著者
渡部晋太郎著
出版者
ユニウス
巻号頁・発行日
2015
著者
櫻井 健一 片山 恵里 茂手木 宏美
出版者
一般社団法人 日本糖尿病学会
雑誌
糖尿病 (ISSN:0021437X)
巻号頁・発行日
vol.58, no.5, pp.323-328, 2015-05-30 (Released:2015-06-01)
参考文献数
20

症例は72歳女性.2型糖尿病経過中にシタグリプチン50 mgを開始し,血糖コントロール良好(HbA1c5 %台)となるも,その後低血糖と思われる症状が出現した.数日間の体調不良・食思不振の後,低血糖性昏睡(血糖値31 mg/dl)にて入院となった.この時の血清インスリンが9.24 uIU/mlと高値であり,インスリンの不適切分泌が疑われた.各種検査により,シタグリプチンとシベンゾリンの併用による薬剤性低血糖が疑われ,両薬を中止したところ低血糖は改善した.シベンゾリンは膵β細胞に対しSU薬と同様にKATPチャネルに作用し,インスリン分泌を促すことが知られている.本症例は高齢であり,腎機能障害を有しており,シタグリプチンとの併用によりインスリン分泌作用が増強したと考えられた.DPP4阻害薬をIa群抗不整脈薬と併用する際には相互作用による重症低血糖に十分留意する必要があると考えられた.
著者
Yoshiaki Kikuchi
出版者
一般社団法人日本体力医学会
雑誌
The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
巻号頁・発行日
vol.4, no.4, pp.299-306, 2015-09-25 (Released:2015-10-02)
参考文献数
77
被引用文献数
2

While bipedalism is a fundamental evolutionary adaptation that is essential for the development of the human brain, the erect body is always an inch or two away from falling. Although the neural substrate underlying automatic detection of one’s own body instability is an important consideration, there have thus far been few functional neuroimaging studies due to the restrictions placed on participants’ movements. Here, we used functional magnetic resonance imaging to investigate the neural substrate underlying whole body instability, based on a self-recognition paradigm that uses video stimuli consisting of one’s own and others’ whole bodies, depicted in both stable and unstable states. Analyses revealed significant activity in the brain regions that should be activated during genuine unstable body (physical) conditions: the right parieto-insular vestibular cortex, inferior frontal junction, posterior insula and parabrachial nucleus. We argue that these right-lateralized cortical and brainstem regions mediate vestibular information processing for detection of vestibular anomalies, defensive motor responding in which the necessary motor responses are automatically prepared/simulated to protect one’s body, and sympathetic activity as an alarm response during whole body instability.
著者
Satoru Kanamori Tomoko Takamiya Shigeru Inoue
出版者
一般社団法人日本体力医学会
雑誌
The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
巻号頁・発行日
vol.4, no.4, pp.315-320, 2015-09-25 (Released:2015-10-02)
参考文献数
45
被引用文献数
1 51

Physical activity may be carried out alone or in a group. No comprehensive studies have been conducted on the associations between group exercise and health outcomes, the mechanisms underlying the associations with health outcomes, and determinants of participation in group exercise. The aim of this article is to review the associations and mechanisms between group exercise and health outcomes, and the determinants of participation in group exercise among healthy adults and the elderly without specific illnesses. Group exercise may reduce the risk of physical and mental illness by improving adherence to physical activity, psychological factors, and social relationships. While there may potentially be various determinants of group exercise, previous research has only examined specific demographic and environmental factors. Among the studies discussed in this review, few studies examined the differences between individual exercise and group exercise. Thus, the unique effects and determinants of group exercise remain unclear. Further studies examining these points are needed to develop a more complete knowledge base on group exercise.
著者
久保 明教
出版者
日本文化人類学会
雑誌
文化人類学 (ISSN:13490648)
巻号頁・発行日
vol.77, no.3, pp.456-468, 2013-01-31

