著者

So-Jeung MOON Ju-Won KIM Jung-Hyang SUR Soon-Wuk JEONG Hee-Myung PARK

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.12, pp.1677-1679, 2011 (Released:2012-01-06)

参考文献数

10

被引用文献数

1 4

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A 14-year-old Maltese dog presented for complete medical examination due to intermittent vomiting and diarrhea observed during the previous two days. A single, solitary, lobulated cystic mass was observed in the liver upon ultrasonographic and computed tomographic examination. After surgical hepatic resection to remove the mass, histological examination revealed a multilocular cyst lined by cuboidal to columnar epithelial cells, which is consistent with biliary cystadenoma. Here, we report the clinical, clinicopathological, histopathological, and diagnostic imaging findings of biliary cystadenoma in a dog.

著者

Atsushi TSUKAMOTO Koichi OHNO Shingo MAEDA Ko NAKASHIMA Kenjiro FUKUSHIMA Yasuhito FUJINO Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.12, pp.1635-1637, 2011 (Released:2012-01-06)

参考文献数

16

被引用文献数

3 13

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We assessed prokinetic action of gastroprokinetic agent, mosapride in dogs. Open-label cross-over study. Six healthy beagles were administered single oral mosapride at doses of 0.5, 0.75, 1, and 2 mg/kg 30 min prior to feeding, followed by 1-week interval. The motility index (MI) of gastric contraction was ultrasonographically evaluated by change rate of antral area and contraction number. Significant increases in MI were observed at doses of 0.75 mg/kg (mean ± SEM, 11.11 ± 0.19), 1 mg/kg (11.65 ± 0.34), and 2 mg/kg (12.04 ± 0.34), compared with that of the control (9.37 ± 0.51). Mosapride administration (2.0 mg/kg, BID) for 1 week had no adverse effects on blood tests or health of the animals. In conclusion, 0.75 to 2 mg/kg of mosapride produces gastric prokinetic actions without adverse effects.

著者

三瀧 英樹 伊藤 友一 三和 真人 日下部 明

出版者

日本腰痛学会

雑誌

日本腰痛学会雑誌 (ISSN:13459074)

巻号頁・発行日

vol.13, no.1, pp.136-143, 2007 (Released:2008-01-22)

参考文献数

18

被引用文献数

1 2

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本研究の目的は,屈曲弛緩現象(Flexion Relaxation Phenomenon; 以下FRP)が年代および測定部位に関係なく腰痛評価の一手段として使用できるかを明らかにすることである.対象は,健常若年群12名,慢性腰痛若年群6名および健常高齢群7名,慢性腰痛高齢群7名である.測定は,表面筋電計を用い,測定部位はL2およびL5レベルとした.FRP出現頻度は,年代別では慢性腰痛若年群より健常若年群が有意に高かったが,健常高齢群と慢性腰痛高齢群では差がなかった.また,測定部位ではL5よりL2でFRP出現頻度が高い傾向にあった.若年者はFRP出現の有無で客観的な腰痛評価が可能であり測定部位は上位腰椎が良いと考えられる.高齢者ではFRPの評価だけでは正しい評価ができないと思われる.

著者

Hidetaka Wakabayashi Hironobu Sashika

出版者

Japan Primary Care Association

雑誌

General Medicine (ISSN:13460072)

巻号頁・発行日

vol.12, no.2, pp.69-74, 2011 (Released:2011-12-28)

参考文献数

13

被引用文献数

19

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Background: To determine whether nutrition is associated with rehabilitation outcome in the disuse syndrome.Methods: A retrospective cohort study was performed in 223 inpatients admitted to a university hospital who were diagnosed by physicians in the rehabilitation department as having the disuse syndrome, and subsequently prescribed physical therapy. Malnutrition was defined as a body mass index<18.5 kg/m2, hemoglobin level<10.0 g/dl, serum albumin level<3.0 g/dl, or total lymphocyte count<1200 cells/mm3. Rehabilitation outcome was defined as whether or not the ADL score improved during rehabilitation. Nutritional status was assessed at referral using the Onodera's prognostic nutritional index (PNI).Results: The study cohort included 136 men and 87 women (mean age 67.5 years; median duration between admission and referral 17 days; median rehabilitation duration 32 days). A total of 202 patients (91%) were defined as being malnourished. Mean PNI was 32.9, with the ADL score improving in 135 patients (61%) during rehabilitation. Rehabilitation outcome was better in patients with normal nutrition compared to malnourished patients (relative risk: 0.72, p=0.04). Patients with a hemoglobin level>10.0 g/dl (relative risk: 0.69, p=0.001), total lymphocyte count>1200 cells/mm3 (relative risk: 0.78, p=0.03), or PNI>35.0 (relative risk: 0.74, p=0.01) had a better rehabilitation outcome. Logistic regression analysis showed that hemoglobin level was associated independently with rehabilitation outcome (odds ratio 2.34, p=0.005).Conclusions: Malnutrition is common in patients with the disuse syndrome. Patients with low hemoglobin level and PNI at referral are more likely to have a poor rehabilitation outcome.

