー摂取による収縮期血圧は、暑感群では0週に比べて1週、摂取完了1週間後(以下、2週)とも低下し(p=0.003)、冷感群では1週に比べて2週で低下した(p=0.023)が、拡張期血圧は両群とも有意な変化はみられなかった。主観的感覚のうち、「疲れ感」は、冷感群で0週に比べ1週、2週とも低下した(p<0.001)。クレペリン検査による作業量は、両群とも0週に比べ1週、2週とも増加したが、変化量では、暑感群に比べ冷感群が有意に高かった(p=0.006)。本研究での女子学生は、ミントティー摂取による安全性への影響はなく、冷感群、暑感群で生理的応答と主観的感覚が異なることが示唆された。なお、本研究では、ミントティーの摂取期間中および摂取完了後1週間の身体計測等の基礎健康調査および問診での気分の悪化や頭痛、嘔吐、下痢などの症状に異常はなかった。