Recently, it has become increasingly difficult to employ "culture" as a comprehensive analytical concept in anthropology. Nevertheless, in the practices of people researched by anthropologists, culture has recently taken on increasing importance as a vital tool to categorize human groups and manage their relations, owing to the ongoing process of globalization. Because of that, the Japanese anthropologist Shoichiro Takezawa has insisted that we must maintain the academic concept of "culture." However, the increasing practical importance of culture does not necessarily connote its importance as an analytical concept. Rather, we need to investigate how the concept works in people's practices today, and whether culture as an academic concept works in their analysis. Also, if the concept of "culture" hardly ever works, we must explore a way to demolish it as a concept and reconstruct analytical methodology. In this paper, I investigate the practices of IT workers in Bangalore, South India, in order to examine how culture is practically utilized there, as well as to try to understand why the academic concept of culture does not work well in analyzing their practices. I also examine the kind of framework required to describe them appropriately. In Chapter 2, I point out that in the Indian IT industry, a vital element for economic success has been identified as the understanding and adoption of foreign (mainly Western) cultures in order to communicate more smoothly with foreign clients, co-workers and customers in the global and virtual workplaces that make up informational networks. In Chapter 3, I examine two ways used to explain the practices of Indian IT workers engaged in managing cultural differences: the narratives of "cross-cultural management" and "sanskritization." Then, I show how the practical concept of culture utilized in these narratives has dual qualities ("something to control and invisible" and "something controlled and visualized"), and demonstrate that the analytical concept of culture hardly ever works for analyzing existing situations in which the practical concept of culture is employed, because it also implicitly contains those dual qualities. In Chapter 4, I examine an event encountered during my field research in Bangalore to suggest that the daily practices of IT workers deeply depend on a heterogeneous "actor network" composed of human/ nonhuman entities from different regions, which cannot be sufficiently comprehended by employing the practical/analytical concept of culture. In Chapter 5, I try to configure an analytical framework sufficient to describe their practices appropriately, connecting the relational ontology proposed by the actor-network theory to a vital idea of anthropology, namely, "their perspective." Referring to Donna Haraway and Marilyn Strathern, I insist that the concept of "their perspective" is not an (inter) subjective viewpoint, but the effect of a recursive movement of the actor network to visualize itself. Finally, I suggest that Indian IT workers are penetrated by different ways of organizing and visualizing the actor network, which are equivalent to four spatialities proposed by the discussion of ANT topology, and that their perspective is being generated and transformed through mutual interferences among them.

2 0 0 0 OA 官報

著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1938年07月27日, 1938-07-27

2 0 0 0 OA 大阪大観

著者
川田友之 編
出版者
大阪大観編纂所
巻号頁・発行日
1914
著者
安藤 綾俊 山元 崇
出版者
公益社団法人 日本薬理学会
雑誌
日本薬理学雑誌 (ISSN:00155691)
巻号頁・発行日
vol.142, no.2, pp.73-78, 2013 (Released:2013-08-09)
参考文献数
12

炎症性腸疾患(Inflammatory bowel disease:IBD)は,根本的な治療法が確立されていない難治性の慢性炎症疾患である.炎症性サイトカインの一種であるIL-12およびIL-23(IL-12/23)が共有するサブユニットに対するヒト化モノクローナル抗体は,生体内で産生されるIL-12/23を中和することで,IBDを対象とした臨床試験において有効性を示した.新規IBD治療薬を目指す取り組みの中で,治療標的分子としてIL-12/23に注目し,Phenotypic screeningの手法を用いて,IL-12/23産生抑制作用を有する低分子化合物APY0201を見出した.APY0201は,サイトカイン選択的な抗炎症作用を有しており,IL-12/23を抑制する一方でTNF-αなどの炎症性サイトカインを抑制しなかった.またマウスIBDモデルに対する1日1回の経口投与により,有意な腸炎抑制効果を確認した.このユニークな抗炎症作用を有するAPY0201の標的分子に興味を持ち,その同定を試みたところ,APY0201がPhosphatidylinositol 3-phosphate 5-kinase(PIKfyve)と呼ばれる脂質キナーゼの一種を阻害することを見出した.またsiRNAの細胞内導入によるPIKfyve遺伝子のノックダウンの実験から,APY0201はPIKfyveの阻害を介してIL-12/23産生阻害作用を示したことが示唆された.PIKfyveは,リン脂質であるホスホイノシチドの代謝に関わる酵素であることが知られているが,既存情報は限られており,抗炎症作用を説明する詳細な分子機序については明らかではない.今回得られた新しい抗炎症治療標的分子に関する情報は,より最適化された化合物探索手法や,IBDの病態生理に関わる分子の機序解明に繋がることが期待される.

