著者

Sandi SUFIANDI Hiromichi OBARA Huai-Che HSU Shin ENOSAWA Hiroshi MIZUNUMA

出版者

The Japan Society of Mechanical Engineers

雑誌

Journal of Biomechanical Science and Engineering (ISSN:18809863)

巻号頁・発行日

pp.17-00421, (Released:2017-12-04)

参考文献数

34

被引用文献数

1

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Improving the process of cell injection during hepatocyte transplantation requires an understanding of the causal relationships that shear, direct contact cells with a solid surface, and cell deformation have on cell viability loss. A linear shear model was used to model this loss of cell viability during their movement on a solid surface as part of the injection step of hepatocyte transplantation. Rat hepatocytes were studied under linear shear using two parallel plates, with a ”tight” condition that had a 25 μm gap, and a ”loose” gap condition with a > 25 μm gap, to determine the effects of cell deformation, and simulate cell viability loss during injection. Cell morphology and deformation were also observed using time-lapse images. Direct contact with a solid surface is deleterious for cells, and live cells became deformed under shear stress until they lost viability. The cell size could decrease or increase during deformation, and a loss of viability could occur due to a loss of membrane integrity or cell rupture. The space limitations in the tight gap could prevent cell expansion, which delayed the process of cell viability loss. In summary, preventing the direct contact of hepatocytes with a solid surface is recommended to improve the cell injection process during transplantation.

著者

[神奈川県立歴史博物館編]

出版者

神奈川県立歴史博物館

巻号頁・発行日

2015

著者

日本聖公会祈祷書版権委員 編

出版者

日本聖公会出版社

巻号頁・発行日

1916

著者

中井 祐一郎 下屋 浩一郎 田村 公江 浅田 淳一 鈴井 江三子 中塚 幹也 新名 隆志 林 大悟

出版者

川崎医科大学

雑誌

基盤研究(C)

巻号頁・発行日

2011-04-28

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出生前診断による選択的人工妊娠中絶について、無記名アンケートによる一般市民の意識を調査した。一般的な人工妊娠中絶については、母体外生存が不可能なことを条件として容認するという者が、男女ともにほぼ2/3であった。非選択的人工殷賑中絶との比較した場合の選択的中絶の道徳的位置付けについては、女性の半数以上がより問題が大きいとした。胎児の選択権については、女性の85%、男性においても75%が認めていないが、権利としては認めないが、状況によってはやむをえないとする回答が過半を占めた。新型出生前診断については、女性の70%、男性でも65%が、妊婦に対する情報提供を限定的にすべきであると回答した。

著者

高瀬克範著

出版者

六一書房

巻号頁・発行日

2004

出版者

[出版者不明]

巻号頁・発行日

2015

著者

野村崇 宇田川洋編

出版者

北海道新聞社

巻号頁・発行日

2001

著者

海保嶺夫著

出版者

雄山閣出版

巻号頁・発行日

1974

著者

河野本道著

出版者

北海道出版企画センター

巻号頁・発行日

1996

著者

明胡廣等奉敕撰

出版者

安正堂刊

巻号頁・発行日

vol.[3], 1560

出版者

東京都商業報国会本部

巻号頁・発行日

1944

著者

市川 三紀

出版者

創価大学大学院

雑誌

創価大学大学院紀要 (ISSN:03883035)

巻号頁・発行日

vol.28, pp.381-403, 2006

著者

小川 吉昭

出版者

県立広島大学

雑誌

県立広島大学人間文化学部紀要 (ISSN:21865590)

巻号頁・発行日

no.9, pp.91-104, 2014

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Gottlob Frege (1848-1925) sieht sich auf die Schwierigkeit der Gleichheit (Identität)gegenüber, denn in a=b drückt die Gleichheitszeichen( =) die Gleichheit der Zeichen a und b aus, und zugleich sind die Zeichen a und b voneinander verschieden.In der „Sinn und Bedeutung"(1892) unterscheidet er den Sinn und den Bedeugung eines Zeichens, der erste drückt die ‚Art des Gegebenseins des Bezeichneten' und die letzere den Gegenstand, den das Zeichen bedeutet. Diese Unterscheidung wendet er auf die Sätze: der Sinn eines Satzes ist der Gedanke und die Bedeutung der Wahrheitswert.Wenn die Bedeutung eines Zeichen oder Satzes betrifft, so muß, nach Freges Voraussetzung,die Ersetzbarkeit bestehen. Aber es gibt Ausnahme, wenn der Satzteil oder Teilsatz in der geraden oder ungeraden Rede aufttritt. So betrachetet Frege von allen Seiten, ‚ob von den Nebensätzen gleichfalls gilt, daß Bedeutug ein Wahrheitswert sei.'