著者

気賀 智也 浅井 正 水口 由紀子 村上 洋介 田中 伸史 冨谷 茂隆

出版者

一般社団法人 表面技術協会

雑誌

表面技術 (ISSN:09151869)

巻号頁・発行日

vol.59, no.4, pp.223-223, 2008 (Released:2008-10-28)

参考文献数

5

被引用文献数

1

著者

出口 弘

出版者

数理社会学会

雑誌

理論と方法 (ISSN:09131442)

巻号頁・発行日

vol.19, no.1, pp.67-86, 2004-03-31 (Released:2008-12-22)

参考文献数

26

被引用文献数

2 1

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本稿で我々は、エージェントベース社会システム科学の研究プログラムにひとつの数理的な基礎を与える、社会学習に関する動学的なモデルとその分岐構造を分析する。そのために代替案選択に関する非定常マルコフ過程を導入し、そこから社会学習動学(SLD)と呼ばれる動的システムを定式化する。SLDは、エージェントベースモデリングとそのシミュレーションに対する理論的枠組みを提供する。この力学系の平衡点を変化させるために境界条件を制御する間接制御に着目しSLDを規範の形成と崩壊のプロセスの分析に適用する。これはもともとR.アクセルロッドによって規範ゲームとメタ規範ゲームとして定式化されエージェントベースシミュレーションによって分析されたものである。本稿ではこれにSLDを用いた再定式化を与えたものを数理的に解析し、幾つかの性質を定理として明らかにする。これは結果として二次の社会的ジレンマ問題に対する一つの解を与える。

著者

Kin-ya Tomizaki Masaki Obi Hisakazu Mihara

出版者

The Chemical Society of Japan

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.85, no.1, pp.69-78, 2012-01-15 (Released:2012-01-15)

参考文献数

23

被引用文献数

2

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We propose a novel, noncompetitive, label-free, and on-chip immunoassay format based on the excluded volume effect by a target antibody that is itself bound to the corresponding epitope on a biochip. The advantage of the present method is that it only requires a biotin-tethering peptide epitope (capture agent) and fluorophore-labeled-avidin (a signal-generating agent) pair for signal readout. The method is based on the interaction between a nonlabeled target antibody and the corresponding peptide epitope of the antigen decelerating the association rate of the fluorophore-labeled avidin to the biotin moiety at the end of the peptide epitope due to the excluded volume effect of the target antibody. This causes significant changes in signal intensity. Without the target antibody, there is no interference in the binding of the signal-generating agent. The use of other specific interactions would allow fine-tuning of the excluded volume and binding rate to the capture agent to improve sensitivity and versatility.

著者

伊藤 弘顕 西川 久仁子 粟野 達也 細川 宗孝 矢澤 進

出版者

一般社団法人 園芸学会

雑誌

園芸学研究 (ISSN:13472658)

巻号頁・発行日

vol.9, no.1, pp.19-23, 2010 (Released:2010-01-26)

参考文献数

24

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乾膜質な花葉をもつ7種の植物種を用いて,細胞壁の形態を電子顕微鏡および偏光顕微鏡を用いて観察した.通常,花葉は一次細胞壁だけの柔細胞で構成される.しかし,少なくとも7種の植物種における乾膜質な花葉では,共通して組織すべての細胞がセルロース配向のある二次細胞壁を発達させていることが明らかとなった.また,二次細胞壁の肥厚形態は植物種によって様々であった.すなわちヘリクリサムなどキク科の植物は管状要素あるいは転送細胞のように網目状あるいは縞状に,センニチコウなどヒユ科の植物は繊維のように層状に,イソマツ科の植物であるスターチスは種皮の厚壁異型細胞のようにひだ状に,細胞壁を発達させていた.