2 0 0 0 OA 三年生の修身

著者
安島健 等編
出版者
大阪宝文館
巻号頁・発行日
1930

2 0 0 0 OA 学者町学生町

著者
出口競 著
出版者
実業之日本社
巻号頁・発行日
1917
著者
宮下 和巳 西村 寿彦 大鐘 武雄 小川 恭孝 鷹取 泰司 長 敬三
出版者
一般社団法人電子情報通信学会
雑誌
電子情報通信学会技術研究報告. RCS, 無線通信システム (ISSN:09135685)
巻号頁・発行日
vol.102, no.86, pp.13-18, 2002-05-17
参考文献数
12
被引用文献数
92

MIMOチャネル情報が送信側で既知の場合,固有ベクトルを用いたマルチビーム形成により直交チャネルを形成し,注水定理による送信電力制御を行うことで,チャネル容量を最大とすることができる.ここでは,この概念に基づき,固有ビーム空間分割多重(E-SDM)方式を提案し,計算機シミュレーションにより従来のSDM方式との比較を行った.その結果,送信素子数5,受信素子数2の場合において,平均誤り率10^-3で約10[dB]の利得が得られることが明らかとなった.
著者
村瀬 博春
出版者
日本認知科学会
雑誌
認知科学 (ISSN:13417924)
巻号頁・発行日
vol.17, no.3, pp.563-571, 2010 (Released:2011-03-08)
参考文献数
16

This article discusses how creativity appears in the composition of a painting concerning Tawaraya Sotatsu's masterpiece ‘Gods of Wind and Thunder’done in the 17th century in Edo period from viewpoint of the design thinking. The design thinking is defined as the spiral flow of dynamic idea, repeating generation of the concept and restructuring of the composition toward composing a desirable figure as a design solution. Early in the 17th century in Edo period when the painting confronted with a certain state of blockage, Sotatsu adopted the method for extracting pictorial elements from predecessors' works without making original figures. It can be thought that Sotatsu regarded creativity as making novel implication, not as making new figures. Analyzing the work, it is confirmed that novel implication appears by making the ambiguity of denying and maintaining the meaning as Gods of Wind and Thunder in hierarchy. Sotatsu's artistic policy stemmed from pursuit of the ideal category of design thinking. Thus, Sotatsu's composition is located on the development of accomplishments such as Noh performance and tea ceremony originated from Zen Buddhism in Japan at the early modern age. In the main discourse the author claims that the fundamental of the design thinking is Endo-exo circulation which is the principle of life, evolution and cognition.
著者
梶田 隆章
出版者
一般社団法人 日本物理学会
雑誌
日本物理学会誌 (ISSN:00290181)
巻号頁・発行日
vol.53, no.10, pp.783-784, 1998

スーパーカミオカンデ共同実験グループは, 本来6月岐阜県高山市で開催された第18回ニュートリノ物理学と天体物理学国際会議("ニュートリノ98")において「ニュートリノ振動の証拠」を発表した. 本稿ではこの発表の要点を報告する. なお, 紙面の関係上物理的背景等について触れないので, そちらは参考文献を参照していただきたい.

2 0 0 0 OA [お伽噺]

著者
小林新吉 著
出版者
小林新吉
巻号頁・発行日
vol.かち[カチ]やま, 1888