著者

野本 和幸

出版者

国際基督教大学キリスト教と文化研究所

雑誌

人文科学研究 : キリスト教と文化 : Christianity and culture (ISSN:00733938)

巻号頁・発行日

no.48, pp.55-101, 2016-12

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フレーゲは、第一に、「数とは何か」という問いに対し、自ら考案した記号言語により、史上初の高階述語論理の公理体系化を達成し、その論理的基礎から、数論全体を論理的に導出しようと試みた。第二に、その体系構成の「予備学」として、日常のドイツ語をいわば「メタ言語」に用い、当の記号言語自身の統語論についてのメタ的説明や、自らの論理的カテゴリー区分(対象と型つきの概念・関係)、意味論的区別(意味と意義等)を解明し、第三に、全欧規模で数学者・論理学者・哲学者と充実した誌上および書簡論争を行った。 以上の論理学・数学基礎論上の仕事に加え、フレーゲは意味と意義の区別をはじめ、現代の意味論・言語哲学の原型を与えた。

出版者

群馬県農業試験場

雑誌

群馬県農業試験場研究報告 (ISSN:13412019)

巻号頁・発行日

no.2, pp.5-8, 1995-03

著者

芳生 秀光

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.9, pp.1143-1156, 2010 (Released:2010-09-01)

参考文献数

77

被引用文献数

2 5

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Mercury and its organic compounds, especially methylmercury are extremely hazardous pollutants that have been released into the environment in substantial quantities by natural events and anthropogenic activities. Due to the acute toxicity of these contaminants, there is an urgent need to develop an effective and affordable technology to remove them from the environments. Recently, attempts have been made to utilize bacterial mer operon-mediated reduction and volatilization of mercurials for environmental remediation of mercury pollution. However, application of this technology to the treatment of mercury-contaminated environments has been limited by social concerns about the release of volatile mercury that will become part of the local mercury cycle and repollute the environment again, into the ambient air. To improve this environmental problem, a new mercury scavenging mechanism that could be expressed in living cells and accumulates mercury from contaminated site without releasing mercury vapor is necessitated. To construct a new biocatalyst that is capable of specifically accumulating mercury from contaminated sites without releasing mercury vapor, we have genetically engineered bacteria and tobacco plant for removal of mercury from wastewater and soils, respectively, to express a mercury transport system and organomercurial lyase enzyme simultaneously, and overexpress polyphosphate, a chelator of divalent metals. The applicability of these new engineered biocatalysts in the environmental remediation of mercurials is evaluated and discussed in this review.

著者

脇田浩二

出版者

地質調査所

雑誌

地域地質研究報告(5万分の1地質図幅)

巻号頁・発行日

1991

被引用文献数

5

著者

松丸 国照

出版者

日本古生物学会

雑誌

日本古生物学會報告・紀事 新編 (ISSN:00310204)

巻号頁・発行日

no.64, pp.338-"350-1", 1966-12-15

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舟伏山石灰岩から産出する紡錘虫化石は12属43種が鑑定され, そのうち1種が新種である。これらの紡錘虫化石は下位のParaschwagerina (Acervoschwagerina)亜帯から上位のYabeina igoi亜帯まで識別される。本地域の紡錘虫化石と青海, 赤坂, 伊吹山のそれとの対比を試みた。

著者

河田 茂磨

出版者

The Society of Inorganic Materials, Japan

雑誌

石膏と石灰 (ISSN:21854351)