著者

Ryohei KONO Yoshiharu OKUNO Ken-ichi INADA Akihiko TOKUDA Hiroshi HASHIZUME Munehito YOSHIDA Misa NAKAMURA Hirotoshi UTSUNOMIYA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.75, no.10, pp.1907-1911, 2011-10-23 (Released:2011-10-23)

参考文献数

35

被引用文献数

19

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Osteoporosis is a serious disease caused by decreased bone mass. There is constant matrix remodeling in bones, by which bone formation is performed by osteoblastic cells, whereas bone resorption is accomplished by osteoclast cells. We investigated the effect of a Japanese apricot (Prunus mume SIBE. et ZUCC.) extract on the proliferation and osteoblastic differentiation in pre-osteoblastic MC3T3-E1 cells. An alkaline phosphatase (ALP) activity assay, cell proliferation assay, alizarin red staining and expression analysis of osteoblastic genes were carried out to assess the proliferation and osteoblastic differentiation. The water-soluble fraction of Prunus mume (PWF) increased the ALP activity, cell proliferation and mineralization. The gene expression of osteopontin and bone morphogenetic protein-2, which are markers in the early period of osteoblastic differentiation, were significantly enhanced by the PWF treatment. PWF therefore stimulated the proliferation and osteoblastic differentiation of cells and may have potential to prevent osteoporosis.

著者

森 勇藏

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.75, no.1, pp.28, 2009-01-05 (Released:2010-11-30)

著者

Noriyuki NAGATA Masashi YUKI Takashi HASEGAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.73, no.12, pp.1585-1589, 2011 (Released:2012-01-06)

参考文献数

25

被引用文献数

10 18

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Intraocular pressure (IOP) evaluated by applanation tonometry via TONO-PEN XL (TP), and rebound tonometry via TonoVet (TV) were compared in enucleated canine eyes with varied pressure of the anterior chamber (AC) and in clinical cases. TV measured IOP values were lower than IOP measurements of TP in the enucleated eyes with 5-10 mmHg of AC (P<0.0001), though there was no significant difference in IOP values obtained with TP and TV on the pressure ranges of 15-20 mmHg. However, TP detected IOP values were lower than IOP measurements of TV in the eyes with over 25 mmHg of AC (P<0.0001). The results of clinical cases were similar to the enucleated eye model. There was no significant difference in IOP values obtained from TP and TV in dogs with normotensive eyes. IOP measurements of TP were lower than those of TV in glaucomatous eyes (P<0.0001). TV was a reliable tonometer for measurement of IOP in hypertensive eyes, whereas it was less accurate than TP in hypotensive eyes. The characteristics of TP and TV should be considered in the evaluation of IOP in practice.

著者

Lobna MKAOUAR Yoshifumi ENDO He XI JUN Soo-Jung LEE Tassanee JAROENSONG Manabu MOCHIZUKI Kazuyuki UCHIDA Hiroyuki NAKAYAMA Nobuo SASAKI Takayuki NAKAGAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1112250747, (Released:2012-01-05)

被引用文献数

4 5

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In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients were assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed a nuclear staining greater than 10%, while benign tumor and hyperplastic tissues showed nuclear staining less than 10%. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI, however no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.

著者

Miho TANAKA Akiko INOUE Kei YAMAMOTO Satoshi TAMAHARA Naoaki MATSUKI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1201050751, (Released:2012-01-10)

被引用文献数

3 5

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Necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE) and granulomatous meningoencephalomyelitis (GME) are common idiopathic inflammatory central nervous system (CNS) diseases with unknown etiology in dogs. We previously showed that IgG autoantibodies in the cerebrospinal fluid (CSF) of NME cases reacted to unknown brain proteins as well as to glial fibrillary acidic protein (GFAP). In the present report, we evaluated the autoantibodies against transglutaminase2 (TG2) in the canine CNS diseases. CSF samples obtained from dogs with NME (n=19), NLE (n=7), GME (n=11) and miscellaneous CNS diseases (n=12) were subjected. CSFs from 20 healthy dogs were used as controls. Indirect fluorescent antibody test on the canine cerebrum revealed astrocyte-binding IgG in the CSF of NME. After absorption of the CSF with bovine GFAP, the CSF still possessed the reactivity to astrocytes. Double-color staining showed clear colocalization of the autoantibodies and anti-human TG2 rabbit polyclonal IgG. An immunoblot assay against human recombinant TG2 revealed anti-TG2 IgG in the CSF from dogs with NME, NLE and GME. The CSF of canine idiopathic encephalitis cases, notably of NME, tended to show high ELISA OD values against human recombinant TG2 compared to healthy controls. The presence of anti-TG2 autoantibodies in the CSF may contribute to the elucidation of the etiology of canine NME, NLE and GME.

著者

大倉 一夫

出版者

日本顎口腔機能学会

雑誌

日本顎口腔機能学会雑誌 (ISSN:13409085)

巻号頁・発行日

vol.6, no.2, pp.139-145, 2000-08-31 (Released:2010-10-13)

参考文献数

28

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ブラキシズムは睡眠時の口腔習癖として古くから知られており, 歯周疾患, 歯の過度な咬耗, 顎機能障害などに影響を与えると考えられている.ブラキシズムを理解することは臨床的に重要であるが, 現在においてもブラキシズムの詳細については未解明の点が多い.本文の目的は睡眠時ブラキシズムを研究あるいは治療の対象とする際の問題点や方法論に関して, 当教室で行われたブラキシズムの研究を例として解説することにある.主に以下の項目について述べる.1.ブラキシズムとは何か?2.ブラキシズム測定上の問題点3.ブラキシズム解析上の問題点4.治療を考慮したブラキシズム把握法5.今後の展望

著者

Hiroyuki Tsutsumi Yoshifumi Kinoshita Takashi Sato Takashi Ishizu

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.59, no.8, pp.1008-1015, 2011-08-01 (Released:2011-08-01)

参考文献数

28

被引用文献数

12 13 5

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Crystals of the complexes of (+)-catechin (CA) of non-galloylated catechin and (−)-catechin-3-O-gallate (Cg) of galloylated catechin with caffeine were prepared, and their stereochemical structures and intermolecular interactions were determined by X-ray crystallographic analysis. CA formed a 1 : 1 complex with caffeine by intermolecular hydrogen bonds, whereas Cg formed a 1 : 2 complex with caffeine, which was formed by face-to-face and offset π–π interactions and intermolecular hydrogen bonds. A solution of two kinds of non-galloylated catechin, CA and (−)-epicatechin (EC), and caffeine (molar ratio 1 : 1 : 2) in water afforded a 1 : 1 : 2 complex, the crystal structure of which had two layers, one layer in which CA and caffeine formed alternate lines and an other layer in which EC and caffeine formed alternate lines. The 1 : 1 : 2 complex was formed by offset π–π and CH–π interactions and intermolecular hydrogen bonds.

著者

Takahiro KOMATSU Hidetomo IWANO Masashi EBISAWA Ai WATABE Yoshifumi ENDO Kazuko HIRAYAMA Hiroyuki TANIYAMA Tsuyoshi KADOSAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1201050749, (Released:2012-01-10)

被引用文献数

2 4

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Cytological diagnosis is not generally conclusive enough to identify histopathological malignancy in canine mammary tumors (CMTs). To establish cytological examination using fine needle biopsy (FNB) samples, gene expressions of hormonal receptors, human epidermal growth factor receptor 2 (HER2), and transcription regulators (Special AT-rich binding protein 1: SATB1 and Snail) were investigated in both tissue and FNB samples of CMTs. In tissue samples of malignant CMTs, especially invasive ones, low expressions of hormonal receptors and high expressions of SATB1 and Snail were detected. On discriminant analysis of tissue samples, 73.2% of CMTs were correctly classified according to histopathological examinations. In FNB samples of malignant CMTs, low expressions of hormonal receptors were detected. On discriminant analysis of FNB samples, 74.2% of CMTs were correctly classified according to histopathological examination. In conclusion, FNB gene expressions had a utility for diagnosis of CMTs malignancy in some degree. By researching more sensitive genes for malignant CMTs, the gene examination of FNB samples from CMTs will become a useful diagnostic tool that can be performed easily without anesthesia and could predict tumor malignancy and invasion prior to surgical removal.