巻号頁・発行日

vol.1958, no.36, pp.139-147, 1958

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Mt. Funafuse is located about 30 km north of the city of Gifu, from which city there is available a bus service to Kanzaki where the mountain stands. The dolomite deposit occurs together with limestone in all places, and the group of these strata is named the Funafuse-Yama limestone group, which is distributed over a long distance from east to west with Mt. Funafuse in the center. Accordingly, it is considered that the dolomite deposit occurs likewise from east to west. This report describes the result of the writer's field survey in the eastern part in the neighbourhood of Kanzaki, Konjima and Iwodo.<BR>Judging from the fossils of <I>Fusulinids</I>, the Funafuse-Yama limestone group probably ranges from middle to upper of the lower permian system. The main genera are <I>Pseudofusulina, Pseudodoliolina, Parafusulina, Neoschwagerina</I>, etc., constituting the three fossil zones at the least.<BR>The strike and dip of the group can hardly be measured in many places ; but the general trend of strike is N. to S. and the strata dip either to the east or to the west. The group is divided into several blocks by the faults running along the strike or across the dip, constituting a complicated geologial structure.<BR>The grade of ore from the group is higher in SiO<SUB>2</SUB> content than that from Kuzuu, Tochigi Pref. Since the group contains laminae of chert and schalstein, the workable high-grade portion is rather limited, which, is worth surveying from the mining point of view with respect to it's distribution because it contains MgO over 17 % and SiO<SUB>2</SUB> below 2 %. Therefore, the writer has been conducting it's distribution survey.<BR>As for the mineral itself, the writer tested the existence of clay minerals in the insoluble residue by means of X-ray diffraction and differential thermal analysis. The test disclosed that it is composed of combined quartz, illite, chlorite, etc. From this studies conducted up to now, the writer is of the opinion that the characteristics of the insoluble residue is more similar to those of the insoluble residue of mesozoic limestone than those of Chichibu palaeozoic occurring without dolomite in the Kanto mountain districts. The writer is now of the opinion that this difference in composition characterizes the basin in which the limestone and dolomite were deposited, rather than difference in age of deposition as was considered in the initial stage of this studies. Another point that strikes the writer is that the dolomite deposit is closely related with black limestone in most places. It is considered this limestone rich in organic matters indicates that it had some bearing on the expedition of dolomitization which is considered to be related with upgrading the MgO component.

著者

河田 茂磨

出版者

無機マテリアル学会

雑誌

石膏と石灰 (ISSN:21854351)

巻号頁・発行日

vol.1958, no.36, pp.139-147, 1958-09-01 (Released:2011-03-07)

参考文献数

3

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Mt. Funafuse is located about 30 km north of the city of Gifu, from which city there is available a bus service to Kanzaki where the mountain stands. The dolomite deposit occurs together with limestone in all places, and the group of these strata is named the Funafuse-Yama limestone group, which is distributed over a long distance from east to west with Mt. Funafuse in the center. Accordingly, it is considered that the dolomite deposit occurs likewise from east to west. This report describes the result of the writer's field survey in the eastern part in the neighbourhood of Kanzaki, Konjima and Iwodo.Judging from the fossils of Fusulinids, the Funafuse-Yama limestone group probably ranges from middle to upper of the lower permian system. The main genera are Pseudofusulina, Pseudodoliolina, Parafusulina, Neoschwagerina, etc., constituting the three fossil zones at the least.The strike and dip of the group can hardly be measured in many places ; but the general trend of strike is N. to S. and the strata dip either to the east or to the west. The group is divided into several blocks by the faults running along the strike or across the dip, constituting a complicated geologial structure.The grade of ore from the group is higher in SiO2 content than that from Kuzuu, Tochigi Pref. Since the group contains laminae of chert and schalstein, the workable high-grade portion is rather limited, which, is worth surveying from the mining point of view with respect to it's distribution because it contains MgO over 17 % and SiO2 below 2 %. Therefore, the writer has been conducting it's distribution survey.As for the mineral itself, the writer tested the existence of clay minerals in the insoluble residue by means of X-ray diffraction and differential thermal analysis. The test disclosed that it is composed of combined quartz, illite, chlorite, etc. From this studies conducted up to now, the writer is of the opinion that the characteristics of the insoluble residue is more similar to those of the insoluble residue of mesozoic limestone than those of Chichibu palaeozoic occurring without dolomite in the Kanto mountain districts. The writer is now of the opinion that this difference in composition characterizes the basin in which the limestone and dolomite were deposited, rather than difference in age of deposition as was considered in the initial stage of this studies. Another point that strikes the writer is that the dolomite deposit is closely related with black limestone in most places. It is considered this limestone rich in organic matters indicates that it had some bearing on the expedition of dolomitization which is considered to be related with upgrading the MgO component.