著者

榎本 有希 六車 崇 久保田 雅也 中川 聡

出版者

一般社団法人 日本救急医学会

雑誌

日本救急医学会雑誌 (ISSN:0915924X)

巻号頁・発行日

vol.21, no.10, pp.828-834, 2010-10-15 (Released:2010-12-04)

参考文献数

11

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目的:小児二相性脳症の臨床経過とその特徴を明らかにし,二相目の発症前における単相性脳症との鑑別の可能性について検討する。対象・方法:2007年4月から2009年8月の間に国立成育医療研究センター集中治療室に痙攣・意識障害で入室した患者について,診療録を後方視的に検討した。単相性脳症群26例と,てんかん・熱性痙攣群 10例を対照群として,第3病日までのlactate dehydrogenase(LDH),fibrin/fibrinogen degradation products(FDP),Dダイマーの最大値を各群間で比較した。結果:脳症と診断された患者は36症例で,そのうち二相性脳症は10例(28%)であった。痙攣重積で発症した脳症22症例中,二相性脳症は8例(36%)で,一相目の痙攣が重積した症例が8例,重積しなかった症例が2例だった。二相目発症の中央値は第5病日(最小第4病日-最大第8病日)だった。ステロイドパルス療法,低体温療法,頭蓋内圧センサー挿入下の脳圧管理などが施行された。10症例中2例で一相目から積極的な治療を施行したが,二相目の発症を予防できなかった。転帰は全例生存で,後遺症なし 1例,軽度の神経障害 5例,重度神経障害 4例であった。 LDHの最大値はてんかん・熱性痙攣と単相性脳症,二相性脳症との間で有意差がみられた(p=0.017,0.002)。FDP,Dダイマーの最大値はてんかん・熱性痙攣と二相性脳症との間に有意差がみられた( p=0.018,p=0.033)が,いずれのマーカーも単相性脳症と二相性脳症の間に有意差は認められなかった。結語:小児では痙攣後,一過性の症状改善の後に再度痙攣や意識障害を来す転帰不良な疾患群が存在する。発生頻度が少なくないにもかかわらず,その発症予測は現時点では不可能である。小児の痙攣後には神経学的症状が軽度であっても二相目発症の可能性を視野に入れた管理が必要である。

著者

In-sok Hwang Juneyoung Lee Dong Gun Lee

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.10, pp.1602-1608, 2011-10-01 (Released:2011-10-01)

参考文献数

36

被引用文献数

8 13

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Cruciferous vegetables contain glucobrassicin which, during metabolism, yields indole-3-carbinol (I3C). The aim of this study was to find whether indole-3-carbinol caused apoptosis and its mechanism in Candida albicans. We found that treatment of Candida albicans with indole-3-carbinol significantly increased the reactive oxygen species and hydroxyl radical accumulation. The hydroxyl radical is one of the most active components of oxygen, and it is the end product of an oxidative damage cellular death pathway. We investigated the general phenotypes of apoptosis and then investigated whether there were other distinct markers of apoptosis. Furthermore, the effects of thiourea as a hydroxyl radical scavenger and protective effect of trehalose, which is the result of the fungal immune system, was also assured. This study indicates that indole-3-carbinol has apoptosis effects, including a production of hydroxyl radicals, cytochrome c release and activation of metacaspase. Both hydroxyl radicals and metacaspases triggered apoptosis in Candida albicans.

著者

内山 郁夫

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.42, no.6, pp.266-269, 2002 (Released:2002-11-23)

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MBGD is a database system for making use of rapidly accumulating microbial genome sequences through comparative analysis. The basic function of MBGD is to create an orthologous gene classification table, which comprises sets of "equivalent" genes among multiple genomes. In MBGD, classification tables can be created on demand with specified set of organisms and parameters. This feature becomes important to understand diversity of genomes using almost a hundred genome sequences now available.

著者

Nobuo Nyui Osamu Yamanaka Riichiro Nakayama Masato Sawano Sachio Kawai

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.64, no.9, pp.715-719, 2000 (Released:2001-05-31)

参考文献数

24

被引用文献数

31 32

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During admission for investigation of dysphagia, an 82-year-old woman suddenly complained of dyspnea, which was followed by cardiogenic shock. Her symptoms, electrocardiogram, echocardiogram and laboratory data were compatible with an extensive acute anterior myocardial infarction. Emergency cardiac catheterization showed no atheromatous narrowing in any coronary artery. However, the contractions of the left and right ventricles were diffusely and severely impaired, except for some hyperkinesis of the basal area. The asynergy, as well as the abnormalities on the ECG, improved almost to normal by the 35th hospital day. An endomyocardial biopsy from the right ventricle during the acute phase showed atypical myocardial damage with proliferation of fine collagen fibers and small round-cell infiltration including polymorphologic leukocytes. This type of transient cardiac disorder has recently been described in Japan, and is called ‘Tako-tsubo cardiomyopathy’ because of the characteristic appearance of the left ventricular asynergy. In the present case, ventricular asynergy was not limited to the left ventricle, but was also present in the right ventricle.